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Drug Profile

Leflunomide in renal transplantation

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Pages 273-281 | Published online: 10 Jan 2014

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Li Cheng, Hao Wang, Zicheng Wang, Houbao Huang, Dong Zhuo & Jian Lin. (2020) Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells. Drug Design, Development and Therapy 14, pages 1897-1908.
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Qing Zhang, Yongqiang Ji, Wei Lv, Tianwei He & Jianping Wang. (2016) Protective effects of leflunomide on renal lesions in a rat model if diabetic nephropathy. Renal Failure 38:1, pages 124-130.
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Articles from other publishers (19)

Bartłomiej Sankowski, Sylwia Michorowska, Emilia Raćkowska, Mariusz Sikora & Joanna Giebułtowicz. (2022) Saliva as Blood Alternative in Therapeutic Monitoring of Teriflunomide—Development and Validation of the Novel Analytical Method. International Journal of Molecular Sciences 23:17, pages 9544.
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Hamza Boucetta, Wei Wu, Tao Hong, Rui Cheng, Jing Jiang, Chengxi Liu, Min Song & Taijun Hang. (2022) Pharmacovigilance of Herb-Drug Interactions: A Pharmacokinetic Study on the Combined Administration of Tripterygium Glycosides Tablets and Leflunomide Tablets in Rats by LC-MS/MS. Pharmaceuticals 15:8, pages 991.
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Li Jin, Yicong Li, Feiyang Pu, Huihui Wang, Derong Zhang, Jialin Bai, Youjun Shang, Zhongren Ma & Xiao-xia Ma. (2021) Inhibiting pyrimidine biosynthesis impairs Peste des Petits Ruminants Virus replication through depletion of nucleoside pools and activation of cellular immunity. Veterinary Microbiology 260, pages 109186.
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Sunrui Chen, Shihao Ding, Yuebang Yin, Lei Xu, Pengfei Li, Maikel P. Peppelenbosch, Qiuwei Pan & Wenshi Wang. (2019) Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication. Antiviral Research 167, pages 35-44.
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Irene Cecchi, Ivan Arias de la Rosa, Elisa Menegatti, Dario Roccatello, Eduardo Collantes-Estevez, Chary Lopez-Pedrera & Nuria Barbarroja. (2018) Neutrophils: Novel key players in Rheumatoid Arthritis. Current and future therapeutic targets. Autoimmunity Reviews 17:11, pages 1138-1149.
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Andrew D. Santeusanio, Benjamin E. Lukens & Judy Eun. (2017) Antiviral treatment of BK virus viremia after kidney transplantation. American Journal of Health-System Pharmacy 74:24, pages 2037-2045.
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Xiulong Xu, Jing Sun, Ruilong Song, Michelle E. Doscas, Ashley J. Williamson, Jingsong Zhou, Jun Sun, Xinan Jiao, Xiufan Liu & Yi Li. (2017) Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation. Oncotarget 8:18, pages 30438-30454.
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Yicheng Chen, Qiaoli Huang, Hua Zhou, Yueping Wang, Xian Hu & Tao Li. (2016) Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells. Oncotarget 7:31, pages 50401-50416.
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Yijin Wang, Wenshi Wang, Lei Xu, Xinying Zhou, Ehsan Shokrollahi, Krzysztof Felczak, Luc J. W. van der Laan, Krzysztof W. Pankiewicz, Dave Sprengers, Nicolaas J. H. Raat, Herold J. Metselaar, Maikel P. Peppelenbosch & Qiuwei Pan. (2016) Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication. Antimicrobial Agents and Chemotherapy 60:5, pages 2834-2848.
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Alexander C. Wiseman. (2016) Immunosuppressive Medications. Clinical Journal of the American Society of Nephrology 11:2, pages 332-343.
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Gerald J. Berry & Randall E. Morris. 2016. Pathology of Transplantation. Pathology of Transplantation 53 79 .
Geoffrey S. Rule, Alan L. Rockwood & Kamisha L. Johnson-Davis. (2015) LC–MS/MS Method for Determination of Teriflunomide, Over a 40,000-Fold Dynamic Range Using Overlapping Calibrators. Therapeutic Drug Monitoring 37:4, pages 472-478.
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Eunbi Kim, Sam Young Yoon & Young Joo Shin. 2015. Studies on the Cornea and Lens. Studies on the Cornea and Lens 3 22 .
Shifeng Yang, Liyi Xie, Wujun Xue, Aiping Yin & Wanhong Lu. (2013) Leflunomide plus oral prednisone in treatment of idiopathic membranous nephropathy: A retrospective clinical study of efficacy and safety. Nephrology 18:9, pages 615-622.
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Young H. Jung, Kyung C. Moon, Jong W. Ha, Sang‐Joon Kim, Il‐Soo Ha, Hae I. Cheong & Hee G. Kang. (2012) Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation . Pediatric Transplantation 17:2.
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Adrian Reuben. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 569 591 .
Lieuko Nguyen, Robert B. McClellan, Abanti Chaudhuri, Steven R. Alexander, Sharon F. Chen, Waldo Concepcion & Paul Grimm. (2012) Conversion From Tacrolimus/Mycophenolic Acid to Tacrolimus/Leflunomide to Treat Cutaneous Warts in a Series of Four Pediatric Renal Allograft Recipients. Transplantation 94:5, pages 450-455.
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Yan Sun, Xi Chen, Jiabin Zhao, Xiaoming Zou, Gang Li, Xiaolin Li, Bin Shen & Shibo Sun. (2012) Combined use of rapamycin and leflunomide in prevention of acute cardiac allografts rejection in rats. Transplant Immunology 27:1, pages 19-24.
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Donald F Smee, Brett L Hurst & Craig W Day. (2012) D282, a Non-Nucleoside Inhibitor of Influenza Virus Infection that Interferes with de novo Pyrimidine Biosynthesis . Antiviral Chemistry and Chemotherapy 22:6, pages 263-272.
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