Citations (326)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (16)
Zainab Jan, Wesam S. Ahmed, Kabir H. Biswas & Puthen Veettil Jithesh. (2023) Identification of a potential DNA methyltransferase (DNMT) inhibitor. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-15.
Read now
Read now
Md Rafi Uz Zama Khan & Vishal Trivedi. (2023) Molecular modelling, docking and network analysis of phytochemicals from Haritaki churna: role of protein cross-talks for their action. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
Read now
Read now
Malliga R. Iyer, Biswajit Kundu & Casey M. Wood. (2022) Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade. Expert Opinion on Therapeutic Patents 32:6, pages 629-647.
Read now
Read now
Shanze Li, Yuming Wang, Chunyan Li, Na Yang, Hongxin Yu, Wenjie Zhou, Siyu Chen, Shenshen Yang & Yubo Li. (2021) Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology. Drug Design, Development and Therapy 15, pages 1883-1902.
Read now
Read now
George Lambrinidis & Anna Tsantili-Kakoulidou. (2021) Multi-objective optimization methods in novel drug design. Expert Opinion on Drug Discovery 16:6, pages 647-658.
Read now
Read now
Thomas Fischer & Rainer Riedl. (2021) Challenges with matrix metalloproteinase inhibition and future drug discovery avenues. Expert Opinion on Drug Discovery 16:1, pages 75-88.
Read now
Read now
Shivalika Pathania, Vinay Randhawa & Manoj Kumar. (2020) Identifying potential entry inhibitors for emerging Nipah virus by molecular docking and chemical-protein interaction network. Journal of Biomolecular Structure and Dynamics 38:17, pages 5108-5125.
Read now
Read now
Ravikanth Nanduri, Rashi Kalra, Ella Bhagyaraj, Anuja P. Chacko, Nancy Ahuja, Drishti Tiwari, Sumit Kumar, Monika Jain, Raman Parkesh & Pawan Gupta. (2019) AutophagySMDB: a curated database of small molecules that modulate protein targets regulating autophagy. Autophagy 15:7, pages 1280-1295.
Read now
Read now
George Lambrinidis & Anna Tsantili-Kakoulidou. (2018) Challenges with multi-objective QSAR in drug discovery. Expert Opinion on Drug Discovery 13:9, pages 851-859.
Read now
Read now
Balaguru Ravikumar & Tero Aittokallio. (2018) Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery. Expert Opinion on Drug Discovery 13:2, pages 179-192.
Read now
Read now
S. Janardhan, L. John, M. Prasanthi, V. Poroikov & G. Narahari Sastry. (2017) A QSAR and molecular modelling study towards new lead finding: polypharmacological approach to Mycobacterium tuberculosis. SAR and QSAR in Environmental Research 28:10, pages 815-832.
Read now
Read now
Justin J. Bailey, Ralf Schirrmacher, Kristen Farrell & Vadim Bernard-Gauthier. (2017) Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 – Part I. Expert Opinion on Therapeutic Patents 27:6, pages 733-751.
Read now
Read now
Miguel Reyes-Parada & Patricio Iturriaga-Vasquez. (2016) The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors. Expert Opinion on Drug Discovery 11:10, pages 969-981.
Read now
Read now
Bianca K. Verlinden, Abraham Louw & Lyn-Marié Birkholtz. (2016) Resisting resistance: is there a solution for malaria?. Expert Opinion on Drug Discovery 11:4, pages 395-406.
Read now
Read now
Gary W Caldwell. (2015) In silico tools used for compound selection during target-based drug discovery and development. Expert Opinion on Drug Discovery 10:8, pages 901-923.
Read now
Read now
Xing Xu, Gaihong Wang, Tingting Zhou, Lili Chen, Jing Chen & Xu Shen. (2014) Novel approaches to drug discovery for the treatment of type 2 diabetes. Expert Opinion on Drug Discovery 9:9, pages 1047-1058.
Read now
Read now
Articles from other publishers (310)
Zhichao Liu, Xi Chen, Wendy Carter, Alicia Moruf, Takashi E. Komatsu, Sonia Pahwa, Kirk Chan-Tack, Kevin Snyder, Nicholas Petrick, Kenny Cha, Madhu Lal-Nag, Qais Hatim, Shraddha Thakkar, Yu Lin, Ruili Huang, Dong Wang, Tucker A. Patterson & Weida Tong. 2024. Comprehensive Precision Medicine. Comprehensive Precision Medicine
144
154
.
Lin Cheng, Fan Xia, Ziyan Li, Chenglong Shen, Zhiqian Yang, Hanlin Hou, Suyue Sun, Yuying Feng, Xihao Yong, Xiaowen Tian, Hongxi Qin, Wei Yan & Zhenhua Shao. (2023) Structure, function and drug discovery of GPCR signaling. Molecular Biomedicine 4:1.
Crossref
Crossref
Sakshi Garg, Kunal Arora, Sumita Singh & K. Nagarajan. 2023. Artificial Intelligence in the Age of Nanotechnology. Artificial Intelligence in the Age of Nanotechnology
42
61
.
Jingjing Deng, Baogeng Hou, Xiaohan Hou, Yuxin Chen, Tao Zhang, Hua Chen, Yuanze Wang & Xiaoyang Li. (2023) Discovery of benzamide-based PI3K/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells. European Journal of Medicinal Chemistry, pages 115915.
Crossref
Crossref
Ganna Petruk, Manoj Puthia, Firdaus Samsudin, Jitka Petrlova, Franziska Olm, Margareta Mittendorfer, Snejana Hyllén, Dag Edström, Ann-Charlotte Strömdahl, Carl Diehl, Simon Ekström, Björn Walse, Sven Kjellström, Peter J. Bond, Sandra Lindstedt & Artur Schmidtchen. (2023) Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs. Nature Communications 14:1.
Crossref
Crossref
Roohi Mohi-ud-din, Apporva Chawla, Pooja Sharma, Prince Ahad Mir, Faheem Hyder Potoo, Željko Reiner, Ivan Reiner, Dilek Arslan Ateşşahin, Javad Sharifi-Rad, Reyaz Hassan Mir & Daniela Calina. (2023) Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects. European Journal of Medical Research 28:1.
Crossref
Crossref
Elizaveta Rogacheva, Lyudmila Kraeva, Alexey Lukin, Lyubov Vinogradova, Kristina Komarova, Mikhail Chudinov, Maxim Gureev & Evgeny Chupakhin. (2023) 5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens. Molecules 28:18, pages 6491.
Crossref
Crossref
Aditya Kate, Ekkita Seth, Ananya Singh, Chandrashekhar Mahadeo Chakole, Meenakshi Kanwar Chauhan, Ravi Kant Singh, Shrirang Maddalwar & Mohit Mishra. (2023) Artificial Intelligence for Computer-Aided Drug
Discovery. Drug Research 73:07, pages 369-377.
Crossref
Crossref
Rekha Y. Halayal, Zabin K. Bagewadi, Raju B. Maliger, Salim Al Jadidi & Sanjay H. Deshpande. (2023) Network pharmacology based anti-diabetic attributes of bioactive compounds from Ocimum gratissimum L. through computational approach. Saudi Journal of Biological Sciences 30:9, pages 103766.
Crossref
Crossref
Xingqiang Wang, Weiqing Zhao, Xiaoyu Zhang, Zongqing Wang, Chang Han, Jiapeng Xu, Guohui Yang, Jiangyun Peng & Zhaofu Li. (2023) An integrative analysis to predict the active compounds and explore polypharmacological mechanisms of Orthosiphon stamineus Benth.. Computers in Biology and Medicine 163, pages 107160.
Crossref
Crossref
Asiye YURTTAŞ & Kamil ÇINAR. (2023) Vitamin B Kompleksinin Fotodinamik Terapiyle Kolon Kanserine EtkisiEffect of Vitamin B Complex on Colon Cancer by Photodynamic Therapy. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 14:2, pages 142-152.
Crossref
Crossref
Boniface Pone Kamdem & Fabrice Fekam Boyom. (2023) Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-Trypanosomatidae Drug Discovery. Drugs and Drug Candidates 2:3, pages 624-652.
Crossref
Crossref
Prashant S. Auti, Sakshi Jagetiya & Atish T. Paul. (2023) Chromone Containing Hybrid Analogs: Synthesis and Applications in Medicinal Chemistry. Chemistry & Biodiversity.
Crossref
Crossref
Taylor G. Eggertsen & Jeffrey J. Saucerman. (2023) Virtual drug screen reveals context‐dependent inhibition of cardiomyocyte hypertrophy. British Journal of Pharmacology.
Crossref
Crossref
R. Özçelik, D. van Tilborg, J. Jiménez‐Luna & F. Grisoni. (2023) Structure‐Based Drug Discovery with Deep Learning**. ChemBioChem 24:13.
Crossref
Crossref
Ashish Kumar, Nishant Kumar, Jeril Kuriakose & Yogesh Kumar. (2023) A Review of Deep Learning-Based Approaches for Detection and Diagnosis of Diverse Classes of Drugs. Archives of Computational Methods in Engineering 30:6, pages 3867-3889.
Crossref
Crossref
Sebastian Braun, Sanja Jelača, Markus Laube, Sven George, Bettina Hofmann, Peter Lönnecke, Dieter Steinhilber, Jens Pietzsch, Sanja Mijatović, Danijela Maksimović-Ivanić & Evamarie Hey-Hawkins. (2023) Synthesis and In Vitro Biological Evaluation of p-Carborane-Based Di-tert-butylphenol Analogs. Molecules 28:11, pages 4547.
Crossref
Crossref
E. Amiri Souri, A. Chenoweth, S. N. Karagiannis & S. Tsoka. (2023) Drug repurposing and prediction of multiple interaction types via graph embedding. BMC Bioinformatics 24:1.
Crossref
Crossref
Pedro Ernesto de Resende, Sarah Soares, Mire Zloh, Simon Gibbons & Paul Stapleton. (2023) LY2183240 regioisomers act as competitive and selective inhibitors of class C β-lactamases. International Journal of Antimicrobial Agents 61:5, pages 106774.
Crossref
Crossref
N. S. Finiuk, I. V. Drapak, B. S. Zimenkovsky & R. S. Stoika. (2023) Study of the anticancer activity of N-(5-methyl-[1,3,4]thiadiazol-2-yl)-propionamide toward human tumor cells in vitro. Biopolymers and Cell 39:1, pages 33-41.
Crossref
Crossref
Nguyen Minh Quang, Hoa Tran Thai, Hoa Le Thi, Nguyen Duc Cuong, Nguyen Quoc Hien, DongQuy Hoang, Vu Thi Bao Ngoc, Vo Ky Minh & Pham Van Tat. (2023) Novel Thiosemicarbazone Quantum Dots in the Treatment of Alzheimer’s Disease Combining In Silico Models Using Fingerprints and Physicochemical Descriptors. ACS Omega 8:12, pages 11076-11099.
Crossref
Crossref
Dong-Woo Lim, Ga-Ram Yu, Jai-Eun Kim & Won-Hwan Park. (2023) Network pharmacology predicts combinational effect of novel herbal pair consist of Ephedrae herba and Coicis semen on adipogenesis in 3T3-L1 cells. PLOS ONE 18:3, pages e0282875.
Crossref
Crossref
Tenzin Adon, Dhivya Shanmugarajan, Hissana Ather, Shaik Mohammad Asif Ansari, Umme Hani, SubbaRao V. Madhunapantula & Yogish Kumar Honnavalli. (2023) Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme. Molecules 28:6, pages 2490.
Crossref
Crossref
Matteo Pavan & Stefano Moro. (2023) Lessons Learnt from COVID-19: Computational Strategies for Facing Present and Future Pandemics. International Journal of Molecular Sciences 24:5, pages 4401.
Crossref
Crossref
Sisir Nandi, Bhumika Chauhan, Heena Tarannum & Mayank Kumar Khede. (2023) Multi-target Polypharmacology of 4-aminoquinoline Compounds against
Malaria, Tuberculosis and Cancer. Current Topics in Medicinal Chemistry 23:5, pages 403-414.
Crossref
Crossref
Chayna Sarkar, Biswadeep Das, Vikram Singh Rawat, Julie Birdie Wahlang, Arvind Nongpiur, Iadarilang Tiewsoh, Nari M. Lyngdoh, Debasmita Das, Manjunath Bidarolli & Hannah Theresa Sony. (2023) Artificial Intelligence and Machine Learning Technology Driven Modern Drug Discovery and Development. International Journal of Molecular Sciences 24:3, pages 2026.
Crossref
Crossref
Méabh MacMahon, Woochang Hwang, Soorin Yim, Eoghan MacMahon, Alexandre Abraham, Justin Barton, Mukunthan Tharmakulasingam, Paul Bilokon, Vasanthi Priyadarshini Gaddi & Namshik Han. (2023) An in silico drug repurposing pipeline to identify drugs with the potential to inhibit SARS-CoV-2 replication. Informatics in Medicine Unlocked 43, pages 101387.
Crossref
Crossref
Vishal Singh, Tayyaba Afshan, Pankaj Tyagi, Pritish Kumar Varadwaj & Amaresh Kumar Sahoo. (2023) Recent development of multi-targeted inhibitors of human topoisomerase II enzyme as potent cancer therapeutics. International Journal of Biological Macromolecules 226, pages 473-484.
Crossref
Crossref
Tânia F.G.G. Cova, Sandra C.C. Nunes & Alberto A.C.C. Pais. 2023. New Insights Into Glioblastoma. New Insights Into Glioblastoma
271
284
.
Tammanna R. Sahrawat, Ritika Patial & Ranbir Chander Sobti. 2023. Drug Repurposing for Emerging Infectious Diseases and Cancer. Drug Repurposing for Emerging Infectious Diseases and Cancer
27
36
.
Geeta Aggarwal, Pankaj Musyuni, Bharti Mangla & Ramesh K. Goyal. 2023. Drug Repurposing for Emerging Infectious Diseases and Cancer. Drug Repurposing for Emerging Infectious Diseases and Cancer
299
328
.
O. A. Bocharova, N. S. Ionov, I. V. Kazeev, V. E. Shevchenko, E. V. Bocharov, R. V. Karpova, O. P. Sheychenko, A. A. Aksyonov, S. V. Chulkova, V. G. Kucheryanu, A. V. Revishchin, G. V. Pavlova, V. S. Kosorukov, D. A. Filimonov, A. A. Lagunin, V. B. Matveev, N. V. Pyatigorskaya, I. S. Stilidi & V. V. Poroikov. (2022) Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study. Molecular Informatics 42:1.
Crossref
Crossref
Shoubao Wang, Zihan Wang, Lianhua Fang, Yang Lv & Guanhua Du. (2022) Advances of the Target-Based and Phenotypic Screenings and Strategies in Drug Discovery. International Journal of Drug Discovery and Pharmacology, pages 2.
Crossref
Crossref
Dimitrios Bakalis, George Lambrinidis, Angeliki Kourounakis & George Manis. (2022) Contribution of Deep Learning in the Investigation of Possible Dual LOX-3 Inhibitors/DPPH Scavengers: The Case of Recently Synthesized Compounds. Bioengineering 9:12, pages 800.
Crossref
Crossref
Fabien Vincent, Arsenio Nueda, Jonathan Lee, Monica Schenone, Marco Prunotto & Mark Mercola. (2022) Phenotypic drug discovery: recent successes, lessons learned and new directions. Nature Reviews Drug Discovery 21:12, pages 899-914.
Crossref
Crossref
Yusheng Cai, Wei Song, Jiaming Li, Ying Jing, Chuqian Liang, Liyuan Zhang, Xia Zhang, Wenhui Zhang, Beibei Liu, Yongpan An, Jingyi Li, Baixue Tang, Siyu Pei, Xueying Wu, Yuxuan Liu, Cheng-Le Zhuang, Yilin Ying, Xuefeng Dou, Yu Chen, Fu-Hui Xiao, Dingfeng Li, Ruici Yang, Ya Zhao, Yang Wang, Lihui Wang, Yujing Li, Shuai Ma, Si Wang, Xiaoyuan Song, Jie Ren, Liang Zhang, Jun Wang, Weiqi Zhang, Zhengwei Xie, Jing Qu, Jianwei Wang, Yichuan Xiao, Ye Tian, Gelin Wang, Ping Hu, Jing Ye, Yu Sun, Zhiyong Mao, Qing-Peng Kong, Qiang Liu, Weiguo Zou, Xiao-Li Tian, Zhi-Xiong Xiao, Yong Liu, Jun-Ping Liu, Moshi Song, Jing-Dong J. Han & Guang-Hui Liu. (2022) The landscape of aging. Science China Life Sciences 65:12, pages 2354-2454.
Crossref
Crossref
Lauren Jones & Alan M. Jones. (2022)
Suspected adverse drug reactions of the type 2 antidiabetic drug class
dipeptidyl‐peptidase IV
inhibitors (
DPP4i
): Can polypharmacology help explain?
. Pharmacology Research & Perspectives 10:6.
Crossref
Crossref
Rima Hajjo, Dima A. Sabbah, Osama H. Abusara & Abdel Qader Al Bawab. (2022) A Review of the Recent Advances in Alzheimer’s Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics. Diagnostics 12:12, pages 2975.
Crossref
Crossref
Ida Cerqua, Simona Musella, Lukas Klaus Peltner, Danilo D’Avino, Veronica Di Sarno, Elisabetta Granato, Vincenzo Vestuto, Rita Di Matteo, Simona Pace, Tania Ciaglia, Rossella Bilancia, Gerardina Smaldone, Francesca Di Matteo, Simone Di Micco, Giuseppe Bifulco, Giacomo Pepe, Manuela Giovanna Basilicata, Manuela Rodriquez, Isabel M. Gomez-Monterrey, Pietro Campiglia, Carmine Ostacolo, Fiorentina Roviezzo, Oliver Werz, Antonietta Rossi & Alessia Bertamino. (2022)
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors:
In Vitro
and
In Vivo
Anti-Inflammatory Characterization
. Journal of Medicinal Chemistry 65:21, pages 14456-14480.
Crossref
Crossref
Hemanshi Chugh & Sonal Singh. 2022. Drug Design Using Machine Learning. Drug Design Using Machine Learning
97
116
.
Hao Zhang, Lu Ren & Rabindra Vishwadev Shivnaraine. (2022) Targeting GPCRs to treat cardiac fibrosis. Frontiers in Cardiovascular Medicine 9.
Crossref
Crossref
Bibhuti Bhusan Kakoti, Rajashri Bezbaruah & Nasima Ahmed. (2022) Therapeutic drug repositioning with special emphasis on neurodegenerative diseases: Threats and issues. Frontiers in Pharmacology 13.
Crossref
Crossref
Myunggyo Lee, Hyejin Shin, Musun Park, Aeyung Kim, Seongwon Cha & Haeseung Lee. (2022) Systems pharmacology approaches in herbal medicine research: a brief review. BMB Reports 55:9, pages 417-428.
Crossref
Crossref
Guojun Sun, Dashun Dong, Zuojun Dong, Qian Zhang, Hui Fang, Chaojun Wang, Shaoya Zhang, Shuaijun Wu, Yichen Dong & Yuehua Wan. (2022) Drug repositioning: A bibliometric analysis. Frontiers in Pharmacology 13.
Crossref
Crossref
Maria Grazia Martina, Filomena Sannio, Emmanuele Crespan, Marialaura Pavone, Alice Simoncini, Francesca Barbieri, Cecilia Perini, Emanuela Pesce, Giovanni Maga, Nicoletta Pedemonte, Jean‐Denis Docquier & Marco Radi. (2022) Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect. ChemMedChem 17:17.
Crossref
Crossref
Felix Meissner, Jennifer Geddes-McAlister, Matthias Mann & Marcus Bantscheff. (2022) The emerging role of mass spectrometry-based proteomics in drug discovery. Nature Reviews Drug Discovery 21:9, pages 637-654.
Crossref
Crossref
Jesse W. Wotring, Sean M. McCarty, Khadija Shafiq, Charles J. Zhang, Theophilus Nguyen, Sophia R. Meyer, Reid Fursmidt, Carmen Mirabelli, Martin C. Clasby, Christiane E. Wobus, Matthew J. O’Meara & Jonathan Z. Sexton. (2022) In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 Treatment. Vaccines 10:8, pages 1284.
Crossref
Crossref
Kanika Verma, Smita Jain, Swati Paliwal, Sarvesh Paliwal & Swapnil Sharma. (2022) A Clinical Perspective of Soluble Epoxide Hydrolase Inhibitors in
Metabolic and Related Cardiovascular Diseases. Current Molecular Pharmacology 15:5, pages 763-778.
Crossref
Crossref
Md. Mominur Rahman, Md. Rezaul Islam, Firoza Rahman, Md. Saidur Rahaman, Md. Shajib Khan, Sayedul Abrar, Tanmay Kumar Ray, Mohammad Borhan Uddin, Most. Sumaiya Khatun Kali, Kamal Dua, Mohammad Amjad Kamal & Dinesh Kumar Chellappan. (2022) Emerging Promise of Computational Techniques in Anti-Cancer Research: At a Glance. Bioengineering 9:8, pages 335.
Crossref
Crossref
Mariia Nesterkina, Vladimir Musatov, Olena Honcharova & Iryna Kravchenko. (2022)
(1
R
,2
S
,5
R
)-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity
. Open Chemistry 20:1, pages 703-707.
Crossref
Crossref
Vinay Randhawa, Shivalika Pathania & Manoj Kumar. (2022) Computational Identification of Potential Multitarget Inhibitors of Nipah Virus by Molecular Docking and Molecular Dynamics. Microorganisms 10:6, pages 1181.
Crossref
Crossref
Abdelsattar M. Omar, Maan T. Khayat, Farid Ahmed, Yosra A. Muhammad, Azizah M. Malebari, Sara M. Ibrahim, Mohammad I. Khan, Dhaval K. Shah, Wayne E. Childers & Moustafa E. El-Araby. (2022) SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases. Frontiers in Oncology 12.
Crossref
Crossref
Andrzej Teisseyre, Mateusz Chmielarz, Anna Uryga, Kamila Środa-Pomianek & Anna Palko-Łabuz. (2022) Co-Application of Statin and Flavonoids as an Effective Strategy to Reduce the Activity of Voltage-Gated Potassium Channels Kv1.3 and Induce Apoptosis in Human Leukemic T Cell Line Jurkat. Molecules 27:10, pages 3227.
Crossref
Crossref
Xin Zhou, Mingsong Shi, Xin Wang & Dingguo Xu. (2022) Exploring the Binding Mechanism of a Supramolecular Tweezer CLR01 to 14-3-3σ Protein via Well-Tempered Metadynamics. Frontiers in Chemistry 10.
Crossref
Crossref
Fatima Noor, Muhammad Tahir ul Qamar, Usman Ali Ashfaq, Aqel Albutti, Ameen S. S. Alwashmi & Mohammad Abdullah Aljasir. (2022) Network Pharmacology Approach for Medicinal Plants: Review and Assessment. Pharmaceuticals 15:5, pages 572.
Crossref
Crossref
S. Asha, T.C. Bessy, J.F. Joe Sherin, C. Vijil vani, C. Vijaya Kumar, M.R. Bindhu, Shanmugam Sureshkumar, Fatimah S. Al-Khattaf & Ashraf Atef Hatamleh. (2022) Efficient photocatalytic degradation of industrial contaminants by Piper longum mediated ZnO nanoparticles. Environmental Research 208, pages 112686.
Crossref
Crossref
NISHA V KALAYIL, SHONA S D’SOUZA, SHOWKHIYA Y KHAN & PALLAVI PAUL. (2022) ARTIFICIAL INTELLIGENCE IN PHARMACY DRUG DESIGN. Asian Journal of Pharmaceutical and Clinical Research, pages 21-27.
Crossref
Crossref
Yuen Ler Chow, Shantanu Singh, Anne E. Carpenter & Gregory P. Way. (2022) Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic. PLOS Computational Biology 18:2, pages e1009888.
Crossref
Crossref
Ernestine Nicaise Djuidje, Riccardo Barbari, Anna Baldisserotto, Elisa Durini, Sabrina Sciabica, Jan Balzarini, Sandra Liekens, Silvia Vertuani & Stefano Manfredini. (2022) Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure–Activity Relationship of a Scaffold Bearing a Five-Membered Ring System. Antioxidants 11:2, pages 407.
Crossref
Crossref
Siyuan Lv, Tingxuan Huang, Ying Lin, Xingwei Yao, Huiyong Yu, Guoxing Liu, Yue Zhang, Tong Liu, Huan Liang & Chengxiang Wang. (2022) In Vitro Antibacterial Experiments of Qixingjian Decoction and Its Synergistic Interaction with Oxacillin against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-12.
Crossref
Crossref
Yi-Sue Jung, Yoonbee Kim & Young-Rae Cho. (2022) Comparative analysis of network-based approaches and machine learning algorithms for predicting drug-target interactions. Methods 198, pages 19-31.
Crossref
Crossref
Abbas Kabir & Aaron Muth. (2022) Polypharmacology: The science of multi-targeting molecules. Pharmacological Research 176, pages 106055.
Crossref
Crossref
Viola Noti & Dimitra Hadjipavlou-Litina. (2022) (E)-1-(3-Benzoyl-4-phenyl-1H-pyrrol-1-yl)-3-phenylprop-2-en-1-one. Molbank 2022:1, pages M1314.
Crossref
Crossref
Luca Pinzi. (2022) On the development of B-Raf inhibitors acting through innovative mechanisms. F1000Research 11, pages 237.
Crossref
Crossref
Luca Pinzi. (2022) On the development of B-Raf inhibitors acting through innovative mechanisms. F1000Research 11, pages 237.
Crossref
Crossref
Yuanze Wang & Micky Tortorella. (2022) Molecular design of dual inhibitors of PI3K and potential molecular target of cancer for its treatment: A review. European Journal of Medicinal Chemistry 228, pages 114039.
Crossref
Crossref
Negar Omidkhah & Razieh Ghodsi. (2022) NO-HDAC dual inhibitors. European Journal of Medicinal Chemistry 227, pages 113934.
Crossref
Crossref
Tammanna R. Sahrawat & R. C. Sobti. 2022. Biomedical Translational Research. Biomedical Translational Research
17
26
.
Ritu Karwasra, Kushagra Khanna, Surender Singh, Shaban Ahmad & Saurabh Verma. 2022. Computational Intelligence in Oncology. Computational Intelligence in Oncology
369
384
.
Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology
781
814
.
Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology
43
72
.
Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology
661
676
.
Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology
1
41
.
Andreas H. Göller, Lara Kuhnke, Antonius ter Laak, Katharina Meier & Alexander Hillisch. 2022. Artificial Intelligence in Drug Design. Artificial Intelligence in Drug Design
61
101
.
Mariia Nesterkina, Serhii Smola, Nataliya Rusakova & Iryna Kravchenko. (2021) Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies. Molecules 27:1, pages 206.
Crossref
Crossref
Gerardo Mata-Torres, Adolfo Andrade-Cetto & Fernanda Espinoza-Hernández. (2021) Approaches to Decrease Hyperglycemia by Targeting Impaired Hepatic Glucose Homeostasis Using Medicinal Plants. Frontiers in Pharmacology 12.
Crossref
Crossref
Thomas M. Privalsky, Alexander M. Soohoo, Jinhua Wang, Christopher T. Walsh, Gerard D. Wright, Eric M. Gordon, Nathanael S. Gray & Chaitan Khosla. (2021) Prospects for Antibacterial Discovery and Development. Journal of the American Chemical Society 143:50, pages 21127-21142.
Crossref
Crossref
Vlad Groza, Mihai Udrescu, Alexandru Bozdog & Lucreţia Udrescu. (2021) Drug Repurposing Using Modularity Clustering in Drug-Drug Similarity Networks Based on Drug–Gene Interactions. Pharmaceutics 13:12, pages 2117.
Crossref
Crossref
Selasi Dankwa, Mary-Margaret Dols, Ling Wei, Elizabeth K.K. Glennon, Heather S. Kain, Alexis Kaushansky & Joseph D. Smith. (2021) Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity. Cell Chemical Biology 28:12, pages 1679-1692.e4.
Crossref
Crossref
Qing Ye, Chang-Yu Hsieh, Ziyi Yang, Yu Kang, Jiming Chen, Dongsheng Cao, Shibo He & Tingjun Hou. (2021) A unified drug–target interaction prediction framework based on knowledge graph and recommendation system. Nature Communications 12:1.
Crossref
Crossref
B. Vandanmagsar, Y. Yu, C. Simmler, T.N. Dang, P. Kuhn, A. Poulev, D.M. Ribnicky, G.F. Pauli & Z.E. Floyd. (2021) Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle. Biomedicine & Pharmacotherapy 143, pages 112188.
Crossref
Crossref
Sheng He, Leon G. Leanse & Yanfang Feng. (2021) Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases. Advanced Drug Delivery Reviews 178, pages 113922.
Crossref
Crossref
Fulvio Ciriaco, Nicola Gambacorta, Domenico Alberga & Orazio Nicolotti. (2021) Quantitative Polypharmacology Profiling Based on a Multifingerprint Similarity Predictive Approach. Journal of Chemical Information and Modeling 61:10, pages 4868-4876.
Crossref
Crossref
Jameela Banu. 2021. Type 2 Diabetes - From Pathophysiology to Cyber Systems. Type 2 Diabetes - From Pathophysiology to Cyber Systems.
Jintae Kim, Sera Park, Dongbo Min & Wankyu Kim. (2021) Comprehensive Survey of Recent Drug Discovery Using Deep Learning. International Journal of Molecular Sciences 22:18, pages 9983.
Crossref
Crossref
Yinyin Wang, Hongbin Yang, Linxiao Chen, Mohieddin Jafari & Jing Tang. (2021) Network-based modeling of herb combinations in traditional Chinese medicine. Briefings in Bioinformatics 22:5.
Crossref
Crossref
Ahmed H. Abdelazeem, Asmaa G. Safi El-Din, Hany H. Arab, Mohammed T. El-Saadi, Samir M. El-Moghazy & Noha H. Amin. (2021) Design, synthesis and anti-inflammatory/analgesic evaluation of novel di-substituted urea derivatives bearing diaryl-1,2,4-triazole with dual COX-2/sEH inhibitory activities. Journal of Molecular Structure 1240, pages 130565.
Crossref
Crossref
Claudia Albertini, Alessandra Salerno, Pedro de Sena Murteira Pinheiro & Maria L. Bolognesi. (2020) From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology. Medicinal Research Reviews 41:5, pages 2606-2633.
Crossref
Crossref
Marcus Miethke, Marco Pieroni, Tilmann Weber, Mark Brönstrup, Peter Hammann, Ludovic Halby, Paola B. Arimondo, Philippe Glaser, Bertrand Aigle, Helge B. Bode, Rui Moreira, Yanyan Li, Andriy Luzhetskyy, Marnix H. Medema, Jean-Luc Pernodet, Marc Stadler, José Rubén Tormo, Olga Genilloud, Andrew W. Truman, Kira J. Weissman, Eriko Takano, Stefano Sabatini, Evi Stegmann, Heike Brötz-Oesterhelt, Wolfgang Wohlleben, Myriam Seemann, Martin Empting, Anna K. H. Hirsch, Brigitta Loretz, Claus-Michael Lehr, Alexander Titz, Jennifer Herrmann, Timo Jaeger, Silke Alt, Thomas Hesterkamp, Mathias Winterhalter, Andrea Schiefer, Kenneth Pfarr, Achim Hoerauf, Heather Graz, Michael Graz, Mika Lindvall, Savithri Ramurthy, Anders Karlén, Maarten van Dongen, Hrvoje Petkovic, Andreas Keller, Frédéric Peyrane, Stefano Donadio, Laurent Fraisse, Laura J. V. Piddock, Ian H. Gilbert, Heinz E. Moser & Rolf Müller. (2021) Towards the sustainable discovery and development of new antibiotics. Nature Reviews Chemistry 5:10, pages 726-749.
Crossref
Crossref
Marcus J. C. Long & Yimon Aye. (2021) Science's Response to CoVID‐19. ChemMedChem 16:15, pages 2288-2314.
Crossref
Crossref
Babatunji Emmanuel Oyinloye, Opeyemi Iwaloye & Basiru Olaitan Ajiboye. (2021) Polypharmacology of Gongronema latifolium leaf secondary metabolites against protein kinases implicated in Parkinson's disease and Alzheimer's disease. Scientific African 12, pages e00826.
Crossref
Crossref
Maria Giovanna Chini, Gianluigi Lauro & Giuseppe Bifulco. (2021) Addressing the Target Identification and Accelerating the Repositioning of Anti‐Inflammatory/Anti‐Cancer Organic Compounds by Computational Approaches. European Journal of Organic Chemistry 2021:21, pages 2966-2981.
Crossref
Crossref
Quy T. N. Tran, W. S. Daniel Tan, W. S. Fred Wong & Christina L. L. Chai. (2021) Polypharmacology of andrographolide: beyond one molecule one target. Natural Product Reports 38:4, pages 682-692.
Crossref
Crossref
Shahinda S. R. Alsayed, Shichun Lun, Anders W. Bailey, Amreena Suri, Chiang-Ching Huang, Mauro Mocerino, Alan Payne, Simone Treiger Sredni, William R. Bishai & Hendra Gunosewoyo. (2021)
Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of
Mycobacterium tuberculosis
and paediatric brain tumour cells
. RSC Advances 11:26, pages 15497-15511.
Crossref
Crossref
Sanower Hossain, Zannat Urbi, Hidayah Karuniawati, Ramisa Binti Mohiuddin, Ahmed Moh Qrimida, Akrm Mohamed Masaud Allzrag, Long Chiau Ming, Ester Pagano & Raffaele Capasso. (2021) Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy. Life 11:4, pages 348.
Crossref
Crossref
Susann Schröder, Matthias Scheunemann, Barbara Wenzel & Peter Brust. (2021) Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016. International Journal of Molecular Sciences 22:8, pages 3832.
Crossref
Crossref
Rana A. Alaaeddine, Perihan A. Elzahhar, Ibrahim AlZaim, Wassim Abou-Kheir, Ahmed S.F. Belal & Ahmed F. El-Yazbi. (2021) The Emerging Role of COX-2, 15-LOX and PPARγ in Metabolic Diseases and Cancer: An Introduction to Novel Multi-target Directed Ligands (MTDLs). Current Medicinal Chemistry 28:11, pages 2260-2300.
Crossref
Crossref
Qais Z. Jaber & Micha Fridman. (2021) Fresh Molecular Concepts to Extend the Lifetimes of Old Antimicrobial Drugs. The Chemical Record 21:4, pages 631-645.
Crossref
Crossref
Aparna Rai, Vikas Kumar, Gaurav Jerath, C. C. Kartha & Vibin Ramakrishnan. (2021) Mapping drug-target interactions and synergy in multi-molecular therapeutics for pressure-overload cardiac hypertrophy. npj Systems Biology and Applications 7:1.
Crossref
Crossref
Eliška Procházková, Oleksandr Kucherak, Eva Stodůlková, Zdeněk Tošner, Ivana Císařová, Miroslav Flieger, Miroslav Kolařík & Ondřej Baszczyňski. (2020)
NMR Structure Elucidation of Naphthoquinones from
Quambalaria cyanescens
. Journal of Natural Products 84:1, pages 46-55.
Crossref
Crossref
Debleena Paul, Gaurav Sanap, Snehal Shenoy, Dnyaneshwar Kalyane, Kiran Kalia & Rakesh K. Tekade. (2021) Artificial intelligence in drug discovery and development. Drug Discovery Today 26:1, pages 80-93.
Crossref
Crossref
Abhinit Kumar, Saurabh Loharch, Sunil Kumar, Rajesh P. Ringe & Raman Parkesh. (2021) Exploiting cheminformatic and machine learning to navigate the available chemical space of potential small molecule inhibitors of SARS-CoV-2. Computational and Structural Biotechnology Journal 19, pages 424-438.
Crossref
Crossref
Dharmendra Kumar Khatri, Amey Kadbhane, Monica Patel, Shweta Nene, Srividya Atmakuri, Saurabh Srivastava & Shashi Bala Singh. (2021) Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders. Current Research in Pharmacology and Drug Discovery 2, pages 100022.
Crossref
Crossref
Parteek Prasher, Mousmee Sharma & Kamal Dua. 2021. Advanced Drug Delivery Systems in the Management of Cancer. Advanced Drug Delivery Systems in the Management of Cancer
27
36
.
György Dormán, Beáta Flachner, István Hajdú & Csaba András. 2021. Nutraceuticals. Nutraceuticals
315
343
.
Samer N. Narouze. 2021. Cannabinoids and Pain. Cannabinoids and Pain
191
204
.
Suresh Kumar. 2021. In Silico Modeling of Drugs Against Coronaviruses. In Silico Modeling of Drugs Against Coronaviruses
213
230
.
Tapan Behl, Aditi Sharma, Lalit Sharma, Aayush Sehgal, Gokhan Zengin, Roxana Brata, Ovidiu Fratila & Simona Bungau. (2020) Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives. Biomedicines 8:12, pages 571.
Crossref
Crossref
Xiao-Yuan Mao. 2020. Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications. Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications.
Malikotsi A. Qhobosheane, Lesetja J. Legoabe, Béatrice Josselin, Stéphane Bach, Sandrine Ruchaud & Richard M. Beteck. (2020) Synthesis and evaluation of C3 substituted chalcone‐based derivatives of 7‐azaindole as protein kinase inhibitors. Chemical Biology & Drug Design 96:6, pages 1395-1407.
Crossref
Crossref
Vishal S. Patil, Sanjay H. Deshpande, Darasaguppe R. Harish, Anuradha S. Patil, Rajashri Virge, Sinjini Nandy & Subarna Roy. (2020) Gene set enrichment analysis, network pharmacology and in silico docking approach to understand the molecular mechanism of traditional medicines for the treatment of diabetes mellitus. Journal of Proteins and Proteomics 11:4, pages 297-310.
Crossref
Crossref
Jeremy Ariey‐Bonnet, Kendall Carrasco, Marion Le Grand, Laurent Hoffer, Stéphane Betzi, Mikael Feracci, Philipp Tsvetkov, Francois Devred, Yves Collette, Xavier Morelli, Pedro Ballester & Eddy Pasquier. (2020)
In silico
molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
. Molecular Oncology 14:12, pages 3083-3099.
Crossref
Crossref
Jie Lyu, Jingyi Jessica Li, Jianzhong Su, Fanglue Peng, Yiling Elaine Chen, Xinzhou Ge & Wei Li. (2020) DORGE: Discovery of Oncogenes and tumoR suppressor genes using Genetic and Epigenetic features. Science Advances 6:46.
Crossref
Crossref
Zeyad D. Nassar, Chui Yan Mah, Margaret M. Centenera, Swati Irani, Martin C. Sadowski, Julia S. Scott, Elizabeth V. Nguyen, Shilpa R. Nagarajan, Max Moldovan, David J. Lynn, Roger J. Daly, Andrew J. Hoy & Lisa M. Butler. (2020) Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition. Molecular Cancer Research 18:10, pages 1500-1511.
Crossref
Crossref
Ivie L. Conlon, Brandon Drennen, Maryanna E. Lanning, Samuel Hughes, Rebecca Rothhaas, Paul T. Wilder, Alexander D. MacKerellJr.Jr. & Steven Fletcher. (2020) Rationally Designed Polypharmacology: α‐Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl‐1 and HDM2. ChemMedChem 15:18, pages 1691-1698.
Crossref
Crossref
Krishnankutty Chandrika Sivakumar, Jin Haixiao, C. Benjamin Naman & T. P. Sajeevan. (2020)
Prospects of
multitarget
drug designing strategies by linking molecular docking and molecular dynamics to explore the
protein–ligand
recognition process
. Drug Development Research 81:6, pages 685-699.
Crossref
Crossref
Sean Lin, Kenji Schorpp, Ina Rothenaigner & Kamyar Hadian. (2020) Image-based high-content screening in drug discovery. Drug Discovery Today 25:8, pages 1348-1361.
Crossref
Crossref
Nargis Jamila, Naeem Khan, Amina Bibi, Adnan Haider, Sadiq Noor Khan, Amir Atlas, Umar Nishan, Aaliya Minhaz, Fatima Javed & Ahtaram Bibi. (2020) Piper longum catkin extract mediated synthesis of Ag, Cu, and Ni nanoparticles and their applications as biological and environmental remediation agents. Arabian Journal of Chemistry 13:8, pages 6425-6436.
Crossref
Crossref
Sven Bulterijs & Bart P. Braeckman. (2020) Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs. Pharmaceuticals 13:8, pages 164.
Crossref
Crossref
David Xu, Donghui Zhou, Khuchtumur Bum-Erdene, Barbara J. Bailey, Kamakshi Sishtla, Sheng Liu, Jun Wan, Uma K. Aryal, Jonathan A. Lee, Clark D. Wells, Melissa L. Fishel, Timothy W. Corson, Karen E. Pollok & Samy O. Meroueh. (2020) Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data. ACS Chemical Biology 15:6, pages 1424-1444.
Crossref
Crossref
Declan Alan Gray & Michaela Wenzel. (2020) Multitarget Approaches against Multiresistant Superbugs. ACS Infectious Diseases 6:6, pages 1346-1365.
Crossref
Crossref
Yue Dong, Xinyong Liu, Yunfei An, Min Liu, Jun Han & Bin Sun. (2020) Potent arylamide derivatives as dual-target antifungal agents: Design, synthesis, biological evaluation, and molecular docking studies. Bioorganic Chemistry 99, pages 103749.
Crossref
Crossref
Pavle J. Randjelović, Niko S. Radulović, Nikola M. Stojanović, Vidoslav S. Dekić, Biljana R. Dekić, Nenad I. Stojiljković & Sonja M. Ilić. (2020) Anxiolytic‐Like Action of Selected 4‐(Alkylamino)‐3‐nitrocoumarin Derivatives in BALB/c Mice. Chemistry & Biodiversity 17:6.
Crossref
Crossref
Neann Mathai, Ya Chen & Johannes Kirchmair. (2020) Validation strategies for target prediction methods. Briefings in Bioinformatics 21:3, pages 791-802.
Crossref
Crossref
Neann Mathai & Johannes Kirchmair. (2020) Similarity-Based Methods and Machine Learning Approaches for Target Prediction in Early Drug Discovery: Performance and Scope. International Journal of Molecular Sciences 21:10, pages 3585.
Crossref
Crossref
Graeme J. Sills & Michael A. Rogawski. (2020) Mechanisms of action of currently used antiseizure drugs. Neuropharmacology 168, pages 107966.
Crossref
Crossref
Simon Wing-Fai Mok, Vincent Kam-Wai Wong, Hang-Hong Lo, Ivo Ricardo de Seabra Rodrigues Dias, Elaine Lai-Han Leung, Betty Yuen-Kwan Law & Liang Liu. (2020) Natural products-based polypharmacological modulation of the peripheral immune system for the treatment of neuropsychiatric disorders. Pharmacology & Therapeutics 208, pages 107480.
Crossref
Crossref
Resat Cinar, Malliga R. Iyer & George Kunos. (2020) The therapeutic potential of second and third generation CB1R antagonists. Pharmacology & Therapeutics 208, pages 107477.
Crossref
Crossref
Angela Corona, Valentina Onnis, Claudia Del Vecchio, Francesca Esposito, Yung-Chi Cheng & Enzo Tramontano. (2020) 2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication. Molecules 25:6, pages 1338.
Crossref
Crossref
Yong Li, Yiqun Li, Dengke Li, Kaiming Li, Zhengyang Quan, Ziyi Wang & Zhenxiao Sun. (2020) Repositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment. Frontiers in Pharmacology 11.
Crossref
Crossref
El Sayed Helmy El Ashry, Laila Fathy Awad, Mohamed Teleb, Nihal Ahmed Ibrahim, Marwa M. Abu-Serie & Mohamed Nabil Abd Al Moaty. (2020) Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology. Bioorganic Chemistry 96, pages 103616.
Crossref
Crossref
Yaxia Yuan, Jianfeng Pei & Luhua Lai. (2020) LigBuilder V3: A Multi-Target de novo Drug Design Approach. Frontiers in Chemistry 8.
Crossref
Crossref
Camilo Henrique da Silva Lima, Júlio César de Araujo Vanelis Soares, Joana Lucius de Sousa Ribeiro, Estela Maris Freitas Muri, Sérgio de Albuquerque & Luiza Rosaria Sousa Dias. (2020) Anti-Trypanosoma cruzi Activity and Molecular Docking Studies of 1Hpyrazolo[ 3, 4-b]pyridine Derivatives. Letters in Drug Design & Discovery 17:2, pages 184-191.
Crossref
Crossref
Žiga Skok, Nace Zidar, Danijel Kikelj & Janez Ilaš. (2019) Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets. Journal of Medicinal Chemistry 63:3, pages 884-904.
Crossref
Crossref
Yueqin Yang, Hariprasad Vankayalapati, Manshu Tang, Yingbo Zheng, Yingri Li, Cong Ma & Kent Lai. (2020) Discovery of Novel Inhibitors Targeting Multi-UDP-hexose Pyrophosphorylases as Anticancer Agents. Molecules 25:3, pages 645.
Crossref
Crossref
Natalie Timme, Youjia Han, Shuai Liu, Hailemichael O. Yosief, Heathcliff Dorado García, Yi Bei, Filippos Klironomos, Ian C. MacArthur, Annabell Szymansky, Jennifer von Stebut, Victor Bardinet, Constantin Dohna, Annette Künkele, Jana Rolff, Patrick Hundsdörfer, Andrej Lissat, Georg Seifert, Angelika Eggert, Johannes H. Schulte, Wei Zhang & Anton G. Henssen. (2020) Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors. Translational Oncology 13:2, pages 221-232.
Crossref
Crossref
Dejuan Sun, Yuqian Zhao, Shouyue Zhang, Lan Zhang, Bo Liu & Liang Ouyang. (2020) Dual-target kinase drug design: Current strategies and future directions in cancer therapy. European Journal of Medicinal Chemistry 188, pages 112025.
Crossref
Crossref
Parinyachat Somchai, Kriengkrai Phongkitkarun, Patipark Kueanjinda, Supawan Jamnongsong, Kulthida Vaeteewoottacharn, Vor Luvira, Seiji Okada, Siwanon Jirawatnotai & Somponnat Sampattavanich. (2020) Novel Analytical Platform For Robust Identification of Cell Migration Inhibitors. Scientific Reports 10:1.
Crossref
Crossref
Bogdan Ionel Tamba, Gabriela Dumitrita Stanciu, Cristina Mariana Urîtu, Elena Rezus, Raluca Stefanescu, Cosmin Teodor Mihai, Andrei Luca, Gabriela Rusu-Zota, Maria-Magdalena Leon-Constantin, Elena Cojocaru, Bogdan Gafton & Teodora Alexa-Stratulat. (2020) Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy. Medicina 56:1, pages 24.
Crossref
Crossref
Andrey V. Ilatovskiy & Ruben Abagyan. 2020. Structural Biology in Drug Discovery. Structural Biology in Drug Discovery
347
361
.
Ankur Omer & Poonam Singh. (2020) An integrated approach of network based system pharmacology approach and molecular docking to explore multiscale role of Pinus roxburghii and investigation into its mechanism. Pharmacognosy Magazine 16:5, pages 586.
Crossref
Crossref
Jakub Staroń, Rafał Kurczab, Dawid Warszycki, Grzegorz Satała, Martyna Krawczyk, Ryszard Bugno, Tomasz Lenda, Piotr Popik, Adam S. Hogendorf, Agata Hogendorf, Krzysztof Dubiel, Mikołaj Matłoka, Rafał Moszczyński-Pętkowski, Jerzy Pieczykolan, Maciej Wieczorek, Paweł Zajdel & Andrzej J. Bojarski. (2020) Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties. European Journal of Medicinal Chemistry 185, pages 111857.
Crossref
Crossref
Pan Pantziarka, Lydie Meheus, Klara Rombauts, Liese Vandeborne & Gauthier Bouche. 2020. Drug Repurposing in Cancer Therapy. Drug Repurposing in Cancer Therapy
1
14
.
Dnyaneshwar Kalyane, Gaurav Sanap, Debleena Paul, Snehal Shenoy, Neelima Anup, Suryanarayana Polaka, Vishakha Tambe & Rakesh K. Tekade. 2020. The Future of Pharmaceutical Product Development and Research. The Future of Pharmaceutical Product Development and Research
73
107
.
Pulok K. Mukherjee, Subhadip Banerjee, Amit Kar & Joydeb Chanda. 2020. Herbal Medicine in India. Herbal Medicine in India
263
280
.
Cindy McReynolds, Christophe Morisseau, Karen Wagner & Bruce Hammock. 2020. Druggable Lipid Signaling Pathways. Druggable Lipid Signaling Pathways
71
99
.
Lucas N. Alberca & Alan Talevi. 2020. Approaching Complex Diseases. Approaching Complex Diseases
63
75
.
Christofer S. Tautermann. 2020. Quantum Mechanics in Drug Discovery. Quantum Mechanics in Drug Discovery
1
17
.
Marco Tutone & Anna Maria Almerico. 2020. Targeting Enzymes for Pharmaceutical Development. Targeting Enzymes for Pharmaceutical Development
29
39
.
Yongmei Yu, Charlotte Simmler, Peter Kuhn, Alexander Poulev, Ilya Raskin, David Ribnicky, Z. Elizabeth Floyd & Guido F. Pauli. (2019)
The DESIGNER Approach Helps Decipher the Hypoglycemic Bioactive Principles of
Artemisia dracunculus
(Russian Tarragon)
. Journal of Natural Products 82:12, pages 3321-3329.
Crossref
Crossref
Misagh Naderi, Jeffrey Mitchell Lemoine, Rajiv Gandhi Govindaraj, Omar Zade Kana, Wei Pan Feinstein & Michal Brylinski. (2019) Binding site matching in rational drug design: algorithms and applications. Briefings in Bioinformatics 20:6, pages 2167-2184.
Crossref
Crossref
Ajay Srivastava, Rajiv Lall, Jamil Talukder, Dan DuBourdieu & Ramesh C. Gupta. (2019) Iron Transport Tocopheryl Polyethylene Glycol Succinate in Animal Health and Diseases. Molecules 24:23, pages 4289.
Crossref
Crossref
Yinyin Wang, Mohieddin Jafari, Yun Tang & Jing Tang. (2019) Predicting Meridian in Chinese traditional medicine using machine learning approaches. PLOS Computational Biology 15:11, pages e1007249.
Crossref
Crossref
Andreia S.P. Pereira, Antonio J. Banegas-Luna, Jorge Peña-García, Horacio Pérez-Sánchez & Zeno Apostolides. (2019) Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening. Molecules 24:22, pages 4030.
Crossref
Crossref
Saurabh Loharch & Raman Parkesh. (2019) Epigenetic drug discovery: systematic assessment of chemical space. Future Medicinal Chemistry 11:21, pages 2803-2819.
Crossref
Crossref
Ibrahim M.S. Eldeen, Jochen Ringe & Noraznawati Ismail. (2019) Inhibition of Pro-inflammatory Enzymes and Growth of an Induced Rheumatoid Arthritis Synovial Fibroblast by Bruguiera cylindrica. International Journal of Pharmacology 15:8, pages 916-925.
Crossref
Crossref
Sureyya Olgen & Lakshmi P. Kotra. (2019) Drug Repurposing in the Development of Anticancer Agents. Current Medicinal Chemistry 26:28, pages 5410-5427.
Crossref
Crossref
James Schuler & Ram Samudrala. (2019) Fingerprinting CANDO: Increased Accuracy with Structure- and Ligand-Based Shotgun Drug Repurposing. ACS Omega 4:17, pages 17393-17403.
Crossref
Crossref
Maria Reinecke, Stephanie Heinzlmeir, Mathias Wilhelm, Guillaume Médard, Susan Klaeger & Bernhard Kuster. 2019. Target Discovery and Validation. Target Discovery and Validation
97
130
.
Diego Alejandro Rodríguez-Soacha, Matthias Scheiner & Michael Decker. (2019) Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. European Journal of Medicinal Chemistry 180, pages 690-706.
Crossref
Crossref
Vineela Parvathaneni, Nishant S. Kulkarni, Aaron Muth & Vivek Gupta. (2019) Drug repurposing: a promising tool to accelerate the drug discovery process. Drug Discovery Today 24:10, pages 2076-2085.
Crossref
Crossref
Ok-Seon Kwon, Wankyu Kim, Hyuk-Jin Cha & Haeseung Lee. (2019) In silico drug repositioning: from large-scale transcriptome data to therapeutics. Archives of Pharmacal Research 42:10, pages 879-889.
Crossref
Crossref
Anshika N. Singh & Neeti Sharma. (2019) Epigenetic Modulators as Potential Multi-targeted Drugs Against Hedgehog Pathway for Treatment of Cancer. The Protein Journal 38:5, pages 537-550.
Crossref
Crossref
Amandeep Kaur, Simranjeet Singh Narang, Anupamjeet Kaur, Sukhmani Mann, Nitesh Priyadarshi, Bhupesh Goyal, Nitin Kumar Singhal & Deepti Goyal. (2019)
Multifunctional Mono-Triazole Derivatives Inhibit Aβ
42
Aggregation and Cu
2+
-Mediated Aβ
42
Aggregation and Protect Against Aβ
42
-Induced Cytotoxicity
. Chemical Research in Toxicology 32:9, pages 1824-1839.
Crossref
Crossref
Suyu Mei & Kun Zhang. (2019) A Multi-Label Learning Framework for Drug Repurposing. Pharmaceutics 11:9, pages 466.
Crossref
Crossref
Nalini Schaduangrat, Veda Prachayasittikul, Saowapak Choomwattana, Prapimpun Wongchitrat, Kamonrat Phopin, Wilasinee Suwanjang, Aijaz Ahmad Malik, Bruno Vincent & Chanin Nantasenamat. (2019) Multidisciplinary approaches for targeting the secretase protein family as a therapeutic route for Alzheimer's disease. Medicinal Research Reviews 39:5, pages 1730-1778.
Crossref
Crossref
Antonio Peón, Hongjian Li, Ghita Ghislat, Kwong‐Sak Leung, Man‐Hon Wong, Gang Lu & Pedro J. Ballester. (2019) MolTarPred: A web tool for comprehensive target prediction with reliability estimation. Chemical Biology & Drug Design 94:1, pages 1390-1401.
Crossref
Crossref
Limeng Jia, Caihong Miao, Fugui Dong, Wei Li, Min Wang, Qi-Huang Zheng & Zhidong Xu. (2019) Facile synthesis of carbon-11-labeled sEH/PDE4 dual inhibitors as new potential PET agents for imaging of sEH/PDE4 enzymes in neuroinflammation. Bioorganic & Medicinal Chemistry Letters 29:13, pages 1654-1659.
Crossref
Crossref
Monika Marcinkowska, Adam Bucki, Dawid Panek, Agata Siwek, Nikola Fajkis, Marek Bednarski, Małgorzata Zygmunt, Justyna Godyń, Alvaro Del Rio Valdivieso, Magdalena Kotańska, Marcin Kołaczkowski & Anna Więckowska. (2019)
Anti‐Alzheimer's multitarget‐directed ligands with serotonin 5‐HT
6
antagonist, butyrylcholinesterase inhibitory, and antioxidant activity
. Archiv der Pharmazie 352:7.
Crossref
Crossref
Anupamjeet Kaur, Sukhmani Mann, Amandeep Kaur, Nitesh Priyadarshi, Bhupesh Goyal, Nitin Kumar Singhal & Deepti Goyal. (2019) Multi-target-directed triazole derivatives as promising agents for the treatment of Alzheimer’s disease. Bioorganic Chemistry 87, pages 572-584.
Crossref
Crossref
Andreia S.P. Pereira, Helena den Haan, Jorge Peña-García, Marién M. Moreno, Horacio Pérez-Sánchez & Zeno Apostolides. (2019) Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server. Molecules 24:10, pages 2002.
Crossref
Crossref
Rongjun He, Brian Finan, John P. Mayer & Richard D. DiMarchi. (2019) Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety. Molecules 24:10, pages 1855.
Crossref
Crossref
Magdalena Wiercioch. (2019) Exploring the Potential of Spherical Harmonics and PCVM for Compounds Activity Prediction. International Journal of Molecular Sciences 20:9, pages 2175.
Crossref
Crossref
Fernanda I. Saldívar-González, B. Angélica Pilón-Jiménez & José L. Medina-Franco. (2019) Chemical space of naturally occurring compounds. Physical Sciences Reviews 4:5.
Crossref
Crossref
Syed Muhammad Usama, Bosheng Zhao & Kevin Burgess. (2019) A Near-IR Fluorescent Dasatinib Derivative That Localizes in Cancer Cells. Bioconjugate Chemistry 30:4, pages 1175-1181.
Crossref
Crossref
Maja Przybyłowska, Szymon Kowalski, Krystyna Dzierzbicka & Iwona Inkielewicz-Stepniak. (2019) Therapeutic Potential of Multifunctional Tacrine Analogues. Current Neuropharmacology 17:5, pages 472-490.
Crossref
Crossref
Carmine Ostacolo, Veronica Di Sarno, Gianluigi Lauro, Giacomo Pepe, Simona Musella, Tania Ciaglia, Vincenzo Vestuto, Giuseppina Autore, Giuseppe Bifulco, Stefania Marzocco, Pietro Campiglia, Isabel M. Gomez-Monterrey & Alessia Bertamino. (2019) Identification of an indol-based multi-target kinase inhibitor through phenotype screening and target fishing using inverse virtual screening approach. European Journal of Medicinal Chemistry 167, pages 61-75.
Crossref
Crossref
Monica Demurtas, Anna Baldisserotto, Ilaria Lampronti, Davide Moi, Gianfranco Balboni, Salvatore Pacifico, Silvia Vertuani, Stefano Manfredini & Valentina Onnis. (2019) Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones. Bioorganic Chemistry 85, pages 568-576.
Crossref
Crossref
Andrés Pizzorno, Blandine Padey, Olivier Terrier & Manuel Rosa-Calatrava. (2019) Drug Repurposing Approaches for the Treatment of Influenza Viral Infection: Reviving Old Drugs to Fight Against a Long-Lived Enemy. Frontiers in Immunology 10.
Crossref
Crossref
Ruchi Kapoor, Thasin A. Peyear, Roger E. KoeppeIIII & Olaf S. Andersen. (2019) Antidepressants are modifiers of lipid bilayer properties. Journal of General Physiology 151:3, pages 342-356.
Crossref
Crossref
Kit-Kay Mak & Mallikarjuna Rao Pichika. (2019) Artificial intelligence in drug development: present status and future prospects. Drug Discovery Today 24:3, pages 773-780.
Crossref
Crossref
Eric M. Jones, Rishi Jajoo, Daniel Cancilla, Nathan B. Lubock, Jeffrey Wang, Megan Satyadi, Rockie Chong, Claire de March, Joshua S. Bloom, Hiroaki Matsunami & Sriram Kosuri. (2019) A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing. Cell Systems 8:3, pages 254-260.e6.
Crossref
Crossref
Jiazhou Chen, Hong Peng, Guoqiang Han, Hongmin Cai & Jiulun Cai. (2019) HOGMMNC: a higher order graph matching with multiple network constraints model for gene–drug regulatory modules identification. Bioinformatics 35:4, pages 602-610.
Crossref
Crossref
Priscila Baltazar Gonçalves & Nelilma Correia Romeiro. (2019) Multi-target natural products as alternatives against oxidative stress in Chronic Obstructive Pulmonary Disease (COPD). European Journal of Medicinal Chemistry 163, pages 911-931.
Crossref
Crossref
Displaying 200 of 326 citing articles. Use the download link below to view the full list of citing articles.
Download full citations list