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Editorial

Freeing vaccine adjuvants from dangerous immunological dogma

Pages 7-10 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Bruno de Paula Oliveira Santos, Monalisa Martins Trentini, Renato Beilner Machado, Mara Rúbia Nunes Celes, André Kipnis, Nikolai Petrovsky & Ana Paula Junqueira-Kipnis. (2017) Advax4 delta inulin combination adjuvant together with ECMX, a fusion construct of four protective mTB antigens, induces a potent Th1 immune response and protects mice against Mycobacterium tuberculosis infection. Human Vaccines & Immunotherapeutics 13:12, pages 2967-2976.
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Nidhi Chauhan, Sukirti Tiwari, Tessy Iype & Utkarsh Jain. (2017) An overview of adjuvants utilized in prophylactic vaccine formulation as immunomodulators. Expert Review of Vaccines 16:5, pages 491-502.
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Nikolai Petrovsky. (2013) Vaccine adjuvant safety: the elephant in the room. Expert Review of Vaccines 12:7, pages 715-717.
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Fadi Saade & Nikolai Petrovsky. (2012) Technologies for enhanced efficacy of DNA vaccines. Expert Review of Vaccines 11:2, pages 189-209.
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Mario Lobigs & Michael S Diamond. (2012) Feasibility of cross-protective vaccination against flaviviruses of the Japanese encephalitis serocomplex. Expert Review of Vaccines 11:2, pages 177-187.
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Nikolai Petrovsky & Peter D Cooper. (2011) Carbohydrate-based immune adjuvants. Expert Review of Vaccines 10:4, pages 523-537.
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Christian Moser, Mario Amacker & Rinaldo Zurbriggen. (2011) Influenza virosomes as a vaccine adjuvant and carrier system. Expert Review of Vaccines 10:4, pages 437-446.
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Antonio Granell, Asun Fernández-del-Carmen & Diego Orzáez. (2010) In planta production of plant-derived and non-plant-derived adjuvants. Expert Review of Vaccines 9:8, pages 843-858.
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C. S. Nworu, C. O. Esimone, M. Tenbusch, G. Nabi, P. Proksch, K. Überla & V. V. Temchura. (2010) Adjuvant Properties of AcF1, an Immunostimulant Fraction of Alchornea cordifolia Extract. Immunological Investigations 39:2, pages 132-158.
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Michel Denis, Gary D. Ainge, David S. Larsen, Wayne B. Severn & Gavin F. Painter. (2009) A synthetic analogue of phosphatidylinositol mannoside is an efficient adjuvant. Immunopharmacology and Immunotoxicology 31:4, pages 577-582.
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Franco Maria Buonaguro, Maria Lina Tornesello & Luigi Buonaguro. (2009) Virus-like particle vaccines and adjuvants: the HPV paradigm. Expert Review of Vaccines 8:10, pages 1379-1398.
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Melina M Georgousakis, David J McMillan, Michael R Batzloff & Kadaba S Sriprakash. (2009) Moving forward: a mucosal vaccine against group A streptococcus. Expert Review of Vaccines 8:6, pages 747-760.
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Articles from other publishers (39)

Xuhan Liu, Yifan LiuXiaoyu Yang, Xinyu LuXiao-Ning XuJiancheng Zhang & Rongjun Chen. (2023) Potentiating the Immune Responses of HBsAg-VLP Vaccine Using a Polyphosphoester-Based Cationic Polymer Adjuvant. ACS Applied Materials & Interfaces 15:42, pages 48871-48881.
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Ai-Mei Chang, Chen-Chih Chen, Jai-Wei Lee, Ding-Liang Hou, Hsiao-Hui Huang & Guan-Ming Ke. (2023) Effects of a novel recombinant Gonadotropin-Releasing Hormone-1 vaccine on the reproductive function of mixed-breed dogs (Canis familiaris) in Taiwan. Vaccine 41:13, pages 2214-2223.
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Haneen Imad Abufares, Leen Oyoun Alsoud, Mohammad A. Y. Alqudah, Mohd Shara, Nelson C. Soares, Karem H. Alzoubi, Waseem El-Huneidi, Yasser Bustanji, Sameh S. M. Soliman & Mohammad H. Semreen. (2022) COVID-19 Vaccines, Effectiveness, and Immune Responses. International Journal of Molecular Sciences 23:23, pages 15415.
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Nedaa Alharbi, Mariusz Skwarczynski & Istvan Toth. (2022) The influence of component structural arrangement on peptide vaccine immunogenicity. Biotechnology Advances 60, pages 108029.
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Maryam Dadar, Youcef Shahali & Naheed Mojgani. 2022. Probiotics in the Prevention and Management of Human Diseases. Probiotics in the Prevention and Management of Human Diseases 417 430 .
Pureum Sun, Yeeun Kim, Hoyoung Lee, Jihyun Kim, Bok Kyung Han, Eunbyeol Go, Somin Kwon, Ju-Gyeong Kang, Sooseong You & Jaeyul Kwon. (2020) Carrot Pomace Polysaccharide (CPP) Improves Influenza Vaccine Efficacy in Immunosuppressed Mice via Dendritic Cell Activation. Nutrients 12:9, pages 2740.
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Gervais Habarugira, Willy W. Suen, Jody Hobson-Peters, Roy A. Hall & Helle Bielefeldt-Ohmann. (2020) West Nile Virus: An Update on Pathobiology, Epidemiology, Diagnostics, Control and “One Health” Implications. Pathogens 9:7, pages 589.
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Laura J. Vet, Yin Xiang Setoh, Alberto A. Amarilla, Gervais Habarugira, Willy W. Suen, Natalee D. Newton, Jessica J. Harrison, Jody Hobson-Peters, Roy A. Hall & Helle Bielefeldt-Ohmann. (2020) Protective Efficacy of a Chimeric Insect-Specific Flavivirus Vaccine against West Nile Virus. Vaccines 8:2, pages 258.
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Zhi-Biao Wang & Jing Xu. (2020) Better Adjuvants for Better Vaccines: Progress in Adjuvant Delivery Systems, Modifications, and Adjuvant–Antigen Codelivery. Vaccines 8:1, pages 128.
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Anna-Mari Reid & Namrita Lall. 2019. Medicinal Plants. Medicinal Plants 187 213 .
Kaitlyn Morse, Yoshifumi Kimizuka, Megan P. K. Chan, Mai Shibata, Yusuke Shimaoka, Shu Takeuchi, Benjamin Forbes, Christopher Nirschl, Binghao Li, Yang Zeng, Roderick T. Bronson, Wataru Katagiri, Ayako Shigeta, Ruxandra F. Sîrbulescu, Huabiao Chen, Rhea Y. Y. Tan, Kosuke Tsukada, Timothy Brauns, Jeffrey Gelfand, Ann Sluder, Joseph J. Locascio, Mark C. Poznansky, Niroshana Anandasabapathy & Satoshi Kashiwagi. (2017) Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine. The Journal of Immunology 199:4, pages 1319-1332.
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T. Barclay & N. Petrovsky. 2017. Micro and Nanotechnology in Vaccine Development. Micro and Nanotechnology in Vaccine Development 127 147 .
Nikolai Petrovsky. (2015) Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs. Drug Safety 38:11, pages 1059-1074.
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Michael G. Agadjanyan, Nikolai Petrovsky & Anahit Ghochikyan. (2015) A fresh perspective from immunologists and vaccine researchers: Active vaccination strategies to prevent and reverse Alzheimer's disease. Alzheimer's & Dementia 11:10, pages 1246-1259.
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Lei Li, Yoshikazu Honda-Okubo, Connie Li, Dimitar Sajkov & Nikolai Petrovsky. (2015) Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine. PLOS ONE 10:7, pages e0132003.
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Huub Savelkoul, Valerie Ferro, Marius Strioga & Virgil Schijns. (2015) Choice and Design of Adjuvants for Parenteral and Mucosal Vaccines. Vaccines 3:1, pages 148-171.
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N. Mahalakshmi, R. Aparnaa & P. Kaliraj. (2014) Evaluation of Immune Response Elicited by Inulin as an Adjuvant with Filarial Antigens in Mice Model. Scandinavian Journal of Immunology 80:4, pages 261-270.
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M. Yaqoob Wani, Tapas Kumar Goswami, Divya Chaudhary, Rajendra Singh & Kuldeep Dhama. (2014) Mitigation of Septic Signs by Pravastatin during LPS Co-Administered Hen-Egg White Lysozyme Immunization in Mice. International Journal of Pharmacology 10:7, pages 389-397.
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. (2014) Vaccines (Vol. 18, No. 03, Full Issue). Asia-Pacific Biotech News 18:03.
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. (2014) FEATURES. Asia-Pacific Biotech News 18:03, pages 27-45.
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Nikolai Petrovsky. 2014. Novel Technologies for Vaccine Development. Novel Technologies for Vaccine Development 179 200 .
Alexander Batista-Duharte, Deivys Portuondo, Iracilda Zeppone Carlos & Oliver Pérez. (2013) An approach to local immunotoxicity induced by adjuvanted vaccines. International Immunopharmacology 17:3, pages 526-536.
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Nikolai Petrovsky, Maximilian Larena, Venkatraman Siddharthan, Natalie A. Prow, Roy A. Hall, Mario Lobigs & John Morrey. (2013) An Inactivated Cell Culture Japanese Encephalitis Vaccine (JE-ADVAX) Formulated with Delta Inulin Adjuvant Provides Robust Heterologous Protection against West Nile Encephalitis via Cross-Protective Memory B Cells and Neutralizing Antibody. Journal of Virology 87:18, pages 10324-10333.
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Mario A. Moreno-Eutimio, Alejandra Tenorio-Calvo, Rodolfo Pastelin-Palacios, Christian Perez-Shibayama, Cristina Gil-Cruz, Rubén López-Santiago, Isabel Baeza, Marcos Fernández-Mora, Laura Bonifaz, Armando Isibasi, Edmundo Calva & Constantino López-Macías. (2013) Salmonella Typhi OmpS1 and OmpS2 porins are potent protective immunogens with adjuvant properties . Immunology 139:4, pages 459-471.
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Fadi Saade, Yoshikazu Honda-Okubo, Samay Trec & Nikolai Petrovsky. (2013) A novel hepatitis B vaccine containing Advax™, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing. Vaccine 31:15, pages 1999-2007.
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Lee S. Jacobson, Heriberto LimaJr.Jr., Michael F. Goldberg, Vasilena Gocheva, Vladislav Tsiperson, Fayyaz S. Sutterwala, Johanna A. Joyce, Bianca V. Gapp, Vincent A. Blomen, Kartik Chandran, Thijn R. Brummelkamp, Felipe Diaz-Griffero & Jürgen Brojatsch. (2013) Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants. Journal of Biological Chemistry 288:11, pages 7481-7491.
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Natalie Prow, Roy Hall & Mario Lobigs. 2013. Neuroviral Infections. Neuroviral Infections 167 192 .
Christian Moser & Mario Amacker. 2013. Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines. Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines 287 307 .
Nikolai Petrovsky. 2013. Encyclopedia of Systems Biology. Encyclopedia of Systems Biology 2092 2094 .
Lei Li, Fadi Saade & Nikolai Petrovsky. (2012) The future of human DNA vaccines. Journal of Biotechnology 162:2-3, pages 171-182.
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Yoshikazu Honda-Okubo, Fadi Saade & Nikolai Petrovsky. (2012) Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses. Vaccine 30:36, pages 5373-5381.
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F. Silveira, S. Rossi, C. Fernández, G. Gosmann, E. Schenkel & F. Ferreira. (2011) Alum‐type Adjuvant Effect of Non‐haemolytic Saponins Purified from Ilex and Passiflora spp. . Phytotherapy Research 25:12, pages 1783-1788.
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R. Colby Layton, Nikolai Petrovsky, Andrew P. Gigliotti, Zemmie Pollock, Jennifer Knight, Nathaniel Donart, John Pyles, Kevin S. Harrod, Peng Gao & Frederick Koster. (2011) Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets. Vaccine 29:37, pages 6242-6251.
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W.E.P. Beyer, J.J.P. Nauta, A.M. Palache, K.M. Giezeman & A.D.M.E. Osterhaus. (2011) Immunogenicity and safety of inactivated influenza vaccines in primed populations: A systematic literature review and meta-analysis. Vaccine 29:34, pages 5785-5792.
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A. D. Cristillo, M. G. Ferrari, L. Hudacik, B. Lewis, L. Galmin, B. Bowen, D. Thompson, N. Petrovsky, P. Markham & R. Pal. (2010) Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations. Journal of General Virology 92:1, pages 128-140.
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M. Lobigs, M. Pavy, R. A. Hall, P. Lobigs, P. Cooper, T. Komiya, H. Toriniwa & N. Petrovsky. (2010) An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. Journal of General Virology 91:6, pages 1407-1417.
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Xue Jun Wang, Kai Gu, Qi Yan Xiong, Liang Shen, Rong Yue Cao, Ming Hui Li, Tai Ming Li, Jie Wu & Jing Jing Liu. (2009) A novel virus-like particle based on hepatitis B core antigen and substrate-binding domain of bacterial molecular chaperone DnaK. Vaccine 27:52, pages 7377-7384.
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Lena Wolff, Jens Flemming, Reinhard Schmitz, Karsten Gröger, Cristina Goso & Christel C. Müller-Goymann. (2009) Comparative stability study of lyophilised aluminium hydroxide adjuvanted vaccine formulations containing a monoclonal antibody as a model antigen and methods used for their characterisation. Colloids and Surfaces A: Physicochemical and Engineering Aspects 339:1-3, pages 82-93.
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O. Haçarız, G. Sayers, M. McCullough, M. Garrett, J. O’Donovan & G. Mulcahy. (2009) The effect of Quil A adjuvant on the course of experimental Fasciola hepatica infection in sheep. Vaccine 27:1, pages 45-50.
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