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Review

Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells

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Pages 227-239 | Published online: 09 Jan 2014

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Andrew Yang, Jessica Jeang, Kevin Cheng, Ting Cheng, Benjamin Yang, T.-C. Wu & Chien-Fu Hung. (2016) Current state in the development of candidate therapeutic HPV vaccines. Expert Review of Vaccines 15:8, pages 989-1007.
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Marjorie Jenkins, Maurizio Chiriva-Internati, Leonardo Mirandola, Catherine Tonroy, Sean S. Tedjarati, Nicole Davis, Nicholas D'Cunha, Lukman Tijani, Fred Hardwick, Diane Nguyen, W. Martin Kast & Everardo Cobos. (2012) Perspective for Prophylaxis and Treatment of Cervical Cancer: An Immunological Approach. International Reviews of Immunology 31:1, pages 3-21.
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Chien-Fu Hung, Barbara Ma, Archana Monie, Shaw-Wei Tsen & T-C Wu. (2008) Therapeutic human papillomavirus vaccines: current clinical trials and future directions. Expert Opinion on Biological Therapy 8:4, pages 421-439.
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Articles from other publishers (53)

Samuel T. Pellom, Claire Smalley Rumfield, Y. Maurice MorillonIIII, Nicholas Roller, Lisa K. Poppe, Douglas E. Brough, Helen Sabzevari, Jeffrey Schlom & Caroline Jochems. (2021) Characterization of recombinant gorilla adenovirus HPV therapeutic vaccine PRGN-2009. JCI Insight 6:7.
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Renjie Wang, Wei Pan, Lei Jin, Weiming Huang, Yuehan Li, Di Wu, Chun Gao, Ding Ma & Shujie Liao. (2020) Human papillomavirus vaccine against cervical cancer: Opportunity and challenge. Cancer Letters 471, pages 88-102.
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Nitin Machindra Kamble, Amal Senevirathne, Hong Bum Koh, Jae Il Lee & John Hwa Lee. (2019) Self-destructing Salmonella via temperature induced gene E of phage PhiX174 improves influenza HA DNA vaccine immune protection against H1N1 infection in mice model. Journal of Immunological Methods 472, pages 7-15.
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J. L. Slon Campos, M. Poggianella & O. R. Burrone. (2018) Long-term stability of antibody responses elicited by Dengue virus envelope DIII-based DNA vaccines. Journal of General Virology 99:8, pages 1078-1085.
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Aleyo Chabeda, Romana J.R. Yanez, Renate Lamprecht, Ann E. Meyers, Edward P. Rybicki & Inga I. Hitzeroth. (2018) Therapeutic vaccines for high-risk HPV-associated diseases. Papillomavirus Research 5, pages 46-58.
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Wenjing Lin, Samuel Hanson, Wenqing Han, Xiaofang Zhang, Na Yao, Hongru Li, Lijuan Zhang & Chun Wang. (2017) Well-defined star polymers for co-delivery of plasmid DNA and imiquimod to dendritic cells. Acta Biomaterialia 48, pages 378-389.
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Wenjing Lin, Na Yao, Hongru Li, Samuel Hanson, Wenqing Han, Chun Wang & Lijuan Zhang. (2016) Co-Delivery of Imiquimod and Plasmid DNA via an Amphiphilic pH-Responsive Star Polymer that Forms Unimolecular Micelles in Water. Polymers 8:11, pages 397.
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Benjamin Yang, Andrew Yang, Shiwen Peng, Xiaowu Pang, Richard B.S. Roden, T.-C. Wu & Chien-Fu Hung. (2015) Co-administration with DNA encoding papillomavirus capsid proteins enhances the antitumor effects generated by therapeutic HPV DNA vaccination. Cell & Bioscience 5:1.
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Christine Hartoonian, Zargham Sepehrizadeh, Mehdi Mahdavi, Arash Arashkia, Yon Suk Jang, Maasoumeh Ebtekar, Mojtaba Tabatabai Yazdi, Babak Negahdari, Azita Nikoo & Kayhan Azadmanesh. (2014) Modulation of hepatitis C virus core DNA vaccine immune responses by co-immunization with CC-chemokine ligand 20 (CCL20) gene as immunoadjuvant. Molecular Biology Reports 41:9, pages 5943-5952.
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Christine Hartoonian, Zargham Sepehrizadeh, Mojtaba Tabatabai Yazdi, Yong Suk Jang, Lida Langroudi, Parisa Amir Kalvanagh, Babak Negahdari, Ali Karami, Massoumeh Ebtekar & Kayhan Azadmanesh. (2014) Enhancement of Immune Responses by Co-delivery of CCL19/MIP-3beta Chemokine Plasmid With HCV Core DNA/Protein Immunization. Hepatitis Monthly 14:3.
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Ye Liu, Fusheng Li, Zhi Qi, Yanling Hao, Kunxue Hong, Yong Liu, Yulong Cong & Yiming Shao. (2013) The effects of HIV Tat DNA on regulating the immune response of HIV DNA vaccine in mice. Virology Journal 10:1.
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Tae Heung KangChih-Ping MaoVictor LaAlexander ChenChien-Fu HungT.-C. Wu. (2013) Innovative DNA Vaccine to Break Immune Tolerance Against Tumor Self-Antigen. Human Gene Therapy 24:2, pages 181-188.
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Jiaying Lin, Jinfeng Xu, Andreas E. Albers & Andreas M. Kaufmann. (2012) New Developments in Therapeutic HPV Vaccines. Current Obstetrics and Gynecology Reports 1:3, pages 106-115.
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Shenghe Tian, Zuqiang Liu, Cara Donahue, Louis D FaloJrJr & Zhaoyang You. (2012) Genetic Targeting of the Active Transcription Factor XBP1s to Dendritic Cells Potentiates Vaccine-induced Prophylactic and Therapeutic Antitumor Immunity. Molecular Therapy 20:2, pages 432-442.
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Qi Zeng, Bianca P. Gomez, Raphael P. Viscidi, Shiwen Peng, Liangmei He, Barbara Ma, T.-C. Wu & Chien-Fu Hung. (2012) Development of a DNA vaccine targeting Merkel cell polyomavirus. Vaccine 30:7, pages 1322-1329.
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Shiwen Peng, Archana Monie, Xiaowu Pang, Chien-Fu Hung & T-C Wu. (2011) Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines. Journal of Biomedical Science 18:1.
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Marijo Bilusic, Christopher Heery & Ravi A. Madan. (2011) Immunotherapy in prostate cancer: Emerging strategies against a formidable foe. Vaccine 29:38, pages 6485-6497.
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Tao Guan, Qiu Xie, Xiao-ling Yang, Guo-liang Wang, Zhi-qiang Zhu, Jian-hua Wang & Bo Niu. (2011) Anti-tumor immunity of gene vaccine with nucleofection technology. Clinical Oncology and Cancer Research 8:2.
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A Wu, Q Zeng, T H Kang, S Peng, E Roosinovich, S I Pai & C-F Hung. (2010) Innovative DNA vaccine for human papillomavirus (HPV)-associated head and neck cancer. Gene Therapy 18:3, pages 304-312.
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Peter Öhlschläger, Elmar Spies, Gerardo Alvarez, Michael Quetting & Marcus Groettrup. (2010) The combination of TLR‐9 adjuvantation and electroporation‐mediated delivery enhances in vivo antitumor responses after vaccination with HPV‐16 E7 encoding DNA . International Journal of Cancer 128:2, pages 473-481.
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Chi-Mu Chuang, Archana Monie, Chien-Fu Hung & T-C Wu. (2010) Treatment with Imiquimod enhances antitumor immunity induced by therapeutic HPV DNA vaccination. Journal of Biomedical Science 17:1.
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Charles G. Drake. (2010) Prostate cancer as a model for tumour immunotherapy. Nature Reviews Immunology 10:8, pages 580-593.
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Jae Yeo Park, Dong-Hoon Jin, Chang-Min Lee, Min Ja Jang, Sun Young Lee, Hyo Seon Shin, Yoon Hee Chung, Kyung Yong Kim, Sung Su Kim, Won Bok Lee, Yong Kyoo Shin, Wang Jae Lee, Yeong-Min Park & Daejin Kim. (2010) CD4+ TH1 Cells Generated by Ii-PADRE DNA at Prime Phase Are Important to Induce Effectors and Memory CD8+ T Cells. Journal of Immunotherapy 33:5, pages 510-522.
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Jun-Han Su, Anjui Wu, Elizabeth Scotney, Barbara Ma, Archana Monie, Chien-Fu Hung & T.-C. Wu. (2010) Immunotherapy for Cervical Cancer. BioDrugs 24:2, pages 109-129.
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T H Kang, J-Y Chung, A Monie, S I Pai, C-F Hung & T-C Wu. (2009) Enhancing DNA vaccine potency by co-administration of xenogenic MHC class-I DNA. Gene Therapy 17:4, pages 531-540.
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Brian D. Livingston, Stephen F. Little, Alain Luxembourg, Barry Ellefsen & Drew Hannaman. (2010) Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques. Vaccine 28:4, pages 1056-1061.
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Ken Lin, Kimberley Doolan, Chien-Fu Hung & T.C. Wu. (2010) Perspectives for Preventive and Therapeutic HPV Vaccines. Journal of the Formosan Medical Association 109:1, pages 4-24.
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Michael C. FlickingerAngela Rodgers & Kenneth Barry Walker. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 8 .
Cheng-Tao Lin, Chih-Feng Yen, Sheng-Wen Shaw, Tzu-Chen Yen, Yin-Ju Chen, Yung-Kuei Soong & Chyong-Huey Lai. (2009) Gene gun administration of therapeutic HPV DNA vaccination restores the efficacy of prolonged defrosted viral based vaccine. Vaccine 27:52, pages 7352-7358.
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S Tian, Z Liu, C Donahue, H S Noh, L D FaloJrJr & Z You. (2009) Transcriptional IL-15-directed in vivo DC targeting DNA vaccine. Gene Therapy 16:10, pages 1260-1270.
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Dan Lu, Talia Hoory, Archana Monie, Annie Wu, Mei-Cheng Wang & Chien-Fu Hung. (2009) Treatment with demethylating agent, 5-aza-2′-deoxycytidine enhances therapeutic HPV DNA vaccine potency. Vaccine 27:32, pages 4363-4369.
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Peter Öhlschläger, Michael Quetting, Gerardo Alvarez, Matthias Dürst, Lutz Gissmann & Andreas M. Kaufmann. (2009) Enhancement of immunogenicity of a therapeutic cervical cancer DNA‐based vaccine by co‐application of sequence‐optimized genetic adjuvants. International Journal of Cancer 125:1, pages 189-198.
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Jing SunDingfeng LiYanling HaoYuwei ZhangWenling FanJingjing FuYunzhang HuYong LiuYiming Shao. (2009) Posttranscriptional Regulatory Elements Enhance Antigen Expression and DNA Vaccine Efficacy. DNA and Cell Biology 28:5, pages 233-240.
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Barbara Ma, Chien‐Fu Hung & T.‐C. Wu. 2009. Tumor‐Associated Antigens. Tumor‐Associated Antigens 317 337 .
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Kaw Yan Chua, I-Chun Kuo & Chiung-Hui Huang. (2009) DNA vaccines for the prevention and treatment of allergy. Current Opinion in Allergy & Clinical Immunology 9:1, pages 50-54.
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Chi-Mu Chuang, Talia Hoory, Archana Monie, Annie Wu, Mei-Cheng Wang & Chien-Fu Hung. (2009) Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4+CD25+ T regulatory cells. Vaccine 27:5, pages 684-689.
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D Kim, A Monie, Y-C Tsai, L He, M-C Wang, C-F Hung & T-C Wu. (2008) Enhancement of CD4+ T-cell help reverses the doxorubicin-induced suppression of antigen-specific immune responses in vaccinated mice. Gene Therapy 15:16, pages 1176-1183.
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S Peng, C Trimble, R D Alvarez, W K Huh, Z Lin, A Monie, C-F Hung & T-C Wu. (2008) Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects. Gene Therapy 15:16, pages 1156-1166.
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Chih Wen Tseng, Archana Monie, Cornelia Trimble, Ronald D. Alvarez, Warner K. Huh, Donald J. Buchsbaum, J. Michael StraughnJr.Jr., Mei-Cheng Wang, Hideo Yagita, Chien-Fu Hung & T.-C. Wu. (2008) Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects. Vaccine 26:34, pages 4314-4319.
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Chih-Wen Tseng, Archana Monie, Chao-Yi Wu, Bruce Huang, Mei-Cheng Wang, Chien-Fu Hung & T.-C. Wu. (2008) Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination. Journal of Molecular Medicine 86:8, pages 899-908.
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K. Dhama, Mahesh Mahendran, P. K. Gupta & A. Rai. (2008) DNA vaccines and their applications in veterinary practice: current perspectives. Veterinary Research Communications 32:5, pages 341-356.
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Daejin Kim, Talia Hoory, Archana Monie, Jenny Pan-Yun Ting, Chien-Fu Hung & T.-C. Wu. (2008) Enhancement of DNA Vaccine Potency through Coadministration of CIITA DNA with DNA Vaccines via Gene Gun. The Journal of Immunology 180:10, pages 7019-7027.
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Chih-Wen Tseng, Chien-Fu Hung, Ronald D. Alvarez, Cornelia Trimble, Warner K. Huh, Daejin Kim, Chi-Mu Chuang, Cheng-Tao Lin, Ya-Chea Tsai, Liangmei He, Archana Monie & T-C. Wu. (2008) Pretreatment with Cisplatin Enhances E7-Specific CD8+ T-Cell–Mediated Antitumor Immunity Induced by DNA Vaccination. Clinical Cancer Research 14:10, pages 3185-3192.
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Yong Sung Park, Jin Hyup Lee, Chien-Fu Hung, T.-C. Wu & Tae Woo Kim. (2008) Enhancement of Antibody Responses to Bacillus anthracis Protective Antigen Domain IV by Use of Calreticulin as a Chimeric Molecular Adjuvant . Infection and Immunity 76:5, pages 1952-1959.
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D Kim, A Monie, L He, Y-C Tsai, C-F Hung & T-C Wu. (2008) Role of IL-2 secreted by PADRE-specific CD4+ T cells in enhancing E7-specific CD8+ T-cell immune responses. Gene Therapy 15:9, pages 677-687.
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Cornelis J.M. Melief & Sjoerd H. van der Burg. (2008) Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines. Nature Reviews Cancer 8:5, pages 351-360.
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Chien-Fu Hung, T. C. Wu, Archana Monie & Richard Roden. (2008) Antigen-specific immunotherapy of cervical and ovarian cancer. Immunological Reviews 222:1, pages 43-69.
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Gerd Döring & Gerald B. Pier. (2008) Vaccines and immunotherapy against Pseudomonas aeruginosa. Vaccine 26:8, pages 1011-1024.
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Antonio Cassone. (2008) Fungal vaccines: real progress from real challenges. The Lancet Infectious Diseases 8:2, pages 114-124.
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Chien-Fu Hung, Archana Monie & T. -C. Wu. 2008. Angiogenesis. Angiogenesis 451 460 .
Daejin KimTalia HooryT.-C. WuChien-Fu Hung. (2007) Enhancing DNA Vaccine Potency by Combining a Strategy to Prolong Dendritic Cell Life and Intracellular Targeting Strategies with a Strategy to Boost CD4 + T Cells . Human Gene Therapy 18:11, pages 1129-1140.
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Bruce Huang, Chih-Ping Mao, Shiwen Peng, Liangmei He, Chien-Fu Hung & T.-C. Wu. (2007) Intradermal administration of DNA vaccines combining a strategy to bypass antigen processing with a strategy to prolong dendritic cell survival enhances DNA vaccine potency. Vaccine 25:45, pages 7824-7831.
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