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Review

Targeting the PI3K–Akt pathway in kidney cancer

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Pages 863-870 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Jongsung Lee & See-Hyoung Park. (2016) Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3. Bioscience, Biotechnology, and Biochemistry 80:10, pages 1947-1953.
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Martina Hager, Heike Haufe, Lukas Lusuardi, Nikolaus Schmeller & Christian Kolbitsch. (2011) PTEN, pAKT, and pmTOR Expression and Subcellular Distribution in Primary Renal Cell Carcinomas and Their Metastases. Cancer Investigation 29:7, pages 427-438.
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Alessio Giubellino, W Marston Linehan & Donald P Bottaro. (2009) Targeting the Met signaling pathway in renal cancer. Expert Review of Anticancer Therapy 9:6, pages 785-793.
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Dominique A Glauser & Werner Schlegel. (2008) FoxO proteins in pancreatic β-cells as potential therapeutic targets in diabetes. Expert Review of Endocrinology & Metabolism 3:2, pages 175-185.
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Articles from other publishers (15)

Renhua Gai, Chao Chen, Wei Zhang, Jian Ma, Xiaomeng Wang, Xiaoqing Chi & Guangxing Li. (2023) Safety and Toxicology Study of Hu7691, a Novel AKT Inhibitor, following Oral Administration in Rats. Toxics 11:11, pages 880.
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Dumitru A. Iacobas, Victoria E. Mgbemena, Sanda Iacobas, Kareena M. Menezes, Huichen Wang & Premkumar B. Saganti. (2020) Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach. Cancers 12:12, pages 3678.
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Fei Wang, Yulian Ding, Xiujuan Lei, Bo Liao & Fangxiang Wu. (2020) Identifying gene signatures for cancer drug repositioning based on sample clustering. IEEE/ACM Transactions on Computational Biology and Bioinformatics, pages 1-1.
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A. L. Kaysheva, A. T. Kopylov, N. E. Kushlinskii, E. S. Gershtein, A. A. Alferov, A. A. Morozov, I. A. Kazantseva, T. O. Pleshakova, A. I. Archakov & Yu. D. Ivanov. (2019) Comparative Analysis of Blood Plasma Proteome in Patients with Renal Cell Carcinoma. Bulletin of Experimental Biology and Medicine 167:1, pages 91-96.
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Robert H. Weiss. (2018) Metabolomics and Metabolic Reprogramming in Kidney Cancer. Seminars in Nephrology 38:2, pages 175-182.
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Hiromi I. Wettersten, Omran Abu Aboud, Primo N. LaraJrJr & Robert H. Weiss. (2017) Metabolic reprogramming in clear cell renal cell carcinoma. Nature Reviews Nephrology 13:7, pages 410-419.
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Y Chen, C Li, H Xie, Y Fan, Z Yang, J Ma, D He & L Li. (2017) Infiltrating mast cells promote renal cell carcinoma angiogenesis by modulating PI3K→AKT→GSK3β→AM signaling. Oncogene 36:20, pages 2879-2888.
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Xingtao Han, Jinjian Yang, Zhankui Jia, Pengtao Wei, Han Zhang, Wenwei Lv, Jiantao Sun & Qingxiang Huo. (2017) Knockdown of Serine‐Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25:3, pages 389-395.
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Kristopher R. Koch, Chen-Ou Zhang, Piotr Kaczmarek, Joseph BarchiJr.Jr., Li Guo, Hanief M. Shahjee & Susan Keay. (2011) The effect of a novel frizzled 8-related antiproliferative factor on in vitro carcinoma and melanoma cell proliferation and invasion. Investigational New Drugs 30:5, pages 1849-1864.
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Le Xu, Yu Zhu, Jiejie Xu, Kerong Wu, Jinfeng Li, Wenping Xu, Haiou Liu, Shanshan Wang, Hankun Yin, Lin Chen, Guomin Wang & Zongming Lin. (2012) Notch1 activation promotes renal cell carcinoma growth via PI 3 K / A kt signaling . Cancer Science 103:7, pages 1253-1258.
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Martina Hager, Heike Haufe, Lukas Lusuardi, Nikolaus Schmeller & Christian Kolbitsch. (2010) p-AKT overexpression in primary renal cell carcinomas and their metastases. Clinical & Experimental Metastasis 27:8, pages 611-617.
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J.-B. Meric, B. Billemont & O. Rixe. (2010) Les nouvelles cibles thérapeutiques dans le cancer du rein. Bulletin du Cancer 97:2, pages S53-S63.
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Rosalyn Adam. (2009) Cell Signaling in Kidney Cancer. The Journal of Urology 182:6, pages 2555-2556.
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Peter J. Van Veldhuizen, Michael Hussey, Primo N. Lara, Philip C. Mack, Regina Gandour-Edwards, Joseph I. Clark, Marianne K. Lange & David E. Crawford. (2009) A Phase II Study of Gemcitabine and Capecitabine in Patients With Advanced Renal Cell Cancer. American Journal of Clinical Oncology 32:5, pages 453-459.
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Martina Hager, Heike Haufe, Ralf Kemmerling, Wolfgang Hitzl, Gregor Mikuz, Patrizia L. Moser & Christian Kolbitsch. (2008) Increased activated Akt expression in renal cell carcinomas and prognosis. Journal of Cellular and Molecular Medicine 13:8b, pages 2181-2188.
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