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Expert Review of Dermatology Volume 5, 2010 - Issue 6
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Review

Statins as potential therapeutic agents for healing disorders

Olivera Stojadinovic Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA;[email protected]
,
Elizabeth Lebrun Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA; Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA
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Irena Pastar Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA; Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA
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Robert Kirsner Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA; Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA
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Stephen C Davis Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA; Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA
&
Marjana Tomic-Canic Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA; Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB, Room 2023-A Miami, FL 33136, USA
Pages 689-698 | Published online: 10 Jan 2014

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Howida Kamal Ibrahim & Rania Hassan Fahmy. (2016) Localized rosuvastatin via implantable bioerodible sponge and its potential role in augmenting bone healing and regeneration. Drug Delivery 23:9, pages 3181-3192.
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Eugenia Cutillas-Marco, Amparo Fuertes Prosper, William B Grant & María M Morales-Suárez-Varela. (2013) Vitamin D status and hypercholesterolemia in Spanish general population. Dermato-Endocrinology 5:3, pages 358-362.
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Articles from other publishers (18)

Seyedeh Maryam Mousavi-Simakani, Amir AzadiNader TanidehNavid OmidifarParisa Ghasemiyeh & Soliman Mohammadi-Samani. (2023) Simvastatin-Loaded Nanostructured Lipid Carriers as Topical Drug Delivery System for Wound Healing Purposes: Preparation, Characterization, and In Vivo Histopathological Studies . Advanced Pharmaceutical Bulletin 13:4, pages 761-771.
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Hira Mahmood, Muhammad Asif, Syed Haroon Khalid, Ikram Ullah Khan, Zunera Chauhdary, Fizza Abdul Razzaq & Sajid Asghar. (2023) Design of a multifunctional carrageenan-tannic acid wound dressing co-loaded with simvastatin and geranium oil. Journal of Drug Delivery Science and Technology 79, pages 104080.
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Alaa Emad Eldeeb, Salwa Salah, Mohammed S. Amer & Nermeen A. Elkasabgy. (2022) 3D nanocomposite alginate hydrogel loaded with pitavastatin nanovesicles as a functional wound dressing with controlled drug release; preparation, in-vitro and in-vivo evaluation. Journal of Drug Delivery Science and Technology 71, pages 103292.
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Bhumika Gupta, Garima Sharma, Pratibha Sharma, Simarjot Kaur Sandhu & Indu Pal Kaur. (2022) Self-Gelling Solid Lipid Nanoparticle Hydrogel Containing Simvastatin as Suitable Wound Dressing: An Investigative Study. Gels 8:1, pages 58.
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Ankit Awasthi, Sachin Kumar Singh, Bimlesh Kumar, Monica Gulati, Rajesh Kumar, Sheetu Wadhwa, Rubiya Khursheed, Leander Corrie, Arya KR, Rajan Kumar, Pooja Patni, Jaskiran Kaur, Sukriti Vishwas & Ankit Yadav. (2021) Treatment Strategies Against Diabetic Foot Ulcer: Success so Far and the Road Ahead. Current Diabetes Reviews 17:4, pages 421-436.
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Masoud Rezvanian, Shiow-Fern Ng, Taradokht Alavi & Waqas Ahmad. (2021) In-vivo evaluation of Alginate-Pectin hydrogel film loaded with Simvastatin for diabetic wound healing in Streptozotocin-induced diabetic rats. International Journal of Biological Macromolecules 171, pages 308-319.
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Hedieh Zolfagharnezhad, Hossein Khalili, Mostafa Mohammadi, Somayeh Niknam & Alireza Vatanara. (2021) Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical Trial. American Journal of Therapeutics 28:1, pages e41-e51.
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Raluca Ion, Madalina Georgiana Necula, Anca Mazare, Valentina Mitran, Patricia Neacsu, Patrik Schmuki & Anisoara Cimpean. (2020) Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants. Current Medicinal Chemistry 27:6, pages 854-902.
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Rebecca Rothe, Sabine Schulze, Christin Neuber, Sandra Hauser, Stefan Rammelt & Jens Pietzsch. (2020) Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation. Clinical Hemorheology and Microcirculation 73:3, pages 439-488.
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Andrew P. Sawaya, Ivan Jozic, Rivka C. Stone, Irena Pastar, Andjela N. Egger, Olivera Stojadinovic, George D. Glinos, Robert S. Kirsner & Marjana Tomic-Canic. (2019) Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling. JCI Insight 4:23.
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Saman Bahrambeigi, Mahdi Rahimi, Bahman Yousefi & Vahid Shafiei‐Irannejad. (2019) New potentials for 3‐hydroxy‐3‐methyl‐glutaryl‐coenzymeA reductase inhibitors: Possible applications in retarding diabetic complications. Journal of Cellular Physiology 234:11, pages 19393-19405.
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Elham Najafi, Motahareh Ahmadi, Mostafa Mohammadi, Mohammad-Taghi Beigmohammadi, Zinat Heidary, Alireza Vatanara & Hossein Khalili. (2018) Topical pentoxifylline for pressure ulcer treatment: a randomised, double-blind, placebo-controlled clinical trial. Journal of Wound Care 27:8, pages 495-502.
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Maria S. Govorkova, Tatyana Milman, Gui-Shuang YingWei PanRona Z. Silkiss. (2018) Inflammatory Mediators in Xanthelasma Palpebrarum: Histopathologic and Immunohistochemical Study. Ophthalmic Plastic & Reconstructive Surgery 34:3, pages 225-230.
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Andrew P. Sawaya, Irena Pastar, Olivera Stojadinovic, Sonja Lazovic, Stephen C. Davis, Joel Gil, Robert S. Kirsner & Marjana Tomic-Canic. (2018) Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5. Journal of Biological Chemistry 293:4, pages 1439-1449.
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Chia-Chi Wang, Po-Wei Yang, Sheau-Fang Yang, Kun-Pin Hsieh, Sung-Pin Tseng & Ying-Chi Lin. (2016) Topical simvastatin promotes healing of Staphylococcus aureus -contaminated cutaneous wounds . International Wound Journal 13:6, pages 1150-1157.
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Irena Pastar, Olivera Stojadinovic, Andrew P. Sawaya, Rivka C. Stone, Linsey E. Lindley, Nkemcho Ojeh, Sasa Vukelic, Herbert H. Samuels & Marjana Tomic-Canic. (2016) Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration. Journal of Cellular Physiology 231:11, pages 2452-2463.
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Gerard J. Fitzmaurice, Billy McWilliams, Lars Nölke, J. Mark Redmond, Jonathan G. McGuinness & Mark E. O'Donnell. (2014) Do Statins Have a Role in the Promotion of Postoperative Wound Healing in Cardiac Surgical Patients?. The Annals of Thoracic Surgery 98:2, pages 756-764.
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Olivera StojadinovicKatherine A. GordonElizabeth LebrunMarjana Tomic-Canic. (2012) Stress-Induced Hormones Cortisol and Epinephrine Impair Wound Epithelization. Advances in Wound Care 1:1, pages 29-35.
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