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Drug Profile

Acarbose: oral antidiabetes drug with additional cardiovascular benefits

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Pages 153-163 | Published online: 10 Jan 2014

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Jie-Hao Xu, Jinhyuk Lee, Shang-Jun Yin, Wei Wang & Yong-Doo Park. (2023) Inhibitory effect of acarbose on tyrosinase: application of molecular dynamics integrating inhibition kinetics. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
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Priyanka Sharma, Tushar Joshi, Tanuja Joshi, Subhash Chandra & Sushma Tamta. (2021) Molecular dynamics simulation for screening phytochemicals as α-amylase inhibitors from medicinal plants. Journal of Biomolecular Structure and Dynamics 39:17, pages 6524-6538.
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Shashank R Joshi, Ambady Ramachandran, Manoj Chadha, Sudip Chatterjee, Rahul Rathod & Sanjay Kalra. (2014) Acarbose plus metformin fixed-dose combination in the management of type 2 diabetes. Expert Opinion on Pharmacotherapy 15:11, pages 1611-1620.
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Violet Kasabri, Fatma U. Afifi & Imad Hamdan. (2011) Evaluation of the acute antihyperglycemic effects of four selected indigenous plants from Jordan used in traditional medicine. Pharmaceutical Biology 49:7, pages 687-695.
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Giuseppe Derosa, Sibilla A. T. Salvadeo, Angela D’Angelo, Ilaria Ferrari, Roberto Mereu, Ilaria Palumbo, Pamela Maffioli, Sabrina Randazzo & Arrigo F. G. Cicero. (2009) Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: a double-blind, cross-over, clinical trial. Current Medical Research and Opinion 25:3, pages 607-615.
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Qi Dong, Na Hu, Huilan Yue, Honglun Wang & Jinliang Ku. (2021) Identification of α-glucosidase inhibitors from the bran of Chenopodium quinoa Willd. by surface plasmon resonance coupled with ultra-performance liquid chromatography and quadrupole-time-of-flight-mass spectrometry. Journal of Chromatography B 1181, pages 122919.
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Wei Ji, Shaomei Yang, Wenyu Zhang, Zhongliang Sun, Qing Wen & Kun He. (2021) Pharmacodynamic comparison of acarbose tablets in Chinese healthy volunteers under chewing and swallowing conditions. Journal of Clinical Pharmacy and Therapeutics 46:3, pages 814-819.
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Rafaella R. Costa, João A. Oliveira-da-Silva, Thiago A. R. Reis, Grasiele S. V. Tavares, Débora V. C. Mendonça, Camila S. Freitas, Daniela P. Lage, Vívian T. Martins, Luciana M. R. Antinarelli, Amanda S. Machado, Raquel S. Bandeira, Fernanda Ludolf, Thaís T. O. Santos, Rory C. F. Brito, Maria V. Humbert, Daniel Menezes-Souza, Mariana C. Duarte, Miguel A. Chávez-Fumagalli, Bruno M. Roatt, Elaine S. Coimbra & Eduardo A. F. Coelho. (2021) Acarbose presents in vitro and in vivo antileishmanial activity against Leishmania infantum and is a promising therapeutic candidate against visceral leishmaniasis. Medical Microbiology and Immunology 210:2-3, pages 133-147.
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Suxiang ChenNabayet SbuhRakesh N. Veedu. (2021) Antisense Oligonucleotides as Potential Therapeutics for Type 2 Diabetes. Nucleic Acid Therapeutics 31:1, pages 39-57.
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Alwin M. Hartman, Varsha R. Jumde, Walid A. M. Elgaher, Evelien M. Te Poele, Lubbert Dijkhuizen & Anna K. H. Hirsch. (2020) Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar‐Based Molecules that Target Bacterial Glucosyltransferase. ChemMedChem 16:1, pages 113-123.
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Bing Zhao, Feifei Wu, Xue Han, Wenwei Zhou, Qiaojuan Shi & Hao Wang. (2020) Protective effects of acarbose against insulitis in multiple low-dose streptozotocin-induced diabetic mice. Life Sciences 263, pages 118490.
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Changlin Li, Jian Kuang, Yishen Zhao, Hui Sun & Haixia Guan. (2020) Effect of type 2 diabetes and antihyperglycemic drug therapy on signs of tumor invasion in papillary thyroid cancer. Endocrine 69:1, pages 92-99.
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Lingshu Zhang, Pingfang Song, Xiaowei Zhang, Christina Metea, Matthew Schleisman, Lisa Karstens, Eric Leung, Jun Zhang, Qiang Xu, Yi Liu, Mark Asquith & Cong-Qiu Chu. (2020) Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis. Frontiers in Pharmacology 10.
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Sherry G. Dodds, Manish Parihar, Martin Javors, Jia Nie, Nicolas Musi, Zelton Dave Sharp & Paul Hasty. (2020) Acarbose improved survival for Apc +/Min mice . Aging Cell 19:2.
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Tae Jung Oh, Jae Myung YuKyung Wan MinHyun Shik SonMoon Kyu LeeKun Ho YoonYoung Duk SongJoong Yeol ParkIn Kyung JeongBong Soo ChaYong Seong KimSei Hyun BaikIn Joo KimDoo Man KimSung Rae KimKwan Woo LeeJeong Hyung ParkIn Kyu LeeTae Sun ParkSung Hee Choi & Sung Woo Park. (2019) Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Diabetes & Metabolism Journal 43:3, pages 276.
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Andrew J. Krentz & Gerardo Rodriguez-Araujo. (2017) Cardiovascular Outcome Trials of Diabetes and Obesity Drugs: Implications for Conditional Approval and Early Phase Clinical Development. Pharmaceutical Medicine 31:6, pages 399-421.
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Andrew J. Krentz. (2016) Hypertension in type 2 diabetes: impact of glucose-lowering medications. Cardiovascular Endocrinology 5:4, pages 137-143.
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Alexey Moskalev, Elizaveta Chernyagina, Vasily Tsvetkov, Alexander Fedintsev, Mikhail Shaposhnikov, Vyacheslav Krut'ko, Alex Zhavoronkov & Brian K. Kennedy. (2016) Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic. Aging Cell 15:3, pages 407-415.
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Pia V Röder, Bingbing Wu, Yixian Liu & Weiping Han. (2016) Pancreatic regulation of glucose homeostasis. Experimental & Molecular Medicine 48:3, pages e219-e219.
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Kenneth S. Polonsky & Charles F. Burant. 2016. Williams Textbook of Endocrinology. Williams Textbook of Endocrinology 1385 1450 .
Chien-Hung Jhong, Jirawat Riyaphan, Shih-Hung Lin, Yi-Chen Chia & Ching-Feng Weng. (2015) Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico . BioFactors 41:4, pages 242-251.
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Wen-Wen Yan, Gui-Hai Chen, Fang Wang, Jing-Jing Tong & Fei Tao. (2015) Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8. Brain Research 1603, pages 22-31.
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Johann Trutz, Aurel Babeș & Katalin Babeș. (2015) The Importance of the Treatment Strategy Changes in the Long-Term Evolution of Type 2 Diabetic Patients with Sub-Optimal Glycaemic Control After Acute Coronary Syndrome. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 22:1.
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Yien Chiong & Carmella Evans-Molina. 2015. PanVascular Medicine. PanVascular Medicine 1541 1593 .
Chris R. Triggle & Hong Ding. (2014) Cardiovascular impact of drugs used in the treatment of diabetes. Therapeutic Advances in Chronic Disease 5:6, pages 245-268.
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M.?. Prieto, J.M. Comas Samper, C. Escobar Cervantes & V. Gasull Molinera. (2014) Seguridad cardiovascular de los antidiab?ticos no insul?nicos. Posicionamiento cient?fico SEMERGEN. SEMERGEN - Medicina de Familia 40:5, pages 261-273.
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Eberhard Standl, Michael J Theodorakis, Michael Erbach, Oliver Schnell & Jaakko Tuomilehto. (2014) On the potential of acarbose to reduce cardiovascular disease. Cardiovascular Diabetology 13:1, pages 81.
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Yien Chiong & Carmella Evans-Molina. 2013. PanVascular Medicine. PanVascular Medicine 1 65 .
Ankur Jindal, Mariana Garcia-Touza, Nidhi Jindal, Adam Whaley-Connell & James R. Sowers. (2013) Diabetic Kidney Disease and the Cardiorenal Syndrome. Endocrinology and Metabolism Clinics of North America 42:4, pages 789-808.
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Silvio E. Inzucchi, Richard M. Bergenstal, John B. Buse, Michaela Diamant, Ele Ferrannini, Michael Nauck, Anne L. Peters, Apostolos Tsapas, Richard Wender & David R. Matthews. (2012) Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Spectrum 25:3, pages 154-171.
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Eberhard Standl & Oliver Schnell. (2012) Alpha-glucosidase inhibitors 2012 – cardiovascular considerations and trial evaluation. Diabetes and Vascular Disease Research 9:3, pages 163-169.
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Silvio E. Inzucchi, Richard M. Bergenstal, John B. Buse, Michaela Diamant, Ele FerranniniMichael Nauck, Anne L. Peters, Apostolos Tsapas, Richard Wender & David R. Matthews. (2012) Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach. Diabetes Care 35:6, pages 1364-1379.
Crossref
. (2012) Prise en charge de l’hyperglycémie chez le patient diabétique de type 2 : une stratégie centrée sur le patient. Médecine des Maladies Métaboliques 6, pages III-XXV.
Crossref
S. E. Inzucchi, R. M. Bergenstal, J. B. Buse, M. Diamant, E. Ferrannini, M. Nauck, A. L. Peters, A. Tsapas, R. Wender & D. R. Matthews. (2012) Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 55:6, pages 1577-1596.
Crossref
Chunlin Li, Yi-Jen Hung, Karim Qamruddin, Mohamed Fahmy Abdel Aziz, Herbert Stein & Birgit Schmidt. (2011) International noninterventional study of acarbose treatment in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice 92:1, pages 57-64.
Crossref
Masayuki Isaji. (2011) SGLT2 inhibitors: molecular design and potential differences in effect. Kidney International 79, pages S14-S19.
Crossref
Toshio HOSAKA, Yoshitaka NII, Hiroyuki TOMOTAKE, Takahiro ITO, Aya TAMANAHA, Yukiko YAMASAKA, Sayaka SASAGA, Kazuhiro EDAZAWA, Rie TSUTSUMI, Emi SHUTO, Naoki OKAHISA, Shinya IWATA & Tohru SAKAI. (2011) Extracts of Common Buckwheat Bran Prevent Sucrose Digestion. Journal of Nutritional Science and Vitaminology 57:6, pages 441-445.
Crossref
John B. Buse, Kenneth S. Polonsky & Charles F. Burant. 2011. Williams Textbook of Endocrinology. Williams Textbook of Endocrinology 1371 1435 .
John O. Nyalala, Shaoke Luo, Danielle N. Campbell, Aliza T. Brown & Mohammed M. Moursi. (2010) The Effects of Acarbose Treatment on Intimal Hyperplasia in a Rat Carotid Endarterectomy Model of Diet-Induced Insulin Resistance. Vascular and Endovascular Surgery 44:7, pages 560-567.
Crossref
G. Derosa, R. Mereu, A. D’Angelo, S. A. Salvadeo, I. Ferrari, E. Fogari, A. Gravina, I. Palumbo, P. Maffioli, S. Randazzo & A. F. G. Cicero. (2010) ORIGINAL ARTICLE: Effect of pioglitazone and acarbose on endothelial inflammation biomarkers during oral glucose tolerance test in diabetic patients treated with sulphonylureas and metformin. Journal of Clinical Pharmacy and Therapeutics 35:5, pages 565-579.
Crossref
Ogusa Kamiyama, Fujiko Sanae, Kyoko Ikeda, Yasuhiko Higashi, Yasuhiro Minami, Naoki Asano, Isao Adachi & Atsushi Kato. (2010) In vitro inhibition of α-glucosidases and glycogen phosphorylase by catechin gallates in green tea. Food Chemistry 122:4, pages 1061-1066.
Crossref
E. I. Krasilnikova, Y. V. Blagosklonnaya, E. I. Baranova, E. N. Grineva, A. A. Bystrova, I. A. Ryumina, A. R. Volkova & T. L. Karonova. (2009) THE ROLE OF ACARBOSE IN THE TREATMENT AND PREVENTION OF DIABETES MELLITUS TYPE 2: NEW OPPORTUNITIES IN CARDIOVASCULAR RISK DECREASE. "Arterial’naya Gipertenziya" ("Arterial Hypertension") 15:6, pages 640-647.
Crossref
Giuseppe Derosa, Angela D'Angelo, Sibilla A.T. Salvadeo, Ilaria Ferrari, Elena Fogari, Alessia Gravina, Roberto Mereu, Ilaria Palumbo, Pamela Maffioli, Sabrina Randazzo & Arrigo F.G. Cicero. (2009) Modulation of adipokines and vascular remodelling markers during OGTT with acarbose or pioglitazone treatment. Biomedicine & Pharmacotherapy 63:10, pages 723-733.
Crossref
Giuseppe Derosa, Pamela Maffioli, Sibilla A.T. Salvadeo, Ilaria Ferrari, Alessia Gravina, Roberto Mereu, Ilaria Palumbo, Angela D'Angelo & Arrigo F.G. Cicero. (2009) Direct comparison among oral hypoglycemic agents and their association with insulin resistance evaluated by euglycemic hyperinsulinemic clamp: the 60's study. Metabolism 58:8, pages 1059-1066.
Crossref
Wim van Biesen, Steven Van Laecke & Raymond Vanholder. (2009) Treatment of type 2 diabetes in chronic kidney disease: meekly follow the herd or call to arms?. Nephrology Dialysis Transplantation 24:7, pages 2286-2287.
Crossref
P. Prabhakar Reddy, Ashok K. Tiwari, R. Ranga Rao, K. Madhusudhana, V. Rama Subba Rao, Amtul Z. Ali, K. Suresh Babu & J. Madhusudana Rao. (2009) New Labdane diterpenes as intestinal ?-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes. Bioorganic & Medicinal Chemistry Letters 19:9, pages 2562-2565.
Crossref
D.B. McNamara, S.N. Murthy, A.N. Fonseca, C.V. Desouza, P.J. Kadowitz & V.A. Fonseca. (2009) Animal models of catheter-induced intimal hyperplasia in type 1 and type 2 diabetes and the effects of pharmacologic intervention. Canadian Journal of Physiology and Pharmacology 87:1, pages 37-50.
Crossref
Srividya Kidambi & Shailendra B. Patel. (2008) Diabetes Mellitus. The Journal of the American Dental Association 139, pages 8S-18S.
Crossref

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