Advanced search
Publication Cover
Expert Review of Vaccines Volume 14, 2015 - Issue 2
Submit an article Journal homepage
1,133
Views
53
CrossRef citations to date
0
Altmetric
SPECIAL FOCUS: RNA Vaccines - Review

The ReNAissanCe of mRNA-based cancer therapy

Sandra Van LintLaboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Medical School of the Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Jette, Belgium
,
Dries RenmansLaboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Medical School of the Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Jette, Belgium
,
Katrijn BroosLaboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Medical School of the Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Jette, Belgium
,
Heleen DewitteLab for General Biochemistry and Physical Pharmacy, Department of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium
,
Ine LentackerLab for General Biochemistry and Physical Pharmacy, Department of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium
,
Carlo HeirmanLaboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Medical School of the Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Jette, Belgium
,
Karine BreckpotLaboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Medical School of the Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Jette, Belgium
&
Kris ThielemansLaboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Medical School of the Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Jette, BelgiumCorrespondence[email protected].
 show all
Pages 235-251 | Published online: 29 Sep 2014

Citations (53)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Carlo Iavarone, Derek T. O’hagan, Dong Yu, Nicolas F. Delahaye & Jeffrey B. Ulmer. (2017) Mechanism of action of mRNA-based vaccines. Expert Review of Vaccines 16:9, pages 871-881.
Read now

Articles from other publishers (52)

Inès Dufait, Els Van Valckenborgh, Eline Menu, David Escors, Mark De Ridder & Karine Breckpot. (2016) Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy. Oncotarget 7:27, pages 42698-42715.
Crossref
Falak Goyal, Anandini Chattopadhyay, Umashanker Navik, Aklank Jain, P. Hemachandra Reddy, Gurjit Kaur Bhatti & Jasvinder Singh Bhatti. (2023) Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach. Advanced Therapeutics.
Crossref
Gang Zhang, Tianyu Tang, Yinfeng Chen, Xing Huang & Tingbo Liang. (2023) mRNA vaccines in disease prevention and treatment. Signal Transduction and Targeted Therapy 8:1.
Crossref
Xiao-ting Jiang & Qiang Liu. (2023) mRNA vaccination in breast cancer: current progress and future direction. Journal of Cancer Research and Clinical Oncology 149:11, pages 9435-9450.
Crossref
Timothy R. Blake, Ole A. W. Haabeth, Adrienne Sallets, Rebecca L. McClellan, Trevor J. Del Castillo, Jose G. Vilches-Moure, Wilson C. Ho, Paul A. Wender, Ronald Levy & Robert M. Waymouth. (2023) Lysine-Derived Charge-Altering Releasable Transporters: Targeted Delivery of mRNA and siRNA to the Lungs. Bioconjugate Chemistry.
Crossref
Wout de Mey, Hanne Locy, Kirsten De Ridder, Phaedra De Schrijver, Dorien Autaers, Asma Lakdimi, Arthur Esprit, Lorenzo Franceschini, Kris Thielemans, Magali Verdonck & Karine Breckpot. (2023) An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells. Frontiers in Immunology 14.
Crossref
Luz M. Garcini, Arlynn M. Ambriz, Alejandro L. Vázquez, Cristina Abraham, Vyas Sarabu, Ciciya Abraham, Autumn K. Lucas-Marinelli, Sarah Lill & Joel Tsevat. (2022) Vaccination for COVID-19 among historically underserved Latino communities in the United States: Perspectives of community health workers. Frontiers in Public Health 10.
Crossref
Alicia M. Davis, Tristan A. Scott & Kevin V. Morris. (2022) Harnessing Rift Valley fever virus NSs gene for cancer gene therapy. Cancer Gene Therapy 29:10, pages 1477-1486.
Crossref
Nitika, Jiao Wei & Ai-Min Hui. (2022) The Delivery of mRNA Vaccines for Therapeutics. Life 12:8, pages 1254.
Crossref
Stephanie Seneff, Greg Nigh, Anthony M. Kyriakopoulos & Peter A. McCullough. (2022) Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs. Food and Chemical Toxicology 164, pages 113008.
Crossref
Gábor Tamás Szabó, Azita Josefine Mahiny & Irena Vlatkovic. (2022) COVID-19 mRNA vaccines: Platforms and current developments. Molecular Therapy 30:5, pages 1850-1868.
Crossref
Randall A. Meyer, G. Patrick Hussmann, Norman C. Peterson, Jose Luis Santos & Anthony D. Tuesca. (2022) A scalable and robust cationic lipid/polymer hybrid nanoparticle platform for mRNA delivery. International Journal of Pharmaceutics 611, pages 121314.
Crossref
Alaknanda Mishra. 2022. Encyclopedia of Animal Cognition and Behavior. Encyclopedia of Animal Cognition and Behavior 4193 4197 .
Simon Beyaert, Jean-Pascal Machiels & Sandra Schmitz. (2021) Vaccine-Based Immunotherapy for Head and Neck Cancers. Cancers 13:23, pages 6041.
Crossref
Ahmed Salah, Hao Wang, Yanqin Li, Meng Ji, Wen-Bin Ou, Nianmin Qi & Yuehong Wu. (2021) Insights Into Dendritic Cells in Cancer Immunotherapy: From Bench to Clinical Applications. Frontiers in Cell and Developmental Biology 9.
Crossref
Furong Qin, Fan Xia, Hongli Chen, Bomiao Cui, Yun Feng, Ping Zhang, Jiao Chen & Min Luo. (2021) A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications. Frontiers in Cell and Developmental Biology 9.
Crossref
Hermann AM Mucke. (2021) Patent highlights December 2020–January 2021. Pharmaceutical Patent Analyst 10:3, pages 103-110.
Crossref
Emily De Lombaerde, Olivier De Wever & Bruno G. De Geest. (2021) Delivery routes matter: Safety and efficacy of intratumoral immunotherapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1875:2, pages 188526.
Crossref
Annkristin Heine, Stefan Juranek & Peter Brossart. (2021) Clinical and immunological effects of mRNA vaccines in malignant diseases. Molecular Cancer 20:1.
Crossref
Lien Van Hoecke, Rein Verbeke, Heleen Dewitte, Ine Lentacker, Karim Vermaelen, Karine Breckpot & Sandra Van Lint. (2021) mRNA in cancer immunotherapy: beyond a source of antigen. Molecular Cancer 20:1.
Crossref
István Tombácz, Drew Weissman & Norbert Pardi. 2021. DNA Vaccines. DNA Vaccines 13 31 .
Arthur Esprit, Wout de Mey, Rajendra Bahadur Shahi, Kris Thielemans, Lorenzo Franceschini & Karine Breckpot. (2020) Neo-Antigen mRNA Vaccines. Vaccines 8:4, pages 776.
Crossref
Laurens Raes, Stephan Stremersch, Juan C. Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, Xavier Saelens, Bart Vandekerckhove, Stefaan De Smedt, Koen Raemdonck & Kevin Braeckmans. (2020) Intracellular Delivery of mRNA in Adherent and Suspension Cells by Vapor Nanobubble Photoporation. Nano-Micro Letters 12:1.
Crossref
Shuqin Xu, Kunpeng Yang, Rose Li & Lu Zhang. (2020) mRNA Vaccine Era—Mechanisms, Drug Platform and Clinical Prospection. International Journal of Molecular Sciences 21:18, pages 6582.
Crossref
Melissa van Dülmen & Andrea Rentmeister. (2020) mRNA Therapies: New Hope in the Fight against Melanoma. Biochemistry 59:17, pages 1650-1655.
Crossref
Yuhua Weng, Chunhui Li, Tongren Yang, Bo Hu, Mengjie Zhang, Shuai Guo, Haihua Xiao, Xing-Jie Liang & Yuanyu Huang. (2020) The challenge and prospect of mRNA therapeutics landscape. Biotechnology Advances 40, pages 107534.
Crossref
Zohreh Jahanafrooz, Behzad Baradaran, Jafar Mosafer, Mahmoud Hashemzaei, Tayebeh Rezaei, Ahad Mokhtarzadeh & Michael R. Hamblin. (2020) Comparison of DNA and mRNA vaccines against cancer. Drug Discovery Today 25:3, pages 552-560.
Crossref
Xiangjun Tang, Shenqi Zhang, Rui Fu, Li Zhang, Kuanming Huang, Hao Peng, Longjun Dai & Qianxue Chen. (2019) Therapeutic Prospects of mRNA-Based Gene Therapy for Glioblastoma. Frontiers in Oncology 9.
Crossref
Kyuri Lee, Minjeong Kim, Yunmi Seo & Hyukjin Lee. (2018) Development of mRNA vaccines and their prophylactic and therapeutic applications. Nano Research 11:10, pages 5173-5192.
Crossref
Ole A. W. Haabeth, Timothy R. BlakeColin J. McKinlayRobert M. WaymouthPaul A. Wender & Ronald Levy. (2018) mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice. Proceedings of the National Academy of Sciences 115:39.
Crossref
Cleo Goyvaerts & Karine Breckpot. (2018) The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road. Frontiers in Immunology 9.
Crossref
Lien Van Hoecke, Sandra Van Lint, Kenny Roose, Alexander Van Parys, Peter Vandenabeele, Johan Grooten, Jan Tavernier, Stefaan De Koker & Xavier Saelens. (2018) Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes. Nature Communications 9:1.
Crossref
Norbert Pardi, Michael J. Hogan, Frederick W. Porter & Drew Weissman. (2018) mRNA vaccines — a new era in vaccinology. Nature Reviews Drug Discovery 17:4, pages 261-279.
Crossref
Fatemeh Nouri Rouz, Mohammad Shirkhoda, Feridon Memari, Hassan Dana, Ghanbar Mahmoodi C, Habibollah Mahmoodzad, Nasim Samarghand, Elahe Gharagozlo, Mohammad Hosein Mohammadi, Ali Reza Maleki, Ehsan Sadeghian, ElhamZainali Nia, Nedazainali Nia, Farimah Hadjilooei, Omid Rezaeian, Saeed Meghdadi, SeyedRohollah Miri, Fatameh Jafari, Elham Rayzan & Vahid Marmari. (2018) Immunotherapy a New Hope for Cancer Treatment: A Review. Pakistan Journal of Biological Sciences 21:3, pages 135-150.
Crossref
Yuhua Wang, Lu Zhang, Zhenghong Xu, Lei Miao & Leaf Huang. (2018) mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma. Molecular Therapy 26:2, pages 420-434.
Crossref
Alaknanda Mishra. 2017. Encyclopedia of Animal Cognition and Behavior. Encyclopedia of Animal Cognition and Behavior 1 5 .
Ludger WeßFrank Schnieders. (2017) Immuno-Oncology—The Translational Runway for Gene Therapy: Gene Therapeutics to Address Multiple Immune Targets. Human Gene Therapy 28:12, pages 1130-1137.
Crossref
Rein Verbeke, Ine Lentacker, Laura Wayteck, Karine Breckpot, Mieke Van Bockstal, Benedicte Descamps, Christian Vanhove, Stefaan C. De Smedt & Heleen Dewitte. (2017) Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA. Journal of Controlled Release 266, pages 287-300.
Crossref
Vimal K. Udhayakumar, Ans De Beuckelaer, Joanne McCaffrey, Cian M. McCrudden, Jonathan L. Kirschman, Daryll Vanover, Lien Van Hoecke, Kenny Roose, Kim Deswarte, Bruno G. De Geest, Stefan Lienenklaus, Philip J. Santangelo, Johan Grooten, Helen O. McCarthy & Stefaan De Koker. (2017) Arginine‐Rich Peptide‐Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide. Advanced Healthcare Materials 6:13, pages 1601412.
Crossref
Ans De Beuckelaer, Johan Grooten & Stefaan De Koker. (2017) Type I Interferons Modulate CD8 + T Cell Immunity to mRNA Vaccines. Trends in Molecular Medicine 23:3, pages 216-226.
Crossref
Ali Ahmad & Charles R. Rinaldo. (2017) A novel anti-HIV immunotherapy to cure HIV. AIDS 31:3, pages 447-449.
Crossref
Zhao Meng, Jonathan O'Keeffe-Ahern, Jing Lyu, Luca Pierucci, Dezhong Zhou & Wenxin Wang. (2017) A new developing class of gene delivery: messenger RNA-based therapeutics. Biomaterials Science 5:12, pages 2381-2392.
Crossref
Jeffrey B Ulmer & Andrew J Geall. (2016) Recent innovations in mRNA vaccines. Current Opinion in Immunology 41, pages 18-22.
Crossref
Jasdave S. ChahalOmar F. KhanChristopher L. CooperJustine S. McPartlanJonathan K. TsosieLucas D. TilleySaima M. SidikSebastian Lourido, Robert Langer, Sina BavariHidde L. PloeghDaniel G. Anderson. (2016) Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose . Proceedings of the National Academy of Sciences 113:29.
Crossref
Bruce A. SullengerSmita Nair. (2016) From the RNA world to the clinic. Science 352:6292, pages 1417-1420.
Crossref
Phong Minh Le, Tram Thi-Bao Tran, Binh Thanh Vu & Phuc Van Pham. (2016) A preliminary comparison of dendritic cell maturation by total cellular RNA to total cellular lysate derived from breast cancer stem cells. Biomedical Research and Therapy 3:6.
Crossref
Maria Gato-Cañas, Hugo Arasanz, Idoia Blanco-Luquin, Estíbaliz Glaría, Virginia Arteta-Sanchez, Grazyna Kochan & David Escors. (2016) Novel immunotherapies for the treatment of melanoma. Immunotherapy 8:5, pages 613-632.
Crossref
Katrijn Broos, Kevin Van der Jeught, Janik Puttemans, Cleo Goyvaerts, Carlo Heirman, Heleen Dewitte, Rein Verbeke, Ine Lentacker, Kris Thielemans & Karine Breckpot. (2016) Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon. Molecular Therapy - Nucleic Acids 5, pages e326.
Crossref
Joke Devoldere, Heleen Dewitte, Stefaan C. De Smedt & Katrien Remaut. (2016) Evading innate immunity in nonviral mRNA delivery: don’t shoot the messenger. Drug Discovery Today 21:1, pages 11-25.
Crossref
Sandra Lazzaro, Cinzia Giovani, Simona Mangiavacchi, Diletta Magini, Domenico Maione, Barbara Baudner, Andrew J. Geall, Ennio De Gregorio, Ugo D'Oro & Cecilia Buonsanti. (2015) CD8 T-cell priming upon mRNA vaccination is restricted to bone-marrow-derived antigen-presenting cells and may involve antigen transfer from myocytes. Immunology 146:2, pages 312-326.
Crossref
Cleo Goyvaerts & Karine Breckpot. (2015) Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines. Journal of Immunology Research 2015, pages 1-18.
Crossref
Kevin Van der Jeught, Patrick Tjok Joe, Lukasz Bialkowski, Carlo Heirman, Lidia Daszkiewicz, Therese Liechtenstein, David Escors, Kris Thielemans & Karine Breckpot. (2014) Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity. Oncotarget 5:20, pages 10100-10113.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.