Citations (72)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (5)
Bianca Rocca, Alfredo Dragani & Francesca Pagliaccia. (2013) Identifying determinants of variability to tailor aspirin therapy. Expert Review of Cardiovascular Therapy 11:3, pages 365-379.
Read now
Read now
Hu Hu & Marc F. Hoylaerts. (2010) The P2X1 ion channel in platelet function. Platelets 21:3, pages 153-166.
Read now
Read now
Florian Krötz, Hae-Young Sohn & Volker Klauss. (2008) Antiplatelet drugs in cardiological practice: Established strategies and new developments. Vascular Health and Risk Management 4:3, pages 637-645.
Read now
Read now
Ernest L Mazzaferri Jr & John J Young. (2008) Abciximab: a review and update for clinicians. Expert Review of Cardiovascular Therapy 6:5, pages 609-618.
Read now
Read now
Céline Montavon, Irene Hoesli, Wolfgang Holzgreve & Dimitrios A. Tsakiris. (2008) Thrombophilia and anticoagulation in pregnancy: indications, risks and management. The Journal of Maternal-Fetal & Neonatal Medicine 21:10, pages 685-696.
Read now
Read now
Articles from other publishers (67)
Maximilian Tscharre & Thomas Gremmel. (2022) Antiplatelet Therapy in Coronary Artery Disease: Now and Then. Seminars in Thrombosis and Hemostasis 49:03, pages 255-271.
Crossref
Crossref
Akhila Dandamudi, Huzoor Akbar, Jose Cancelas & Yi Zheng. (2023) Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International Journal of Molecular Sciences 24:3, pages 2519.
Crossref
Crossref
Ehraz Mehmood Siddiqui, Sidharth Mehan, Sonalika Bhalla & Ambika Shandilya. (2022) Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage. Current Research in Neurobiology 3, pages 100055.
Crossref
Crossref
Lei Wang & Chaojun Tang. (2020) Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives. International Journal of Molecular Sciences 21:24, pages 9760.
Crossref
Crossref
Anael Viana Pinto Alberto, Natiele Carla da Silva Ferreira, Rafael Ferreira Soares & Luiz Anastacio Alves. (2020) Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources. Frontiers in Pharmacology 11.
Crossref
Crossref
Samuel Pearce, Julian T. Maingard, Kenny Li, Hong Kuan Kok, Christen D. Barras, Jeremy H. Russell, Joshua A. Hirsch, Ronil V. Chandra, Ash Jhamb, Vincent Thijs, Mark Brooks & Hamed Asadi. (2020) Antiplatelet Drugs for Neurointerventions: Part 1 Clinical Pharmacology. Clinical Neuroradiology 30:3, pages 425-433.
Crossref
Crossref
Samir Jawhara. (2020) How Fungal Glycans Modulate Platelet Activation via Toll-Like Receptors Contributing to the Escape of Candida albicans from the Immune Response. Antibiotics 9:7, pages 385.
Crossref
Crossref
Deyu Kong, Tao Xue, Bin Guo, Jianjun Cheng, Shunyin Liu, Jianhai Wei, Zhengyu Lu, Haoran Liu, Guoqing Gong, Tian Lan, Wenhao Hu & Yushe Yang. (2019)
Optimization of P2Y
12
Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties
. Journal of Medicinal Chemistry 62:6, pages 3088-3106.
Crossref
Crossref
Marco Cattaneo. 2019. Platelets. Platelets
937
956
.
Imadul Islam, Shendong Yuan, Robert G. Wei, Wei Xu, Michael Morrissey, Raju Mohan, Dewan Zheng, Andrea DiMella, Laura Dunning, Michael Snider, Babu Subramanyam, Jih-Lie Tseng, Judi A. Bryant & Brad O. Buckman. (2018) Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process. Bioorganic & Medicinal Chemistry Letters 28:9, pages 1459-1463.
Crossref
Crossref
Milka Koupenova & Katya Ravid. (2018) Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity. Frontiers in Pharmacology 9.
Crossref
Crossref
Alexandra M. Sible & James J. Nawarskas. (2017) Cangrelor. Cardiology in Review 25:3, pages 133-139.
Crossref
Crossref
Maurizio Tomaiuolo, Lawrence F. Brass & Timothy J. Stalker. (2017) Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis. Interventional Cardiology Clinics 6:1, pages 1-12.
Crossref
Crossref
Hong-Hui Yang, Yan Chen & Chuan-Yu Gao. (2016)
Associations of
P2Y12R
gene polymorphisms with susceptibility to coronary heart disease and clinical efficacy of antiplatelet treatment with clopidogrel
. Cardiovascular Therapeutics 34:6, pages 460-467.
Crossref
Crossref
Sean ConroyNicholas KindonBarrie KellamMichael J. Stocks. (2016) Drug-like Antagonists of P2Y Receptors—From Lead Identification to Drug Development. Journal of Medicinal Chemistry 59:22, pages 9981-10005.
Crossref
Crossref
Noemí Mañé, Verónica Jiménez-Sábado & Marcel Jiménez. (2016) BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. Neuropharmacology 110, pages 376-385.
Crossref
Crossref
Fredrik Zetterberg & Peder Svensson. (2016) State of affairs: Design and structure–activity relationships of reversible P2Y 12 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 26:12, pages 2739-2754.
Crossref
Crossref
Se-Uk Kwon, Hoon-Yeon Lee, Mingjie Xin, Su-Jeong Ji, Hyoung-Kwon Cho, Dae-Sung Kim, Dae-Ki Kim & Young-Mi Lee. (2016) Antithrombotic activity of Vitis labrusca extract on rat platelet aggregation. Blood Coagulation & Fibrinolysis 27:2, pages 141-146.
Crossref
Crossref
M Holinstat & PF Bray. (2016) Protease receptor antagonism to target blood platelet therapies. Clinical Pharmacology & Therapeutics 99:1, pages 72-81.
Crossref
Crossref
SE-UK KWON, JI-YOON CHA, HOON-YEON LEE, MINGJIE XIN, SU-JEONG JI, DAE-KI KIM, DO-SIM PARK, MI-KYUNG PYO & YOUNG-MI LEE. (2015) Chloroform fraction of Euphorbia maculata has antiplatelet activity via suppressing thromboxane B2 formation. Molecular Medicine Reports 11:6, pages 4255-4261.
Crossref
Crossref
Xiao-Chen Bao, Hong Chen, Yi-Qun Fang, Heng-Rong Yuan, Pu You, Jun Ma & Fang-Fang Wang. (2015) Clopidogrel reduces the inflammatory response of lung in a rat model of decompression sickness. Respiratory Physiology & Neurobiology 211, pages 9-16.
Crossref
Crossref
Jennifer X. Qiao, Tammy C. Wang, Sheldon Hiebert, Carol H. Hu, William A. Schumacher, Steven A. Spronk, Charles G. Clark, Ying Han, Ji Hua, Laura A. Price, Hong Shen, Silvi A. Chacko, Gerry Everlof, Jeffrey S. Bostwick, Thomas E. Steinbacher, Yi-Xin Li, Christine S. Huang, Dietmar A. Seiffert, Robert Rehfuss, Ruth R. Wexler & Patrick Y. S. Lam. (2014)
4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y
1
Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution
. ChemMedChem 9:10, pages 2327-2343.
Crossref
Crossref
Carol H. Hu, Jennifer X. Qiao, Ying Han, Tammy C. Wang, Ji Hua, Laura A. Price, Qimin Wu, Hong Shen, Christine S. Huang, Robert Rehfuss, Ruth R. Wexler & Patrick Y.S. Lam. (2014) 2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 24:11, pages 2481-2485.
Crossref
Crossref
Indera Anita Jagroop. (2013) Plant extracts inhibit ADP-induced platelet activation in humans: their potential therapeutic role as ADP antagonists. Purinergic Signalling 10:2, pages 233-239.
Crossref
Crossref
Yoon T. Jeon, Wu Yang, Jennifer X. Qiao, Ling Li, Rejean Ruel, Carl Thibeault, Sheldon Hiebert, Tammy C. Wang, Yufeng Wang, Yajun Liu, Charles G. Clark, Henry S. Wong, Juliang Zhu, Dauh-Rurng Wu, Dawn Sun, Bang-Chi Chen, Arvind Mathur, Silvi A. Chacko, Mary Malley, Xue-Qing Chen, Hong Shen, Christine S. Huang, William A. Schumacher, Jeffrey S. Bostwick, Anne B. Stewart, Laura A. Price, Ji Hua, Danshi Li, Paul C. Levesque, Dietmar A. Seiffert, Robert Rehfuss, Ruth R. Wexler & Patrick Y.S. Lam. (2014) Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent. Bioorganic & Medicinal Chemistry Letters 24:5, pages 1294-1298.
Crossref
Crossref
Jennifer X. Qiao, Tammy C. Wang, Réjean Ruel, Carl Thibeault, Alexandre L’Heureux, William A. Schumacher, Steven A. Spronk, Sheldon Hiebert, Gilles Bouthillier, John Lloyd, Zulan Pi, Dora M. Schnur, Lynn M. Abell, Ji Hua, Laura A. Price, Eddie Liu, Qimin Wu, Thomas E. Steinbacher, Jeffrey S. Bostwick, Ming Chang, Joanna Zheng, Qi Gao, Baoqing Ma, Patricia A. McDonnell, Christine S. Huang, Robert Rehfuss, Ruth R. Wexler & Patrick Y. S. Lam. (2013)
Conformationally Constrained
ortho-
Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y
1
Antagonist
. Journal of Medicinal Chemistry 56:22, pages 9275-9295.
Crossref
Crossref
Christian Gachet & Béatrice Hechler. (2013)
The
P2Y
receptors and thrombosis
. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 2:6, pages 241-253.
Crossref
Crossref
Nicholas S. Kirkby, Martina H. Lundberg, Melissa V. Chan, Ivana Vojnovic, Antonia B. Solomon, Michael Emerson, Jane A. Mitchell & Timothy D. Warner. (2013)
Blockade of the purinergic P2Y
12
receptor greatly increases the platelet inhibitory actions of nitric oxide
. Proceedings of the National Academy of Sciences 110:39, pages 15782-15787.
Crossref
Crossref
Fenila Jacob, Claudina Pérez Novo, Claus Bachert & Koen Van Crombruggen. (2013) Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signalling 9:3, pages 285-306.
Crossref
Crossref
Joseph A. Jakubowski, Chunmei Zhou, David S. Small, Kenneth J. Winters, D. Richard Lachno, Andrew L. FrelingerIIIIII, Jo Howard, Timothy G. Mant, Stipo Jurcevic & Christopher D. Payne. (2013)
A phase 1 study of prasugrel in patients with sickle cell disease: pharmacokinetics and effects on
ex vivo
platelet reactivity
. British Journal of Clinical Pharmacology 75:6, pages 1433-1444.
Crossref
Crossref
Tammy C. Wang, Jennifer X. Qiao, Charles G. Clark, Ji Jua, Laura A. Price, Qimin Wu, Ming Chang, Joanna Zheng, Christine S. Huang, Gerry Everlof, William A. Schumacher, Pancras C. Wong, Dietmar A. Seiffert, Anne B. Stewart, Jeffrey S. Bostwick, Earl J. Crain, Carol A. Watson, Robert Rehfuss, Ruth R. Wexler & Patrick Y.S. Lam. (2013) Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility. Bioorganic & Medicinal Chemistry Letters 23:11, pages 3239-3243.
Crossref
Crossref
Marco Cattaneo. 2013. Platelets. Platelets
1117
1138
.
Dirk Lievens & Philipp von Hundelshausen. 2012. Atherosclerosis. Atherosclerosis
393
440
.
B Labarthe, J Babin, M Bryckaert, P Théroux & A Bonnefoy. (2012) Effects of P2Y1 receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrel. British Journal of Pharmacology 166:1, pages 221-231.
Crossref
Crossref
Soha Namazi, Javad Kojuri, Andia Khalili & Negar Azarpira. (2012) The impact of genetic polymorphisms of P2Y12, CYP3A5 and CYP2C19 on clopidogrel response variability in Iranian patients. Biochemical Pharmacology 83:7, pages 903-908.
Crossref
Crossref
Jeffrey I. Weitz. 2012. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine
1844
1867
.
Timothy D. Warner, Sven Nylander & Carl Whatling. (2011) Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy. British Journal of Clinical Pharmacology 72:4, pages 619-633.
Crossref
Crossref
J. Douglas Kirk, Michael Kontos & Deborah B. Diercks. (2011) Upstream treatment of acute coronary syndrome in the ED. The American Journal of Emergency Medicine 29:4, pages 446-456.
Crossref
Crossref
Shintaro Ishikawa, Makoto Murai, Takao Sato, Masataka Sunagawa, Erika Tokita, Steven K.H. Aung, Kazuhito Asano & Tadashi Hisamitsu. (2011) Promotion of Blood Fluidity by Inhibition of Platelet Adhesion Using Electroacupuncture Stimulation. Journal of Acupuncture and Meridian Studies 4:1, pages 44-53.
Crossref
Crossref
Richard Hall & C. David Mazer. (2011) Antiplatelet Drugs. Anesthesia & Analgesia 112:2, pages 292-318.
Crossref
Crossref
Jorge F. Saucedo. (2010) Balancing the benefits and risks of antiplatelet agents in patients with non-ST-segment elevated acute coronary syndromes and undergoing percutaneous coronary intervention. Journal of Thrombosis and Thrombolysis 30:2, pages 200-209.
Crossref
Crossref
S. Amadio, C. Montilli, R. Magliozzi, G. Bernardi, R. Reynolds & C. Volonte. (2009) P2Y12 Receptor Protein in Cortical Gray Matter Lesions in Multiple Sclerosis. Cerebral Cortex 20:6, pages 1263-1273.
Crossref
Crossref
Younis Baqi & Christa E Müller. (2010) Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions. Nature Protocols 5:5, pages 945-953.
Crossref
Crossref
John J. Parlow, Mary W. Burney, Brenda L. Case, Thomas J. Girard, Kerri A. Hall, Peter K. Harris, Ronald R. Hiebsch, Rita M. Huff, Rhonda M. Lachance, Deborah A. Mischke, Stephen R. Rapp, Rhonda S. Woerndle & Michael D. Ennis. (2010)
Piperazinyl Glutamate Pyridines as Potent Orally Bioavailable P2Y
12
Antagonists for Inhibition of Platelet Aggregation
. Journal of Medicinal Chemistry 53:5, pages 2010-2037.
Crossref
Crossref
Bozena Studzińska, Anna Seroka, Marta Lepicka, Katarzyna Roszek & Michal Komoszyński. (2010) The increase of adenylate kinase activity in the blood can control aggregation of platelets in coronary or peripheral arterial ischemia. Health 02:03, pages 246-252.
Crossref
Crossref
George M. Brenner & Craig W. Stevens. 2010. Pharmacology. Pharmacology
169
178
.
Jeffrey I. Weitz. 2010. Rutherford's Vascular Surgery. Rutherford's Vascular Surgery
541
555
.
Kristina Hoffmann, Younis Baqi, María Sol Morena, Markus Glänzel, Christa E. Müller & Ivar von Kügelgen. (2009)
Interaction of New, Very Potent Non-Nucleotide Antagonists with Arg256 of the Human Platelet P2Y
12
Receptor
. Journal of Pharmacology and Experimental Therapeutics 331:2, pages 648-655.
Crossref
Crossref
John J. Parlow, Mary W. Burney, Brenda L. Case, Thomas J. Girard, Kerri A. Hall, Ronald R. Hiebsch, Rita M. Huff, Rhonda M. Lachance, Deborah A. Mischke, Stephen R. Rapp, Rhonda S. Woerndle & Michael D. Ennis. (2009) Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation. Bioorganic & Medicinal Chemistry Letters 19:21, pages 6148-6156.
Crossref
Crossref
J.J.J. VAN GIEZEN, L. NILSSON, P. BERNTSSON, B.M. WISSING, F. GIORDANETTO, W. TOMLINSON & P.J. GREASLEY. (2009) Ticagrelor binds to human P2Y12 independently from ADP but antagonizes ADP‐induced receptor signaling and platelet aggregation. Journal of Thrombosis and Haemostasis 7:9, pages 1556-1565.
Crossref
Crossref
Jorge F. Saucedo. (2009) Oral Antiplatelet Therapy in Unstable Angina/Non–ST-Segment Elevation Myocardial Infarction, ST-Segment Elevation Myocardial Infarction, and Percutaneous Coronary Intervention: Is it Time for a Guideline Update?. The American Journal of Cardiology 104:5, pages 4C-8C.
Crossref
Crossref
John J. Parlow, Mary W. Burney, Brenda L. Case, Thomas J. Girard, Kerri A. Hall, Ronald R. Hiebsch, Rita M. Huff, Rhonda M. Lachance, Deborah A. Mischke, Stephen R. Rapp, Rhonda S. Woerndle & Michael D. Ennis. (2009) Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation. Bioorganic & Medicinal Chemistry Letters 19:16, pages 4657-4663.
Crossref
Crossref
Stephen D. Wiviott & Elliott M. Antman. 2009. New Therapeutic Agents in Thrombosis and Thrombolysis. New Therapeutic Agents in Thrombosis and Thrombolysis
471
484
.
Deepak Thomas & Robert P. Giugliano. (2009) Antiplatelet Therapy in Percutaneous Coronary Intervention. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine 8:1, pages 12-19.
Crossref
Crossref
S. Richard, M. Toussaint-Hacquard & T. Lecompte. (2009) Variabilité de réponse plaquettaire à l’aspirine et nouvelles cibles thérapeutiques. Journal des Maladies Vasculaires 34:1, pages 16-25.
Crossref
Crossref
Kristina Hoffmann, Uta Sixel, Francesca Di Pasquale & Ivar von Kügelgen. (2008) Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y12-receptor. Biochemical Pharmacology 76:10, pages 1201-1213.
Crossref
Crossref
Mary K. Boudreaux. (2008) Characteristics, diagnosis, and treatment of inherited platelet disorders in mammals. Journal of the American Veterinary Medical Association 233:8, pages 1251-1259.
Crossref
Crossref
Joshua F. Zeidner, William H. Frishman & Robert G. Lerner. (2008) Investigational Antiplatelet Drugs for the Treatment and Prevention of Coronary Artery Disease. Cardiology in Review 16:5, pages 250-259.
Crossref
Crossref
Lisa T. Newsome, Michael A. Kutcher & Roger L. Royster. (2008) Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention. Anesthesia & Analgesia 107:2, pages 552-569.
Crossref
Crossref
Simon F. De Meyer, Karen Vanhoorelbeke, Katleen Broos, Isabelle I. Salles & Hans Deckmyn. (2008) Antiplatelet drugs. British Journal of Haematology 142:4, pages 515-528.
Crossref
Crossref
N.L. DOVLATOVA, J.A. JAKUBOWSKI, A. SUGIDACHI & S. HEPTINSTALL. (2008) The reversible P2Y12 antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function. Journal of Thrombosis and Haemostasis 6:7, pages 1153-1159.
Crossref
Crossref
James D. Douketis, Peter B. Berger, Andrew S. Dunn, Amir K. Jaffer, Alex C. Spyropoulos, Richard C. Becker & Jack Ansell. (2008) The Perioperative Management of Antithrombotic Therapy. Chest 133:6, pages 299S-339S.
Crossref
Crossref
Jeffrey A. Pfefferkorn, Chulho Choi, Thomas Winters, Robert Kennedy, Liguo Chi, Lisa A. Perrin, Gina Lu, Yun-Wen Ping, Tom McClanahan, Richard Schroeder, Michael T. Leininger, Andrew Geyer, Sabine Schefzick & James Atherton. (2008) P2Y1 receptor antagonists as novel antithrombotic agents. Bioorganic & Medicinal Chemistry Letters 18:11, pages 3338-3343.
Crossref
Crossref
Christoph Bode & Kurt Huber. (2008) Antiplatelet therapy in percutaneous coronary intervention. European Heart Journal Supplements 10:suppl_A, pages A13-A20.
Crossref
Crossref
Judi Bryant, Joseph M. Post, Serene Alexander, Yi-Xin Wang, Lorraine Kent, Sabine Schirm, Jih-Lie Tseng, Babu Subramanyam, Brad Buckman, Imadul Islam, Shendong Yuan, Mark E. Sullivan, Mike Snider & John Morser. (2008) Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): In vitro effects on platelets. Thrombosis Research 122:4, pages 523-532.
Crossref
Crossref
Joseph A. Jakubowski, Kenneth J. Winters, Hideo Naganuma & Lars Wallentin. (2007) Prasugrel: A Novel Thienopyridine Antiplatelet Agent. A Review of Preclinical and Clinical Studies and the Mechanistic Basis for Its Distinct Antiplatelet Profile. Cardiovascular Drug Reviews 25:4, pages 357-374.
Crossref
Crossref
Jonathan D. Rich & Stephen D. Wiviott. (2007) New antiplatelet therapies for acute coronary syndromes. Current Cardiology Reports 9:4, pages 303-311.
Crossref
Crossref