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Expert Review of Anti-infective Therapy Volume 11, 2013 - Issue 10
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Pathogenesis of Staphylococcus aureus necrotizing pneumonia: the role of PVL and an influenza coinfection

Bettina LöfflerInstitute of Medical Microbiology, University Hospital of Münster, Domagkstraße 10, D-48149 Münster, GermanyCorrespondence[email protected]
,
Silke NiemannInstitute of Medical Microbiology, University Hospital of Münster, Domagkstraße 10, D-48149 Münster, Germany
,
Christina EhrhardtInstitute of Molecular Virology, University Hospital of Münster, Von Esmarch-Str. 56, D-48149 Münster, Germany
,
Dagmar HornDepartment of Pharmacy, University Hospital of Münster, Albert-Schweitzer-Campus 1, D-48149 Münster, Germany
,
Christian LanckohrDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Münster, Albert-Schweitzer-Campus 1, D-48149 Münster, Germany
,
Gerard LinaCIRI, Université Lyon1, Inserm U1111, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Hospices Civils de Lyon, Lyon, France
,
Stephan LudwigInstitute of Molecular Virology, University Hospital of Münster, Von Esmarch-Str. 56, D-48149 Münster, Germany
&
Georg PetersInstitute of Medical Microbiology, University Hospital of Münster, Domagkstraße 10, D-48149 Münster, Germany
 show all
Pages 1041-1051 | Published online: 10 Jan 2014

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Matteo Bassetti, Laura Labate, Monica Melchio, Chiara Robba, Denise Battaglini, Lorenzo Ball, Paolo Pelosi & Daniele Roberto Giacobbe. (2022) Current pharmacotherapy for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Expert Opinion on Pharmacotherapy 23:3, pages 361-375.
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Maud Pichon, Maïte Micaelo, Saida Rasoanandrasana & Anne-Marie Menn. (2021) Molecular characterization of Staphylococcus aureus isolates derived from severe pneumonia: a retrospective monocentre study. Infectious Diseases 53:11, pages 811-819.
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Katsura Hayakawa, Tetsuo Yamaguchi, Daisuke Ono, Hajime Suzuki, Jiro Kamiyama, Shigemasa Taguchi & Kazuya Kiyota. (2020) Two Cases of Intrafamilial Transmission of Community-Acquired Methicillin-Resistant Staphylococcus aureus Producing Both PVL and TSST-1 Causing Fatal Necrotizing Pneumonia and Sepsis. Infection and Drug Resistance 13, pages 2921-2927.
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Sami Hraiech, Laurent Papazian, Jean-Marc Rolain & Fabienne Bregeon. (2015) Animal models of polymicrobial pneumonia. Drug Design, Development and Therapy 9, pages 3279-3292.
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Doo Ryeon Chung & Kyungmin Huh. (2015) Novel pandemic influenza A (H1N1) and community-associated methicillin-resistant Staphylococcus aureus pneumonia. Expert Review of Anti-infective Therapy 13:2, pages 197-207.
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Joyce van Eck, Sharon Bak, Emma de Jong, Debby Vriens & Peter van Wijngaarden. (2023) Necrotizing pneumonia after COVID-19 infection due to Panton-Valentine Leucocidin-producing, methicillin-susceptible Staphylococcus aureus. Clinical Infection in Practice 20, pages 100241.
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Mouhammad J. Alawad, Sabeen Zara, Ahmad Elgohari, Abdulsalam Saif Ibrahim & Hamad Abdel Hadi. (2023) Catastrophic complications of PVL‐MRSA necrotizing pneumonia presenting as respiratory failure and rhabdomyolysis, case report and review of the literature . Clinical Case Reports 11:5.
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Raj D. Shah & Richard G. Wunderink. (2017) Viral Pneumonia and Acute Respiratory Distress Syndrome. Clinics in Chest Medicine 38:1, pages 113-125.
Crossref
E. Escudier, L. Pagani, J. Gaillat, M. Sirodot & A. Levrat. (2015) Discussion autour d’un cas mortel de pneumonie nécrosante à Staphylococcus aureus sécrétant la leucocidine de Panton-ValentineDiscussion of a fatal case of necrotizing pneumonia due to Panton-Valentine leukocidin-producing Staphylococcus aureus. Réanimation 25:3, pages 361-365.
Crossref
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Crossref
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Crossref
Tamara Reyes-Robles & Victor J. Torres. 2017. Staphylococcus aureus. Staphylococcus aureus 121 144 .

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