339
Views
17
CrossRef citations to date
0
Altmetric
Review

The P2X1 ion channel in platelet function

&
Pages 153-166 | Received 30 Dec 2009, Accepted 06 Jan 2010, Published online: 04 Mar 2010
 

Abstract

Following vascular injury, the adenosine nucleotide ATP is released from the dense granules of adhering and activated platelets, as well as from injured endothelial cells and damaged red blood cells. ATP instantaneously interacts with the ion channel P2X1 in the platelet membrane, through autocrine and paracrine mechanisms, amplifying the initial phase of a platelet activation event. A multitude of platelet activation studies in vitro and in vivo have identified P2X1 as a receptor with a distinct pharmacological profile, capable of regulating various intracellular signaling cascades, implicated in platelet function. This review discusses findings on the function of the platelet P2X1 receptor and its downstream signaling pathways, collected over the last two decades, against more recent in vivo observations in thrombosis models in P2X1 gene-deficient and transgenic mice. Our present understanding of its physiology has identified platelet P2X1 as a target in the management of thrombosis, its inhibition potentially capable of platelet function modulation. In view of the availability of specific agonists and antagonists, P2X1 is also discussed as a therapeutic target for antithrombotic therapy.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access
  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart
* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.