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Expert Review of Gastroenterology & Hepatology Volume 5, 2011 - Issue 2
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Review

Insulin resistance in nonalcoholic steatohepatitis: necessary but not sufficient – death of a dogma from analysis of therapeutic studies?

Amedeo Lonardo Università di Modena e Reggio Emilia, Azienda USL di Modena, Modena, Italy; Unità Operativa Medicina Interna, Nuovo Ospedale Civile Sant’Agostino Estense (NOCSAE), Via Giardini 1135, Baggiovara Modena, 41100 Italy;[email protected]
,
Stefano Bellentani Centro Studi Fegato, Azienda USL di Modena, Carpi, Italy; Centro Studi Fegato, Azienda USL di Modena, Carpi, Italy
,
Vlad Ratziu Université Pierre et Marie Curie Paris VI, Assistance Publique Hôpitaux de Paris, INSERM UMRS 893, France; Université Pierre et Marie Curie Paris VI, Assistance Publique Hôpitaux de Paris, INSERM UMRS 893, France
&
Paola Loria Università di Modena e Reggio Emilia, Azienda USL di Modena, Modena, Italy; Unità Operativa Medicina Interna, Nuovo Ospedale Civile Sant’Agostino Estense (NOCSAE), Via Giardini 1135, Baggiovara Modena, 41100 Italy; Università di Modena e Reggio Emilia, Azienda USL di Modena, Modena, Italy; Unità Operativa Medicina Interna, Nuovo Ospedale Civile Sant’Agostino Estense (NOCSAE), Via Giardini 1135, Baggiovara Modena, 41100 Italy
Pages 279-289 | Published online: 10 Jan 2014

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Khalid Alswat, Faisal M Sanai, Waleed Al-hamoudi, Mona Ismail, Yaser Dahlan, Hamdan Saleh AlGhamdi, Ibrahim Altraif, Abduljaleel Alalwan, Mohamed M A Babatin & Saleh A Alqahtani. (2021) Clinical and Metabolic Characteristics of Non-Alcoholic Fatty Liver Disease Patients in Saudi Arabia: Data from the Systematic Observatory Liver Disease (SOLID) Registry. Diabetes, Metabolic Syndrome and Obesity 14, pages 1167-1175.
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Amedeo Lonardo, Stefano Ballestri, Giovanni Targher & Paola Loria. (2015) Diagnosis and management of cardiovascular risk in nonalcoholic fatty liver disease. Expert Review of Gastroenterology & Hepatology 9:5, pages 629-650.
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Amedeo Lonardo, Paola Loria, Curtis Argo & Stephen Caldwell. (2011) Perspectives on cellular dysfunction in nonalcoholic steatohepatitis: a case of ‘multiorganelle failure’? Proceedings of a virtual workshop on nonalcoholic steatohepatitis. Expert Review of Gastroenterology & Hepatology 5:2, pages 135-139.
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Balamurugan Ramatchandirin, Alexia Pearah & Ling He. (2023) Regulation of Liver Glucose and Lipid Metabolism by Transcriptional Factors and Coactivators. Life 13:2, pages 515.
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Sebastian Zenovia & Irina Girleanu. 2023. Essentials of Non-Alcoholic Fatty Liver Disease. Essentials of Non-Alcoholic Fatty Liver Disease 9 17 .
Sonal Sharma, Jonathan G. Stine, Thomas Verbeek & Dmitri Bezinover. (2022) Management of Patients With Non-alcoholic Steatohepatitis Undergoing Liver Transplantation: Considerations for the Anesthesiologist. Journal of Cardiothoracic and Vascular Anesthesia 36:8, pages 2616-2627.
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Ajit Venniyoor, Abdul Aziz Al Farsi & Bassim Al Bahrani. (2021) The Troubling Link Between Non-alcoholic Fatty Liver Disease (NAFLD) and Extrahepatic Cancers (EHC). Cureus.
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Shubham A. Salunkhe, Deepak Chitkara, Ram I. Mahato & Anupama Mittal. (2021) Lipid based nanocarriers for effective drug delivery and treatment of diabetes associated liver fibrosis. Advanced Drug Delivery Reviews 173, pages 394-415.
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Amedeo Lonardo. (2021) Renaming NAFLD to MAFLD: Could the LDE System Assist in This Transition?. Journal of Clinical Medicine 10:3, pages 492.
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Omid Asbaghi, Razieh Choghakhori, Damoon Ashtary-Larky & Amir Abbasnezhad. (2020) Effects of the Mediterranean diet on cardiovascular risk factors in non-alcoholic fatty liver disease patients: A systematic review and meta-analysis. Clinical Nutrition ESPEN 37, pages 148-156.
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Amedeo Lonardo & Stefano Ballestri. (2020) Perspectives of nonalcoholic fatty liver disease research: a personal point of view. Exploration of Medicine 1:3, pages 85-107.
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Paulina Kur, Agnieszka Kolasa-Wołosiuk, Kamila Misiakiewicz-Has & Barbara Wiszniewska. (2020) Sex Hormone-Dependent Physiology and Diseases of Liver. International Journal of Environmental Research and Public Health 17:8, pages 2620.
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Simona Marchisello, Antonino Di Pino, Roberto Scicali, Francesca Urbano, Salvatore Piro, Francesco Purrello & Agata Maria Rabuazzo. (2019) Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview. International Journal of Molecular Sciences 20:8, pages 1948.
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Amedeo Lonardo, Stefano Ballestri, Alessandro Mantovani, Fabio Nascimbeni, Simonetta Lugari & Giovanni Targher. (2019) Pathogenesis of hypothyroidism-induced NAFLD: Evidence for a distinct disease entity?. Digestive and Liver Disease 51:4, pages 462-470.
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Amedeo Lonardo, Simonetta Lugari, Stefano Ballestri, Fabio Nascimbeni, Enrica Baldelli & Mauro Maurantonio. (2018) A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?. Acta Diabetologica 56:4, pages 385-396.
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Jayanta Paul, Raj Vigna Venugopal, Lorance Peter, Shihaz Hussain, Kula Naresh Kumar Shetty & Mohit P Shetti. (2018) Effects of lifestyle modification on liver enzyme and Fibroscan in Indian patients with non-alcoholic fatty liver disease. Gastroenterology Report 6:1, pages 49-53.
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Amedeo Lonardo, Fabio Nascimbeni, Mauro Maurantonio, Alessandra Marrazzo, Luca Rinaldi & Luigi Elio Adinolfi. (2017) Nonalcoholic fatty liver disease: Evolving paradigms. World Journal of Gastroenterology 23:36, pages 6571-6592.
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Stefano Ballestri, Fabio Nascimbeni, Enrica Baldelli, Alessandra Marrazzo, Dante Romagnoli & Amedeo Lonardo. (2017) NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk. Advances in Therapy 34:6, pages 1291-1326.
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Amedeo Lonardo, Fabio Nascimbeni, Giovanni Targher, Mauro Bernardi, Ferruccio Bonino, Elisabetta Bugianesi, Alessandro Casini, Amalia Gastaldelli, Giulio Marchesini, Fabio Marra, Luca Miele, Filomena Morisco, Salvatore Petta, Fabio Piscaglia, Gianluca Svegliati-Baroni, Luca Valenti & Stefano Bellentani. (2017) AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions. Digestive and Liver Disease 49:5, pages 471-483.
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Yaru Li, Jing Wang, Yuhan Tang, Xu Han, Bing Liu, Hua Hu, Xiulou Li, Kun Yang, Jing Yuan, Xiaoping Miao, Ping Yao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Handong Yang, Frank B. Hu, Tangchun Wu & Meian He. (2017) Bidirectional association between nonalcoholic fatty liver disease and type 2 diabetes in Chinese population: Evidence from the Dongfeng-Tongji cohort study. PLOS ONE 12:3, pages e0174291.
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Yue Zhang, Hiroshi Takemori, Chang Wang, JiaHui Fu, MingWang Xu, Liang Xiong, NingXu Li & XiuYing Wen. (2017) Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention. Life Sciences 173, pages 107-115.
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Lorena del Rocio Ibarra-Reynoso, Hilda Lissette López-Lemus, Ma Eugenia Garay-Sevilla & Juan Manuel Malacara. (2017) Effect of Restriction of Foods with High Fructose Corn Syrup Content on Metabolic Indices and Fatty Liver in Obese Children. Obesity Facts 10:4, pages 332-340.
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Stefano Ballestri, Fabio Nascimbeni, Dante Romagnoli & Amedeo Lonardo. (2016) The independent predictors of non-alcoholic steatohepatitis and its individual histological features.. Hepatology Research 46:11, pages 1074-1087.
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Amedeo Lonardo, Silvia Sookoian, Carlos J. Pirola & Giovanni Targher. (2016) Non-alcoholic fatty liver disease and risk of cardiovascular disease. Metabolism 65:8, pages 1136-1150.
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Ardeshir Algooneh, Sulaiman Almazeedi, Salman Al-Sabah, Maha Ahmed & Feras Othman. (2015) Non-alcoholic fatty liver disease resolution following sleeve gastrectomy. Surgical Endoscopy 30:5, pages 1983-1987.
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Stefano Ballestri, Fabio Nascimbeni, Dante Romagnoli, Enrica Baldelli & Amedeo Lonardo. (2016) The Role of Nuclear Receptors in the Pathophysiology, Natural Course, and Drug Treatment of NAFLD in Humans. Advances in Therapy 33:3, pages 291-319.
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Fabio Piscaglia, Gianluca Svegliati‐Baroni, Andrea Barchetti, Anna Pecorelli, Sara Marinelli, Claudio Tiribelli & Stefano Bellentani. (2016) Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study. Hepatology 63:3, pages 827-838.
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Fatma Yahyaoğlu Gökmen, Süleyman Ahbab, Hayriye Esra Ataoğlu, Betül Çavuşoğlu Türker, Faik Çetin, Fatih Türker, Rabia Yahyaoğlu Mamaç & Mustafa Yenigün. (2016) FT3/FT4 ratio predicts non-alcoholic fatty liver disease independent of metabolic parameters in patients with euthyroidism and hypothyroidism. Clinics 71:4, pages 221-225.
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Amedeo Lonardo, Stefano Ballestri, Giovanni Guaraldi, Fabio Nascimbeni, Dante Romagnoli, Stefano Zona & Giovanni Targher. (2016) Fatty liver is associated with an increased risk of diabetes and cardiovascular disease - Evidence from three different disease models: NAFLD, HCV and HIV. World Journal of Gastroenterology 22:44, pages 9674.
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Ivana Mikolasevic, Lidija Orlic, Neven Franjic, Goran Hauser, Davor Stimac & Sandra Milic. (2016) Transient elastography (FibroScan ® ) with controlled attenuation parameter in the assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease - Where do we stand? . World Journal of Gastroenterology 22:32, pages 7236.
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Amedeo Lonardo, Stefano Bellentani, Curtis K. Argo, Stefano Ballestri, Christopher D. Byrne, Stephen H. Caldwell, Helena Cortez-Pinto, Antonio Grieco, Mariana V. Machado, Luca Miele & Giovanni Targher. (2015) Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups. Digestive and Liver Disease 47:12, pages 997-1006.
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Harmesh N. Chaudhari & Jong Won Yun. (2016) DJ-1 deficiency alleviates steatosis in cultured hepatocytes. Biotechnology and Bioprocess Engineering 20:6, pages 1152-1161.
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Sven Francque, An Verrijken, Sandrine Caron, Janne Prawitt, Réjane Paumelle, Bruno Derudas, Philippe Lefebvre, Marja-Riitta Taskinen, Wim Van Hul, Ilse Mertens, Guy Hubens, Eric Van Marck, Peter Michielsen, Luc Van Gaal & Bart Staels. (2015) PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis. Journal of Hepatology 63:1, pages 164-173.
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Amedeo Lonardo, Stefano Ballestri, Giulio Marchesini, Paul Angulo & Paola Loria. (2015) Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome. Digestive and Liver Disease 47:3, pages 181-190.
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Rifaat Safadi, Fred M. Konikoff, Mahmud Mahamid, Shira Zelber-Sagi, Maya Halpern, Tuvia Gilat, Ran Oren, Rifaat Safadi, Fred M. Konikoff, Alice Hershkovitz, Tuvia Gilat, Maya Halpern, Ziva Rosenthal-Galili, Eli Zuckerman, Saif Abu-Mouch, Alexander Fich, Emanuel Sikuler, Assaf Issachar, Nimmer Assy, Yaacov Baruch, Yoav Lurie, Moshe Graif, Naftali Stern, Mariana Yaron, Annat Blank, Dafna Ben Bashat, Shira Zelber-Sagi, Mahmud Mahamid, Meir Mizrahi & Ran Oren. (2014) The Fatty Acid–Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease. Clinical Gastroenterology and Hepatology 12:12, pages 2085-2091.e1.
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Fatiha Nassir & Jamal Ibdah. (2014) Role of Mitochondria in Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences 15:5, pages 8713-8742.
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P. Loria, G. Marchesini, F. Nascimbeni, S. Ballestri, M. Maurantonio, F. Carubbi, V. Ratziu & A. Lonardo. (2014) Cardiovascular risk, lipidemic phenotype and steatosis. A comparative analysis of cirrhotic and non-cirrhotic liver disease due to varying etiology. Atherosclerosis 232:1, pages 99-109.
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Luca Montesi, Arianna Mazzotti, Simona Moscatiello, Gabriele Forlani & Giulio Marchesini. (2013) Insulin resistance: mechanism and implications for carcinogenesis and hepatocellular carcinoma in NASH. Hepatology International 7:S2, pages 814-822.
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Stefano BallestriErica MeschiariEnrica BaldelliFrancesca E. MusumeciDante RomagnoliTommaso TrentiRomeo G. ZennaroAmedeo LonardoPaola Loria. (2013) Relationship of Serum Fetuin-A Levels with Coronary Atherosclerotic Burden and NAFLD in Patients Undergoing Elective Coronary Angiography. Metabolic Syndrome and Related Disorders 11:4, pages 289-295.
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Grace Lai-Hung Wong. (2013) Transient elastography: Kill two birds with one stone?. World Journal of Hepatology 5:5, pages 264.
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Paola Loria, Amedeo Lonardo & Frank Anania. (2013) Liver and diabetes. A vicious circle. Hepatology Research 43:1, pages 51-64.
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Zheng Sun & Mitchell A. Lazar. (2013) Dissociating fatty liver and diabetes. Trends in Endocrinology & Metabolism 24:1, pages 4-12.
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Stefano Bellentani, Claudio Tiribelli & Giorgio Bedogni. 2013. Alcohol, Nutrition, and Health Consequences. Alcohol, Nutrition, and Health Consequences 497 506 .
V. Nobili, G. Bedogni, R. Berni Canani, P. Brambilla, S. Cianfarani, A. Pietrobelli & C. Agostoni. (2012) The potential role of fatty liver in paediatric metabolic syndrome: a distinct phenotype with high metabolic risk?. Pediatric Obesity 7:6.
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Y. Yilmaz. (2012) Review article: is non-alcoholic fatty liver disease a spectrum, or are steatosis and non-alcoholic steatohepatitis distinct conditions?. Alimentary Pharmacology & Therapeutics 36:9, pages 815-823.
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Anna Alisi & Valerio Nobili. (2012) Non-alcoholic fatty liver disease in children now: Lifestyle changes and pharmacologic treatments. Nutrition 28:7-8, pages 722-726.
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Zheng Sun, Russell A Miller, Rajesh T Patel, Jie Chen, Ravindra Dhir, Hong Wang, Dongyan Zhang, Mark J Graham, Terry G Unterman, Gerald I Shulman, Carole Sztalryd, Michael J Bennett, Rexford S Ahima, Morris J Birnbaum & Mitchell A Lazar. (2012) Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Medicine 18:6, pages 934-942.
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Amedeo Lonardo & Paola Loria. (2012) If steatosis is the atherosclerosis of the liver, are statins the “aspirin” for steatosis?. Digestive and Liver Disease 44:6, pages 451-452.
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Mauro Maurantonio, Stefano Ballestri, Maria Rosaria Odoardi, Amedeo Lonardo & Paola Loria. (2011) Treatment of Atherogenic Liver Based on the Pathogenesis of Nonalcoholic Fatty Liver Disease: A Novel Approach to Reduce Cardiovascular Risk?. Archives of Medical Research 42:5, pages 337-353.
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