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Molecular processes leading to aberrant androgen receptor signaling and castration resistance in prostate cancer

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Pages 753-764 | Published online: 10 Jan 2014

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Emmy Boerrigter, Levi N. Groen, Nielka P. Van Erp, Gerald W. Verhaegh & Jack A. Schalken. (2020) Clinical utility of emerging biomarkers in prostate cancer liquid biopsies. Expert Review of Molecular Diagnostics 20:2, pages 219-230.
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Guo-qiang Qin, Hui-chan He, Zhao-dong Han, Yu-xiang Liang, Sheng-bang Yang, Ya-qiang Huang, Liang Zhou, Hao Fu, Jie-xian Li, Fu-neng Jiang & Wei-de Zhong. (2014) Combined overexpression of HIVEP3 and SOX9 predicts unfavorable biochemical recurrence-free survival in patients with prostate cancer. OncoTargets and Therapy 7, pages 137-146.
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Articles from other publishers (32)

Mohamed Youssef, Nermine Moussa, Maged W. Helmy & Medhat Haroun. (2022) Unraveling the therapeutic potential of GANT61/Dactolisib combination as a novel prostate cancer modality. Medical Oncology 39:10.
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Hao-Wen Chuang, Jian-Hua Pan, Yi-Xuan Cai, Darius Rupa, Ting-Syuan Huang, Tzu-Chien Kuo, Chiao-Wen Lin, Chi-Wei Chen, Chia-Chin Lin, Herng-Sheng Lee & Ta-Chun Yuan. (2022) Reciprocal regulation of CIP2A and AR expression in prostate cancer cells. Discover Oncology 13:1.
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Yashika Jawa, Sangeeta Kumari, Gargi Bagchi & Rakesh K. Tyagi. 2022. Post-Transcriptional Gene Regulation in Human Disease. Post-Transcriptional Gene Regulation in Human Disease 149 165 .
Niklas Klümper, Marthe von Danwitz, Johannes Stein, Doris Schmidt, Anja Schmidt, Glen Kristiansen, Michael Muders, Michael Hölzel, Manuel Ritter, Abdullah Alajati & Jörg Ellinger. (2020) Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers. Cancers 12:11, pages 3439.
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Mary-Ellen Taplin, Emmanuel S. Antonarakis, Karen J. Ferrante, Kerry Horgan, Brent Blumenstein, Fred Saad, Jun Luo & Johann S. de Bono. (2019) Androgen Receptor Modulation Optimized for Response—Splice Variant: A Phase 3, Randomized Trial of Galeterone Versus Enzalutamide in Androgen Receptor Splice Variant-7–expressing Metastatic Castration-resistant Prostate Cancer. European Urology 76:6, pages 843-851.
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Xiaodong Chen, Feng Chen, Yu Ren, Guobin Weng, Peter C. Keng, Yuhchyau Chen & Soo Ok Lee. (2019) Glucocorticoid receptor upregulation increases radioresistance and triggers androgen independence of prostate cancer. The Prostate 79:12, pages 1414-1426.
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Ezgi Avsar Abdik, Ferda Kaleagasioglu, Hüseyin Abdik, Fikrettin Sahin & Martin R. Berger. (2019) ABT-737 and erufosine combination against castration-resistant prostate cancer. Anti-Cancer Drugs 30:4, pages 383-393.
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Michael Mark, Dirk Klingbiel, Ulrich Mey, Ralph Winterhalder, Christian Rothermundt, Silke Gillessen, Roger von Moos, Michael Pollak, Gabriela Manetsch, Räto Strebel & Richard Cathomas. (2019) Impact of Addition of Metformin to Abiraterone in Metastatic Castration-Resistant Prostate Cancer Patients With Disease Progressing While Receiving Abiraterone Treatment (MetAb-Pro): Phase 2 Pilot Study. Clinical Genitourinary Cancer 17:2, pages e323-e328.
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Michael T. Schweizer, Kathleen Haugk, Jožefa S. McKiernan, Roman Gulati, Heather H. Cheng, Jessica L. Maes, Ruth F. Dumpit, Peter S. Nelson, Bruce Montgomery, Jeannine S. McCune, Stephen R. Plymate & Evan Y. Yu. (2018) A phase I study of niclosamide in combination with enzalutamide in men with castration-resistant prostate cancer. PLOS ONE 13:6, pages e0198389.
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S. Prekovic, T. Van den Broeck, L. Moris, E. Smeets, F. Claessens, S. Joniau, C. Helsen & G. Attard. (2018) Treatment-induced changes in the androgen receptor axis: Liquid biopsies as diagnostic/prognostic tools for prostate cancer. Molecular and Cellular Endocrinology 462, pages 56-63.
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Gianmarco Leone, Marcello Tucci, Consuelo Buttigliero, Clizia Zichi, Daniele Pignataro, Paolo Bironzo, Francesca Vignani, Giorgio V Scagliotti & Massimo Di Maio. (2018) Antiandrogen withdrawal syndrome (AAWS) in the treatment of patients with prostate cancer. Endocrine-Related Cancer 25:1, pages R1-R9.
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Nancy Devlin, Michael Herdman, Marco Pavesi, De Phung, Shevani Naidoo, Tomasz M. Beer, Bertrand Tombal, Yohann Loriot, Cristina Ivanescu, Teresa Parli, Mark Balk & Stefan Holmstrom. (2017) Health-related quality of life effects of enzalutamide in patients with metastatic castration-resistant prostate cancer: an in-depth post hoc analysis of EQ-5D data from the PREVAIL trial. Health and Quality of Life Outcomes 15:1.
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Daniele Marcoccia, Marco Pellegrini, Marco Fiocchetti, Stefano Lorenzetti & Maria Marino. (2017) Food components and contaminants as (anti)androgenic molecules. Genes & Nutrition 12:1.
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Vincent Liu, Wing Yau, Chun Tam, Kwok-Ming Yao & Stephen Shiu. (2017) Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy. International Journal of Molecular Sciences 18:6, pages 1130.
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J. Morote, L. Regis, A. Celma & J. Planas. (2016) Measurement of serum testosterone during androgenic suppression in patients with prostate cancer: A systematic review. Actas Urológicas Españolas (English Edition) 40:8, pages 477-484.
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J. Morote, L. Regis, A. Celma & J. Planas. (2016) Determinación de la testosterona sérica durante la supresión androgénica en pacientes con cáncer de próstata: una revisión sistemática. Actas Urológicas Españolas 40:8, pages 477-484.
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Jack Schalken & John M. Fitzpatrick. (2016) Enzalutamide: targeting the androgen signalling pathway in metastatic castration-resistant prostate cancer. BJU International 117:2, pages 215-225.
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Michael T. Schweizer & Evan Y. Yu. (2015) Persistent androgen receptor addiction in castration-resistant prostate cancer. Journal of Hematology & Oncology 8:1.
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Yuanyuan Qu, Bo Dai, Dingwei Ye, Yunyi Kong, Kun Chang, Zhongwei Jia, Xiaoqun Yang, Hailiang Zhang, Yao Zhu & Guohai Shi. (2015) Constitutively Active AR-V7 Plays an Essential Role in the Development and Progression of Castration-Resistant Prostate Cancer. Scientific Reports 5:1.
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Sarah K. Martin & Natasha Kyprianou. 2015. 123 158 .
Styliani Karanika, Theodoros Karantanos, Jianhua Yin, Likun Li & Timothy C. Thompson. (2014) WITHDRAWN: Novel anti-androgen receptor signaling agents: Understanding the mechanisms of resistance. Asian Journal of Urology.
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H. Pu, C. Horbinski, P. J. Hensley, E. A. Matuszak, T. Atkinson & N. Kyprianou. (2014) PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis. Carcinogenesis 35:11, pages 2592-2601.
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Styliani Karanika, Theodoros Karantanos, Jianhua Yin, Likun Li & Timothy C. Thompson. (2014) Novel anti-androgen receptor signaling agents: Understanding the mechanisms of resistance. Asian Journal of Urology 1:1, pages 30-39.
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Mary Nakazawa, Emmanuel S. Antonarakis & Jun Luo. (2014) Androgen Receptor Splice Variants in the Era of Enzalutamide and Abiraterone. Hormones and Cancer 5:5, pages 265-273.
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Cynthia C. T. Sprenger & Stephen R. Plymate. (2014) The Link Between Androgen Receptor Splice Variants and Castration-Resistant Prostate Cancer. Hormones and Cancer 5:4, pages 207-217.
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Cora N. SternbergDaniel P. PetrylakRavi A. MadanChris Parker. (2014) Progress in the Treatment of Advanced Prostate Cancer. American Society of Clinical Oncology Educational Book:34, pages 117-131.
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Sarah K. Martin, Michael V. Fiandalo & Natasha Kyprianou. 2013. Androgen-Responsive Genes in Prostate Cancer. Androgen-Responsive Genes in Prostate Cancer 227 255 .
Stephen R. Plymate & Jun Luo. 2013. Androgen-Responsive Genes in Prostate Cancer. Androgen-Responsive Genes in Prostate Cancer 201 213 .
Wei-de Zhong, Guo-qiang Qin, Qi-shan Dai, Zhao-dong Han, Shan-ming Chen, Xiao-hui Ling, Xin Fu, Chao Cai, Jia-hong Chen, Xi-bin Chen, Zhuo-yuan Lin, Ye-han Deng, Shu-lin Wu, Hui-chan He & Chin-lee Wu. (2012) SOXs in human prostate cancer: implication as progression and prognosis factors. BMC Cancer 12:1.
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Faris Azzouni & James Mohler. (2012) Biology of Castration-Recurrent Prostate Cancer. Urologic Clinics of North America 39:4, pages 435-452.
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Saroj Niraula, Kim Chi & Anthony Michael Joshua. (2011) Beyond Castration—Defining Future Directions in the Hormonal Treatment of Prostate Cancer. Hormones and Cancer 3:1-2, pages 3-13.
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Rong Hu, William B. Isaacs & Jun Luo. (2011) A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities. The Prostate 71:15, pages 1656-1667.
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