Advanced search
Publication Cover
Expert Review of Anticancer Therapy Volume 4, 2004 - Issue 4
Submit an article Journal homepage
132
Views
43
CrossRef citations to date
0
Altmetric
Review

Role of TGF-β in cancer and the potential for therapy and prevention

Virginia G Kaklamani Northwestern University Feinberg School of Medicine, Division of Hematology/Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, 676 N. St Clair Street, Suite 880, Chicago, IL 60611, USA. [email protected]
&
Boris Pasche Northwestern University Feinberg School of Medicine, Division of Hematology/Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, 676 N. St Clair Street, Suite 880, Chicago, IL 60611, USA. [email protected]
Pages 649-661 | Published online: 10 Jan 2014

Citations (43)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Haihong Hu, Taolan Zhang, Yiwen Wu, Meina Deng, Huiling Deng & Xiaoyan Yang. (2022) Cross-regulation between microRNAs and key proteins of signaling pathways in hepatocellular carcinoma. Expert Review of Gastroenterology & Hepatology 16:8, pages 753-765.
Read now

Articles from other publishers (42)

Monu Kumar Kashyap, Akash Ved, Rajiv Ratan Singh Yadav, Akhand Pratap Singh, Mahima Kushwaha & Karuna S. Shukla. (2023) The Cell Death and Signal Transduction Mechanisms in Colorectal Carcinogenesis: Recent Advances. Anti-Cancer Agents in Medicinal Chemistry 23:12, pages 1361-1375.
Crossref
Zaoqu Liu, Meixin Shi, Yuqing Ren, Hui Xu, Siyuan Weng, Wenjing Ning, Xiaoyong Ge, Long Liu, Chunguang Guo, Mengjie Duo, Lifeng Li, Jing Li & Xinwei Han. (2023) Recent advances and applications of CRISPR-Cas9 in cancer immunotherapy. Molecular Cancer 22:1.
Crossref
Gabriela Fernanda Mora & Mariana Rodríguez Zubieta. (2021) Galectin-1 and Galectin-3 Expression in Lesional Skin of Patients With Systemic Sclerosis—Association With Disease Severity. JCR: Journal of Clinical Rheumatology 27:8, pages 317-323.
Crossref
Richard J. Lightbody, Janice M.W. Taylor, Yvonne Dempsie & Annette Graham. (2021) Induction of microRNA hsa-let-7d-5p, and repression of HMGA2, contribute protection against lipid accumulation in macrophage ‘foam’ cells. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866:11, pages 159005.
Crossref
Lukman O Afolabi, Mariam O Afolabi, Musbahu M Sani, Wahab O Okunowo, Dehong Yan, Liang Chen, Yaou Zhang & Xiaochun Wan. (2021) Exploiting the CRISPR‐Cas9 gene‐editing system for human cancers and immunotherapy. Clinical & Translational Immunology 10:6.
Crossref
Pandurangan Ashokkumar, Thomas Divya, Kalaivani Kumar, Vadivel Dineshbabu, Bakthavatchalam Velavan & Ganapasam Sudhandiran. (2018) Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review. World Journal of Gastrointestinal Oncology 10:9, pages 244-259.
Crossref
Ruijuan Hao, Zhe Zheng, Xiaodong Du, Qingheng Wang, Junhui Li, Yuewen Deng & Weiyao Chen. (2018) Molecular cloning and characteristics analysis of Pmtgfbr1 from Pinctada fucata martensii. Biotechnology Reports 19, pages e00262.
Crossref
Kamil Torres, Łukasz Pietrzyk, Zbigniew Plewa, Karolina Załuska-Patel, Mariusz Majewski, Elżbieta Radzikowska & Anna Torres. (2018) TGF-β and inflammatory blood markers in prediction of intraperitoneal adhesions. Advances in Medical Sciences 63:2, pages 220-223.
Crossref
Ye Tao, Erich M. Sturgis, Zhigang Huang, Ying Wang, Peng Wei, Jennifer Rui Wang, Qingyi Wei & Guojun Li. (2018) TGFβ1 Genetic Variants Predict Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy . Clinical Cancer Research 24:9, pages 2225-2233.
Crossref
Hala Fawzy Mohamed Kamel & Hiba Saeed A. Bagader Al-Amodi. (2017) Exploitation of Gene Expression and Cancer Biomarkers in Paving the Path to Era of Personalized Medicine. Genomics, Proteomics & Bioinformatics 15:4, pages 220-235.
Crossref
Simone Mocellin, Daunia Verdi, Karen A Pooley & Donato Nitti. (2015) Genetic variation and gastric cancer risk: a field synopsis and meta-analysis. Gut 64:8, pages 1209-1219.
Crossref
Lu-Kai Wang, Tzu-Hung Hsiao, Tse-Ming Hong, Hsuan-Yu Chen, Shih-Han Kao, Wen-Lung Wang, Sung-Liang Yu, Ching-Wen Lin & Pan-Chyr Yang. (2014) MicroRNA-133a Suppresses Multiple Oncogenic Membrane Receptors and Cell Invasion in Non-Small Cell Lung Carcinoma. PLoS ONE 9:5, pages e96765.
Crossref
Humam Kadara, Junya Fujimoto, Suk-Young Yoo, Yuho Maki, Adam C. Gower, Mohamed Kabbout, Melinda M. Garcia, Chi-Wan Chow, Zuoming Chu, Gabriella Mendoza, Li Shen, Neda Kalhor, Waun Ki Hong, Cesar Moran, Jing Wang, Avrum Spira, Kevin R. Coombes & Ignacio I. Wistuba. (2014) Transcriptomic Architecture of the Adjacent Airway Field Cancerization in Non–Small Cell Lung Cancer. JNCI: Journal of the National Cancer Institute 106:3.
Crossref
Tokunbo Yerokun, Tamra Neblett & Chénel Johnson. (2014) Molecular Profile of Human Serine Palmitoyltransferase-1 Proximate of Chromosome 9 Disease Susceptibility Gene Cluster in Inflammatory Cancer Cell Lines. Journal of Cancer Therapy 05:10, pages 885-901.
Crossref
Daniel Völler, Corinna Ott & Anja Bosserhoff. (2013) MicroRNAs in malignant melanoma. Clinical Biochemistry 46:10-11, pages 909-917.
Crossref
Hao Yang, Feng Fang, Ruimin Chang & Lianyue Yang. (2013) MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma. Hepatology 58:1, pages 205-217.
Crossref
Hongtuan Zhang, Hui Ma, Yong Xu & Liang Li. (2013) Association of SMAD7 rs12953717 Polymorphism with Cancer: A Meta-Analysis. PLoS ONE 8:3, pages e58170.
Crossref
Huihui Guo, Zhenmin Bao, Jiqin Li, Shanshan Lian, Shi Wang, Yan He, Xiaoteng Fu, Lingling Zhang & Xiaoli Hu. (2012) Molecular Characterization of TGF-β Type I Receptor Gene (Tgfbr1) in Chlamys farreri, and the Association of Allelic Variants with Growth Traits. PLoS ONE 7:11, pages e51005.
Crossref
Xueli Zhang, Liang Wu, Youhua Sheng, Wenhua Zhou, Zhongming Huang, Jun Qu, Ganglong Gao, Duan Cai & Ming Zhang. (2011) The association of polymorphisms on TGFBR1 and colorectal cancer risk: a meta-analysis. Molecular Biology Reports 39:3, pages 2567-2574.
Crossref
Xin Li, Xue-xi Yang, Ni-ya Hu, Jing-zhe Sun, Fen-xia Li & Ming Li. (2011) A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population. Molecular Biology Reports 38:8, pages 5093-5097.
Crossref
David R Goudie, Mariella D'Alessandro, Barry Merriman, Hane Lee, Ildikó Szeverényi, Stuart Avery, Brian D O'Connor, Stanley F Nelson, Stephanie E Coats, Arlene Stewart, Lesley Christie, Gabriella Pichert, Jean Friedel, Ian Hayes, Nigel Burrows, Sean Whittaker, Anne-Marie Gerdes, Sigurd Broesby-Olsen, Malcolm A Ferguson-Smith, Chandra Verma, Declan P Lunny, Bruno Reversade & E Birgitte Lane. (2011) Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nature Genetics 43:4, pages 365-369.
Crossref
Jae Hwi Song, Hwa Sung Lee, Jung Hwan Yoon, Young Hwi Kang, Suk Woo Nam, Jung Young Lee & Won Sang Park. (2010) TGFBR2 frameshift mutation in gastric tumors with microsatellite instability. Molecular & Cellular Toxicology 6:3, pages 321-326.
Crossref
A L Teixeira, R Ribeiro, A Morais, F Lobo, A Fraga, F Pina, F M Calais-da-Silva, F E Calais-da-Silva & R Medeiros. (2009) Combined analysis of EGF+61G>A and TGFB1+869T>C functional polymorphisms in the time to androgen independence and prostate cancer susceptibility. The Pharmacogenomics Journal 9:5, pages 341-346.
Crossref
Mehran Gholamin, Omeed Moaven, Bahram Memar, Moein Farshchian, Hossein Naseh, Reza Malekzadeh, Masoud Sotoudeh, Mohammad Taghi Rajabi-Mashhadi, Mohammad Naser Forghani, Farid Farrokhi & Mohammad Reza Abbaszadegan. (2009) Overexpression and Interactions of Interleukin-10, Transforming Growth Factor β, and Vascular Endothelial Growth Factor in Esophageal Squamous Cell Carcinoma. World Journal of Surgery 33:7, pages 1439-1445.
Crossref
Marie Lundberg, Mervi Pajusto, Walter J. Koskinen, Antti A. Mäkitie, Leena‐Maija Aaltonen & Petri S. Mattila. (2009) Association between transforming growth factor β1 genetic polymorphism and response to chemoradiotherapy in head and neck squamous cell cancer. Head & Neck 31:5, pages 664-672.
Crossref
Anthony R. Calabro, Roula Konsoula & Frank A. Barile. (2008) Evaluation of in vitro cytotoxicity and paracellular permeability of intact monolayers with mouse embryonic stem cells. Toxicology in Vitro 22:5, pages 1273-1284.
Crossref
Xiaodi Chen, Richard B. Halberg, Ryan P. Burch & William F. Dove. (2008) Intestinal adenomagenesis involves core molecular signatures of the epithelial–mesenchymal transition. Journal of Molecular Histology 39:3, pages 283-294.
Crossref
Gustavo C. Rodriguez, B.J. Rimel, William Watkin, Jane M. Turbov, Cathy Barry, Hongyan Du, George L. Maxwell & J.M. Cline. (2008) Progestin Treatment Induces Apoptosis and Modulates Transforming Growth Factor-β in the Uterine Endometrium. Cancer Epidemiology, Biomarkers & Prevention 17:3, pages 578-584.
Crossref
Keun-Sook KimHye Seung JungYun Jae ChungTae Sik JungHye Won JangMyung-Shik LeeKwang-Won KimJae Hoon Chung. (2008) Overexpression of USF Increases TGF-β1 Protein Levels, But G1 Phase Arrest was not Induced in FRTL-5 Cells. Journal of Korean Medical Science 23:5, pages 870.
Crossref
Olav Gressner & Tilman Saurbruch. (2008) Embryonal Rhabdomyosarcoma Secondary to an Open Fracture of the Tibia: A Case Report and Review of Literature. Southern Medical Journal 101:1, pages 99-101.
Crossref
Nancy L. McCartney-Francis & Sharon M. Wahl. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume II. Transforming Growth Factor-β in Cancer Therapy, Volume II 553 570 .
Patrick Micke, Aristidis Moustakas, Mitsuhiro Ohshima & Kai Kappert. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume II. Transforming Growth Factor-β in Cancer Therapy, Volume II 417 441 .
Yun-Kyoung Lee, Jin-Taek Hwang, Young-Min Kim & Ock-Jin Park. (2007) Cell Survival, Apoptosis and AMPK-COX-2 Signaling Pathway of Mammary Tumor Cells after Genistein Treatment Combined with Estrogen. Preventive Nutrition and Food Science 12:4, pages 197-201.
Crossref
B Song, S Margolin, J Skoglund, X Zhou, J Rantala, S Picelli, B Werelius & A Lindblom. (2007) TGFBR1*6A and Int7G24A variants of transforming growth factor-β receptor 1 in Swedish familial and sporadic breast cancer. British Journal of Cancer 97:8, pages 1175-1179.
Crossref
Walter J.A. Brokelman, Lena Holmdahl, Maria Bergström, Peter Falk, Jean H.G. Klinkonbijl & Michael M.P.J. Reijnen. (2007) Peritoneal transforming growth factor beta-1 expression during laparoscopic surgery: a clinical trial. Surgical Endoscopy 21:9, pages 1537-1541.
Crossref
Cecilia M. Daroqui, Juan M. Ilarregui, Natalia Rubinstein, Mariana Salatino, Marta A. Toscano, Paula Vazquez, Andrei Bakin, Lydia Puricelli, Elisa Bal de Kier Joffé & Gabriel A. Rabinovich. (2006) Regulation of galectin-1 expression by transforming growth factor β1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape. Cancer Immunology, Immunotherapy 56:4, pages 491-499.
Crossref
T.K. Sawyer. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 959 992 .
Lin Yang, Hector Avila, Heng Wang, Jose Trevino, Gary E. Gallick, Yasuhiko Kitadai, Takamitsu Sasaki & Douglas D. Boyd. (2006) Plasticity in Urokinase-Type Plasminogen Activator Receptor (uPAR) Display in Colon Cancer Yields Metastable Subpopulations Oscillating in Cell Surface uPAR Density—Implications in Tumor Progression. Cancer Research 66:16, pages 7957-7967.
Crossref
Changyi QuanMoon-Seon ParkSung-Whan JoSang-Cheol LeeWun-Jae Kim. (2006) Effects of Transforming Growth Factor-β1 and Its Receptor on the Development, Recurrence and Progression of Human Bladder Cancer. Korean Journal of Urology 47:4, pages 426.
Crossref
Xian Luo, James M. Slater & Daila S. Gridley. (2005) Enhancement of radiation effects by pXLG-mEndo in a lung carcinoma model. International Journal of Radiation Oncology*Biology*Physics 63:2, pages 553-564.
Crossref
Thomas B. Thompson, Thomas F. Lerch, Robert W. Cook, Teresa K. Woodruff & Theodore S. Jardetzky. (2005) The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding. Developmental Cell 9:4, pages 535-543.
Crossref
John J Letterio. (2005) TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia. Oncogene 24:37, pages 5701-5712.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.