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Review

Hydrogen sulfide in the pathogenesis of atherosclerosis and its therapeutic potential

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Pages 97-108 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Doina Popov. (2013) An outlook on vascular hydrogen sulphide effects, signalling, and therapeutic potential. Archives of Physiology and Biochemistry 119:5, pages 189-194.
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Yuan Zhang, Zhi-Han Tang, Zhong Ren, Shun-Lin Qu, Mi-Hua Liu, Lu-Shan Liu & Zhi-Sheng Jiang. (2013) Hydrogen Sulfide, the Next Potent Preventive and Therapeutic Agent in Aging and Age-Associated Diseases. Molecular and Cellular Biology 33:6, pages 1104-1113.
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Articles from other publishers (44)

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Zhengzheng Li, Gang Feng, Peng Zhai, Yihang Jiang, Miaozhuang Fan, Cong Zhao, Zhourui Xu, Xiaomei Wang, Ming Ying, Ken-Tye Yong, Biqin Dong & Gaixia Xu. (2022) A biocompatible ratiometric fluorescent nanoprobe for intracellular hydrogen sulfide accurate detection based on rare earth nanoparticle. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 280, pages 121532.
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Zorislava Bajic, Tanja Sobot, Ranko Skrbic, Milos P. Stojiljkovic, Nenad Ponorac, Amela Matavulj & Dragan M. Djuric. (2022) Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure—How Strong Is That Link?. Biomolecules 12:4, pages 536.
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Rohan Gupta, Mehar Sahu, Rahul Tripathi, Rashmi K. Ambasta & Pravir Kumar. (2022) Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations. Ageing Research Reviews 76, pages 101579.
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Jun Ma, Changgui Shi, Zhongyang Liu, Bin Han, Lei Guo, Lei Zhu & Tianwen Ye. (2019) Hydrogen sulfide is a novel regulator implicated in glucocorticoids-inhibited bone formation. Aging 11:18, pages 7537-7552.
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Deshka L. Neill, Yu-Chung Chang, Wei Chen, Lei Li & Ming Xian. (2019) A smartphone based device for the detection of sulfane sulfurs in biological systems. Sensors and Actuators B: Chemical 292, pages 263-269.
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Ju-Peng Chen, Yi-Meng Duan, Wen-Jun Zheng, Qi Zhang, Qianshou Zong, Shaojin Chen, Kun-Peng Wang & Zhi-Qiang Hu. (2019) Perylenequinone-based “turn on” fluorescent probe for hydrogen sulfide with high sensitivity in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 218, pages 206-212.
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Tao Ma, Fangjun Huo & Caixia Yin. (2019) A ‘naked-eye’ ratiometric and NIR fluorescent detection for hydrogen sulphide with quick response and high selectivity for and its bioimaging. Dyes and Pigments 165, pages 31-37.
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Tao Ma, Fangjun Huo, Ying Wen, Timothy E. Glass & Caixia Yin. (2019) A novel water-soluble fluorescence probe based on ICT lighten for detecting hydrogen sulfide and its application in bioimaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 214, pages 355-359.
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Ayndrila Ghosh, Sujoy Das, Himadri S. Sarkar, Shampa Kundu & Prithidipa Sahoo. (2018) Consumption of H 2 S from Our Daily Diet: Determination by a Simple Chemosensing Method . ACS Omega 3:9, pages 11617-11623.
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Aline de Freitas Brito, Caio Victor Coutinho de Oliveira, Glêbia Alexa Cardoso, Joana Marcela Sales de Lucena, Jordanna di Paula dos Santos Sousa & Alesandra Araújo de Souza. 2018. Free Radicals, Antioxidants and Diseases. Free Radicals, Antioxidants and Diseases.
Eva Latorre, Roberta Torregrossa, Mark E. Wood, Matthew Whiteman & Lorna W. Harries. (2018) Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2. Aging 10:7, pages 1666-1681.
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Qi Zhao, Jin Kang, Ying Wen, Fangjun Huo, Yongbin Zhang & Caixia Yin. (2018) “Turn-on” fluorescent probe for detection of H 2 S and its applications in bioimaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 189, pages 8-12.
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Sheng-Chao Ma, Yin-Ju Hao, Yun Jiao, Yan-Hua Wang, Ling-Bo Xu, Cai-Yan Mao, Xiao-Ling Yang, An-Ning Yang, Jue Tian, Ming-Hao Zhang, Shao-Ju Jin, Hua Xu, Yi-Deng Jiang & Hui-Ping Zhang. (2017) Homocysteine-induced oxidative stress through TLR4/NF-κB/DNMT1-mediated LOX-1 DNA methylation in endothelial cells. Molecular Medicine Reports 16:6, pages 9181-9188.
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Nancy L. KanagyCsaba SzaboAndreas Papapetropoulos. (2017) Vascular biology of hydrogen sulfide. American Journal of Physiology-Cell Physiology 312:5, pages C537-C549.
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Peter Rose, Philip K. Moore & Yi Zhun Zhu. (2016) H2S biosynthesis and catabolism: new insights from molecular studies. Cellular and Molecular Life Sciences 74:8, pages 1391-1412.
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Hongzhu LiSarathi ManiLingyun Wu, Ming FuTian Shuang, Changqing XuRui Wang. (2017) The interaction of estrogen and CSE/H 2 S pathway in the development of atherosclerosis . American Journal of Physiology-Heart and Circulatory Physiology 312:3, pages H406-H414.
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Yiren Wang, Huan Wang, Xing Zhao, Yuting Jin, Houqing Xiong, Jingli Yuan & Jing Wu. (2017) A β-diketonate–europium( iii ) complex-based fluorescent probe for highly sensitive time-gated luminescence detection of copper and sulfide ions in living cells . New Journal of Chemistry 41:13, pages 5981-5987.
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Heng-Jing Hu, Zhi-Sheng Jiang, Sheng-Hua Zhou & Qi-Ming Liu. (2016) Hydrogen sulfide suppresses angiotensin II-stimulated endothelin-1 generation and subsequent cytotoxicity-induced endoplasmic reticulum stress in endothelial cells via NF-κB. Molecular Medicine Reports 14:5, pages 4729-4740.
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Kai Qu, Ya-mi Liu, Xing-lan He, Hai Zhang, Kai Zhang, Juan Peng, Ya-ling Tang, Xiao-hua Yu, Jun-fa Zeng, Jian-jun Lei, Dang-heng Wei & Zuo Wang. (2016) H 2 S inhibits apo(a) expression and secretion through PKCα/FXR and Akt/HNF4α pathways in HepG2 cells . Cell Biology International 40:8, pages 906-916.
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Yan Yao, Xin Zhang, Hai-peng Chen, Liang Li, Wei Xie, Gang Lan, Zhen-wang Zhao, Xi-Long Zheng, Zong-bao Wang & Chao-ke Tang. (2016) MicroRNA-186 promotes macrophage lipid accumulation and secretion of pro-inflammatory cytokines by targeting cystathionine γ-lyase in THP-1 macrophages. Atherosclerosis 250, pages 122-132.
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William R. Dunn, Stephen P.H. Alexander, Vera Ralevic & Richard E. Roberts. (2016) Effects of hydrogen sulphide in smooth muscle. Pharmacology & Therapeutics 158, pages 101-113.
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Xiaodong Tian, Zhiyan Li, Choiwan Lau & Jianzhong Lu. (2015) Visualization of in Vivo Hydrogen Sulfide Production by a Bioluminescence Probe in Cancer Cells and Nude Mice. Analytical Chemistry 87:22, pages 11325-11331.
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Kazi N. Islam, David J. Polhemus, Erminia Donnarumma, Luke P. Brewster & David J. Lefer. (2015) Hydrogen Sulfide Levels and Nuclear Factor‐Erythroid 2‐Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI). Journal of the American Heart Association 4:5.
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Roberta d'Emmanuele di Villa Bianca, Emma Mitidieri, Erminia Donnarumma, Teresa Tramontano, Vincenzo Brancaleone, Giuseppe Cirino, Mariarosaria Bucci & Raffaella Sorrentino. (2015) Hydrogen sulfide is involved in dexamethasone-induced hypertension in rat. Nitric Oxide 46, pages 80-86.
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Ioanna Andreadou, Efstathios K Iliodromitis, Tienush Rassaf, Rainer Schulz, Andreas Papapetropoulos & Péter Ferdinandy. (2014) The role of gasotransmitters NO , H 2 S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning . British Journal of Pharmacology 172:6, pages 1587-1606.
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Hongzhu Li, Yuehong Wang, Can Wei, Shuzhi Bai, Yajun Zhao, Hongxia Li, Bo Wu, Rui Wang, Lingyun Wu & Changqing Xu. (2015) Mediation of exogenous hydrogen sulfide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K/Akt/GSK-3β pathway in isolated aging rat hearts. Cell & Bioscience 5:1, pages 11.
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Zhichao Dai, Lu Tian, Bo Song, Zhiqiang Ye, Xiangli Liu & Jingli Yuan. (2014) Ratiometric Time-Gated Luminescence Probe for Hydrogen Sulfide Based on Lanthanide Complexes. Analytical Chemistry 86:23, pages 11883-11889.
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Meng Teng Peh, Azzahra Binti Anwar, David S.W. Ng, Mohamed Shirhan Bin Mohamed Atan, Srinivasan Dinesh Kumar & Philip K. Moore. (2014) Effect of feeding a high fat diet on hydrogen sulfide (H2S) metabolism in the mouse. Nitric Oxide 41, pages 138-145.
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Scott L. Melideo, Michael R. Jackson & Marilyn Schuman Jorns. (2014) Biosynthesis of a Central Intermediate in Hydrogen Sulfide Metabolism by a Novel Human Sulfurtransferase and Its Yeast Ortholog. Biochemistry 53:28, pages 4739-4753.
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Suowen Xu, Zhiping Liu & Peiqing Liu. (2014) Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis. International Journal of Cardiology 172:2, pages 313-317.
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Dongjian Zhu, Lin Xue, Guoping Li, Yanke Che & Hua Jiang. (2014) A turn-on fluorescent probe for detection of hydrogen sulfide in aqueous solution and living cells. Organic Chemistry Frontiers 1:5, pages 501.
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Zhiqiang Ye, Xin An, Bo Song, Wenzhu Zhang, Zhichao Dai & Jingli Yuan. (2014) A novel dinuclear ruthenium( ii )–copper( ii ) complex-based luminescent probe for hydrogen sulfide . Dalton Transactions 43:34, pages 13055.
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Xian-Hui Wang, Fen Wang, Shou-Jiang You, Yong-Jun Cao, Li-Dan Cao, Qiao Han, Chun-Feng Liu & Li-Fang Hu. (2013) Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage. Cellular Signalling 25:11, pages 2255-2262.
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Oscar Leonard, Jonas Spaak & David Goldsmith. (2013) Regression of vascular calcification in chronic kidney disease – feasible or fantasy? A review of the clinical evidence. British Journal of Clinical Pharmacology 76:4, pages 560-572.
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Paul N. Hopkins. (2013) Molecular Biology of Atherosclerosis. Physiological Reviews 93:3, pages 1317-1542.
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Sarathi ManiHongzhu LiAshley UntereinerLingyun WuGuangdong YangRichard C. AustinJeffrey G. DickhoutŠárka LhotákQing H. MengRui Wang. (2013) Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis. Circulation 127:25, pages 2523-2534.
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Eloise Streeter, Hooi H Ng & Joanne L Hart. (2013) Hydrogen sulfide as a vasculoprotective factor. Medical Gas Research 3:1, pages 9.
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Asha Ford, Mohammad Al-Magableh, Tracey A. Gaspari & Joanne L. Hart. (2013) Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE −/− Mice . International Journal of Vascular Medicine 2013, pages 1-8.
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Ling Li, Mohamed Shirhan Bin Mohamed & Philip K. Moore. 2013. Hydrogen Sulfide and its Therapeutic Applications. Hydrogen Sulfide and its Therapeutic Applications 63 82 .
Benjamin Lee PredmoreDavid Joseph LeferGabriel Gojon. (2012) Hydrogen Sulfide in Biochemistry and Medicine. Antioxidants & Redox Signaling 17:1, pages 119-140.
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Ciro ColettaAndreas Papapetropoulos, Katalin ErdelyiGabor OlahKatalin MódisPanagiotis Panopoulos, Antonia Asimakopoulou, Domokos GeröIraida Sharina, Emil Martin & Csaba Szabo. (2012) Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proceedings of the National Academy of Sciences 109:23, pages 9161-9166.
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Chunrong Liu, Bo Peng, Sheng Li, Chung-Min Park, A. Richard Whorton & Ming Xian. (2012) Reaction Based Fluorescent Probes for Hydrogen Sulfide. Organic Letters 14:8, pages 2184-2187.
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Weimin Xuan, Rong Pan, Yanting Cao, Kejian Liu & Wei Wang. (2012) A fluorescent probe capable of detecting H2S at submicromolar concentrations in cells. Chemical Communications 48:86, pages 10669.
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