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GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential

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Fabio Massimo Perrotta, Silvia Scriffignano, Francesco Ciccia & Ennio Lubrano. (2022) Therapeutic Targets for Ankylosing Spondylitis – Recent Insights and Future Prospects. Open Access Rheumatology: Research and Reviews 14, pages 57-66.
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Li Mo, Shuzhen Hong, Yi Li, Zurong Hu, Baoyi Han, Zaomei Wei & Jie Jia. (2020) Sevoflurane inhibited inflammatory response induced by TNF-α in human trophoblastic cells through p38MAPK signaling pathway. Journal of Receptors and Signal Transduction 40:3, pages 218-223.
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Xiaoqing Li, Shirong Zhou, Yao Wang, Hui Lian, Anxin Zuo, Kaihua Zhou, Ling Tong, Zhujun Zhou & Jimin Gao. (2019) The pilot-scale preparation of the SA-hGM-CSF bi-functional fusion protein. Bioengineered 10:1, pages 108-120.
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Urmi Dhagat, Timothy R. Hercus, Sophie E. Broughton, Tracy L. Nero, Karen S. Cheung Tung Shing, Emma F. Barry, Christy A. Thomson, Steve Bryson, Emil F. Pai, Barbara J. McClure, John W. Schrader, Angel F. Lopez & Michael W. Parker. (2018) The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. mAbs 10:7, pages 1018-1029.
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Masayoshi Kanbori, Hiroshi Suzuka, Tsutomu Yajima, Emika Kishino, Ryuji Morishige, Shigeki Momohara, Atsushi Kawakami & Miyo Ota. (2018) Postmarketing surveillance evaluating the safety and effectiveness of golimumab in Japanese patients with rheumatoid arthritis. Modern Rheumatology 28:1, pages 66-75.
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Chiara Crotti, Maria Gabriella Raimondo, Andrea Becciolini, Martina Biggioggero & Ennio Giulio Favalli. (2017) Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date. Drug Design, Development and Therapy 11, pages 211-223.
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Con Panousis, Urmi Dhagat, Kirsten M. Edwards, Veronika Rayzman, Matthew P. Hardy, Hal Braley, Gail M. Gauvreau, Timothy R. Hercus, Steven Smith, Roma Sehmi, Laura McMillan, Mara Dottore, Barbara J. McClure, Louis J. Fabri, Gino Vairo, Angel F Lopez, Michael W. Parker, Andrew D. Nash, Nicholas J. Wilson, Michael J. Wilson & Catherine M. Owczarek. (2016) CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors. mAbs 8:3, pages 436-453.
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Thomas S. McCormick, Rana B. Hejal, Luis O. Leal & Mahmoud A. Ghannoum. (2022) GM-CSF: Orchestrating the Pulmonary Response to Infection. Frontiers in Pharmacology 12.
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Jianan Zhao, Shicheng Guo, Steven J. Schrodi & Dongyi He. (2021) Molecular and Cellular Heterogeneity in Rheumatoid Arthritis: Mechanisms and Clinical Implications. Frontiers in Immunology 12.
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Shengjie Li, Aoxiang Zhuge, Kaicen Wang, Longxian Lv, Xiaoyuan Bian, Liya Yang, Jiafeng Xia, Xianwan Jiang, Wenrui Wu, Shuting Wang, Qiangqiang Wang & Lanjuan Li. (2021) Ketogenic diet aggravates colitis, impairs intestinal barrier and alters gut microbiota and metabolism in DSS-induced mice. Food & Function 12:20, pages 10210-10225.
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Valentina M. T. Bart, Robert J. Pickering, Philip R. Taylor & Natacha Ipseiz. (2021) Macrophage reprogramming for therapy. Immunology 163:2, pages 128-144.
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Takao Sudo, Yasutaka Motomura, Daisuke Okuzaki, Tetsuo Hasegawa, Takafumi Yokota, Junichi Kikuta, Tomoka Ao, Hiroki Mizuno, Takahiro Matsui, Daisuke Motooka, Ryosuke Yoshizawa, Takashi Nagasawa, Yuzuru Kanakura, Kazuyo Moro & Masaru Ishii. (2021) Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. Journal of Experimental Medicine 218:5.
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Adrian A. Achuthan, Kevin M.C. Lee & John A. Hamilton. (2021) Targeting GM-CSF in inflammatory and autoimmune disorders. Seminars in Immunology 54, pages 101523.
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Florian Ingelfinger, Donatella De Feo & Burkhard Becher. (2021) GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation. Seminars in Immunology 54, pages 101518.
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Philip W. Tipton, E. Richard Stanley, Violeta Chitu & Zbigniew K. Wszolek. (2021) Is Pre‐Symptomatic Immunosuppression Protective in CSF1R ‐ Related Leukoencephalopathy? . Movement Disorders 36:4, pages 852-856.
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Sung-Jae Choi. (2021) Biologic therapies for the treatment of rheumatoid arthritis. Journal of the Korean Medical Association 64:2, pages 95-104.
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Kinal Bhatt, Radhika Garimella, Rahima Taugir, Isha Mehta, Muhammad Jamal, Rupalakshmi Vijayan, Rita Offor, Kanayo Nwankwo, Uroosa Arif, Khurram Waheed, Priyanka Kumari, Maulik Lathiya, George Michel, Naushira Pandya, John Halpern, Hassan Nasir & Marcos A. Sanchez-Gonzalez. (2021) Effectiveness of Mavrilimumab in Viral Infections Including SARS-CoV-2 Infection - A Brief Review. Infection & Chemotherapy 53:1, pages 1.
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Ioanna Tremi, Somaira Nowsheen, Khaled Aziz, Shankar Siva, Jessica Ventura, Vasiliki I. Hatzi, Olga A. Martin & Alexandros G. Georgakilas. 2021. Cancer. Cancer 131 147 .
Ahuva D. Cices & Jeffrey M. Weinberg. 2021. Advances in Psoriasis. Advances in Psoriasis 303 310 .
Despina Michailidou, Tomas Mustelin & Christian Lood. (2020) Role of Neutrophils in Systemic Vasculitides. Frontiers in Immunology 11.
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Zubeyir Elmazoglu, Zehra Aydın Bek, Gülistan Sanem Sarıbaş, Candan Özoğul, Berna Goker, Berivan Bitik, Cem Nuri Aktekin & Çimen Karasu. (2020) TLR4, RAGE, and p‐JNK/JNK mediated inflammatory aggression in osteoathritic human chondrocytes are counteracted by redox‐sensitive phenolic olive compounds: Comparison with ibuprofen. Journal of Tissue Engineering and Regenerative Medicine 14:12, pages 1841-1857.
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Ying Ying Kong, Kirsty Wilson, Vasso Apostolopoulos & Magdalena Plebanski. (2020) Dendritic Cells and Myeloid Derived Suppressor Cells Fully Responsive to Stimulation via Toll-Like Receptor 4 Are Rapidly Induced from Bone-Marrow Cells by Granulocyte-Macrophage Colony-Stimulating Factor. Vaccines 8:3, pages 522.
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Rina Aharoni, Raya Eilam, Nofar Schottlender, Lihi Radomir, Sandra Leistner-Segal, Tali Feferman, Dana Hirsch, Michael Sela & Ruth Arnon. (2020) Glatiramer acetate increases T- and B -regulatory cells and decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) in an animal model of multiple sclerosis. Journal of Neuroimmunology 345, pages 577281.
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Pattara Rattanawong, Win Shen, Hicham El Masry, Dan Sorajja, Komandoor Srivathsan, Arturo Valverde & Luis R. Scott. (2020) Guidance on Short‐Term Management of Atrial Fibrillation in Coronavirus Disease 2019. Journal of the American Heart Association 9:14.
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John A. Hamilton. (2020) GM-CSF in inflammation. Journal of Experimental Medicine 217:1.
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Peter C. Taylor, Didier Saurigny, Jiri Vencovsky, Tsutomu Takeuchi, Tadashi Nakamura, Galina Matsievskaia, Barbara Hunt, Thomas Wagner & Bernard Souberbielle. (2019) Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial. Arthritis Research & Therapy 21:1.
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Ke Wang, Meng Lv, Ying-Jun Chang, Xiang-Yu Zhao, Xiao-Su Zhao, Yuan-Yuan Zhang, Yu-Qian Sun, Zhi-Dong Wang, Pan Suo, Yang Zhou, Dan Liu, Shu-Zhen Zhai, Yan Hong, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu & Xiao-Jun Huang. (2019) Early myeloid-derived suppressor cells (HLA-DR−/lowCD33+CD16−) expanded by granulocyte colony-stimulating factor prevent acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post allo-HSCT. Journal of Hematology & Oncology 12:1.
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Shing T. Law & Peter C. Taylor. (2019) Role of biological agents in treatment of rheumatoid arthritis. Pharmacological Research 150, pages 104497.
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Clement Angkawidjaja & Takashi Torashima. (2019) Crystal structure of the Fab region of a neutralizing antibody against granulocyte-macrophage colony-stimulating factor. Acta Crystallographica Section F Structural Biology Communications 75:10, pages 634-639.
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John A. Hamilton. (2019) GM-CSF-Dependent Inflammatory Pathways. Frontiers in Immunology 10.
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Haotian Wang, Rujiang Jia, Tiansuo Zhao, Xin Li, Mingxiao Lang, Chungen Lan, Hongwei Wang, Zengxun Li, Bodong Zhou, Liangliang Wu, Yan Sun, Xiuchao Wang, He Ren & Jihui Hao. (2019) HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma. Cancer Letters 453, pages 10-20.
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Roghayeh Shirvani, Sajjad Yazdanpanah, Mohammad Barshan-tashnizi & Maryam Shahali. (2019) A Novel Methanol-Free Platform for Extracellular Expression of rhGM-CSF in Pichia pastoris. Molecular Biotechnology 61:7, pages 521-527.
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Ming-Chin Lee, Derek C. Lacey, Andrew J. Fleetwood, Adrian Achuthan, John A. Hamilton & Andrew D. Cook. (2019) GM-CSF– and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation. The Journal of Immunology 202:10, pages 3033-3040.
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Mohit Sachdeva, Philippe Duchateau, Stéphane Depil, Laurent Poirot & Julien Valton. (2019) Granulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators. Journal of Biological Chemistry 294:14, pages 5430-5437.
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Pavel N. Lobachevsky, Jessica Ventura, Lina Giannakandropoulou, Helen Forrester, Jason S. Palazzolo, Nicole M. Haynes, Andrew W. Stevenson, Christopher J. Hall, Joel Mason, Gerasimos Pollakis, Ioannis S. Pateras, Vassilis Gorgoulis, Georgia I. Terzoudi, John A. Hamilton, Carl N. Sprung, Alexandros G. Georgakilas & Olga A. Martin. (2019) A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation. International Journal of Radiation Oncology*Biology*Physics 103:5, pages 1184-1193.
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Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J. Fleetwood, Irmgard Förster, John A. Hamilton & Andrew D. Cook. (2018) CCL17 blockade as a therapy for osteoarthritis pain and disease. Arthritis Research & Therapy 20:1.
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Reem Saleh, Ming-Chin Lee, Stella H. Khiew, Cynthia Louis, Andrew J. Fleetwood, Adrian Achuthan, Irmgard Förster, Andrew D. Cook & John A. Hamilton. (2018) CSF-1 in Inflammatory and Arthritic Pain Development. The Journal of Immunology 201:7, pages 2042-2053.
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Amy T. Hsu, Tanya J. Lupancu, Ming-Chin Lee, Andrew J. Fleetwood, Andrew D. Cook, John A. Hamilton & Adrian Achuthan. (2018) Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages. Journal of Biological Chemistry 293:29, pages 11415-11423.
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