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Review

Vaccine development for non-typeable Haemophilus influenzae and Moraxella catarrhalis: progress and challenges

Pages 843-853 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Dabin Ren & Michael E Pichichero. (2016) Vaccine targets against Moraxella catarrhalis. Expert Opinion on Therapeutic Targets 20:1, pages 19-33.
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Yi-Chien Ho, Pei-Lun Lee, Yu-Chiao Wang, Shiou-Chien Chen & Kow-Tong Chen. (2015) The economic burden of childhood invasive pneumococcal diseases and pneumonia in Taiwan: Implications for a pneumococcal vaccination program. Human Vaccines & Immunotherapeutics 11:5, pages 1081-1087.
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Fatme Mawas, Mei Mei Ho & Michael J Corbel. (2009) Current progress with Moraxella catarrhalis antigens as vaccine candidates. Expert Review of Vaccines 8:1, pages 77-90.
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Thuan Tong Tan & Kristian Riesbeck. (2007) Current progress of adhesins as vaccine candidates for Moraxella catarrhalis. Expert Review of Vaccines 6:6, pages 949-956.
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Articles from other publishers (42)

Sean Patrick Fitzwater, Geoffrey D. Kahn, Aruna Chandran & Mathuram Santosham. 2023. Plotkin's Vaccines. Plotkin's Vaccines 348 364.e9 .
Sanjesh Singh, Jennifer C. Wilson, Allan W. Cripps, Helen Massa, Victoria Ozberk, I. Darren Grice & Ian R. Peak. (2020) Immunological characterisation of truncated lipooligosaccharide-outer membrane protein based conjugate vaccine against Moraxella catarrhalis and nontypeable Haemophilus influenzae. Vaccine 38:2, pages 309-317.
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Stephen R. Thomas, Stephanie Leung, Katy Knox, Tom M. A. Wilkinson, Karl J. Staples, Pascal Lestrate, Dominique Wauters, Andrew Gorringe & Stephen C. Taylor. (2018) Development of flow cytometric opsonophagocytosis and antibody-mediated complement deposition assays for non-typeable Haemophilus influenzae. BMC Microbiology 18:1.
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M. Wigand, T. K. Hoffmann, A. F. Ryan, B. Wollenberg & A. Leichtle. (2018) Rolle des angeborenen Immunsystems bei Otitis mediaThe role of innate immunity in otitis media. HNO 66:6, pages 464-471.
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Srinivas Acharya Nanduri, Andrea R. Sutherland, Lance K. Gordon & Mathuram Santosham. 2018. Plotkin's Vaccines. Plotkin's Vaccines 301 318.e10 .
Anne G. M. Schilder, Tasnee Chonmaitree, Allan W. Cripps, Richard M. Rosenfeld, Margaretha L. Casselbrant, Mark P. Haggard & Roderick P. Venekamp. (2016) Otitis media. Nature Reviews Disease Primers 2:1.
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Chinh C. Ngo, Helen M. Massa, Ruth B. Thornton & Allan W. Cripps. (2016) Predominant Bacteria Detected from the Middle Ear Fluid of Children Experiencing Otitis Media: A Systematic Review. PLOS ONE 11:3, pages e0150949.
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Linda E. Winter & Stephen J. Barenkamp. (2016) Naturally Acquired HMW1- and HMW2-Specific Serum Antibodies in Adults and Children Mediate Opsonophagocytic Killing of Nontypeable Haemophilus influenzae. Clinical and Vaccine Immunology 23:1, pages 37-46.
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J. WAN SAI CHEONG, H. SMITH, C. HENEY, J. ROBSON, S. SCHLEBUSCH, J. FU & C. NOURSE. (2015) Trends in the epidemiology of invasive Haemophilus influenzae disease in Queensland, Australia from 2000 to 2013: what is the impact of an increase in invasive non-typable H. influenzae (NTHi)? . Epidemiology and Infection 143:14, pages 2993-3000.
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Matthew K. Siggins, Simren K. Gill, Paul R. Langford, Yanwen Li, Shamez N. Ladhani & John S. Tregoning. (2015) PHiD-CV induces anti-Protein D antibodies but does not augment pulmonary clearance of nontypeable Haemophilus influenzae in mice. Vaccine 33:38, pages 4954-4961.
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Timothy F. Murphy. 2015. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 2463 2470.e2 .
Nicole R. Luke-Marshall, Thomas S. Mang, Lisa A. Hansen & Anthony A. Campagnari. (2014) Moraxella catarrhalis is susceptible to antimicrobial photodynamic therapy with Photofrin . Lasers in Surgery and Medicine 46:9, pages 712-717.
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Linda E. Winter & Stephen J. Barenkamp. (2014) Antibodies to the HMW1/HMW2 and Hia Adhesins of Nontypeable Haemophilus influenzae Mediate Broad-Based Opsonophagocytic Killing of Homologous and Heterologous Strains. Clinical and Vaccine Immunology 21:5, pages 613-621.
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Rachel Balder, Teresa L Shaffer & Eric R Lafontaine. (2013) Moraxella catarrhalis uses a twin-arginine translocation system to secrete the β-lactamase BRO-2. BMC Microbiology 13:1.
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L. V. Michel, J. Snyder, R. Schmidt, J. Milillo, K. Grimaldi, B. Kalmeta, M. N. Khan, S. Sharma, L. K. Wright & M. E. Pichichero. (2013) Dual Orientation of the Outer Membrane Lipoprotein P6 of Nontypeable Haemophilus influenzae. Journal of Bacteriology 195:14, pages 3252-3259.
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Teresa L. Shaffer, Rachel Balder, Sean W. Buskirk, Robert J. Hogan & Eric R. Lafontaine. (2013) Use of the Chinchilla Model to Evaluate the Vaccinogenic Potential of the Moraxella catarrhalis Filamentous Hemagglutinin-like Proteins MhaB1 and MhaB2. PLoS ONE 8:7, pages e67881.
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Margarita Smidt, Patrick Bättig, Suzanne J. C. Verhaegh, Axel Niebisch, Markus Hanner, Sanja Selak, Wolfgang Schüler, Eva Morfeldt, Christel Hellberg, Eszter Nagy, Urban Lundberg, John P. Hays, Andreas Meinke & Birgitta Henriques-Normark. (2013) Comprehensive Antigen Screening Identifies Moraxella catarrhalis Proteins That Induce Protection in a Mouse Pulmonary Clearance Model. PLoS ONE 8:5, pages e64422.
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Ryoichi Saito, Shiho Matsuoka, Yuji Fujinami, Shotaro Nonaka, Shizuko Ichinose, Tetsuo Kubota & Noboru Okamura. (2013) Role of Moraxella catarrhalis outer membrane protein CD in bacterial cell morphology and autoaggregation. Research in Microbiology 164:3, pages 236-243.
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Aruna Chandran, James P. Watt & Mathuram Santosham. 2013. Vaccines. Vaccines 167 182 .
J. R. MacNeil, A. C. Cohn, M. Farley, R. Mair, J. Baumbach, N. Bennett, K. Gershman, L. H. Harrison, R. Lynfield, S. Petit, A. Reingold, W. Schaffner, A. Thomas, F. Coronado, E. R. Zell, L. W. Mayer, T. A. Clark & N. E. Messonnier. (2011) Current Epidemiology and Trends in Invasive Haemophilus influenzae Disease--United States, 1989-2008. Clinical Infectious Diseases 53:12, pages 1230-1236.
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Mark Underwood & Lauren Bakaletz. (2011) Innate Immunity and the Role of Defensins in Otitis Media. Current Allergy and Asthma Reports 11:6.
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Amit A. Lugade, Anna Bianchi-Smiraglia, Vandana Pradhan, Galina Elkin, Timothy F. Murphy & Yasmin Thanavala. (2011) Lipid Motif of a Bacterial Antigen Mediates Immune Responses via TLR2 Signaling. PLoS ONE 6:5, pages e19781.
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Nicole R. Luke-Marshall, Shauna L. Sauberan & Anthony A. Campagnari. (2011) Comparative analyses of the Moraxella catarrhalis type-IV pilus structural subunit PilA. Gene 477:1-2, pages 19-23.
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Andrew D. Cox, Frank St. Michael, Chantelle M. Cairns, Suzanne Lacelle, Amy Lea Filion, Dhamodharan Neelamegan, Cory Q. Wenzel, Heather Horan & James C. Richards. (2011) Investigating the potential of conserved inner core oligosaccharide regions of Moraxella catarrhalis lipopolysaccharide as vaccine antigens: accessibility and functional activity of monoclonal antibodies and glycoconjugate derived sera. Glycoconjugate Journal 28:3-4, pages 165-182.
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Lea Vacca Michel, Breanna Kalmeta, Mark McCreary, Joy Snyder, Paul Craig & Michael E. Pichichero. (2011) Vaccine candidate P6 of nontypable Haemophilus influenzae is not a transmembrane protein based on protein structural analysis. Vaccine 29:8, pages 1624-1627.
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Sandra E. Talbird, Thomas N. Taylor, Joaquín Caporale, Afisi S. Ismaila & Jorge Gomez. (2010) Residual economic burden of Streptococcus pneumoniae- and nontypeable Haemophilus influenzae- associated disease following vaccination with PCV-7: A multicountry analysis. Vaccine 28, pages G14-G22.
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TIMOTHY F. MURPHY. 2010. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 2771 2776 .
Mary P.E. Slack. 2010. Infectious Diseases. Infectious Diseases 1738 1756 .
Elizabeth A. Ruckdeschel, Aimee L. Brauer, Antoinette Johnson & Timothy F. Murphy. (2009) Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis. Vaccine 27:50, pages 7065-7072.
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Timothy F. Murphy, Lauren O. Bakaletz & Pierre R. Smeesters. (2009) Microbial Interactions in the Respiratory Tract. Pediatric Infectious Disease Journal 28:10, pages S121-S126.
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Megan A. O'Brien, Lisa A. Prosser, Jack L. Paradise, G. Thomas Ray, Martin Kulldorff, Marcia Kurs-Lasky, Virginia L. Hinrichsen, Jyotsna Mehta, D. Kathleen Colborn & Tracy A. Lieu. (2009) New Vaccines Against Otitis Media: Projected Benefits and Cost-effectiveness. Pediatrics 123:6, pages 1452-1463.
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Stephen J. Barenkamp. 2009. Feigin and Cherry's Textbook of Pediatric Infectious Diseases. Feigin and Cherry's Textbook of Pediatric Infectious Diseases 1734 1756 .
Michael J. Brooks, Jennifer L. Sedillo, Nikki Wagner, Wei Wang, Ahmed S. Attia, Henry Wong, Cassie A. Laurence, Eric J. Hansen & Scott D. Gray-Owen. (2008) Moraxella catarrhalis Binding to Host Cellular Receptors Is Mediated by Sequence-Specific Determinants Not Conserved among All UspA1 Protein Variants . Infection and Immunity 76:11, pages 5322-5329.
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Shengqing Yu, Hang Xie, Anup Datta, Natasha Naidu & Xin-Xing Gu. (2008) Galactose Residues on the Lipooligosaccharide of Moraxella catarrhalis 26404 Form the Epitope Recognized by the Bactericidal Antiserum from Conjugate Vaccination . Infection and Immunity 76:9, pages 4251-4258.
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Elizabeth A. Ruckdeschel, Charmaine Kirkham, Alan J. Lesse, Zihua Hu & Timothy F. Murphy. (2008) Mining the Moraxella catarrhalis Genome: Identification of Potential Vaccine Antigens Expressed during Human Infection . Infection and Immunity 76:4, pages 1599-1607.
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Albert Sabirov & Dennis W. Metzger. (2008) Mouse models for the study of mucosal vaccination against otitis media. Vaccine 26:12, pages 1501-1524.
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Aruna Chandran, James P. Watt & Mathuram Santosham. 2008. Vaccines. Vaccines 157 176 .
Nicole R. Luke, Joseph A. Jurcisek, Lauren O. Bakaletz & Anthony A. Campagnari. (2007) Contribution of Moraxella catarrhalis Type IV Pili to Nasopharyngeal Colonization and Biofilm Formation . Infection and Immunity 75:12, pages 5559-5564.
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Shengqing Yu & Xin-Xing Gu. (2007) Biological and Immunological Characteristics of Lipooligosaccharide-Based Conjugate Vaccines for Serotype C Moraxella catarrhalis . Infection and Immunity 75:6, pages 2974-2980.
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Thuan Tong  Tan, Jens Jørgen Christensen, Morten Hanefeld Dziegiel, Arne Forsgren & Kristian Riesbeck. (2006) Comparison of the Serological Responses to Moraxella catarrhalis Immunoglobulin D-Binding Outer Membrane Protein and the Ubiquitous Surface Proteins A1 and A2 . Infection and Immunity 74:11, pages 6377-6386.
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Timothy F. Murphy, Charmaine Kirkham & Alan J. Lesse. (2006) Construction of a Mutant and Characterization of the Role of the Vaccine Antigen P6 in Outer Membrane Integrity of Nontypeable Haemophilus influenzae . Infection and Immunity 74:9, pages 5169-5176.
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Larry Lutwick & Laila Fernandes. (2006) The other siblings: Respiratory infections caused by Moraxella catarrhalis and Haemophilus influenzae. Current Infectious Disease Reports 8:3, pages 215-221.
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