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Review

Recent advances in the field of tubulin polymerization inhibitors

Pages 695-708 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Jie Zhou, Yi Zhang, Yi-Wen Cui, Zhan-Mei Li, Hong-Rui Song, Jin-Hua Dong, Xiao-Guang Chen & Bai-Ling Xu. (2011) Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastatin A-4. Journal of Asian Natural Products Research 13:4, pages 330-340.
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Articles from other publishers (37)

Jian Song, Yong-Feng Guan, Wen-Bo Liu, Chun-Hong Song, Xin-Yi Tian, Ting Zhu, Xiang-Jing Fu, Ying-Qiu Qi & Sai-Yang Zhang. (2022) Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities. European Journal of Medicinal Chemistry 238, pages 114467.
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Ashima Dhiman, Rupam Sharma & Rajesh K. Singh. (2022) Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021). Acta Pharmaceutica Sinica B 12:7, pages 3006-3027.
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Godshelp O. Egharevba, Ahmed Kamal, Omotayo O. Dosumu, Sunitha Routhu, Olatomide A. Fadare, Stephen O. Oguntoye, Stanislaus N. Njinga & Abimbola P. Oluyori. (2022) Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies. Scientific Reports 12:1.
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Lufeng Zheng, Ren Ren, Xiaolian Sun, Yunting Zou, Yiru Shi, Bin Di & Miao-Miao Niu. (2021) Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation. Journal of Medicinal Chemistry 64:21, pages 15702-15715.
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Kunalika Jain, Jashaswi Basu, Megha Roy, Jyoti Yadav, Shivprasad Patil & Chaitanya A. Athale. (2022) Polymerization kinetics of tubulin from mung seedlings modeled as a competition between nucleation and GTP‐hydrolysis rates. Cytoskeleton 78:9, pages 436-447.
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Neha V. Bhilare, Pratibha B. Auti, Vinayak S. Marulkar & Vilas J. Pise. (2021) Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review. Mini-Reviews in Medicinal Chemistry 21:2, pages 217-232.
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Yunjiang Zhou, Bin Di & Miao-Miao Niu. (2019) Structure-Based Pharmacophore Design and Virtual Screening for Novel Tubulin Inhibitors with Potential Anticancer Activity. Molecules 24:17, pages 3181.
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Vijay K. Patel, Avineesh Singh, Deepak K. Jain, Preeti Patel, Ravichandran Veerasamy, Prabodh C. Sharma & Harish Rajak. (2017) Combretastatin A-4 based thiophene derivatives as antitumor agent: Development of structure activity correlation model using 3D-QSAR, pharmacophore and docking studies. Future Journal of Pharmaceutical Sciences 3:2, pages 71-78.
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LING HUI, CHUNYAN SANG, DONGHONG WANG, XIAOHUI WANG, MEILIANG WANG, QINGHUA JIA, MINGREN MA & SHIWU CHEN. (2016) Newly synthesized podophyllotoxin derivative, LJ12, induces apoptosis and mitotic catastrophe in non-small cell lung cancer cells in vitro. Molecular Medicine Reports 13:1, pages 339-346.
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Ram C. Mishra, Sushma R. Gundala, Prasanthi Karna, Manu Lopus, Kamlesh K. Gupta, Mulpuri Nagaraju, Donald Hamelberg, Vibha Tandon, Dulal Panda, Michelle D. Reid & Ritu Aneja. (2015) Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents. Bioorganic & Medicinal Chemistry Letters 25:10, pages 2133-2140.
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Ahmed Kamal, N.V. Subba Reddy, V. Lakshma Nayak, Narasimha Rao Bolla, A.V. Subba Rao & B. Prasad. (2014) Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. Bioorganic & Medicinal Chemistry 22:13, pages 3465-3477.
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Ahmed Kamal, N. V. Subba Reddy, V. Lakshma Nayak, V. Saidi Reddy, B. Prasad, Vijaykumar D. Nimbarte, Vunnam Srinivasulu, M. V. P. S. Vishnuvardhan & C. Suresh Reddy. (2013) Synthesis and Biological Evaluation of Benzo[ b ]furans as Inhibitors of Tubulin Polymerization and Inducers of Apoptosis . ChemMedChem 9:1, pages 117-128.
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M. V. Ramana Reddy, Muralidhar R. Mallireddigari, Venkat R. Pallela, Stephen C. Cosenza, Vinay K. Billa, Balaiah Akula, D. R. C. Venkata Subbaiah, E. Vijaya Bharathi, Amol Padgaonkar, Hua Lv, James M. Gallo & E. Premkumar Reddy. (2013) Design, Synthesis, and Biological Evaluation of ( E )- N -Aryl-2-arylethenesulfonamide Analogues as Potent and Orally Bioavailable Microtubule-Targeted Anticancer Agents . Journal of Medicinal Chemistry 56:13, pages 5562-5586.
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Etienne Brachet, Abdallah Hamze, Jean-François Peyrat, Jean-Daniel Brion & Mouad Alami. (2010) Pd-Catalyzed Reaction of Sterically Hindered Hydrazones with Aryl Halides: Synthesis of Tetra-Substituted Olefins Related to iso -Combretastatin A4 . Organic Letters 12:18, pages 4042-4045.
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Jia-Kun Shen, Hua-ping Du, Min Yang, Yun-Gui Wang & Jie Jin. (2009) Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Annals of Hematology 88:8, pages 743-752.
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Jing Chen, Xiaowu Dong, Tao Liu, Jianshu Lou, Chaoyi Jiang, Wenhai Huang, Qiaojun He, Bo Yang & Yongzhou Hu. (2009) Design, synthesis, and quantitative structure–activity relationship of cytotoxic γ-carboline derivatives. Bioorganic & Medicinal Chemistry 17:9, pages 3324-3331.
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K.- H. Altmann, G. Höfle, R. Müller, J. Mulzer & K. PrantzKarl-Heinz Altmann. 2009. The Epothilones: An Outstanding Family of Anti-Tumor Agents. The Epothilones: An Outstanding Family of Anti-Tumor Agents 157 220 .
Zhenglai FangYunlong SongTaradas SarkarErnest HamelWilliam E. FoglerGregory E. AgostonPhillip E. FanwickMark Cushman. (2008) Stereoselective Synthesis of 3,3-Diarylacrylonitriles as Tubulin Polymerization Inhibitors. The Journal of Organic Chemistry 73:11, pages 4241-4244.
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Carolyn A. Moores & Ronald A. Milligan. (2008) Visualisation of a Kinesin-13 Motor on Microtubule End Mimics. Journal of Molecular Biology 377:3, pages 647-654.
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Karl-Heinz Altmann & Klaus Memmert. 2008. Natural Compounds as Drugs. Natural Compounds as Drugs 273 334 .
Maurizio Botta, Stefano Forli, Matteo Magnani & Fabrizio Manetti. 2009. Tubulin-Binding Agents. Tubulin-Binding Agents 279 328 .
Anne Zuse, Helge Prinz, Klaus Müller, Peter Schmidt, Eckhard G. Günther, Frank Schweizer, Jochen H.M. Prehn & Marek Los. (2007) 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity. European Journal of Pharmacology 575:1-3, pages 34-45.
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Venusia Gasparotto, Ignazio Castagliuolo & Maria Grazia Ferlin. (2007) 3-Substituted 7-Phenyl-Pyrroloquinolinones Show Potent Cytotoxic Activity in Human Cancer Cell Lines. Journal of Medicinal Chemistry 50:22, pages 5509-5513.
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Andrea Brancale & Romano Silvestri. (2006) Indole, a core nucleus for potent inhibitors of tubulin polymerization. Medicinal Research Reviews 27:2, pages 209-238.
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Karl-Heinz Altmann & Jürg Gertsch. (2007) Anticancer drugs from nature—natural products as a unique source of new microtubule-stabilizing agents. Nat. Prod. Rep. 24:2, pages 327-357.
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Jing‐Ping Liou, Neeraj Mahindroo, Chun‐Wei Chang, Fu‐Ming Guo, Sandy Wen‐Hsing Lee, Uan‐Kang Tan, Teng‐Kuang Yeh, Ching‐Chuan Kuo, Yi‐Wei Chang, Ping‐Hsun Lu, Yen‐Shih Tung, Ke‐Ta Lin, Jang‐Yang Chang & Hsing‐Pang Hsieh. (2006) Structure–Activity Relationship Studies of 3‐Aroylindoles as Potent Antimitotic Agents. ChemMedChem 1:10, pages 1106-1118.
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Laixing Hu, Zhuo-rong Li, Yan Li, Jinrong Qu, Yi-He Ling, Jian-dong Jiang & David W. Boykin. (2006) Synthesis and Structure−Activity Relationships of Carbazole Sulfonamides as a Novel Class of Antimitotic Agents Against Solid Tumors. Journal of Medicinal Chemistry 49:21, pages 6273-6282.
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Gurmeet KaurMelinda HollingsheadSusan HolbeckVesna Schauer-Vukašinović, Richard F. CamalierAlexander Dömling & Seema Agarwal. (2006) Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochemical Journal 396:2, pages 235-242.
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Simon Moroney & Andreas Plückthun. 2005. Modern Biopharmaceuticals. Modern Biopharmaceuticals 1147 1186 .
Gillian M. Tozer, Chryso Kanthou & Bruce C. Baguley. (2005) Disrupting tumour blood vessels. Nature Reviews Cancer 5:6, pages 423-435.
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Gabriella De Martino, Giuseppe La Regina, Antonio Coluccia, Michael C. Edler, Maria Chiara Barbera, Andrea Brancale, Elizabeth Wilcox, Ernest Hamel, Marino Artico & Romano Silvestri. (2004) Arylthioindoles, Potent Inhibitors of Tubulin Polymerization. Journal of Medicinal Chemistry 47:25, pages 6120-6123.
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Matthias Gerlach, Eckhard Claus, Silke Baasner, Gilbert Müller, Emmanuel Polymeropoulos, Peter Schmidt, Eckhard Günther & Jürgen Engel. (2004) Design and Synthesis of a Focused Library of Novel Aryl‐ and Heteroaryl‐Ketopiperazides. Archiv der Pharmazie 337:12, pages 695-703.
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Jian Song, Ting Zhu, Yong-Feng Guan, Chun-Hong Song, Xin-Yi Tian, Hong-Li Li, Yan Zhang, Xiang-Jing Fu & Sai-Yang Zhang. (2022) Discovery of Novel Coumarin-Indole Derivatives  As Tubulin Polymerization Inhibitors with Potent Anti-Gastric Cancer Activities. SSRN Electronic Journal.
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