Advanced search
Publication Cover
Expert Review of Molecular Diagnostics Volume 6, 2006 - Issue 5
Submit an article Journal homepage
584
Views
134
CrossRef citations to date
0
Altmetric
Review

Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics

Natalie J Serkova Associate Professor of Anesthesiology and Radiology, University of Colorado Health Sciences Center, Biomedical MRI/MRS Cancer Center Core, Department of Anesthesiology, Denver, CO 80262, USA. [email protected]
&
Claus U Niemann Associate Professor of Anesthesia and Surgery, Division of Transplantation, University of California, San Francisco, CA 94143–0648, USA. [email protected]
Pages 717-731 | Published online: 09 Jan 2014

Citations (134)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (11)

C. Gar, M. Rottenkolber, C. Prehn, J. Adamski, J. Seissler & A. Lechner. (2018) Serum and plasma amino acids as markers of prediabetes, insulin resistance, and incident diabetes. Critical Reviews in Clinical Laboratory Sciences 55:1, pages 21-32.
Read now
Georgios Theophilou, Maria Paraskevaidi, Kássio MG Lima, Maria Kyrgiou, Pierre L Martin-Hirsch & Francis L Martin. (2015) Extracting biomarkers of commitment to cancer development: potential role of vibrational spectroscopy in systems biology. Expert Review of Molecular Diagnostics 15:5, pages 693-713.
Read now
Sonal Gupta & Kanika Chawla. (2013) Oncometabolomics in cancer research. Expert Review of Proteomics 10:4, pages 325-336.
Read now
Komal Raina, Chapla Agarwal, Ritambhara Wadhwa, Natalie J. Serkova & Rajesh Agarwal. (2013) Energy deprivation by silibinin in colorectal cancer cells. Autophagy 9:5, pages 697-713.
Read now
Ahmad Raza Khan, Poonam Rana, M. Memita Devi, Shubhra Chaturvedi, Salim Javed, Rajendra P. Tripathi & Subash Khushu. (2011) Nuclear magnetic resonance spectroscopy-based metabonomic investigation of biochemical effects in serum of γ-irradiated mice. International Journal of Radiation Biology 87:1, pages 91-97.
Read now
Justyna E. Wolak, Charles R. Esther$suffix/text()$suffix/text() & Thomas M. O’Connell. (2009) Metabolomic analysis of bronchoalveolar lavage fluid from cystic fibrosis patients. Biomarkers 14:1, pages 55-60.
Read now
JoachimD. Pleil. (2008) Role of Exhaled Breath Biomarkers in Environmental Health Science. Journal of Toxicology and Environmental Health, Part B 11:8, pages 613-629.
Read now
GA Nagana Gowda, Shucha Zhang, Haiwei Gu, Vincent Asiago, Narasimhamurthy Shanaiah & Daniel Raftery. (2008) Metabolomics-based methods for early disease diagnostics. Expert Review of Molecular Diagnostics 8:5, pages 617-633.
Read now
Miroslava Cuperlovic-Culf, Nabil Belacel & Adrian Culf. (2008) Integrated analysis of transcriptomics and metabolomics profiles. Expert Opinion on Medical Diagnostics 2:5, pages 497-509.
Read now
Natalie J. Serkova, Nichole A. Reisdorph & Martha C. Tissot van Patot. (2008) Metabolic Markers of Hypoxia: Systems Biology Application in Biomedicine. Toxicology Mechanisms and Methods 18:1, pages 81-95.
Read now
Claus U Niemann & Natalie J Serkova. (2007) Biochemical mechanisms of nephrotoxicity: application for metabolomics. Expert Opinion on Drug Metabolism & Toxicology 3:4, pages 527-544.
Read now

Articles from other publishers (123)

Pablo Melgarejo, Dámaris Núñez-Gómez, Francisca Hernández, Rafael Martínez-Font, Vicente Lidón Noguera, Juan José Martínez-Nicolás & Pilar Legua. (2023) Lemon Peel and Juice: Metabolomic Differentiation. Horticulturae 9:4, pages 510.
Crossref
Klevis Haxhiaj, David S. Wishart & Burim N. Ametaj. (2022) Mastitis: What It Is, Current Diagnostics, and the Potential of Metabolomics to Identify New Predictive Biomarkers. Dairy 3:4, pages 722-746.
Crossref
Roberta Esposito, Serena Federico, Francesca Glaviano, Emanuele Somma, Valerio Zupo & Maria Costantini. (2022) Bioactive Compounds from Marine Sponges and Algae: Effects on Cancer Cell Metabolome and Chemical Structures. International Journal of Molecular Sciences 23:18, pages 10680.
Crossref
Maria S. Chumachenko, Tatsiana V. Waseem & Sergei V. Fedorovich. (2022) Metabolomics and metabolites in ischemic stroke. Reviews in the Neurosciences 33:2, pages 181-205.
Crossref
Anjana Singh, Ved Prakash, Nikhil Gupta, Ashish Kumar, Ravi Kant & Dinesh Kumar. (2022) Serum Metabolic Disturbances in Lung Cancer Investigated through an Elaborative NMR-Based Serum Metabolomics Approach. ACS Omega 7:6, pages 5510-5520.
Crossref
Priyanka Narad, Romasha Gupta & Abhishek Sengupta. 2022. Bioinformatics in Agriculture. Bioinformatics in Agriculture 139 160 .
Abdul-Hamid Emwas, Kacper Szczepski, Benjamin Gabriel Poulson, Ryan McKay, Leonardo Tenori, Edoardo Saccenti, Joanna Lachowicz & Mariusz Jaremko. 2022. Metabolomics Perspectives. Metabolomics Perspectives 149 218 .
Siva Nageswara Rao Gajula, Devi Naga Jyothi Bale & Satheesh Kumar Nanjappan. 2022. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 2493 2516 .
Umesh Kumar, Abhai Kumar, Smita Singh, Payal Arya, Sandeep Kumar Singh, Rameshwar Nath Chaurasia, Anup Singh & Dinesh Kumar. (2021) An elaborative NMR based plasma metabolomics study revealed metabolic derangements in patients with mild cognitive impairment: a study on north Indian population. Metabolic Brain Disease 36:5, pages 957-968.
Crossref
Federica Murgia, Stefano Angioni, Maurizio Nicola D’Alterio, Silvia Pirarba, Antonio Noto, Maria Laura Santoru, Laura Tronci, Vassilios Fanos, Luigi Atzori & Francesca Congiu. (2020) Metabolic Profile of Patients with Severe Endometriosis: a Prospective Experimental Study. Reproductive Sciences 28:3, pages 728-735.
Crossref
Siva Nageswara Rao Gajula, Devi Naga Jyothi Bale & Satheesh Kumar Nanjappan. 2020. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1 24 .
Mohd Adnan Siddiqui, Swarnima Pandey, Afzal Azim, Neeraj Sinha & Mohammed Haris Siddiqui. (2020) Metabolomics: An emerging potential approach to decipher critical illnesses. Biophysical Chemistry 267, pages 106462.
Crossref
E. O. Korobkova, M. V. Kozhevnikova, I. S. Ilgisonis, G. A. Shakaryants, S. A. Appolonova, A. V. Kukharenko, E. V. Larcova, A. A. Maltseva, N. V. Khabarova & Yu. N. Belenkov. (2020) Metabolomic profiling in patients with metabolic syndrome. Kardiologiia 60:3, pages 37-43.
Crossref
Qiongju Cao, Huili Liu, Gaonan Zhang, Xiaohua Wang, Anne Manyande & Hongying Du. (2020) 1 H-NMR based metabolomics reveals the nutrient differences of two kinds of freshwater fish soups before and after simulated gastrointestinal digestion . Food & Function 11:4, pages 3095-3104.
Crossref
Neda Gholizadeh, Jay Pundavela, Rajakumar Nagarajan, Anthony Dona, Scott Quadrelli, Tapan Biswas, Peter B. Greer & Saadallah Ramadan. (2020) Nuclear magnetic resonance spectroscopy of human body fluids and in vivo magnetic resonance spectroscopy: Potential role in the diagnosis and management of prostate cancer. Urologic Oncology: Seminars and Original Investigations 38:4, pages 150-173.
Crossref
Akhila Viswan, Chandan Singh, Arvind M. Kayastha, Afzal Azim & Neeraj Sinha. (2019) An NMR based panorama of the heterogeneous biology of acute respiratory distress syndrome (ARDS) from the standpoint of metabolic biomarkers. NMR in Biomedicine 33:2.
Crossref
Boran Hu, Yang Cao, Jiangyu Zhu, Wenbiao Xu & Wenjuan Wu. (2019) Analysis of metabolites in chardonnay dry white wine with various inactive yeasts by 1H NMR spectroscopy combined with pattern recognition analysis. AMB Express 9:1.
Crossref
Youngja H Park, Taewoon Kong, James R. Roede, Dean P. Jones & Kichun Lee. (2019) A biplot correlation range for group-wise metabolite selection in mass spectrometry. BioData Mining 12:1.
Crossref
Federica Murgia, Ambra Iuculano, Cristina Peddes, Maria Laura Santoru, Laura Tronci, Monica Deiana, Luigi Atzori & Giovanni Monni. (2019) Metabolic fingerprinting of chorionic villous samples in normal pregnancy and chromosomal disorders. Prenatal Diagnosis 39:10, pages 848-858.
Crossref
Abdul-Hamid Emwas, Raja Roy, Ryan T. McKay, Leonardo Tenori, Edoardo Saccenti, G. A. Nagana Gowda, Daniel Raftery, Fatimah Alahmari, Lukasz Jaremko, Mariusz Jaremko & David S. Wishart. (2019) NMR Spectroscopy for Metabolomics Research. Metabolites 9:7, pages 123.
Crossref
Neha Arora, Durgesh Dubey, Meenakshi Sharma, Alok Patel, Anupam Guleria, Parul A. Pruthi, Dinesh Kumar, Vikas Pruthi & Krishna Mohan Poluri. (2018) NMR-Based Metabolomic Approach To Elucidate the Differential Cellular Responses during Mitigation of Arsenic(III, V) in a Green Microalga. ACS Omega 3:9, pages 11847-11856.
Crossref
Federica Murgia, Silvia Svegliati, Simone Poddighe, Milena Lussu, Aldo Manzin, Tatiana Spadoni, Colomba Fischetti, Armando Gabrielli & Luigi Atzori. (2018) Metabolomic profile of systemic sclerosis patients. Scientific Reports 8:1.
Crossref
Charlene Wu, Chi-Hung Chen, Hsin-Chang Chen, Hao-Jan Liang, Shu-Ting Chen, Wan-Yu Lin, Kuen-Yuh Wu, Su-Yin Chiang & Ching-Yu Lin. (2017) Nuclear magnetic resonance- and mass spectrometry-based metabolomics to study maleic acid toxicity from repeated dose exposure in rats. Journal of Applied Toxicology 37:12, pages 1493-1506.
Crossref
Hoe Suk Kim, Lianji Tian, Hyeonjin Kim & Woo Kyung Moon. (2017) Investigation of discriminant metabolites in tamoxifen-resistant and choline kinase-alpha-downregulated breast cancer cells using 1H-nuclear magnetic resonance spectroscopy. PLOS ONE 12:6, pages e0179773.
Crossref
Ana Capati, Omkar B Ijare & Tedros Bezabeh. (2017) Diagnostic Applications of Nuclear Magnetic Resonance–Based Urinary Metabolomics. Magnetic Resonance Insights 10, pages 1178623X1769434.
Crossref
Joanna Kruk, Marek Doskocz, Elżbieta Jodłowska, Anna Zacharzewska, Joanna Łakomiec, Kornelia Czaja & Jacek Kujawski. (2016) NMR Techniques in Metabolomic Studies: A Quick Overview on Examples of Utilization. Applied Magnetic Resonance 48:1, pages 1-21.
Crossref
Wei Guo, Chunying Jiang, Liu Yang, Tianqi Li, Xia Liu, Mengxia Jin, Kai Qu, Huili Chen, Xiangju Jin, Hongyue Liu, Haibo Zhu & Yinghong Wang. (2016) Quantitative Metabolomic Profiling of Plasma, Urine, and Liver Extracts by 1 H NMR Spectroscopy Characterizes Different Stages of Atherosclerosis in Hamsters . Journal of Proteome Research 15:10, pages 3500-3510.
Crossref
Michael E. Kurczy, Erica M. Forsberg, Michael P. Thorgersen, Farris L. PooleIIII, H. Paul Benton, Julijana Ivanisevic, Minerva L. Tran, Judy D. Wall, Dwayne A. Elias, Michael W. W. Adams & Gary Siuzdak. (2016) Global Isotope Metabolomics Reveals Adaptive Strategies for Nitrogen Assimilation. ACS Chemical Biology 11:6, pages 1677-1685.
Crossref
Atul Rawat, Durgesh Dubey, Anupam Guleria, Umesh Kumar, AmitK Keshari, Swati Chaturvedi, Anand Prakash, Sudipta Saha & Dinesh Kumar. (2016) 1 H NMR-based serum metabolomics reveals erythromycin-induced liver toxicity in albino Wistar rats . Journal of Pharmacy And Bioallied Sciences 8:4, pages 327.
Crossref
Ewa Gralka, Claudio Luchinat, Leonardo Tenori, Barbara Ernst, Martin Thurnheer & Bernd Schultes. (2015) Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner. The American Journal of Clinical Nutrition 102:6, pages 1313-1322.
Crossref
Sunil KoundalSonia GandhiTanzeer KaurAvik MazumderSubash Khushu. (2015) “Omics” of High Altitude Biology: A Urinary Metabolomics Biomarker Study of Rats Under Hypobaric Hypoxia. OMICS: A Journal of Integrative Biology 19:12, pages 757-765.
Crossref
Leonardo Tenori, Catherine Oakman, Patrick G. Morris, Ewa Gralka, Natalie Turner, Silvia Cappadona, Monica Fornier, Cliff Hudis, Larry Norton, Claudio Luchinat & Angelo Di Leo. (2015) Serum metabolomic profiles evaluated after surgery may identify patients with oestrogen receptor negative early breast cancer at increased risk of disease recurrence. Results from a retrospective study. Molecular Oncology 9:1, pages 128-139.
Crossref
M. Thamara P.R. PereraRoger HigdonDouglas A. RichardsMichael A. SilvaNick MurphyEugene KolkerDarius F. Mirza. (2014) Biomarker Differences between Cadaveric Grafts Used in Human Orthotopic Liver Transplantation as Identified by Coulometric Electrochemical Array Detection (CEAD) Metabolomics. OMICS: A Journal of Integrative Biology 18:12, pages 767-777.
Crossref
Jeremiah Bowers, Emma Hughes, Nicholas Skill, Mary Maluccio & Daniel Raftery. (2014) Detection of hepatocellular carcinoma in hepatitis C patients: Biomarker discovery by LC–MS. Journal of Chromatography B 966, pages 154-162.
Crossref
Lungile SitoleFrancois SteffensTjaart P.J. KrügerDebra Meyer. (2014) Mid-ATR-FTIR Spectroscopic Profiling of HIV/AIDS Sera for Novel Systems Diagnostics in Global Health. OMICS: A Journal of Integrative Biology 18:8, pages 513-523.
Crossref
Anand Prakash Yadav, Shubhra Chaturvedi, Kamla Prasad Mishra, Sunil Pal, Lilly Ganju & Shashi Bala Singh. (2014) Evidence for altered metabolic pathways during environmental stress: 1H‐NMR spectroscopy based metabolomics and clinical studies on subjects of sea-voyage and Antarctic-stay. Physiology & Behavior 135, pages 81-90.
Crossref
Robert Powers. (2014) The Current State of Drug Discovery and a Potential Role for NMR Metabolomics. Journal of Medicinal Chemistry 57:14, pages 5860-5870.
Crossref
Ivano Bertini, Claudio Luchinat, Massimo Miniati, Simonetta Monti & Leonardo Tenori. (2013) Phenotyping COPD by 1H NMR metabolomics of exhaled breath condensate. Metabolomics 10:2, pages 302-311.
Crossref
William Mullen, Daisuke Saigusa, Takaaki Abe, Jerzy Adamski & Harald Mischak. (2014) Proteomics and Metabolomics as Tools to Unravel Novel Culprits and Mechanisms of Uremic Toxicity: Instrument or Hype?. Seminars in Nephrology 34:2, pages 180-190.
Crossref
Sarah Schönig, Andreas Recke, Misa Hirose, Ralf J Ludwig & Karsten Seeger. (2013) Metabolite analysis distinguishes between mice with epidermolysis bullosa acquisita and healthy mice. Orphanet Journal of Rare Diseases 8:1.
Crossref
Nichole Reisdorph, Robert Stearman, Katerina Kechris, Tzu Lip Phang, Richard Reisdorph, Jessica Prenni, David J. Erle, Christopher Coldren, Kevin Schey, Alexey Nesvizhskii & Mark Geraci. (2013) Hands-on Workshops as An Effective Means of Learning Advanced Technologies Including Genomics, Proteomics and Bioinformatics. Genomics, Proteomics & Bioinformatics 11:6, pages 368-377.
Crossref
Kyu‐Bong Kim, Ji‐Young Yang, Seung Jun Kwack, Hyung Sik Kim, Do Hyun Ryu, Yeon‐Joo Kim, Jung Yun Bae, Duck Soo Lim, Seul Min Choi, Mi Jung Kwon, Du Yeon Bang, Seong Kwang Lim, Young Woo Kim, Geum‐Sook Hwang & Byung‐Mu Lee. (2012) Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary 1 H‐NMR spectroscopy . Journal of Applied Toxicology 33:11, pages 1251-1259.
Crossref
Ting F. Leung, Fanny W. S. Ko & Gary W. K. Wong. (2013) Recent advances in asthma biomarker research. Therapeutic Advances in Respiratory Disease 7:5, pages 297-308.
Crossref
Bo Wang, Aaron M. Goodpaster & Michael A. Kennedy. (2013) Coefficient of variation, signal-to-noise ratio, and effects of normalization in validation of biomarkers from NMR-based metabonomics studies. Chemometrics and Intelligent Laboratory Systems 128, pages 9-16.
Crossref
Emmanuel Appiah-Amponsah, Kwadwo Owusu-Sarfo, G.A. Gowda, Tao Ye & Daniel Raftery. (2013) Combining Hydrophilic Interaction Chromatography (HILIC) and Isotope Tagging for Off-Line LC-NMR Applications in Metabolite Analysis. Metabolites 3:3, pages 575-591.
Crossref
Siwei Wei, Lingyan Liu, Jian Zhang, Jeremiah Bowers, G.A. Nagana Gowda, Harald Seeger, Tanja Fehm, Hans J. Neubauer, Ulrich Vogel, Susan E. Clare & Daniel Raftery. (2012) Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer. Molecular Oncology 7:3, pages 297-307.
Crossref
Ying-Yong Zhao. (2013) Metabolomics in chronic kidney disease. Clinica Chimica Acta 422, pages 59-69.
Crossref
Erica L. Bradshaw-Pierce, Todd M. Pitts, Gillian Kulikowski, Heather Selby, Andrea L. Merz, Daniel L. Gustafson, Natalie J. Serkova, S. Gail Eckhardt & Colin D. Weekes. (2013) Utilization of Quantitative In Vivo Pharmacology Approaches to Assess Combination Effects of Everolimus and Irinotecan in Mouse Xenograft Models of Colorectal Cancer. PLoS ONE 8:3, pages e58089.
Crossref
Komal Raina, Kameswaran Ravichandran, Subapriya Rajamanickam, Kendra M. Huber, Natalie J. Serkova & Rajesh Agarwal. (2013) Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study. Cancer Prevention Research 6:1, pages 40-50.
Crossref
Lungile J. Sitole, Aurelia A. Williams & Debra Meyer. (2013) Metabonomic analysis of HIV-infected biofluids. Mol. BioSyst. 9:1, pages 18-28.
Crossref
Carolyn Compton & Andrea Kelly. 2013. Genomic and Personalized Medicine. Genomic and Personalized Medicine 229 236 .
Quincy TengQuincy Teng. 2013. Structural Biology. Structural Biology 311 392 .
Xiaocong Fang, Chunxue Bai & Xiangdong Wang. (2012) Bioinformatics insights into acute lung injury/acute respiratory distress syndrome. Clinical and Translational Medicine 1:1.
Crossref
Christian M. Metallo. (2012) Expanding the Reach of Cancer Metabolomics. Cancer Prevention Research 5:12, pages 1337-1340.
Crossref
Catherine Oakman, Leonardo Tenori, Silvia Cappadona S, Claudio Luchinat, Ivano Bertini & Angelo Di Leo. (2012) Targeting Metabolomics in Breast Cancer. Current Breast Cancer Reports 4:4, pages 249-256.
Crossref
Hashim Farooq, Ronald Soong, Denis Courtier-Murias, Clemens Anklin & André Simpson. (2012) Tailoring 1 H Spin Dynamics in Small Molecules via Supercooled Water: A Promising Approach for Metabolite Identification and Validation . Analytical Chemistry 84:15, pages 6759-6766.
Crossref
Leonardo Tenori, Catherine Oakman, Wederson M. Claudino, Patrizia Bernini, Silvia Cappadona, Stefano Nepi, Laura Biganzoli, Michael C. Arbushites, Claudio Luchinat, Ivano Bertini & Angelo Di Leo. (2012) Exploration of serum metabolomic profiles and outcomes in women with metastatic breast cancer: A pilot study. Molecular Oncology 6:4, pages 437-444.
Crossref
Uwe Christians, Volker Schmitz, Jost Klawitter & Jelena Klawitter. 2012. Analytical Techniques for Clinical Chemistry. Analytical Techniques for Clinical Chemistry 691 774 .
Youngja Park, Tiejun Zhao, Nana Gletsu Miller, Seoung Bum Kim, Carolyn Jonas Accardi, Thomas R. Ziegler, Xiaoping Hu & Dean P. Jones. (2012) Sulfur amino acid-free diet results in increased glutamate in human midbrain: A pilot magnetic resonance spectroscopic study. Nutrition 28:3, pages 235-241.
Crossref
Natalie J Serkova & Mark S Brown. (2012) Quantitative analysis in magnetic resonance spectroscopy: from metabolic profiling to in vivo biomarkers . Bioanalysis 4:3, pages 321-341.
Crossref
Tao Ye, Cheng Zheng, Shucha Zhang, G. A. Nagana Gowda, Olga Vitek & Daniel Raftery. (2011) “Add to Subtract”: A Simple Method to Remove Complex Background Signals from the 1 H Nuclear Magnetic Resonance Spectra of Mixtures . Analytical Chemistry 84:2, pages 994-1002.
Crossref
Jinglin Zhou & Wei Li. 2012. Interface Oral Health Science 2011. Interface Oral Health Science 2011 31 37 .
Patrizia Bernini, Ivano Bertini, Claudio Luchinat, Leonardo Tenori & Adriana Tognaccini. (2011) The Cardiovascular Risk of Healthy Individuals Studied by NMR Metabonomics of Plasma Samples. Journal of Proteome Research 10:11, pages 4983-4992.
Crossref
Siwei Wei, Jian Zhang, Lingyan Liu, Tao Ye, G. A. Nagana Gowda, Fariba Tayyari & Daniel Raftery. (2011) Ratio Analysis Nuclear Magnetic Resonance Spectroscopy for Selective Metabolite Identification in Complex Samples. Analytical Chemistry 83:20, pages 7616-7623.
Crossref
Haitham Mutlak & Kai Zacharowski. (2011) Metabolomics in acute lung injury: A new approach for monitoring therapeutic interventions*. Critical Care Medicine 39:10, pages 2375-2376.
Crossref
Ritu Tyagi, Poonam Rana, Ahmad Raza Khan, Deepak Bhatnagar, M Memita Devi, Shubhra Chaturvedi, Rajendra P. Tripathi & Subash Khushu. (2011) Study of acute biochemical effects of thallium toxicity in mouse urine by NMR spectroscopy. Journal of Applied Toxicology 31:7, pages 663-670.
Crossref
Jia Liu, Lawrence Litt, Mark R. Segal, Mark J. S. Kelly, Jeffrey G. Pelton & Myungwon Kim. (2011) Metabolomics of Oxidative Stress in Recent Studies of Endogenous and Exogenously Administered Intermediate Metabolites. International Journal of Molecular Sciences 12:10, pages 6469-6501.
Crossref
Natalie J. Serkova, Theodore J. Standiford & Kathleen A. Stringer. (2011) The Emerging Field of Quantitative Blood Metabolomics for Biomarker Discovery in Critical Illnesses. American Journal of Respiratory and Critical Care Medicine 184:6, pages 647-655.
Crossref
GA Nagana Gowda. (2011) NMR spectroscopy for discovery and quantitation of biomarkers of disease in human bile. Bioanalysis 3:16, pages 1877-1890.
Crossref
Youngja Park, Ngoc-Anh Le, Tianwei Yu, Fred Strobel, Nana Gletsu-Miller, Carolyn J. Accardi, Kichun S. Lee, Shaoxiong Wu, Thomas R. Ziegler & Dean P. Jones. (2011) A Sulfur Amino Acid–Free Meal Increases Plasma Lipids in Humans. The Journal of Nutrition 141:8, pages 1424-1431.
Crossref
Kiyoko Bando, Takeshi Kunimatsu, Jun Sakai, Juki Kimura, Hitoshi Funabashi, Takaki Seki, Takeshi Bamba & Eiichiro Fukusaki. (2010) GC‐MS‐based metabolomics reveals mechanism of action for hydrazine induced hepatotoxicity in rats. Journal of Applied Toxicology 31:6, pages 524-535.
Crossref
Catherine Oakman, Leonardo Tenori, Laura Biganzoli, Libero Santarpia, Silvia Cappadona, Claudio Luchinat & Angelo Di Leo. (2011) Uncovering the metabolomic fingerprint of breast cancer. The International Journal of Biochemistry & Cell Biology 43:7, pages 1010-1020.
Crossref
Faqing Tang, Chunlei Xie, Damao Huang, Yuan Wu, Maomao Zeng, Lunchao Yi, Yongfang Wang, Wenhua Mei, Ya Cao & Lunquan Sun. (2011) Novel potential markers of nasopharyngeal carcinoma for diagnosis and therapy. Clinical Biochemistry 44:8-9, pages 711-718.
Crossref
Renata Bujak, Emilia Daghir, Joanna Rybka, Piotr Koslinski & Michał Jan Markuszewski. (2011) Metabolomics in urogenital cancer. Bioanalysis 3:8, pages 913-923.
Crossref
Peter Sandusky, Emmanuel Appiah-Amponsah & Daniel Raftery. (2011) Use of optimized 1D TOCSY NMR for improved quantitation and metabolomic analysis of biofluids. Journal of Biomolecular NMR 49:3-4, pages 281-290.
Crossref
Pascal Mercier, Michael J. Lewis, David Chang, David Baker & David S. Wishart. (2011) Towards automatic metabolomic profiling of high-resolution one-dimensional proton NMR spectra. Journal of Biomolecular NMR 49:3-4, pages 307-323.
Crossref
Jia Liu, Lawrence Litt, Mark R Segal, Mark JS Kelly, Hikari AI Yoshihara & Thomas L James. (2010) Outcome-Related Metabolomic Patterns from 1 H/ 31 P NMR after Mild Hypothermia Treatments of Oxygen—Glucose Deprivation in a Neonatal Brain Slice Model of Asphyxia . Journal of Cerebral Blood Flow & Metabolism 31:2, pages 547-559.
Crossref
Haiwei Gu, Zhengzheng Pan, Bowei Xi, Vincent Asiago, Brian Musselman & Daniel Raftery. (2011) Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: Application to the detection of breast cancer. Analytica Chimica Acta 686:1-2, pages 57-63.
Crossref
Bernhard SchattkaMurray AlexanderSarah Low YingAngela ManR. Anthony Shaw. (2010) Metabolic Fingerprinting of Biofluids by Infrared Spectroscopy: Modeling and Optimization of Flow Rates for Laminar Fluid Diffusion Interface Sample Preconditioning. Analytical Chemistry 83:2, pages 555-562.
Crossref
Jeffrey C. Sirota, Jelena Klawitter & Charles L. Edelstein. (2011) Biomarkers of Acute Kidney Injury. Journal of Toxicology 2011, pages 1-10.
Crossref
Kathleen A. StringerNatalie J. SerkovaAlla KarnovskyKenneth GuireRobert PaineIIIIII & Theodore J. Standiford. (2011) Metabolic consequences of sepsis-induced acute lung injury revealed by plasma 1 H-nuclear magnetic resonance quantitative metabolomics and computational analysis . American Journal of Physiology-Lung Cellular and Molecular Physiology 300:1, pages L4-L11.
Crossref
C. P. Diggle, M. Shires, C. McRae, D. Crellin, J. Fisher, I. M. Carr, A. F. Markham, B. E. Hayward, A. Asipu & D. T. Bonthron. (2010) Both isoforms of ketohexokinase are dispensable for normal growth and development. Physiological Genomics 42A:4, pages 235-243.
Crossref
Ahmad Raza Khan, Poonam Rana, M. Memita Devi, Shubhra Chaturvedi, Salim Javed, Rajendra P. Tripathi & Subash Khushu. (2010) Nuclear magnetic resonance spectroscopy-based metabonomic investigation of biochemical effects in serum of γ-irradiated mice. International Journal of Radiation Biology, pages 1-7.
Crossref
Marco Vincenti, Matthias Behrends, Kim Dang, Yeon H. Park, Ryutaro Hirose, Annabel Blasi-Ibanez, Tao Liu, Natalie J. Serkova & Claus U. Niemann. (2010) Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats. Journal of Gastroenterology 45:11, pages 1103-1110.
Crossref
Shao-Peng Chen, Jian Wu, Xiao-Dong Yu, Jing-Juan Xu & Hong-Yuan Chen. (2010) Multi-parameter detection of diabetes mellitus on multichannel poly(dimethylsiloxane) analytical chips coupled with nanoband microelectrode arrays. ELECTROPHORESIS 31:18, pages 3097-3106.
Crossref
Miroslava Čuperlović-Culf, David A. Barnett, Adrian S. Culf & Ian Chute. (2010) Cell culture metabolomics: applications and future directions. Drug Discovery Today 15:15-16, pages 610-621.
Crossref
Qian Shang, Jun-Feng Xiang & Ya-Lin Tang. (2010) NMR-based metabonomics: a useful platform of oncology research. Bioanalytical Reviews 1:2-4, pages 117-140.
Crossref
Mitchell J. Cohen, Natalie J. Serkova, Jeanine Wiener-Kronish, Jean-Francois Pittet & Claus U. Niemann. (2010) 1H-NMR-Based Metabolic Signatures of Clinical Outcomes in Trauma Patients—Beyond Lactate and Base Deficit. Journal of Trauma: Injury, Infection & Critical Care 69:1, pages 31-40.
Crossref
GA Nagana Gowda. (2010) Human bile as a rich source of biomarkers for hepatopancreatobiliary cancers. Biomarkers in Medicine 4:2, pages 299-314.
Crossref
Tao Ye, Shucha Zhang, Huaping Mo, Fariba Tayyari, G. A. Nagana Gowda & Daniel Raftery. (2010) 13 C-Formylation for Improved Nuclear Magnetic Resonance Profiling of Amino Metabolites in Biofluids . Analytical Chemistry 82:6, pages 2303-2309.
Crossref
Christina E. Kostara, Athanasios Papathanasiou, Manh Thong Cung, Moses S. Elisaf, John Goudevenos & Eleni T. Bairaktari. (2010) Evaluation of Established Coronary Heart Disease on the Basis of HDL and Non-HDL NMR Lipid Profiling. Journal of Proteome Research 9:2, pages 897-911.
Crossref
Martha C. Tissot van PatotAndrew J. MurrayVirginia BeckeyTereza Cindrova-DaviesJemma Johns, Lisa Zwerdlinger, Eric Jauniaux, Graham J. BurtonNatalie J. Serkova. (2010) Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 298:1, pages R166-R172.
Crossref
Shucha Zhang, G. A. Nagana Gowda, Tao Ye & Daniel Raftery. (2010) Advances in NMR-based biofluid analysis and metabolite profiling. The Analyst 135:7, pages 1490.
Crossref
Harri Koskela, Outi Heikkilä, Ilkka Kilpeläinen & Sami Heikkinen. (2010) Quantitative two-dimensional HSQC experiment for high magnetic field NMR spectrometers. Journal of Magnetic Resonance 202:1, pages 24-33.
Crossref
Joanna TeulFrancisco J. RupérezAntonia GarciaJulie VaysseStéphane BalayssacVéronique GilardMyriam Malet-MartinoJose Luis Martin-VenturaLuis Miguel Blanco-ColioJosé TuñónJesús EgidoCoral Barbas. (2009) Improving Metabolite Knowledge in Stable Atherosclerosis Patients by Association and Correlation of GC-MS and 1 H NMR Fingerprints . Journal of Proteome Research 8:12, pages 5580-5589.
Crossref
Monica L Mo, Bernhard Ø Palsson & Markus J Herrgård. (2009) Connecting extracellular metabolomic measurements to intracellular flux states in yeast. BMC Systems Biology 3:1.
Crossref
Emmanuel Appiah-Amponsah, Narasimhamurthy Shanaiah, G.A. Nagana Gowda, Kwadwo Owusu-Sarfo, Tao Ye & Daniel Raftery. (2009) Identification of 4-deoxythreonic acid present in human urine using HPLC and NMR techniques. Journal of Pharmaceutical and Biomedical Analysis 50:5, pages 878-885.
Crossref
Tedros Bezabeh, Ray L. Somorjai & Ian C. P. Smith. (2009) MR metabolomics of fecal extracts: applications in the study of bowel diseases. Magnetic Resonance in Chemistry 47:S1, pages S54-S61.
Crossref
Haiwei Gu, Zhengzheng Pan, Bowei Xi, Bryan E. Hainline, Narasimhamurthy Shanaiah, Vincent Asiago, G. A. Nagana Gowda & Daniel Raftery. (2009) 1 H NMR metabolomics study of age profiling in children . NMR in Biomedicine 22:8, pages 826-833.
Crossref
Youngja Park, Seoung Bum Kim, Bing Wang, Roberto A. Blanco, Ngoc-Anh Le, Shaoxiong Wu, Carolyn J. Accardi, R. Wayne Alexander, Thomas R. Ziegler & Dean P. Jones. (2009) Individual variation in macronutrient regulation measured by proton magnetic resonance spectroscopy of human plasma. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 297:1, pages R202-R209.
Crossref
T. Bezabeh, R. Somorjai, B. Dolenko, N. Bryskina, B. Levin, C. N. Bernstein, E. Jeyarajah, A. H. Steinhart, D. T. Rubin & I. C. P. Smith. (2009) Detecting colorectal cancer by 1 H magnetic resonance spectroscopy of fecal extracts . NMR in Biomedicine 22:6, pages 593-600.
Crossref
Tao Ye, Huaping Mo, Narasimhamurthy Shanaiah, G. A. Nagana Gowda, Shucha Zhang & Daniel Raftery. (2009) Chemoselective 15 N Tag for Sensitive and High-Resolution Nuclear Magnetic Resonance Profiling of the Carboxyl-Containing Metabolome . Analytical Chemistry 81:12, pages 4882-4888.
Crossref
Andrea L Merz & Natalie J Serkova. (2009) Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer. Biomarkers in Medicine 3:3, pages 289-306.
Crossref
Martha C. Tissot van Patot, Natalie J. Serkova, Manuel Haschke, Douglas J. Kominsky, Robert C. Roach, Uwe Christians, Thomas K. Henthorn & Benjamin Honigman. (2009) Enhanced leukocyte HIF-1α and HIF-1 DNA binding in humans after rapid ascent to 4300 m. Free Radical Biology and Medicine 46:11, pages 1551-1557.
Crossref
Komal Raina, Natalie J. Serkova & Rajesh Agarwal. (2009) Silibinin Feeding Alters the Metabolic Profile in TRAMP Prostatic Tumors: 1H-NMRS–Based Metabolomics Study. Cancer Research 69:9, pages 3731-3735.
Crossref
Jennifer L. Spratlin, Natalie J. Serkova & S. Gail Eckhardt. (2009) Clinical Applications of Metabolomics in Oncology: A Review. Clinical Cancer Research 15:2, pages 431-440.
Crossref
Harri Koskela. 2009. 1 31 .
Natalie J. Serkova & Kristine Glunde. 2009. Tumor Biomarker Discovery. Tumor Biomarker Discovery 273 295 .
M. C. Walsh, A. Nugent, L. Brennan & M. J. Gibney. (2008) Understanding the metabolome - challenges for metabolomics. Nutrition Bulletin 33:4, pages 316-323.
Crossref
Ronghui Lei, Chunqi Wu, Baohua Yang, Huazhai Ma, Chang Shi, Quanjun Wang, Qingxiu Wang, Ye Yuan & Mingyang Liao. (2008) Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: A rapid in vivo screening method for nanotoxicity. Toxicology and Applied Pharmacology 232:2, pages 292-301.
Crossref
Ignasi Barba, Nicolas Chatauret, David García-Dorado & Juan Córdoba. (2008) A 1H nuclear magnetic resonance-based metabonomic approach for grading hepatic encephalopathy and monitoring the effects of therapeutic hypothermia in rats. Liver International 28:8, pages 1141-1148.
Crossref
I. García-Pérez, M. Vallejo, A. García, C. Legido-Quigley & C. Barbas. (2008) Metabolic fingerprinting with capillary electrophoresis. Journal of Chromatography A 1204:2, pages 130-139.
Crossref
Philippe A. Guy, Isabelle Tavazzi, Stephen J. Bruce, Ziad Ramadan & Sunil Kochhar. (2008) Global metabolic profiling analysis on human urine by UPLC–TOFMS: Issues and method validation in nutritional metabolomics. Journal of Chromatography B 871:2, pages 253-260.
Crossref
Natalie J. Serkova, Zachary Van Rheen, Meghan Tobias, Joshua E. Pitzer, J. Erby Wilkinson & Kathleen A. Stringer. (2008) Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology 295:1, pages L152-L161.
Crossref
Daniel Raftery & G.A. Nagana Gowda. (2008) An Approaching New Wave of Multicomponent Biomarker Diagnostics?. Journal of Urology 179:6, pages 2089-2090.
Crossref
Evelyn C. Soo, David J. McNally, Jean-Robert Brisson & Christopher W. Reid. 2008. Campylobacter. Campylobacter 523 542 .
Natalie J. Serkova, Eduard J. Gamito, Richard H. Jones, Colin O'Donnell, Jaimi L. Brown, Spencer Green, Holly Sullivan, Tammy Hedlund & E. David Crawford. (2008) The metabolites citrate, myo‐inositol, and spermine are potential age‐independent markers of prostate cancer in human expressed prostatic secretions. The Prostate 68:6, pages 620-628.
Crossref
Que N. Van, Haleem J. Issaq, Qiujie Jiang, Qiaoli Li, Gary M. Muschik, Timothy J. Waybright, Hong Lou, Michael Dean, Jouni Uitto & Timothy D. Veenstra. (2007) Comparison of 1D and 2D NMR Spectroscopy for Metabolic Profiling. Journal of Proteome Research 7:2, pages 630-639.
Crossref
Mika Ala-Korpela. (2008) Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics. Clinical Chemistry and Laboratory Medicine 46:1.
Crossref
Haiyan Huang, Yihua Yu, Xiaoping Yi & Yuanxing Zhang. (2007) Nitrogen metabolism of asparagine and glutamate in Vero cells studied by 1H/15N NMR spectroscopy. Applied Microbiology and Biotechnology 77:2, pages 427-436.
Crossref
Natalie J. Serkova, James C. Rose, L. Elaine Epperson, Hannah V. Carey & Sandra L. Martin. (2007) Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR. Physiological Genomics 31:1, pages 15-24.
Crossref
Silvia Carraro, Serge Rezzi, Fabiano Reniero, Károly Héberger, Giuseppe Giordano, Stefania Zanconato, Claude Guillou & Eugenio Baraldi. (2007) Metabolomics Applied to Exhaled Breath Condensate in Childhood Asthma. American Journal of Respiratory and Critical Care Medicine 175:10, pages 986-990.
Crossref
Rowan E. MooreJennifer KirwanMary K. DohertyPhillip D. Whitfield. (2017) Biomarker Discovery in Animal Health and Disease: The Application of Post-Genomic Technologies. Biomarker Insights 2, pages 117727190700200.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.