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Fumarates for the treatment of multiple sclerosis: potential mechanisms of action and clinical studies

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Pages 1683-1690 | Published online: 09 Jan 2014

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Alessandra Lugaresi, Maria di Ioia, Daniela Travaglini, Erika Pietrolongo, Eugenio Pucci & Marco Onofrj. (2013) Risk-benefit considerations in the treatment of relapsing-remitting multiple sclerosis. Neuropsychiatric Disease and Treatment 9, pages 893-914.
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Samaneh Zoghi, Zahra Amirghofran, Alireza Nikseresht, Nahid Ashjazadeh, Eskandar Kamali-Sarvestani & Nahid Rezaei. (2011) Cytokine Secretion Pattern in Treatment of Lymphocytes of Multiple Sclerosis Patients with Fumaric Acid Esters. Immunological Investigations 40:6, pages 581-596.
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Kenneth P Johnson. (2010) Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis. Therapeutics and Clinical Risk Management 6, pages 153-172.
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Alexandra Schröder, Ralf A Linker & Ralf Gold. (2009) Plasmapheresis for neurological disorders. Expert Review of Neurotherapeutics 9:9, pages 1331-1339.
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Articles from other publishers (19)

F. Piehl. (2020) Current and emerging disease‐modulatory therapies and treatment targets for multiple sclerosis. Journal of Internal Medicine 289:6, pages 771-791.
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Roberto Motterlini, Aniket Nikam, Sylvie Manin, Anthony Ollivier, Jayne Louise Wilson, Sabrina Djouadi, Lucie Muchova, Thierry Martens, Michael Rivard & Roberta Foresti. (2019) HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide. Redox Biology 20, pages 334-348.
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Lilla Landeck, Khusru Asadullah, Adriana Amasuno, Ignasi Pau-Charles & Ulrich Mrowietz. (2018) Dimethyl fumarate (DMF) vs. monoethyl fumarate (MEF) salts for the treatment of plaque psoriasis: a review of clinical data. Archives of Dermatological Research 310:6, pages 475-483.
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Elizabeth A. Mills & Yang Mao-Draayer. (2018) Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird’s Eye View. Frontiers in Immunology 9.
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Sheena L. Dupuy, Shahamat Tauhid, Shelley Hurwitz, Renxin Chu, Fawad Yousuf & Rohit Bakshi. (2016) The Effect of Dimethyl Fumarate on Cerebral Gray Matter Atrophy in Multiple Sclerosis. Neurology and Therapy 5:2, pages 215-229.
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A. Egeberg. (2016) Fumarates for treatment of psoriasis. British Journal of Dermatology 175:5, pages 857-857.
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Zaidoon Al-Jaderi & Azzam A. Maghazachi. (2016) Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases. Frontiers in Immunology 7.
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Elżbieta Miller, Dominika Książek-Winiarek, Tomasz Włodarczyk & Andrzej Głąbiński. 2016. Reactive Oxygen Species in Biology and Human Health. Reactive Oxygen Species in Biology and Human Health 167 185 .
Heidi Vego, Kristin L Sand, Rune A Høglund, Lars-Egil Fallang, Glenn Gundersen, Trygve Holmøy & Azzam A Maghazachi. (2014) Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CD107a. Cellular & Molecular Immunology 13:1, pages 57-64.
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Geoffrey O. Gillard, Brian Collette, John Anderson, Jianhua Chao, Robert H. Scannevin, David J. Huss & Jason D. Fontenot. (2015) DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner. Journal of Neuroimmunology 283, pages 74-85.
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Aran Groves, Yasuyuki Kihara & Jerold Chun. (2013) Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. Journal of the Neurological Sciences 328:1-2, pages 9-18.
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Anshul Shakya, Shyam Sunder Chatterjee & Vikas Kumar. (2012) Holistic Psychopharmacology of <i>Fumaria indica</i> (Fumitory). Chinese Medicine 03:04, pages 182-199.
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Alexander Fl?gel, Christian Schl?ger, Fred L?hder & Francesca Odoardi. (2011) Autoimmune disease in the brain ? how to spot the culprits and how to keep them in check. Journal of the Neurological Sciences 311, pages S3-S11.
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Ralf A. Linker, De-Hyung Lee, Sarah Ryan, Anne M. van Dam, Rebecca Conrad, Pradeep Bista, Weike Zeng, Xiaoping Hronowsky, Alex Buko, Sowmya Chollate, Gisa Ellrichmann, Wolfgang Brück, Kate Dawson, Susan Goelz, Stefan Wiese, Robert H. Scannevin, Matvey Lukashev & Ralf Gold. (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134:3, pages 678-692.
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Gisa Ellrichmann, Elisabeth Petrasch-Parwez, De-Hyung Lee, Christiane Reick, Larissa Arning, Carsten Saft, Ralf Gold & Ralf A. Linker. (2011) Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease. PLoS ONE 6:1, pages e16172.
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Maike M. Schmidt & Ralf Dringen. (2010) Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione. Neurochemistry International 57:4, pages 460-467.
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Darius Moharregh-Khiabani, Alexander Blank, Thomas Skripuletz, Elvira Miller, Alexandra Kotsiari, Viktoria Gudi & Martin Stangel. (2010) Effects of Fumaric Acids on Cuprizone Induced Central Nervous System De- and Remyelination in the Mouse. PLoS ONE 5:7, pages e11769.
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Sabine Amslinger. (2010) The Tunable Functionality of α,β-Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems. ChemMedChem 5:3, pages 351-356.
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MH Han & L Steinman. (2009) Systems biology for identification of molecular networks in multiple sclerosis. Multiple Sclerosis Journal 15:5, pages 529-530.
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