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Drug Profile

Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity

Pages 1311-1317 | Published online: 10 Jan 2014

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Tochi M Okwuosa, Sarah Anzevino & Ruta Rao. (2017) Cardiovascular disease in cancer survivors. Postgraduate Medical Journal 93:1096, pages 82-90.
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Vinodh Guvvala, Venkatesan Chidambaram Subramanian, Jayashree Anireddy & Mahesh Konda. (2016) Study on the Isolation and Chemical Investigation of Potential Impurities in Dexrazoxane Using 2D-NMR and LC-PDA-MS. Organic Process Research & Development 21:1, pages 11-17.
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Enas M. Malik & Christa E. Müller. (2016) Anthraquinones As Pharmacological Tools and Drugs. Medicinal Research Reviews 36:4, pages 705-748.
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Sabry M. Attia, Sheikh F. Ahmad, Quaiser Saquib, Gamaleldin I. Harisa, Abdulaziz A. Al-Khedhairy & Saleh A. Bakheet. (2016) Dexrazoxane mitigates epirubicin-induced genotoxicity in mice bone marrow cells. Mutagenesis 31:2, pages 137-145.
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Carine E. HamoMichelle W. BloomDaniela CardinaleBonnie KyAnju NohriaLea BaerHal SkopickiDaniel J. LenihanMihai GheorghiadeAlexander R. LyonJaved Butler. (2016) Cancer Therapy–Related Cardiac Dysfunction and Heart Failure. Circulation: Heart Failure 9:2.
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Robin K. Kuriakose, Rakesh C. Kukreja & Lei Xi. (2016) Potential Therapeutic Strategies for Hypertension-Exacerbated Cardiotoxicity of Anticancer Drugs. Oxidative Medicine and Cellular Longevity 2016, pages 1-9.
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Richard M. Steingart, Howard Weinstein, John Sasso, Lee W. Jones, Michelle Johnson, Carol Chen, Jennifer Liu, Nancy Roistacher, Shawn C. Pun, Jonathan W. Weinsaft, Eileen McAleer, Dipti Gupta, Anthony Yu, Michael Baum & Wendy Schaffer. 2016. Clinical Cardio-Oncology. Clinical Cardio-Oncology 345 378 .
S. M. Attia, S. F. Ahmad & S. A. Bakheet. (2015) Impact of dexrazoxane on doxorubicin-induced aneuploidy in somatic and germinal cells of male mice. Cancer Chemotherapy and Pharmacology 77:1, pages 27-33.
Crossref
M J Cross, B R Berridge, P J M Clements, L Cove-Smith, T L Force, P Hoffmann, M Holbrook, A R Lyon, H R Mellor, A A Norris, M Pirmohamed, J D Tugwood, J E Sidaway & B K Park. (2015) Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. British Journal of Pharmacology 172:4, pages 957-974.
Crossref
Linfeng Li, Adedoyin Abraham, Qiong Zhou, Hadi Ali, Jeremy O'Brien, Brayden Hamill, John Arcaroli, Wells Messersmith & Daniel LaBarbera. (2014) An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent. Marine Drugs 12:9, pages 4833-4850.
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Crossref
Onkar S. Bains, András Szeitz, Joanna M. Lubieniecka, Gina E. Cragg, Thomas A. Grigliatti, K. Wayne Riggs & Ronald E. Reid. (2013) A Correlation between Cytotoxicity and Reductase-Mediated Metabolism in Cell Lines Treated with Doxorubicin and Daunorubicin. Journal of Pharmacology and Experimental Therapeutics 347:2, pages 375-387.
Crossref
Snezana K. Bjelogrlic, Silvana T. Lukic & Slavisa M. Djuricic. (2013) Activity of Dexrazoxane and Amifostine Against Late Cardiotoxicity Induced by the Combination of Doxorubicin and Cyclophosphamide In Vivo . Basic & Clinical Pharmacology & Toxicology 113:4, pages 228-238.
Crossref
Anat Rabinovich, Dana Weiss, Maya Weissman, Victor Novack & Itai Levi. (2012) Dexrazoxane does not affect treatment outcome in non‐Hodgkin's lymphoma patients. American Journal of Hematology 87:8, pages 830-832.
Crossref
Angelo Carbone, Peter J. Psaltis, Adam J. Nelson, Robert Metcalf, James D. Richardson, Michael Weightman, Anthony Thomas, John W. Finnie, Glenn D. Young & Stephen G. Worthley. (2012) Dietary Omega-3 Supplementation Exacerbates Left Ventricular Dysfunction in an Ovine Model of Anthracycline-Induced Cardiotoxicity. Journal of Cardiac Failure 18:6, pages 502-511.
Crossref
Rene Kizek, Vojtech Adam, Jan Hrabeta, Tomas Eckschlager, Svatopluk Smutny, Jaroslav V. Burda, Eva Frei & Marie Stiborova. (2012) Anthracyclines and ellipticines as DNA-damaging anticancer drugs: Recent advances. Pharmacology & Therapeutics 133:1, pages 26-39.
Crossref
Feifei Che, Yu Liu & Caigang Xu. (2011) Prevention and Treatment of Doxorubicin-Induced Cardiotoxicity by Dexrazoxane and Schisandrin B in Rabbits. International Journal of Toxicology 30:6, pages 681-689.
Crossref
Steven E Lipshultz, Rebecca E Scully, Stuart R Lipsitz, Stephen E Sallan, Lewis B Silverman, Tracie L Miller, Elly V Barry, Barbara L Asselin, Uma Athale, Luis A Clavell, Eric Larsen, Albert Moghrabi, Yvan Samson, Bruno Michon, Marshall A Schorin, Harvey J Cohen, Donna S Neuberg, E John Orav & Steven D Colan. (2010) Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. The Lancet Oncology 11:10, pages 950-961.
Crossref
W L Salzer, M Devidas, W L Carroll, N Winick, J Pullen, S P Hunger & B A Camitta. (2009) Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984–2001: a report from the children's oncology group. Leukemia 24:2, pages 355-370.
Crossref
Richard D. Olson & Barry J. Cusack. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.

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