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Review

Gender disparities in Parkinson’s disease

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Pages 407-416 | Published online: 10 Jan 2014

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Jessica L. Podcasy & C. Neill Epperson. (2016) Considering sex and gender in Alzheimer disease and other dementias . Dialogues in Clinical Neuroscience 18:4, pages 437-446.
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Mélanie Bourque, Marc Morissette & Thérèse Di Paolo. (2024) Neuroactive steroids and Parkinson’s disease: Review of human and animal studies. Neuroscience & Biobehavioral Reviews 156, pages 105479.
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Felwah S. Al-Zaid, Michael J. Hurley, David T. Dexter & Glenda E. Gillies. (2023) Neuroprotective role for RORA in Parkinson’s disease revealed by analysis of post-mortem brain and a dopaminergic cell line. npj Parkinson's Disease 9:1.
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Takayasu Mishima, Shih-Wei Chiu, Hidemoto Saiki, Takuhiro Yamaguchi, Yasushi Shimo, Tetsuya Maeda, Hirohisa Watanabe, Kenichi Kashihara, Masahiro Nomoto, Nobutaka Hattori & Yoshio Tsuboi. (2023) Risk factors for developing dyskinesia among Parkinson's disease patients with wearing-off: J-FIRST. Journal of the Neurological Sciences 448, pages 120619.
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Léon-Charles Tranchevent, Rashi Halder & Enrico Glaab. (2023) Systems level analysis of sex-dependent gene expression changes in Parkinson’s disease. npj Parkinson's Disease 9:1.
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Amandine Isenbrandt, Katherine Coulombe, Marc Morissette, Mélanie Bourque, Jérôme Lamontagne-Proulx, Thérèse Di Paolo & Denis Soulet. (2023) Three-Dimensional Analysis of Sex- and Gonadal Status- Dependent Microglial Activation in a Mouse Model of Parkinson’s Disease. Pharmaceuticals 16:2, pages 152.
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Rhonda Voskuhl & Yuichiro Itoh. (2022) The X factor in neurodegeneration. Journal of Experimental Medicine 219:12.
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A. U. Hamadyanova, K. O. Kuznetsov, E. I. Gaifullina, D. A. Kalandin, R. R. Khamidullina, I. F. Khalitova, R. M. Faizov, N. O. Kamaletdinova, B. F. Aslanova, A. G. Nakieva, L. E. Burangulova & G. O. Gaisina. (2022) Androgens and Parkinson’s disease: the role in humans and in experiment. Problems of Endocrinology 68:6, pages 146-156.
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Yangfan Zhao & Sarah A. Gagliano Taliun. (2022) Lipid-lowering drug targets and Parkinson's disease: A sex-specific Mendelian randomization study. Frontiers in Neurology 13.
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Stephan Listabarth, Magdalena Groemer, Thomas Waldhoer, Benjamin Vyssoki, Nathalie Pruckner, Sandra Vyssoki, Alexander Glahn, Deirdre Maria König-Castillo & Daniel König. (2022) Cognitive decline and alcohol consumption in the aging population—A longitudinal analysis of the Survey of Health, Ageing and Retirement in Europe. European Psychiatry 65:1.
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Mélanie BourqueDenis SouletThérèse Di Paolo. (2021) Androgens and Parkinson's Disease: A Review of Human Studies and Animal Models. Androgens: Clinical Research and Therapeutics 2:1, pages 294-303.
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Nicole Petersen, Andrea J. Rapkin, Kyoji Okita, Kaitlin R. Kinney, Tomi Mizuno, Mark A. Mandelkern & Edythe D. London. (2021) Striatal dopamine D2-type receptor availability and peripheral 17β-estradiol. Molecular Psychiatry 26:6, pages 2038-2047.
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Bhupesh Vaidya, Kritika Dhamija, Priyanka Guru & Shyam Sunder Sharma. (2021) Parkinson's disease in women: Mechanisms underlying sex differences. European Journal of Pharmacology 895, pages 173862.
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Meagan R. Conner, Doyeon Jang, Brenda J. Anderson & Mary F. Kritzer. (2020) Biological Sex and Sex Hormone Impacts on Deficits in Episodic-Like Memory in a Rat Model of Early, Pre-motor Stages of Parkinson's Disease. Frontiers in Neurology 11.
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Nobutaka Hattori, Hiroki Kitabayashi, Tomoyuki Kanda, Takanobu Nomura, Keizo Toyama & Akihisa Mori. (2020) A Pooled Analysis From Phase 2b and 3 Studies in Japan of Istradefylline in Parkinson's Disease. Movement Disorders 35:8, pages 1481-1487.
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Ye Zhang, Rong Ren, Larry D. Sanford, Linghui Yang, Junying Zhou, Lu Tan, Taomei Li, Jihui Zhang, Yun-Kwok Wing, Jie Shi, Lin Lu & Xiangdong Tang. (2020) Sleep in Parkinson's disease: A systematic review and meta-analysis of polysomnographic findings. Sleep Medicine Reviews 51, pages 101281.
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Nirmal K. Sampathkumar, Juan I. Bravo, Yilin Chen, Prakroothi S. Danthi, Erin K. Donahue, Rochelle W. Lai, Ryan Lu, Lewis T. Randall, Nika Vinson & Bérénice A. Benayoun. (2019) Widespread sex dimorphism in aging and age-related diseases. Human Genetics 139:3, pages 333-356.
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Julia M. Marquis, Samantha E. Lettenberger & Cynthia A. Kelm-Nelson. (2020) Early-onset Parkinsonian behaviors in female Pink1-/- rats. Behavioural Brain Research 377, pages 112175.
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Angus D. Macleod & Carl E. Counsell. (2019) Treatment Responsiveness of Motor Features in Parkinson's Disease: A Matched Case‐Control Analysis. Movement Disorders Clinical Practice 7:1, pages 45-51.
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José M.M. Bispo, João E.C. Melo, Auderlan M. Gois, Pollyana C. Leal, Lívia C.R.F. Lins, Marina F. Souza, Katty A.A.L. Medeiros, Alessandra M. Ribeiro, Regina H. Silva, Murilo Marchioro & José R. Santos. (2019) Sex differences in the progressive model of parkinsonism induced by reserpine in rats. Behavioural Brain Research 363, pages 23-29.
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Mélanie Bourque, Marc Morissette & Thérèse Di Paolo. (2019) Repurposing sex steroids and related drugs as potential treatment for Parkinson's disease. Neuropharmacology 147, pages 37-54.
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Michael T. Hayes. 2019. Neurology and Psychiatry of Women. Neurology and Psychiatry of Women 213 217 .
Michelle E. Fullard, Dylan P. Thibault, Veronica Todaro, Susan Foster, Lori Katz, Robin Morgan, Drew S. Kern, Jason M. Schwalb, Enrique Urrea Mendoza, Nabila Dahodwala, Lisa Shulman & Allison W. Willis. (2018) Sex disparities in health and health care utilization after Parkinson diagnosis: Rethinking PD associated disability. Parkinsonism & Related Disorders 48, pages 45-50.
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T. N. Seyfried, H. Choi, A. Chevalier, D. Hogan, Z. Akgoc & J. S. Schneider. (2018) Sex-Related Abnormalities in Substantia Nigra Lipids in Parkinson’s Disease. ASN Neuro 10, pages 175909141878188.
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Peter T. Nelson, Wang-Xia Wang, Sarah A. Janse & Katherine L. Thompson. (2018) MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls. Brain Research 1678, pages 374-383.
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Marc Morissette, Nadhir Litim & Thérèse Di Paolo. 2018. Discovery and Development of Neuroprotective Agents from Natural Products. Discovery and Development of Neuroprotective Agents from Natural Products 9 61 .
Cassandra E. Meyer, Florian Kurth, Stefano Lepore, Josephine L. Gao, Hadley Johnsonbaugh, Mandavi R. Oberoi, Stephen J. Sawiak & Allan MacKenzie-Graham. (2017) In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice. NeuroImage 163, pages 197-205.
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Julieta Mendes-Oliveira, Filipa Lopes Campos, Rita Alexandra Videira & Graça Baltazar. (2017) GPER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment. Brain, Behavior, and Immunity 64, pages 296-307.
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Erika Betancourt, Jonathan Wachtel, Michalis Michaelos, Michael Haggerty, Jessica Conforti & Mary F. Kritzer. (2017) The impact of biological sex and sex hormones on cognition in a rat model of early, pre-motor Parkinson’s disease. Neuroscience 345, pages 297-314.
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Santosh K. Yadav, Nagarajan Kathiresan, Suyash Mohan, Georgia Vasileiou, Anup Singh, Deepak Kaura, Elias R. Melhem, Rakesh K. Gupta, Ena Wang, Francesco M. Marincola, Arijitt Borthakur & Mohammad Haris. (2016) Gender-based analysis of cortical thickness and structural connectivity in Parkinson’s disease. Journal of Neurology 263:11, pages 2308-2318.
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Mei Dai, Benjamin Liou, Brittany Swope, Xiaohong Wang, Wujuan Zhang, Venette Inskeep, Gregory A. Grabowski, Ying Sun & Dao Pan. (2016) Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease. PLOS ONE 11:9, pages e0162367.
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Nadhir Litim, Marc Morissette & Thérèse Di Paolo. (2016) Neuroactive gonadal drugs for neuroprotection in male and female models of Parkinson's disease. Neuroscience & Biobehavioral Reviews 67, pages 79-88.
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Gretchen N. Neigh & Liana Merrill. 2016. Sex Differences in Physiology. Sex Differences in Physiology 17 44 .
Anne Almey, Teresa A. Milner & Wayne G. Brake. (2015) Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females. Hormones and Behavior 74, pages 125-138.
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Hannah Loke, Vincent Harley & Joohyung Lee. (2015) Biological factors underlying sex differences in neurological disorders. The International Journal of Biochemistry & Cell Biology 65, pages 139-150.
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Valtteri Kaasinen, Juho Joutsa, Tommi Noponen, Jarkko Johansson & Marko Seppänen. (2015) Effects of aging and gender on striatal and extrastriatal [ 123 I]FP-CIT binding in Parkinson's disease. Neurobiology of Aging 36:4, pages 1757-1763.
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D.G. Lichter & S.G. Finnegan. (2020) Influence of Gender on Tourette Syndrome Beyond Adolescence. European Psychiatry 30:2, pages 334-340.
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Roberto Yunes, Sebastián Casas, Eliana Gaglio & Ricardo Cabrera. (2015) Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3 α -Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of Receptors Involvement . Parkinson's Disease 2015, pages 1-9.
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Chizoba C. Umeh, Adriana Pérez, Erika F. Augustine, Rohit Dhall, Richard B. Dewey, Zoltan Mari, David K. Simon, Anne-Marie A. Wills, Chadwick W. Christine, Jay S. Schneider & Oksana Suchowersky. (2014) No Sex Differences in Use of Dopaminergic Medication in Early Parkinson Disease in the US and Canada - Baseline Findings of a Multicenter Trial. PLoS ONE 9:12, pages e112287.
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Glenda E. Gillies, Ilse S. Pienaar, Shiv Vohra & Zahi Qamhawi. (2014) Sex differences in Parkinson’s disease. Frontiers in Neuroendocrinology 35:3, pages 370-384.
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Diego Orcioli-Silva, Fabio Augusto Barbieri, Lucas Simieli, Natália Madalena Rinaldi, Rodrigo Vitório & Lilian Teresa Bucken Gobbi. (2014) Effects of a multimodal exercise program on the functional capacity of Parkinson's disease patients considering disease severity and gender. Motriz: Revista de Educação Física 20:1, pages 100-106.
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