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Pyrazinamide: the importance of uncovering the mechanisms of action in mycobacteria

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Muhammad Tahir Khan & Shaukat Iqbal Malik. (2020) Structural dynamics behind variants in pyrazinamidase and pyrazinamide resistance. Journal of Biomolecular Structure and Dynamics 38:10, pages 3003-3017.
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Jorddy N. Cruz, José F. S. Costa, André S. Khayat, Kamil Kuca, Carlos A. L. Barros & A. M. J. C. Neto. (2019) Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13. Journal of Biomolecular Structure and Dynamics 37:6, pages 1616-1627.
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Zhimin Cao, Yuanbo Lan, Ling Chen, Min Xiang, Zhiyuan Peng, Jianyong Zhang & Hong Zhang. (2019) Resistance To First-Line Antituberculosis Drugs And Prevalence Of pncA Mutations In Clinical Isolates Of Mycobacterium tuberculosis From Zunyi, Guizhou Province Of China. Infection and Drug Resistance 12, pages 3093-3102.
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Sharabh Sinha, Qingyou Du, Sofija Jovanović, Andriy Sukhodub & Aleksandar Jovanović. (2019) Pyrazinamide may possess cardioprotective properties. The Journal of Antibiotics 72:9, pages 714-717.
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Jan Zitko, Alžběta Mindlová, Ondřej Valášek, Ondřej Jand’ourek, Pavla Paterová, Jiří Janoušek, Klára Konečná & Martin Doležal. (2018) Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents. Molecules 23:9, pages 2390.
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Mansi Aggarwal, Aditi Singh, Sonam Grover, Bharati Pandey, Anchala Kumari & Abhinav Grover. (2017) Role of pnc A gene mutations W68R and W68G in pyrazinamide resistance . Journal of Cellular Biochemistry 119:3, pages 2567-2578.
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Jan Zitko, Ondřej Jand'ourek, Pavla Paterová, Lucie Navrátilová, Jiří Kuneš, Jarmila Vinšová & Martin Doležal. (2018) Design, synthesis and antimycobacterial activity of hybrid molecules combining pyrazinamide with a 4-phenylthiazol-2-amine scaffold. MedChemComm 9:4, pages 685-696.
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Xiangzhong Sun, Yaxin Li, Wenrong He, Chenggong Ji, Peixue Xia, Yichuan Wang, Shuo Du, Hongjiang Li, Natasha Raikhel, Junyu Xiao & Hongwei Guo. (2017) Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nature Communications 8:1.
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James C. Johnston, Leslie Chiang & Kevin Elwood. 2017. Tuberculosis and Nontuberculous Mycobacterial Infections. Tuberculosis and Nontuberculous Mycobacterial Infections 725 734 .
James C. Johnston, Leslie Chiang & Kevin Elwood. (2017) Mycobacterium kansasii . Microbiology Spectrum 5:1.
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Lisa J Hill & Adrian C Williams. (2017) Meat Intake and the Dose of Vitamin B 3 – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures? . International Journal of Tryptophan Research 10, pages 117864691770466.
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Alice L. den Hertog, Sandra Menting, Richard Pfeltz, Matthew Warns, Salman H. Siddiqi & Richard M. Anthony. (2016) Pyrazinamide Is Active against Mycobacterium tuberculosis Cultures at Neutral pH and Low Temperature. Antimicrobial Agents and Chemotherapy 60:8, pages 4956-4960.
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Margarida S. Miranda, Darío J.R. Duarte & Joel F. Liebman. (2016) What is the enthalpy of formation of pyrazine-2-carboxylic acid?. The Journal of Chemical Thermodynamics 97, pages 261-263.
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Kevin A. Nash. (2016) Multidrug Resistance in Mycobacteria. Current Clinical Microbiology Reports 3:1, pages 53-61.
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