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Neutrophils and emerging targets for treatment in chronic obstructive pulmonary disease

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Pages 1055-1068 | Published online: 10 Jan 2014

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Alisha Arora & Archana Singh. (2023) Exploring the role of neutrophils in infectious and noninfectious pulmonary disorders. International Reviews of Immunology 0:0, pages 1-21.
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Malcolm Begg, J Nicole Hamblin, Emily Jarvis, Glyn Bradley, Stephen Mark, David Michalovich, Mark Lennon, Hannah E Wajdner, Augustin Amour, Robert Wilson, Ken Saunders, Rikako Tanaka, Saki Arai, Teresa Tang, Cedric Van Holsbeke, Jan De Backer, Wim Vos, Ingrid L Titlestad, J Mark FitzGerald, Kieran Killian, Jean Bourbeau, Claude Poirier, François Maltais, Anthony Cahn & Edith M Hessel. (2021) Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 1621-1636.
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Irene Rodríguez-Arce, Xabier Morales, Mikel Ariz, Begoña Euba, Nahikari López-López, Maider Esparza, Derek W. Hood, José Leiva, Carlos Ortíz-de-Solórzano & Junkal Garmendia. (2021) Development and multimodal characterization of an elastase-induced emphysema mouse disease model for the COPD frequent bacterial exacerbator phenotype. Virulence 12:1, pages 1672-1688.
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Yujie Wang, Jiayan Xu, Yaqi Meng, Ian M Adcock & Xin Yao. (2018) Role of inflammatory cells in airway remodeling in COPD. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 3341-3348.
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John Wong, Bruce E Magun & Lisa J Wood. (2016) Lung inflammation caused by inhaled toxicants: a review. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 1391-1401.
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Anne B Chang, Robyn L Marsh, Heidi C Smith-Vaughan & Lucas R Hoffman. (2015) Emerging drugs for bronchiectasis: an update. Expert Opinion on Emerging Drugs 20:2, pages 277-297.
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Articles from other publishers (54)

JunMei Wang, Chunxiu Ren, Lingling Jin & Wuliji Batu. (2023) Seabuckthorn Wuwei Pulvis attenuates chronic obstructive pulmonary disease in rat through gut microbiota-short chain fatty acids axis. Journal of Ethnopharmacology 314, pages 116591.
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Mahtab Tapak, Somaye Sadeghi, Tooba Ghazanfari & Nariman Mosaffa. (2023) Chemical exposure and alveolar macrophages responses: ‘the role of pulmonary defense mechanism in inhalation injuries’. BMJ Open Respiratory Research 10:1, pages e001589.
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Meizhen Xie, Yulei Hao, Liangshu Feng, Tian Wang, Mengyue Yao, Hui Li, Di Ma & Jiachun Feng. (2023) Neutrophil Heterogeneity and its Roles in the Inflammatory Network after Ischemic Stroke. Current Neuropharmacology 21:3, pages 621-650.
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Dongyan Song, Jose M. Adrover, Christy Felice, Lisa N. Christensen, Xue-Yan He, Joseph R. Merrill, John E. Wilkinson, Tobias Janowitz, Scott K. Lyons, Mikala Egeblad & Nicholas K. Tonks. (2022) PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils. JCI Insight 7:14.
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Weilin Xue, Jianying Ma, Yue Li & Chunxia Xie. (2022) Role of CD4+ T and CD8+ T Lymphocytes-Mediated Cellular Immunity in Pathogenesis of Chronic Obstructive Pulmonary Disease. Journal of Immunology Research 2022, pages 1-9.
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Elisabeth Taucher, Iurii Mykoliuk, Joerg Lindenmann & Freyja-Maria Smolle-Juettner. (2022) Implications of the Immune Landscape in COPD and Lung Cancer: Smoking Versus Other Causes. Frontiers in Immunology 13.
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Kevin Mou, Stanley M. H. Chan, Kurt Brassington, Aleksandar Dobric, Simone N. De Luca, Huei Jiunn Seow, Stavros Selemidis, Steven Bozinovski & Ross Vlahos. (2022) Influenza A Virus-Driven Airway Inflammation may be Dissociated From Limb Muscle Atrophy in Cigarette Smoke-Exposed Mice. Frontiers in Pharmacology 13.
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Abdolmohammad Ranhbar, Bahram Sohrabi, Reza Hajizadeh, MahdiKarimi Shoar, Hadiseh Kavandi, Sahar Ghodratizadeh, Hanieh Sakha & Kamran Mohammadi. (2022) Neutrophil-to-Lymphocyte Ratio and Outpatient Management of Low-Risk Acute Pulmonary Embolism. Heart and Mind 6:3, pages 183.
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Kavita Rawat, Saima Syeda & Anju Shrivastava. (2022) Hyperactive neutrophils infiltrate vital organs of tumor bearing host and contribute to gradual systemic deterioration via upregulated NE, MPO and MMP-9 activity. Immunology Letters 241, pages 35-48.
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Farzaneh Sohrabi, Mahin Dianat, Mohammad Badavi, Maryam Radan & Seyyed Ali Mard. (2021) Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats. Environmental Science and Pollution Research 28:40, pages 56822-56834.
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Shuo Wang, Xiaoxue Lai, Cong Li, Meng Chen, Miao Hu, Xinrong Liu, Yanzhi Song & Yihui Deng. (2021) Sialic acid-conjugate modified doxorubicin nanoplatform for treating neutrophil-related inflammation. Journal of Controlled Release 337, pages 612-627.
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Ryan J. Lu, Shalina Taylor, Kévin Contrepois, Minhoo Kim, Juan I. Bravo, Mathew Ellenberger, Nirmal K. Sampathkumar & Bérénice A. Benayoun. (2021) Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex- and age-related functional regulation. Nature Aging 1:8, pages 715-733.
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Jason Girkin, Su-Ling Loo, Camille Esneau, Steven Maltby, Francesca Mercuri, Brendon Chua, Andrew T. Reid, Punnam Chander Veerati, Chris L. Grainge, Peter A.B. Wark, Darryl Knight, David Jackson, Christophe Demaison & Nathan W. Bartlett. (2021) TLR2-mediated innate immune priming boosts lung anti-viral immunity. European Respiratory Journal 58:1, pages 2001584.
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Barbara Gierlikowska, Albert Stachura, Wojciech Gierlikowski & Urszula Demkow. (2021) Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils—The Current Knowledge, Pharmacological Modulation and Future Prospects. Frontiers in Pharmacology 12.
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Kavita Rawat, Saima Syeda & Anju Shrivastava. (2021) Neutrophil-derived granule cargoes: paving the way for tumor growth and progression. Cancer and Metastasis Reviews 40:1, pages 221-244.
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Carolin K. Koss, Christian T. Wohnhaas, Jonathan R. Baker, Cornelia Tilp, Michèl Przibilla, Carmen Lerner, Silvia Frey, Martina Keck, Cara M. M. Williams, Daniel Peter, Meera Ramanujam, Jay Fine, Florian Gantner, Matthew Thomas, Peter J. Barnes, Louise E. Donnelly & Karim C. El Kasmi. (2021) IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice. Communications Biology 4:1.
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Anjali Trivedi, Meraj A. Khan, Geetanjali Bade & Anjana Talwar. (2021) Orchestration of Neutrophil Extracellular Traps (Nets), a Unique Innate Immune Function during Chronic Obstructive Pulmonary Disease (COPD) Development. Biomedicines 9:1, pages 53.
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Javier Checa & Josep M. Aran. (2020) Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology. International Journal of Molecular Sciences 21:23, pages 9317.
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Zhen Cahilog, Hailin Zhao, Lingzhi Wu, Azeem Alam, Shiori Eguchi, Hao Weng & Daqing Ma. (2020) The Role of Neutrophil NETosis in Organ Injury: Novel Inflammatory Cell Death Mechanisms. Inflammation 43:6, pages 2021-2032.
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Tamás Németh, Markus Sperandio & Attila Mócsai. (2020) Neutrophils as emerging therapeutic targets. Nature Reviews Drug Discovery 19:4, pages 253-275.
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Marina Jerebtsova, Asrar Ahmad, Xiaomei Niu, Ornela Rutagarama & Sergei Nekhai. (2020) HIV-1 Transcription Inhibitor 1E7-03 Restores LPS-Induced Alteration of Lung Leukocytes’ Infiltration Dynamics and Resolves Inflammation in HIV Transgenic Mice. Viruses 12:2, pages 204.
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Fernanda Miriane Bruni, Erica Maria Martins Coutinho, Aline Ingrid Andrade-Barros, Lidiane Zito Grund, Monica Lopes-Ferreira & Carla Lima. (2020) Anaphylaxis induced by Thalassophryne nattereri venom in mice is an IgE/IgG1-mediated, IL-4-dependent phenomenon. Scientific Reports 10:1.
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Dong-Kyu Kim, Jin Youp Kim, Young Eun Han, Joon Kon Kim, Hee-Suk Lim, Kyoung Mi Eun, Seung Koo Yang & Dae Woo Kim. (2020) Elastase-Positive Neutrophils Are Associated With Refractoriness of Chronic Rhinosinusitis With Nasal Polyps in an Asian Population. Allergy, Asthma & Immunology Research 12:1, pages 42.
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Louis-Philippe Boulet, Marie-Eve Boulay, Harvey O. Coxson, Cameron J. Hague, Joanne Milot, Johane Lepage & François Maltais. (2020) Asthma with Irreversible Airway Obstruction in Smokers and Nonsmokers: Links between Airway Inflammation and Structural Changes. Respiration 99:12, pages 1090-1100.
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Charalambos Michaeloudes, Pankaj K. Bhavsar, Sharon Mumby, Bingling Xu, Christopher Kim Ming Hui, Kian Fan Chung & Ian M. Adcock. (2020) Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases. Journal of Innate Immunity 12:1, pages 31-46.
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Stephan F. van Eeden & James C. Hogg. (2020) Immune-Modulation in Chronic Obstructive Pulmonary Disease: Current Concepts and Future Strategies. Respiration 99:7, pages 550-565.
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Jeanne Allinne, George Scott, Wei Keat Lim, Dylan Birchard, Jonas S. Erjefält, Caroline Sandén, Li-Hong Ben, Amit Agrawal, Navneet Kaur, Jee Hae Kim, Vishal Kamat, Wen Fury, Tammy Huang, Neil Stahl, George D. Yancopoulos, Andrew J. Murphy, Matthew A. Sleeman & Jamie M. Orengo. (2019) IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation. Journal of Allergy and Clinical Immunology 144:6, pages 1624-1637.e10.
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Yun-Ho Kim, Min-Kyung Kang, Eun-Jung Lee, Dong Kim, Hyeongjoo Oh, Soo-Il Kim, Su Oh, Kyung-Hee Kim, Sang-Jae Park, Yean-Jung Choi & Young-Hee Kang. (2019) Dried Yeast Extracts Curtails Pulmonary Oxidative Stress, Inflammation and Tissue Destruction in a Model of Experimental Emphysema. Antioxidants 8:9, pages 349.
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Vivek Dharwal, Rajat Sandhir & Amarjit S. Naura. (2019) PARP-1 inhibition provides protection against elastase-induced emphysema by mitigating the expression of matrix metalloproteinases. Molecular and Cellular Biochemistry 457:1-2, pages 41-49.
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Won-Kyung YangSeung-Hyung KimIn Chul JungYang-Chun Park. (2019) Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease . Journal of Medicinal Food 22:1, pages 87-96.
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Daisy Karina Aguilar-López, Carlos Olvera-Sandoval, Diego Estrada-Luna, Jeannett Alejandra Izquierdo-Vega, Ashutosh Sharma & Gabriel Betanzos-Cabrera. 2019. Oxidative Stress in Lung Diseases. Oxidative Stress in Lung Diseases 3 26 .
Won-Kyung Yang, Yee Ran Lyu, Seung-Hyung Kim & Yang Chun Park. (2018) Effects of GHX02 on Chronic Obstructive Pulmonary Disease Mouse Model. Journal of Korean Medicine 39:4, pages 126-135.
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Yun-Ho Kim, Yean-Jung Choi, Min-Kyung Kang, Eun-Jung Lee, Dong Yeon Kim, Hyeongjoo Oh & Young-Hee Kang. (2018) Oleuropein Curtails Pulmonary Inflammation and Tissue Destruction in Models of Experimental Asthma and Emphysema. Journal of Agricultural and Food Chemistry 66:29, pages 7643-7654.
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Kyoung-Hee Lee, Jinwoo Lee, Jiyeong Jeong, Jisu Woo, Chang-Hoon Lee & Chul-Gyu Yoo. (2018) Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells. Experimental & Molecular Medicine 50:7, pages 1-9.
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Hathairat Thammason, Pichit Khetkam, Wachirachai Pabuprapap, Apichart Suksamrarn & Duangkamol Kunthalert. (2018) Ethyl rosmarinate inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in alveolar macrophages. European Journal of Pharmacology 824, pages 17-23.
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Daqi Xu, Marissa L. Matsumoto, Brent S. McKenzie & Ali A. Zarrin. (2018) TPL2 kinase action and control of inflammation. Pharmacological Research 129, pages 188-193.
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Jon Florence, Agnieszka Krupa, Laela Booshehri, Adrian Gajewski & Anna Kurdowska. (2018) Disrupting the Btk Pathway Suppresses COPD-Like Lung Alterations in Atherosclerosis Prone ApoE−/− Mice Following Regular Exposure to Cigarette Smoke. International Journal of Molecular Sciences 19:2, pages 343.
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Toshiyuki Mitsuyama, Kazushige Uchida, Kimi Sumimoto, Yuri Fukui, Tsukasa Ikeura, Toshiro Fukui, Akiyoshi Nishio, Nobuaki Shikata, Yoshiko Uemura, Sohei Satoi, Nobumasa Mizuno, Kenji Notohara, Tooru Shimosegawa, Giuseppe Zamboni, Luca Frulloni & Kazuichi Okazaki. (2018) Neutrophil infiltrations compared between types 1 and 2 autoimmune pancreatitis1型自己免疫性膵炎(LPSP)と2型自己免疫性膵炎(IDCP)の好中球浸潤の比較. The Journal of Kansai Medical University 69:0, pages 7-18.
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Samia Boukhenouna, Mark A. Wilson, Karim Bahmed & Beata Kosmider. (2018) Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease. Oxidative Medicine and Cellular Longevity 2018, pages 1-9.
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Chhinder P. Sodhi, Christine Wohlford-Lenane, Yukihiro Yamaguchi, Thomas Prindle, William B. Fulton, Sanxia Wang, Paul B. McCrayJr.Jr., Mark Chappell, David J. Hackam & Hongpeng Jia. (2018) Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg 9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration . American Journal of Physiology-Lung Cellular and Molecular Physiology 314:1, pages L17-L31.
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Zhilin Zeng, Miao Li, Meijia Wang, Xiaomei Wu, Qinghai Li, Qin Ning, Jianping Zhao, Yongjian Xu & Jungang Xie. (2017) Increased expression of Siglec-9 in chronic obstructive pulmonary disease. Scientific Reports 7:1.
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Huifeng Yu, Anabel Gonzalez-Gil, Yadong Wei, Steve M Fernandes, Ryan N Porell, Katarina Vajn, James C Paulson, Corwin M Nycholat & Ronald L Schnaar. (2017) Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties. Glycobiology 27:7, pages 657-668.
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Yun-Ho Kim, Yean-Jung Choi, Min-Kyung Kang, Sin-Hye Park, Lucia Dwi Antika, Eun-Jung Lee, Dong Yeon Kim & Young-Hee Kang. (2017) Astragalin Inhibits Allergic Inflammation and Airway Thickening in Ovalbumin-Challenged Mice. Journal of Agricultural and Food Chemistry 65:4, pages 836-845.
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Jinping Liu, Zhiqiang Pang, Guoqiang Wang, Xuewa Guan, Keyong Fang, Ziyan Wang & Fang Wang. (2017) Advanced Role of Neutrophils in Common Respiratory Diseases. Journal of Immunology Research 2017, pages 1-21.
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Thomas K. Wright, Peter G. Gibson, Jodie L. Simpson, Vanessa M. McDonald, Lisa G. Wood & Katherine J. Baines. (2016) Neutrophil extracellular traps are associated with inflammation in chronic airway disease. Respirology 21:3, pages 467-475.
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Antoine Guillon, Youenn Jouan, Deborah Brea, Fabien Gueugnon, Emilie Dalloneau, Thomas Baranek, Clémence Henry, Eric Morello, Jean-Christophe Renauld, Muriel Pichavant, Philippe Gosset, Yves Courty, Patrice Diot & Mustapha Si-Tahar. (2015) Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence. European Respiratory Journal 46:3, pages 771-782.
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David CL Lam, Stanley CH Chan, Judith CW Mak, Craig Freeman, Mary SM Ip & Daisy KY Shum. (2015) S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation. Scientific Reports 5:1.
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Toshiyuki Mitsuyama, Kazushige Uchida, Kimi Sumimoto, Yuri Fukui, Tsukasa Ikeura, Toshiro Fukui, Akiyoshi Nishio, Nobuaki Shikata, Yoshiko Uemura, Sohei Satoi, Nobumasa Mizuno, Kenji Notohara, Tooru Shimosegawa, Giuseppe Zamboni, Luca Frulloni & Kazuichi Okazaki. (2015) Comparison of neutrophil infiltration between type 1 and type 2 autoimmune pancreatitis. Pancreatology 15:3, pages 271-280.
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Gaetano Caramori, Paul Kirkham, Adam Barczyk, Antonino Di Stefano & Ian Adcock. (2015) Molecular pathogenesis of cigarette smoking-induced stable COPD. Annals of the New York Academy of Sciences 1340:1, pages 55-64.
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Joon-Ho Hwang, Beom-Joon Lee, Hee Jae Jung, Kwan-Il Kim, Jun-Yong Choi, Myungsoo Joo & Sung-Ki Jung. (2015) Effects of Chung-Pae Inhalation Therapy on a Mouse Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-7.
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Weibin Tang, Jianlin Xie, Song Xu, Haining Lv, Mingbao Lin, Shaopeng Yuan, Jinye Bai, Qi Hou & Shishan Yu. (2014) Novel Nitric Oxide-Releasing Derivatives of Brusatol as Anti-Inflammatory Agents: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies. Journal of Medicinal Chemistry 57:18, pages 7600-7612.
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