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The FGF/FGF receptor axis as a therapeutic target in breast cancer

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Pages 391-402 | Published online: 10 Jan 2014

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Vanessa Benham, Debrup Chakraborty, Blair Bullard & Jamie J. Bernard. (2018) A role for FGF2 in visceral adiposity-associated mammary epithelial transformation. Adipocyte 7:2, pages 113-120.
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Swarnali Kar, Nilanjana Maji, Kamalika Sen, Stuti Roy, Atanu Maity, Shubhra Ghosh Dastidar, Somsubhra Nath, Gautam Basu & Moitri Basu. (2023) Reprogramming of glucose metabolism via PFKFB4 is critical in FGF16-driven invasion of breast cancer cells. Bioscience Reports 43:8.
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Jenny M. Hogstrom, Kayla A. Cruz, Laura M. Selfors, Madelyn N. Ward, Tejas S. Mehta, Naama Kanarek, Jordana Philips, Vandana Dialani, Gerburg Wulf, Laura C. Collins, Jaymin M. Patel & Taru Muranen. (2023) Simultaneous isolation of hormone receptor–positive breast cancer organoids and fibroblasts reveals stroma-mediated resistance mechanisms. Journal of Biological Chemistry 299:8, pages 105021.
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Sheetal Rajpal, Ankit Rajpal, Manoj Agarwal, Virendra Kumar, Ajith Abraham, Divya Khanna & Naveen Kumar. (2023) XAI-CNVMarker: Explainable AI-based copy number variant biomarker discovery for breast cancer subtypes. Biomedical Signal Processing and Control 84, pages 104979.
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Min Yang, Ying Zhang, Min Li, Xinglong Liu & Mohammad Darvishi. (2023) The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies. Cancer Cell International 23:1.
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Liwei Ruan, Songou Zhang, Xiaozhen Chen, Wenqing Liang & Qiong Xie. (2022) Role of anti-angiogenic factors in the pathogenesis of breast cancer: A review of therapeutic potential. Pathology - Research and Practice 236, pages 153956.
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Son H. Pham, Kaylah Pratt, Rachel K. Okolicsanyi, Lotta E. Oikari, Chieh Yu, Ian W. Peall, KM Taufiqul Arif, Te-Arn Chalmers, Martina Gyimesi, Lyn R. Griffiths & Larisa M. Haupt. (2022) Syndecan-1 and -4 influence Wnt signaling and cell migration in human breast cancers. Biochimie 198, pages 60-75.
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Xiaofeng Du, Donald P. McManus, Conor E. Fogarty, Malcolm K. Jones & Hong You. (2022) Schistosoma mansoni Fibroblast Growth Factor Receptor A Orchestrates Multiple Functions in Schistosome Biology and in the Host-Parasite Interplay. Frontiers in Immunology 13.
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Yu Gao, Yiwei Wang, Juan Yu & Rende Guo. (2021) FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei. Cell Biochemistry and Biophysics 80:2, pages 311-320.
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Jinyoung Suh, Do-Hee Kim, Su-Jung Kim, Nam-Chul Cho, Yeon-Hwa Lee, Jeong-Hoon Jang & Young-Joon Surh. (2022) Nuclear Localization of Fibroblast Growth Factor Receptor 1 in Breast Cancer Cells Interacting with Cancer Associated Fibroblasts. Journal of Cancer Prevention 27:1, pages 68-76.
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Vladan Milosevic, Reidunn J. Edelmann, Johanna Hol Fosse, Arne Östman & Lars A. Akslen. 2022. Biomarkers of the Tumor Microenvironment. Biomarkers of the Tumor Microenvironment 31 52 .
Nilaja Badodekar, Akshita Sharma, Vikrant Patil, Gaurang Telang, Rakesh Sharma, Shankargouda Patil, Nishant Vyas & Indumathi Somasundaram. (2021) Angiogenesis induction in breast cancer: A paracrine paradigm. Cell Biochemistry and Function 39:7, pages 860-873.
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Hui Qu, Mu Zhou, Zhennan Yan, He Wang, Vinod K. Rustgi, Shaoting Zhang, Olivier Gevaert & Dimitris N. Metaxas. (2021) Genetic mutation and biological pathway prediction based on whole slide images in breast carcinoma using deep learning. npj Precision Oncology 5:1.
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Maria Francesca Santolla, Marianna Talia & Marcello Maggiolini. (2021) S100A4 Is Involved in Stimulatory Effects Elicited by the FGF2/FGFR1 Signaling Pathway in Triple-Negative Breast Cancer (TNBC) Cells. International Journal of Molecular Sciences 22:9, pages 4720.
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Sara Santorelli, Deborah P. Fischer, Michael K. Harte, Johanna Laru & Kay M. Marshall. (2021) In vivo effects of AZD4547, a novel fibroblast growth factor receptor inhibitor, in a mouse model of endometriosis. Pharmacology Research & Perspectives 9:2.
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Maria Francesca Santolla & Marcello Maggiolini. (2020) The FGF/FGFR System in Breast Cancer: Oncogenic Features and Therapeutic Perspectives. Cancers 12:10, pages 3029.
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Ayman M. Ibrahim, Matthew A. Moss, Zane Gray, Michelle D. Rojo, Caitlin M. Burke, Kathryn L. Schwertfeger, Camila O. dos Santos & Heather L. Machado. (2020) Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion. Frontiers in Oncology 10.
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Heba T. Abdel‐Mohsen, Eman A. Abd El‐Meguid, Ahmed M. El Kerdawy, Abeer E. E. Mahmoud & Mamdouh M. Ali. (2020) Design, synthesis, and molecular docking of novel 2‐arylbenzothiazole multiangiokinase inhibitors targeting breast cancer. Archiv der Pharmazie 353:4, pages 1900340.
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Jihyun Kim, Doyeong Yu, Youngmee Kwon, Keun Seok Lee, Sung Hoon Sim, Sun-Young Kong, Eun Sook Lee, In Hae Park & Charny Park. (2020) Genomic Characteristics of Triple-Negative Breast Cancer Nominate Molecular Subtypes That Predict Chemotherapy Response. Molecular Cancer Research 18:2, pages 253-263.
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Dominika Piasecka, Marcin Braun, Kamila Kitowska, Kamil Mieczkowski, Radzislaw Kordek, Rafal Sadej & Hanna Romanska. (2019) FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer. Journal of Experimental & Clinical Cancer Research 38:1.
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Jordan W. Strober & Matthew J. Brady. (2019) Dietary Fructose Consumption and Triple-Negative Breast Cancer Incidence. Frontiers in Endocrinology 10.
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Sulma I. Mohammed, Odalys Torres‐Luquis, Elwood Walls & Frank Lloyd. (2019) Lymph‐circulating tumor cells show distinct properties to blood‐circulating tumor cells and are efficient metastatic precursors. Molecular Oncology 13:6, pages 1400-1418.
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Gaurav Pandey, Nicholas Borcherding, Ryan Kolb, Paige Kluz, Wei Li, Sonia Sugg, Jun Zhang, Dazhi A. Lai & Weizhou Zhang. (2019) ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer. Cancers 11:5, pages 718.
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Aradhana Rani, Justin Stebbing, Georgios Giamas & John Murphy. (2019) Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy. Frontiers in Endocrinology 10.
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M. Campone, T. Bachelot, F. Penault-Llorca, A. Pallis, V. Agrapart, M. J. Pierrat, C. Poirot, F. Dubois, L. Xuereb, C. J. Bossard, N. Guigal-Stephan, B. Lockhart & F. Andre. (2019) A phase Ib dose allocation study of oral administration of lucitanib given in combination with fulvestrant in patients with estrogen receptor-positive and FGFR1-amplified or non-amplified metastatic breast cancer. Cancer Chemotherapy and Pharmacology 83:4, pages 743-753.
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Sandeep Vellanki, Eun Huh, Stephen Saville & Soo Lee. (2019) Candida albicans Morphology-Dependent Host FGF-2 Response as a Potential Therapeutic Target. Journal of Fungi 5:1, pages 22.
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Wei Wei, Zilong You, Shanshan Sun, Yuhang Wang, Xianyu Zhang, Da Pang & Yongdong Jiang. (2018) Prognostic implications of fibroblast growth factor receptor 4 polymorphisms in primary breast cancer. Molecular Carcinogenesis 57:8, pages 988-996.
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Manman Wei, Xia Peng, Li Xing, Yang Dai, Ruimin Huang, Meiyu Geng, Ao Zhang, Jing Ai & Zilan Song. (2018) Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors. European Journal of Medicinal Chemistry 154, pages 9-28.
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Caroline M. Alexander. 2018. WNT Signaling in Health and Disease. WNT Signaling in Health and Disease 271 298 .
Luigi Formisano, Kimberly M. Stauffer, Christian D. Young, Neil E. Bhola, Angel L. Guerrero-Zotano, Valerie M. Jansen, Mónica M. Estrada, Katherine E. Hutchinson, Jennifer M. Giltnane, Luis J. Schwarz, Yao Lu, Justin M. Balko, Olivier Deas, Stefano Cairo, Jean-Gabriel Judde, Ingrid A. Mayer, Melinda Sanders, Teresa C. Dugger, Roberto Bianco, Thomas Stricker & Carlos L. Arteaga. (2017) Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer. Clinical Cancer Research 23:20, pages 6138-6150.
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Nataša Todorović-Raković, Marko Radulovic, Tijana Vujasinović, Zaki Abu Rabi, Jelena Milovanović & Dragica Nikolić-Vukosavljević. (2017) bFGF in tumor tissue independently prognosticates disease outcome of a natural course of invasive breast cancer. Cancer Biomarkers 20:2, pages 151-158.
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Nuša Trošt, Samuel Peña-Llopis, Sajjan Koirala, Jurij Stojan, Patrick Ryan Potts, Klementina Fon Tacer & Elisabeth D. Martinez. (2015) γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers. Oncotarget 7:3, pages 2611-2628.
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Katharina von Loga, Jule Kohlhaussen, Lia Burkhardt, Ronald Simon, Stefan Steurer, Susanne Burdak-Rothkamm, Frank Jacobsen, Guido Sauter & Till Krech. (2015) FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma. PLOS ONE 10:11, pages e0141867.
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Jeffrey S. Ross, Siraj M. Ali, Kai Wang, Depinder Khaira, Norma A. Palma, Juliann Chmielecki, Gary A. Palmer, Deborah Morosini, Julia A. Elvin, Sandra V. Fernandez, Vincent A. Miller, Philip J. Stephens & Massimo Cristofanilli. (2015) Comprehensive genomic profiling of inflammatory breast cancer cases reveals a high frequency of clinically relevant genomic alterations. Breast Cancer Research and Treatment 154:1, pages 155-162.
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Stacey J. ColemanCharo BruceAthina-Myrto ChioniHemant M. KocherRichard P. Grose. (2014) The ins and outs of fibroblast growth factor receptor signalling. Clinical Science 127:4, pages 217-231.
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