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Editorials

Hypothesis: glutaminyl cyclase inhibitors decrease risks of Alzheimer’s disease and related dementias

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Ashwani Kumar, Kiran Bagri, Manisha Nimbhal & Parvin Kumar. (2021) In silico exploration of the fingerprints triggering modulation of glutaminyl cyclase inhibition for the treatment of Alzheimer’s disease using SMILES based attributes in Monte Carlo optimization. Journal of Biomolecular Structure and Dynamics 39:18, pages 7181-7193.
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Judite R.M. Coimbra & Jorge A.R. Salvador. (2021) A patent review of glutaminyl cyclase inhibitors (2004–present). Expert Opinion on Therapeutic Patents 31:9, pages 809-836.
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Articles from other publishers (8)

Judite R.M. Coimbra, Paula I. Moreira, Armanda E. Santos & Jorge A.R. Salvador. (2023) Therapeutic potential of glutaminyl cyclases: Current status and emerging trends. Drug Discovery Today, pages 103644.
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Carlos Elias Conti Filho, Lairane Bridi Loss, Clairton Marcolongo-Pereira, Joamyr Victor Rossoni Junior, Rafael Mazioli Barcelos, Orlando Chiarelli-Neto, Bruno Spalenza da Silva, Roberta Passamani Ambrosio, Fernanda Cristina de Abreu Quintela Castro, Sarah Fernandes Teixeira & Nathana Jamille Mezzomo. (2023) Advances in Alzheimer’s disease’s pharmacological treatment. Frontiers in Pharmacology 14.
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Nguyen Van Manh, Van-Hai Hoang, Van T.H. Ngo, Soosung Kang, Jin Ju Jeong, Hee-Jin Ha, Hee Kim, Young-Ho Kim, Jihyae Ann & Jeewoo Lee. (2022) Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents. European Journal of Medicinal Chemistry 244, pages 114837.
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Nguyen Van Manh, Van-Hai Hoang, Van T.H. Ngo, Jihyae Ann, Tae-ho Jang, Jung-Hye Ha, Jae Young Song, Hee-Jin Ha, Hee Kim, Young-Ho Kim, Jiyoun Lee & Jeewoo Lee. (2021) Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design. European Journal of Medicinal Chemistry 226, pages 113819.
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Ana Xu, Feng He, Chenggong Yu, Ying Qu, Qiuqiong Zhang, Jiahui Lv, Xiangna Zhang, Yingying Ran, Chao Wei & Jingde Wu. (2019) The Development of Small Molecule Inhibitors of Glutaminyl Cyclase and Isoglutaminyl Cyclase for Alzheimer's Disease. ChemistrySelect 4:35, pages 10591-10600.
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Van-Hai Hoang, Van T. H. Ngo, Minghua Cui, Nguyen Van Manh, Phuong-Thao Tran, Jihyae Ann, Hee-Jin Ha, Hee Kim, Kwanghyun Choi, Young-Ho Kim, Hyerim Chang, Stephani Joy Y. Macalino, Jiyoun Lee, Sun Choi & Jeewoo Lee. (2019) Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer’s Agents by Structure-Based Design. Journal of Medicinal Chemistry 62:17, pages 8011-8027.
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Hayrettin Ozan Gulcan, Açelya Mavideniz, Mustafa Fethi Sahin & Ilkay Erdogan Orhan. (2019) Benzimidazole-derived Compounds Designed for Different Targets of Alzheimer’s Disease. Current Medicinal Chemistry 26:18, pages 3260-3278.
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Manman Li, Yao Dong, Xi Yu, Yue Li, Yongdong Zou, Yizhi Zheng, Zhendan He, Zhigang Liu, Junmin Quan, Xianzhang Bu & Haiqiang Wu. (2017) Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer’s Disease. Journal of Medicinal Chemistry 60:15, pages 6664-6677.
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