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A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease

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Lindsey E. Dayer, Ross Wagner, Danviona King, Mrinmayee Lakkad, Leigh Ann Wilson, Collin Montgomery & Jacob T Painter. (2022) Impact of Hydroxyurea Starting Dose on Pain Outcomes in Patients with Sickle Cell Disease. Journal of Pain & Palliative Care Pharmacotherapy 36:4, pages 223-227.
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P Waller & AD Blann. (2019) Non-coding RNAs – A primer for the laboratory scientist. British Journal of Biomedical Science 76:4, pages 157-165.
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Alexandra Kolliopoulou, Stavroula Siamoglou, Anne John, Argyro Sgourou, Alexandra Kourakli, Argiris Symeonidis, Efthymia Vlachaki, Panagiota Chalkia, Stamatia Theodoridou, Bassam R. Ali, Theodora Katsila, George P. Patrinos & Adamantia Papachatzopoulou. (2019) Role of Genomic Biomarkers in Increasing Fetal Hemoglobin Levels Upon Hydroxyurea Therapy and in β-Thalassemia Intermedia: A Validation Cohort Study. Hemoglobin 43:1, pages 27-33.
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Bhaskar V. K. S. Lakkakula & Smaranika Pattnaik. (2021) The HBG2 rs7482144 (C > T) Polymorphism is Linked to HbF Levels but not to the Severity of Sickle Cell Anemia. Journal of Pediatric Genetics 12:02, pages 129-134.
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Neha Kargutkar, Madhavi Sawant-Mulay, Priya Hariharan, S. Chandrakala & Anita Nadkarni. (2023) Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patients. Scientific Reports 13:1.
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Aline Renata Pavan, Juliana Romano Lopes, Carlos Henrique Lima Imperador, Chung Man Chin & Jean Leandro dos Santos. (2022) Perspectives and challenges to discovering hemoglobin-inducing agents in Sickle Cell Disease. Frontiers in Medicine 9.
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Sari Peretz, Leonid Livshits, Etheresia Pretorius, Asya Makhro, Anna Bogdanova, Max Gassmann, Ariel Koren & Carina Levin. (2022) The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism. Frontiers in Physiology 13.
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Olayemi Adeniyi, Rafael Baptista, Sumana Bhowmick, Alan Cookson, Robert J. Nash, Ana Winters, Jianying Shen & Luis A. J. Mur. (2022) Isolation and Characterisation of Quercitrin as a Potent Anti-Sickle Cell Anaemia Agent from Alchornea cordifolia. Journal of Clinical Medicine 11:8, pages 2177.
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Rahyssa Rodrigues Sales, Bárbara Lisboa Nogueira, Jéssica Abdo Gonçalves Tosatti, Karina Braga Gomes & Marcelo Rizzatti Luizon. (2022) Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? A Systematic Review and Pathway Analysis. Frontiers in Pharmacology 12.
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Nirmani Yasara, Anuja Premawardhena & Sachith Mettananda. (2021) A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic. Orphanet Journal of Rare Diseases 16:1.
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Filomena Longo, Andrea Piolatto, Giovanni Battista Ferrero & Antonio Piga. (2021) Ineffective Erythropoiesis in β-Thalassaemia: Key Steps and Therapeutic Options by Drugs. International Journal of Molecular Sciences 22:13, pages 7229.
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James B. Papizan, Shaina N. Porter, Akshay Sharma & Shondra M. Pruett-Miller. (2021) Therapeutic gene editing strategies using CRISPR-Cas9 for the β-hemoglobinopathies. The Journal of Biomedical Research 35:2, pages 115.
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Steven Holshouser, Rebecca Cafiero, Mayra Robinson, Joy Kirkpatrick, Robert A. CaseroJr.Jr., Hyacinth I. Hyacinth & Patrick M. Woster. (2020) Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease. ACS Omega 5:24, pages 14750-14758.
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Lei Yu, Greggory Myers & James D. Engel. (2020) Small molecule therapeutics to treat the β-globinopathies. Current Opinion in Hematology 27:3, pages 129-140.
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Rebekah Shaw, Sarah Kappa & Robert S. Nickel. (2020) Inpatient Ordering of Home Hydroxyurea by Residents for Hospitalized Patients With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology 42:1, pages e38-e41.
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Li Liu, Xingguo Zhu, Alexander Yu, Christina M Ward & Betty S Pace. (2019) δ-Aminolevulinate induces fetal hemoglobin expression by enhancing cellular heme biosynthesis. Experimental Biology and Medicine 244:14, pages 1220-1232.
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Carmen Cantisani, Norbert Kiss, Ahmad Faiq Naqeshbandi, Giulio Tosti, Sonia Tofani, Claudio Cartoni, Ida Carmosino & Franca Cantoresi. (2019) Nonmelanoma skin cancer associated with Hydroxyurea treatment: Overview of the literature and our own experience. Dermatologic Therapy 32:5.
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