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Drug Profile

Cladribine for multiple sclerosis: review and current status

Pages 721-727 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Trygve Holmøy, Øivind Torkildsen & Kjell-Morten Myhr. (2017) An update on cladribine for relapsing-remitting multiple sclerosis. Expert Opinion on Pharmacotherapy 18:15, pages 1627-1635.
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Emanuele D’Amico, Carmela Leone, Cinzia Caserta & Francesco Patti. (2015) Oral drugs in multiple sclerosis therapy: an overview and a critical appraisal. Expert Review of Neurotherapeutics 15:7, pages 803-824.
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Jan Thöne & Gisa Ellrichmann. (2013) Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culprits. Drug, Healthcare and Patient Safety 5, pages 37-47.
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Giancarlo Comi, Hans-Peter Hartung, Nuwan C Kurukulasuriya, Steven J Greenberg & Matthew Scaramozza. (2013) Cladribine tablets for the treatment of relapsing–remitting multiple sclerosis. Expert Opinion on Pharmacotherapy 14:1, pages 123-136.
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Kenneth P Johnson. (2010) Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis. Therapeutics and Clinical Risk Management 6, pages 153-172.
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Julie A Murphy, Jacklyn A Harris & Andrew J Crannage. (2010) Potential short-term use of oral cladribine in treatment of relapsing-remitting multiple sclerosis. Neuropsychiatric Disease and Treatment 6, pages 619-625.
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Rina Aharoni. (2010) Immunomodulatory drug treatment in multiple sclerosis. Expert Review of Neurotherapeutics 10:9, pages 1423-1436.
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Mathias Buttmann. (2010) Treating multiple sclerosis with monoclonal antibodies: a 2010 update. Expert Review of Neurotherapeutics 10:5, pages 791-809.
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Jack C Sipe. (2010) Cladribine tablets: a potential new short-course annual treatment for relapsing multiple sclerosis. Expert Review of Neurotherapeutics 10:3, pages 365-375.
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Darren S Sigal & Alan Saven. (2008) Cladribine in indolent non-Hodgkin’s lymphoma. Expert Review of Anticancer Therapy 8:4, pages 535-545.
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Thomas P. Leist & Patrick Vermersch. (2007) The potential role for cladribine in the treatment of multiple sclerosis: clinical experience and development of an oral tablet formulation. Current Medical Research and Opinion 23:11, pages 2667-2676.
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Richard E Gonsette. (2007) Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis. Expert Opinion on Pharmacotherapy 8:8, pages 1103-1116.
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Mark S Freedman. (2006) Disease-modifying drugs for multiple sclerosis: current and future aspects. Expert Opinion on Pharmacotherapy 7:sup1, pages S1-S9.
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Articles from other publishers (53)

Jasem Al-Hashel, Samar Farouk Ahmed, Malak AlMojel & Raed Alroughani. (2023) A prospective observational longitudinal study with a two-year follow-up of multiple sclerosis patients on Cladribine. Clinical Neurology and Neurosurgery 232, pages 107885.
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Fardin Nabizadeh, Mobin Mohamadi, Shayan Rahmani, Rayan Rajabi, Fatemeh Afrashteh, Soroush Najdaghi & Omid Mirmosayyeb. (2023) Safety and efficacy of cladribine in multiple sclerosis: a systematic review and meta-analysis. Neurological Sciences 44:9, pages 3045-3057.
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Hussein Baharlooi, Amir Hossein Mansourabadi, Moein Minbashi Moeini, Leila Mohamed Khosroshahi & Maryam Azimi. (2021) Nucleic Acids as Novel Therapeutic Modalities to Address Multiple Sclerosis Onset and Progression. Cellular and Molecular Neurobiology 42:8, pages 2611-2627.
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Syed Saqib Ali, Ruchika Raj, Tejinder Kaur, Brenna Weadick, Debasis Nayak, Minnsung No, Jane Protos, Hannah Odom, Kajal Desai, Avinash K. Persaud, Joanne Wang & Rajgopal Govindarajan. (2022) Solute Carrier Nucleoside Transporters in Hematopoiesis and Hematological Drug Toxicities: A Perspective. Cancers 14:13, pages 3113.
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Kottil Rammohan, Patricia K. Coyle, Elke Sylvester, Andrew Galazka, Fernando Dangond, Megan Grosso & Thomas P. Leist. (2020) The Development of Cladribine Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review. Drugs 80:18, pages 1901-1928.
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Yamel Rito, Verónica Rivas-Alonso & Erwin Chiquete. (2020) Cladribina para el tratamiento de la esclerosis múltiple remitente recurrente: nueva alternativa para Latinoamérica. Latin american journal of clinical sciences and medical technology 2:2, pages 97-105.
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Francesco Aruta, Aniello Iovino, Claudia Costa, Fiore Manganelli & Rosa Iodice. (2020) Lichenoid rash: A new side effect of oral Cladribine. Multiple Sclerosis and Related Disorders 41, pages 102023.
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Nora Möhn, Thomas Skripuletz, Kurt-Wolfram Sühs, Sylvia Menck, Elke Voß & Martin Stangel. (2019) Therapy with cladribine is efficient and safe in patients previously treated with natalizumab. Therapeutic Advances in Neurological Disorders 12, pages 175628641988759.
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Mark S. Freedman, Daniel Selchen, Alexandre Prat & Paul S. Giacomini. (2018) Managing Multiple Sclerosis: Treatment Initiation, Modification, and Sequencing. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45:5, pages 489-503.
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Serkan Yavuz, Aysu Çetin, Atilla Akdemir, Doğukan Doyduk, Ali Dişli, Gurbet Çelik Turgut, Alaattin Şen & Yılmaz Yıldırır. (2017) Synthesis and Functional Investigations of Computer Designed Novel Cladribine-Like Compounds for the Treatment of Multiple Sclerosis. Archiv der Pharmazie 350:11, pages 1700185.
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Gavin Giovannoni. (2017) Cladribine to Treat Relapsing Forms of Multiple Sclerosis. Neurotherapeutics 14:4, pages 874-887.
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Erick W. Co & Julian P. Henschke. 2016. Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 2. Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 2 271 321 .
C.D. De Gasperis-Brigante, J.L. Parker, P.W. O’Connor & T.R. Bruno. (2016) Reducing clinical trial risk in multiple sclerosis. Multiple Sclerosis and Related Disorders 5, pages 81-88.
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Eric M. Williamson & Joseph R. Berger. (2015) Infection Risk in Patients on Multiple Sclerosis Therapeutics. CNS Drugs 29:3, pages 229-244.
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Stefan H.P. Kraus, Felix Luessi, Bettina Trinschek, Steffen Lerch, Mario Hubo, Laura Poisa-Beiro, Magdalena Paterka, Helmut Jonuleit, Frauke Zipp & Valérie Jolivel. (2014) Cladribine exerts an immunomodulatory effect on human and murine dendritic cells. International Immunopharmacology 18:2, pages 347-357.
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Paul W. O’Connor & Jiwon Oh. 2014. Multiple Sclerosis and Related Disorders. Multiple Sclerosis and Related Disorders 465 501 .
Krystyna Mitosek-Szewczyk, Jacek Tabarkiewicz, Barbara Wilczynska, Katarzyna Lobejko, Jerzy Berbecki, Marcin Nastaj, Ewa Dworzanska, Beata Kolodziejczyk, Zbigniew Stelmasiak & Jacek Rolinski. (2013) Impact of cladribine therapy on changes in circulating dendritic cell subsets, T cells and B cells in patients with multiple sclerosis. Journal of the Neurological Sciences 332:1-2, pages 35-40.
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Vikramjeet Singh, Elke Verena Voss, Karelle Bénardais & Martin Stangel. (2012) Effects of 2-Chlorodeoxyadenosine (Cladribine) on Primary Rat Microglia. Journal of Neuroimmune Pharmacology 7:4, pages 939-950.
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Alfred W. Sandrock & Richard A. Rudick. 2012. Translational Neuroscience. Translational Neuroscience 178 196 .
Shiv Saidha, Christopher Eckstein & Peter A. Calabresi. (2012) New and emerging disease modifying therapies for multiple sclerosis. Annals of the New York Academy of Sciences 1247:1, pages 117-137.
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Gavin Giovannoni & Stuart D. Cook. 2011. Multiple Sclerosis Therapeutics. Multiple Sclerosis Therapeutics 358 369 .
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Colleen E. Miller & Margaret A. Umhauer. (2011) Emerging Oral Therapies for Multiple Sclerosis. Journal of Neuroscience Nursing 43:1, pages 3-14.
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Francesca BagnatoIstvan Pirko. (2011) Novel Agents and Emerging Treatment Strategies in Multiple Sclerosis. What Role for Cladribine?. Clinical Medicine Insights: Therapeutics 3, pages CMT.S6456.
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Ralf Gold. (2011) Oral Therapies for Multiple Sclerosis. CNS Drugs 25:1, pages 37-52.
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Thomas P. Leist & Robert Weissert. (2011) Cladribine. Clinical Neuropharmacology 34:1, pages 28-35.
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Amy Perrin Ross & Ben W. Thrower. (2010) Recent Developments in the Early Diagnosis and Management of Multiple Sclerosis. Journal of Neuroscience Nursing 42:6, pages 342-353.
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Amer M. Awad & Olaf Stüve. (2010) IMMUNOPATHOGENESIS OF MULTIPLE SCLEROSIS. CONTINUUM: Lifelong Learning in Neurology 16, pages 166-180.
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S. Schmidt. (2010) Cladribin-Tabletten bei schubförmiger Multipler SkleroseOral cladribine for relapsing-remitting multiple sclerosis. Der Nervenarzt 81:10, pages 1231-1241.
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Bernd C. KieseierDouglas R. Jeffery. (2010) Chemotherapeutics in the treatment of multiple sclerosis. Therapeutic Advances in Neurological Disorders 3:5, pages 277-291.
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William M. Carroll. (2010) Oral Therapy for Multiple Sclerosis — Sea Change or Incremental Step?. New England Journal of Medicine 362:5, pages 456-458.
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H.-P. Hartung, B.C. Kieseier & O. Aktas. (2010) CladribinCladribin. Der Nervenarzt 81:2, pages 194-202.
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Michael NamakaChristine Leong, Michael Prout, Josee-Anne Le Dorze, Mike LimerickEmma Frost & Farid Esfahani. (2010) Emerging Therapies for the Management of Multiple Sclerosis. Clinical Medicine Insights: Therapeutics 2, pages CMT.S2213.
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Heinz Wiendl, Nico Melzer, Christoph Kleinschnitz & Sven G. Meuth. 2010. MULTIPLE SCLEROSIS 3. MULTIPLE SCLEROSIS 3 388 426 .
J.N. Latosińska, M. Latosińska, J. Seliger, V. Žagar & Z. Kazimierczuk. (2009) Electron density distribution in cladribine (2-chloro-2′-deoxyadenosine) – A drug against leukemia and multiple sclerosis – Studied by multinuclear NQR spectroscopy and DFT calculations. Chemical Physics Letters 476:4-6, pages 293-302.
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Sven G. Meuth, Stefan Bittner & Heinz Wiendl. (2014) Immunotherapy of multiple sclerosis. Acta Neuropsychiatrica 21:S2, pages 27-34.
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Jeffrey L. Bennett & Olaf Stüve. (2009) Update on Inflammation, Neurodegeneration, and Immunoregulation in Multiple Sclerosis. Clinical Neuropharmacology 32:3, pages 121-132.
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T. Kopadze, M. Döbert, V. I. Leussink, T. Dehmel & B. C. Kieseier. (2009) Cladribine impedes in vitro migration of mononuclear cells: a possible implication for treating multiple sclerosis . European Journal of Neurology 16:3, pages 409-412.
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Hans-Peter Hartung. (2009) New oral therapies may offer improved treatment options for patients with multiple sclerosis. Current Opinion in Neurology 22:Suppl 1, pages S10-S14.
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Sven G. Meuth, Christoph Kleinschnitz & Heinz Wiendl. (2008) Recent clinical trials and future therapies. Journal of Neurology 255:S6, pages 93-96.
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Peter Rieckmann, Anthony Traboulsee, Virginia Devonshire & Joel Oger. (2008) Review: Escalating immunotherapy of multiple sclerosis. Therapeutic Advances in Neurological Disorders 1:3, pages 181-192.
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Ralf A. Linker, Bernd C. Kieseier & Ralf Gold. (2008) Identification and development of new therapeutics for multiple sclerosis. Trends in Pharmacological Sciences 29:11, pages 558-565.
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Kathleen Costello & Jack C. Sipe. (2008) Cladribine Tabletsʼ Potential in Multiple Sclerosis Treatment. Journal of Neuroscience Nursing 40:5, pages 275-280.
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H. Wiendl, K. V. Toyka, P. Rieckmann, R. Gold, H.-P. Hartung & R. Hohlfeld. (2008) Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations. Journal of Neurology 255:10, pages 1449-1463.
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B. A. Cohen & P. Rieckmann. (2007) Emerging oral therapies for multiple sclerosis. International Journal of Clinical Practice 61:11, pages 1922-1930.
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Oliver Neuhaus, Bernd C. Kieseier & Hans-Peter Hartung. (2007) Immunosuppressive agents in multiple sclerosis. Neurotherapeutics 4:4, pages 654-660.
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C. Kleinschnitz, S.G. Meuth, B.C. Kieseier & H. Wiendl. (2007) Multiple-Sklerose-Update zur Pathophysiologie und neuen immuntherapeutischen AnsätzenUpdate on pathophysiologic and immunotherapeutic approaches for the treatment of multiple sclerosis. Der Nervenarzt 78:8, pages 883-911.
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J. E. Martinez-Rodriguez, D. Cadavid, L. J. Wolansky, L. Pliner & S. D. Cook. (2007) Cladribine in aggressive forms of multiple sclerosis. European Journal of Neurology 14:6, pages 686-689.
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William R. Hartman, D. Eric Walters & Patricia Hentosh. (2007) Presence of the anti-leukemic nucleotide analog, 2-chloro-2′-deoxyadenosine-5′-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP). Archives of Biochemistry and Biophysics 459:2, pages 223-232.
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Bernd C Kieseier & Heinz Wiendl. (2007) Oral Disease-Modifying Treatments for Multiple Sclerosis. CNS Drugs 21:6, pages 483-502.
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Heinz Wiendl & Reinhard Hohlfeld. 2007. Immune Regulation and Immunotherapy in Autoimmune Disease. Immune Regulation and Immunotherapy in Autoimmune Disease 289 338 .
Peter Rieckmann. (2006) Immunmodulatorische Stufentherapie der Multiplen SkleroseEscalating immunomodulatory therapy of multiple sclerosis. Der Nervenarzt 77:12, pages 1506-1518.
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Julie A Brousil, Russel J Roberts & Amanda L Schlein. (2016) Cladribine: An Investigational Immunomodulatory Agent for Multiple Sclerosis. Annals of Pharmacotherapy 40:10, pages 1814-1821.
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