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Cardiopulmonary exercise testing in patients with pulmonary hypertension: clinical recommendations based on a review of the evidence

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Pages 279-295 | Received 24 Aug 2015, Accepted 18 Jan 2016, Published online: 06 Feb 2016

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Ross Arena, Justin M. Canada, Dejana Popovic, Cory R. Trankle, Marco Giuseppe Del Buono, Alexander Lucas & Antonio Abbate. (2020) Cardiopulmonary exercise testing – refining the clinical perspective by combining assessments. Expert Review of Cardiovascular Therapy 18:9, pages 563-576.
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Abraham Samuel Babu, Norman R. Morris, Ross Arena & Jonathan Myers. (2018) Exercise-based evaluations and interventions for pulmonary hypertension with connective tissue disorders. Expert Review of Respiratory Medicine 12:7, pages 615-622.
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Tian-Xiang Chen, Bigyan Pudasaini, Jian Guo, Su-Gang Gong, Rong Jiang, Lan Wang, Qin-Hua Zhao, Wen-Hui Wu, Ping Yuan & Jin-Ming Liu. (2018) Sex-specific cardiopulmonary exercise testing indices to estimate the severity of inoperable chronic thromboembolic pulmonary hypertension. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 385-397.
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Michael G. Risbano, Corrine R. Kliment, Daniel G. Dunlap, Carl Koch, Luiz Campedelli, Karla Yoney, S. Mehdi Nouraie, Frank Sciurba & Alison Morris. (2023) Invasive Cardiopulmonary Exercise Testing Identifies Distinct Physiologic Endotypes in Postacute Sequelae of SARS-CoV-2 Infection. CHEST Pulmonary 1:3, pages 100010.
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Beatrice Pezzuto & Piergiuseppe Agostoni. (2023) The Current Role of Cardiopulmonary Exercise Test in the Diagnosis and Management of Pulmonary Hypertension. Journal of Clinical Medicine 12:17, pages 5465.
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Yi Qin, Zhao-hui Jin, Zhen-ying Zhang, Ke-ke Chen, Xin Yu, Hong-jiao Yan, Rui-dan Wang, Yuan Su, Ai-xian Liu, Jia-ning Xi & Bo-yan Fang. (2023) Predictive Value of Exercise Blood Pressure Changes for Orthostatic Hypotension in Patients With Parkinson’s Disease. Journal of Clinical Neurology 19:1, pages 67.
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М. Delcroix, А. Torbicki, D. Gopalan, O. Sitbon, F. A. Klok, I. Lang, D. Jenkins, N. H. Kim, M. Humbert, X. JaisA. V. Noordegraaf, J. Pepke-Zaba, P. Brénot, P. Dorfmuller, E. Fadel, H.-A. Ghofrani, M. M. Hoeper, P. Jansa, M. Madani, H. Matsubara, T. Ogo, A. D’Armini , N. Galie, B. Meyer, P. Corkery, G. Meszaros, E. Mayer & G. Simonneau. (2022) ERS statement on chronic thromboembolic pulmonary hypertension. PULMONOLOGIYA 32:1, pages 13-52.
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Marion Delcroix, Adam Torbicki, Deepa Gopalan, Olivier Sitbon, Frederikus A. Klok, Irene Lang, David Jenkins, Nick H. Kim, Marc Humbert, Xavier Jais, Anton Vonk Noordegraaf, Joanna Pepke-Zaba, Philippe Brénot, Peter Dorfmuller, Elie Fadel, Hossein-Ardeschir Ghofrani, Marius M. Hoeper, Pavel Jansa, Michael Madani, Hiromi Matsubara, Takeshi Ogo, Ekkehard Grünig, Andrea D'Armini, Nazzareno Galie, Bernhard Meyer, Patrick Corkery, Gergely Meszaros, Eckhard Mayer & Gérald Simonneau. (2021) ERS statement on chronic thromboembolic pulmonary hypertension. European Respiratory Journal 57:6, pages 2002828.
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Ross Arena, Jonathan Myers, Mathew Harber, Shane A. Phillips, Richard Severin, Cemal Ozemek, James E. Peterman & Leonard A. Kaminsky. (2021) The V˙E/V˙co 2 Slope During Maximal Treadmill Cardiopulmonary Exercise Testing. Journal of Cardiopulmonary Rehabilitation and Prevention 41:3, pages 194-198.
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Laura C. Price, Guillermo Martinez, Aimee Brame, Thomas Pickworth, Chinthaka Samaranayake, David Alexander, Benjamin Garfield, Tuan-Chen Aw, Colm McCabe, Bhashkar Mukherjee, Carl Harries, Aleksander Kempny, Michael Gatzoulis, Philip Marino, David G. Kiely, Robin Condliffe, Luke Howard, Rachel Davies, Gerry Coghlan, Benjamin E. Schreiber, James Lordan, Dolores Taboada, Sean Gaine, Martin Johnson, Colin Church, Samuel V. Kemp, Davina Wong, Andrew Curry, Denny Levett, Susanna Price, Stephane Ledot, Anna Reed, Konstantinos Dimopoulos & Stephen John Wort. (2021) Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery: a systematic review and expert consensus statement. British Journal of Anaesthesia 126:4, pages 774-790.
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Simon Green & Deidre Stuart. (2021) Oxygen and pulmonary arterial hypertension: effects, mechanisms, and therapeutic benefits. European Journal of Preventive Cardiology 28:1, pages 127-136.
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Sahachat Aueyingsak, Wilaiwan Khrisanapant, Upa Kukongviriyapun, Orapin Pasurivong, Pailin Ratanawatkul, Chinadol Wanitpongpan & Burabha Pussadhamma. (2020) Correlation Between N-Terminal Pro-Brain Natriuretic Peptide Levels and Cardiopulmonary Exercise Testing in Patients With Pre-Capillary Pulmonary Hypertension: A Pilot Study. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 14, pages 117954842095404.
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Bigyan Pudasaini, Guo-ling Yang, Chen Yang, Jian Guo, Ping Yuan, Yang Wen-lan, Rui Zhang, Lan Wang, Qin-Hua Zhao, Su-Gang Gong, Rong Jiang, Tian-Xiang Chen, Xiong Wei & Jin-Ming Liu. (2018) Characteristics of exercise capacity in female systemic lupus erythematosus associated pulmonary arterial hypertension patients. BMC Cardiovascular Disorders 18:1.
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Simon Green & Christopher Askew. (2018) V̇o 2peak is an acceptable estimate of cardiorespiratory fitness but not V̇ o 2max . Journal of Applied Physiology 125:1, pages 229-232.
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Yi Tang, Lei Yao, Zhihong Liu, Wenlin Xie, Xiuping Ma, Qin Luo, Zhihui Zhao, Zhiwei Huang, Liu Gao, Qi Jin, Xue Yu, Changming Xiong, Xinhai Ni, Yinkun Yan & Wenwei Qi. (2018) Peak circulatory power is a strong prognostic factor in patients with idiopathic pulmonary arterial hypertension. Respiratory Medicine.
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I. N. Taran, Z. S. Valieva, T. V. Martynyuk & I. Ye. Chazova. (2017) CARDIOPULMONARY EXCERSISE TESTING IN RISK STRATIFICATION IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION. Eurasian heart journal:4, pages 86-99.
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Jason Weatherald, Stefania Farina, Noemi Bruno & Pierantonio Laveneziana. (2017) Cardiopulmonary Exercise Testing in Pulmonary Hypertension. Annals of the American Thoracic Society 14:Supplement_1, pages S84-S92.
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Yi Tang, Qin Luo, Zhihong Liu, Xiuping Ma, Zhihui Zhao, Zhiwei Huang, Liu Gao, Qi Jin, Changming Xiong & Xinhai Ni. (2017) Oxygen Uptake Efficiency Slope Predicts Poor Outcome in Patients With Idiopathic Pulmonary Arterial Hypertension. Journal of the American Heart Association 6:7.
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Ping Yuan, Tian-Xiang Chen, Bigyan Pudasaini, Jie Zhang, Jian Guo, Si-Jin Zhang, Lan Wang, Qin-Hua Zhao, Su-Gang Gong, Rong Jiang, Wen-Hui Wu, Jing He, Jin-Ming Liu & Qing-Hua Hu. (2017) Sex-specific cardiopulmonary exercise testing indices related to hemodynamics in idiopathic pulmonary arterial hypertension. Therapeutic Advances in Respiratory Disease 11:3, pages 135-145.
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Qin-Hua Zhao, Lan Wang, Bigyan Pudasaini, Rong Jiang, Ping Yuan, Su-Gang Gong, Jian Guo, Qiang Xiao, Hui Liu, Cheng Wu, Zhi-Cheng Jing & Jin-Ming Liu. (2017) Cardiopulmonary exercise testing improves diagnostic specificity in patients with echocardiography-suspected pulmonary hypertension. Clinical Cardiology 40:2, pages 95-101.
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Abraham Samuel Babu, Ross Arena & Norman R. Morris. 2017. Exercise for Cardiovascular Disease Prevention and Treatment. Exercise for Cardiovascular Disease Prevention and Treatment 153 172 .

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