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Review

Recent approaches in hantavirus vaccine development

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Pages 67-76 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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SD Dowall, KR Buttigieg, SJD Findlay-Wilson, E Rayner, G Pearson, A Miloszewska, VA Graham, MW Carroll & R Hewson. (2016) A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease. Human Vaccines & Immunotherapeutics 12:2, pages 519-527.
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Marco Goeijenbier, Jiri Wagenaar, Marga Goris, Byron Martina, Heikki Henttonen, Antti Vaheri, Chantal Reusken, Rudy Hartskeerl, Albert Osterhaus & Eric Van Gorp. (2013) Rodent-borne hemorrhagic fevers: under-recognized, widely spread and preventable – epidemiology, diagnostics and treatment. Critical Reviews in Microbiology 39:1, pages 26-42.
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Detlev H. Krüger, Günther Schönrich & Boris Klempa . (2011) Human pathogenic hantaviruses and prevention of infection. Human Vaccines 7:6, pages 685-693.
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Jonas Klingström & Clas Ahlm. (2011) Hantavirus protein interactions regulate cellular functions and signaling responses. Expert Review of Anti-infective Therapy 9:1, pages 33-47.
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Articles from other publishers (45)

Ayushi Sehgal, Sanya Mehta, Kritika Sahay, Ekaterina Martynova, Albert Rizvanov, Manoj Baranwal, Sara Chandy, Svetlana Khaiboullina, Emmanuel Kabwe & Yuriy Davidyuk. (2023) Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention. Viruses 15:2, pages 561.
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Amit Joshi, Nillohit Mitra Ray, Joginder Singh, Atul Kumar Upadhyay & Vikas Kaushik. (2021) T-cell epitope-based vaccine designing against Orthohantavirus: a causative agent of deadly cardio-pulmonary disease. Network Modeling Analysis in Health Informatics and Bioinformatics 11:1.
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Sumel Ashique, Navjot K Sandhu, Supratim Das, Sk. Niyamul Haque & Kartick Koley. (2022) Global Comprehensive Outlook of Hantavirus Contagion on Humans: A Review. Infectious Disorders - Drug Targets 22:3.
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Thomas Tipih, Mark Heise & Felicity Jane Burt. (2021) Immunogenicity of a DNA-Based Sindbis Replicon Expressing Crimean–Congo Hemorrhagic Fever Virus Nucleoprotein. Vaccines 9:12, pages 1491.
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Kamil Leis, Patryk Kaczor, Aleksandra Baska, Jakub Kazik, Michalina Kolan, Katarzyna Grudlewska-Buda, Natalia Wiktorczyk & Krzysztof Skowron. (2021) Orthohantavirus Spp. – Review Of Genus. Postępy Mikrobiologii - Advancements of Microbiology 60:1, pages 91-102.
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Kalpa Dheerasekara, Saranga Sumathipala & Rohitha Muthugala. (2020) Hantavirus Infections—Treatment and Prevention. Current Treatment Options in Infectious Diseases 12:4, pages 410-421.
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Mara Lucia Gravinatti, Carla Meneguin Barbosa, Rodrigo Martins Soares & Fábio Gregori. (2020) Synanthropic rodents as virus reservoirs and transmitters. Revista da Sociedade Brasileira de Medicina Tropical 53.
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Xiaoxia Dai, Can Jian, Li Na, Xiaofeng Wang, Yu Dai & Dexin Li. (2019) Production and characterization of Hantaan virus-like particles from baculovirus expression system. Biochemical Engineering Journal 152, pages 107373.
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Touraj Aligholipour Farzani, Katalin Földes, Alireza Hanifehnezhad, Burcu Yener Ilce, Seval Bilge Dagalp, Neda Amirzadeh Khiabani, Koray Ergünay, Feray Alkan, Taner Karaoglu, Hurrem Bodur & Aykut Ozkul. (2019) Bovine Herpesvirus Type 4 (BoHV-4) Vector Delivering Nucleocapsid Protein of Crimean-Congo Hemorrhagic Fever Virus Induces Comparable Protective Immunity against Lethal Challenge in IFNα/β/γR−/− Mice Models. Viruses 11:3, pages 237.
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Megan M. Slough, Kartik Chandran & Rohit K. Jangra. (2019) Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors. mBio 10:1.
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Lev Levanov, Rommel Paneth Iheozor-Ejiofor, Åke Lundkvist, Olli Vapalahti & Alexander Plyusnin. (2019) Defining of MAbs-neutralizing sites on the surface glycoproteins Gn and Gc of a hantavirus using vesicular stomatitis virus pseudotypes and site-directed mutagenesis. Journal of General Virology 100:2, pages 145-155.
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Svetlana Malkhazova, Varvara Mironova, Natalia Shartova & Dmitry OrlovSvetlana Malkhazova, Varvara Mironova, Natalia Shartova & Dmitry Orlov. 2019. Mapping Russia's Natural Focal Diseases. Mapping Russia's Natural Focal Diseases 69 197 .
Stuart D. Dowall, Miles W. Carroll & Roger Hewson. (2017) Development of vaccines against Crimean-Congo haemorrhagic fever virus. Vaccine 35:44, pages 6015-6023.
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Anuradha Roy & Mohammad A. Mir. (2017) Development of High-Throughput Screening Assay for Antihantaviral Therapeutics. SLAS Discovery 22:6, pages 767-774.
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Hong Jiang, Xuyang Zheng, Limei Wang, Hong Du, Pingzhong Wang & Xuefan Bai. (2017) Hantavirus infection: a global zoonotic challenge. Virologica Sinica 32:1, pages 32-43.
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Qikang Ying, Tiejun Ma, Linfeng Cheng, Xiaoxiao Zhang, Agnieszka D. Truax, Ruixue Ma, Ziyu Liu, Yingfeng Lei, Liang Zhang, Wei Ye, Fanglin Zhang, Zhikai Xu, Lei Shang, Rongrong Liu, Fang Wang & Xingan Wu. (2016) Construction and immunological characterization of CD40L or GM-CSF incorporated Hantaan virus like particle. Oncotarget 7:39, pages 63488-63503.
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Salwa Mohd Mostafa & Abul BMMK Islam. (2016) An in silico approach predicted potential therapeutics that can confer protection from maximum pathogenic Hantaviruses . Future Virology 11:6, pages 411-428.
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D. Reil, C. Imholt, S. Drewes, R. G. Ulrich, J. A. Eccard & J. Jacob. (2016) Environmental conditions in favour of a hantavirus outbreak in 2015 in Germany?. Zoonoses and Public Health 63:2, pages 83-88.
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Joon Young Song, Heung Jeong Woo, Hee Jin Cheong, Ji Yun Noh, Luck Ju Baek & Woo Joo Kim. (2016) Long-term immunogenicity and safety of inactivated Hantaan virus vaccine (Hantavax™) in healthy adults. Vaccine 34:10, pages 1289-1295.
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Cong Jin & Dexin Li. 2015. Human Emerging and Re‐emerging Infections. Human Emerging and Re‐emerging Infections 43 71 .
Dong-Bo Jiang, Yuan-Jie Sun, Lin-Feng Cheng, Ge-Fei Zhang, Chen Dong, Bo-Quan Jin, Chao-Jun Song, Ying Ma, Fang-Lin Zhang & Kun Yang. (2015) Construction and evaluation of DNA vaccine encoding Hantavirus glycoprotein N-terminal fused with lysosome-associated membrane protein. Vaccine 33:29, pages 3367-3376.
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Charles F. Fulhorst & Michael D. Bowen. 2015. Manual of Clinical Microbiology . Manual of Clinical Microbiology 1660 1668 .
Marcos L. Moreli, Ariany C. Marques-Silva, Vagner A. Pimentel & Vivaldo G. da Costa. (2014) Effectiveness of the ribavirin in treatment of hantavirus infections in the Americas and Eurasia: a meta-analysis. VirusDisease 25:3, pages 385-389.
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Evgeniy A. Tkachenko, Tamara K. Dzagurova & Peter E. Tkachenko. 2014. Novel Technologies for Vaccine Development. Novel Technologies for Vaccine Development 113 151 .
Lan Yu, Wentao Bai, Xingan Wu, Liang Zhang, Lei Zhang, Puyuan Li, Fang Wang, Ziyu Liu, Fanglin Zhang & Zhikai Xu. (2013) A recombinant pseudotyped lentivirus expressing the envelope glycoprotein of Hantaan virus induced protective immunity in mice. Virology Journal 10:1.
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Evelyn Ly. (2013) A closer look at hantaviruses. Nursing 43:9, pages 65-67.
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Darryl Falzarano & Heinz Feldmann. (2013) Vaccines for viral hemorrhagic fevers—progress and shortcomings. Current Opinion in Virology 3:3, pages 343-351.
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Kyle S. Brown, Hideki Ebihara & Heinz Feldmann. (2012) Development of a minigenome system for Andes virus, a New World hantavirus. Archives of Virology 157:11, pages 2227-2233.
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Ellen F. Boudreau, Matthew Josleyn, Diane Ullman, Diana Fisher, Lonnie Dalrymple, Karen Sellers-Myers, Peter Loudon, Janice Rusnak, Robert Rivard, Connie Schmaljohn & Jay W. Hooper. (2012) A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome. Vaccine 30:11, pages 1951-1958.
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Reeta S. Mani, V. Ravi, Anita Desai & S.N. Madhusudana. (2012) Emerging Viral Infections in India. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 82:1, pages 5-21.
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Meda M. Higa, Josiah Petersen, Jay Hooper & Robert W. Doms. (2012) Efficient production of Hantaan and Puumala pseudovirions for viral tropism and neutralization studies. Virology 423:2, pages 134-142.
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Pu-Yuan Li, Lan Yu, Xing-An Wu, Wen-Tao Bai, Kai Li, Hai-Tao Wang, Gang Hu, Liang Zhang, Fang-Lin Zhang & Zhi-Kai Xu. (2012) Modification of the adenoviral transfer vector enhances expression of the Hantavirus fusion protein GnS0.7 and induces a strong immune response in C57BL/6 mice. Journal of Virological Methods 179:1, pages 90-96.
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Kyle S. Brown, David Safronetz, Andrea Marzi, Hideki Ebihara & Heinz Feldmann. (2011) Vesicular Stomatitis Virus-Based Vaccine Protects Hamsters against Lethal Challenge with Andes Virus. Journal of Virology 85:23, pages 12781-12791.
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Xin LüFanglin ZhangYucheng LiXiaoping XueWen YinZhikai Xu. (2011) Antigenic Characterization of Expressed Complete and Different Truncated Recombinant Nucleocapsid Proteins of Hantaan Virus by Monoclonal Antibodies. Hybridoma 30:5, pages 445-450.
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A. Zimmermann, B. Lorenz & W. Schmidt. (2011) Beidseitiges akutes Engwinkelglaukom im Rahmen einer Hantavirus-InfektionBilateral acute angle-closure glaucoma due to an infection with Hantavirus. Der Ophthalmologe 108:8, pages 753-758.
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