292
Views
49
CrossRef citations to date
0
Altmetric
Review

JAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms

&
Pages 323-337 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Brett Stevens, Julia Maxson, Jeffrey Tyner, Clayton A. Smith, Jonathan A. Gutman, William Robinson, Craig T. Jordan, Choon-Kee Lee, Karen Swisshelm, Jennifer Tobin, Qi Wei, Jeffrey Schowinsky, Sean Rinella, Hea Gie Lee & Daniel A. Pollyea. (2016) Clonality of neutrophilia associated with plasma cell neoplasms: report of a SETBP1 mutation and analysis of a single institution series. Leukemia & Lymphoma 57:4, pages 927-934.
Read now
Tugba Kevser Uzuncakmak, Sarenur Yilmaz, Ayse Serap Karadag, Necmettin Akdeniz & Ibrahim Akalin. (2015) Lentiginoses in polycythemia vera patient: Is there a role for JAK2 (V617F) mutation?. JAK-STAT 4:1.
Read now
Pearlie K Epling-Burnette, Jessica McDaniel, Sheng Wei & Alan F List. (2012) Emerging immunosuppressive drugs in myelodysplastic syndromes. Expert Opinion on Emerging Drugs 17:4, pages 519-541.
Read now
Bernd Groner. (2012) Determinants of the extent and duration of STAT3 signaling. JAK-STAT 1:3, pages 211-215.
Read now

Articles from other publishers (45)

Hannah Cherniawsky & Habib Moshref Razavi. (2023) A case of MDS / MPN overlap syndrome with ring sideroblasts and thrombocytosis: Tackling the quandary of thrombosis versus hemorrhage . Clinical Case Reports 11:6.
Crossref
Tim Kong, Angelo B. A. Laranjeira, Kangning Yang, Daniel A. C. Fisher, LaYow Yu, Laure Poittevin De La Frégonnière, Anthony Z. Wang, Marianna B. Ruzinova, Jared S. Fowles, Mary C. Fulbright, Maggie J. Cox, Hamza Celik, Grant A. Challen, Sidong Huang & Stephen T. Oh. (2022) DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression. Nature Cancer.
Crossref
Tuba GÜLLÜ KOCA, Fahir ÖZKALEMKAŞ, Vildan OZKOCAMAN, Tuba ERSAL & Şeyma ESENBUĞA. (2022) Comparison of Clinical Data and Treatment Responses of Patients with Essential Thrombocythemia Using Anagrelide by JAK2 Gene Mutation Status. Turkish Journal of Internal Medicine 4, pages 7-11.
Crossref
Panhong Gou, Wenchao Zhang & Stephane Giraudier. (2022) Insights into the Potential Mechanisms of JAK2V617F Somatic Mutation Contributing Distinct Phenotypes in Myeloproliferative Neoplasms. International Journal of Molecular Sciences 23:3, pages 1013.
Crossref
Zhu Shen, Wenfei Du, Cecelia Perkins, Lenn Fechter, Vanita Natu, Holden Maecker, Jesse Rowley, Jason Gotlib, James Zehnder & Anandi Krishnan. (2021) Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms. Cell Reports Medicine 2:10, pages 100425.
Crossref
Ayşe UYSAL, Şule ALTINER, Said ÇELİK, Serhat UYSAL & Alper Han ÇEBİ. (2020) Genetic analysis of BCR-ABL negative chronic myeloproliferative diseases at initial diagnosis and their clinical effectsBCR-ABL negatif kronik myeloproliferatif hastalıkların tanı anındaki genetik analizleri ve bunların klinik etkileri. Cukurova Medical Journal 45:3, pages 933-939.
Crossref
Ajda Anžič Drofenik, Matjaž Vrtovec, Mojca Božič Mijovski, Matjaž Sever, Irena Preložnik Zupan, Nataša Kejžar & Aleš Blinc. (2020) Progression of coronary calcium burden and carotid stiffness in patients with essential thrombocythemia associated with JAK2 V617F mutation. Atherosclerosis 296, pages 25-31.
Crossref
Anabel Flores, Lawrence S. Argetsinger, Lukas K.J. StadlerAlvaro E. Malaga, Paul B. Vander, Lauren C. DeSantis, Ray M. Joe, Joel M. Cline, Julia M. KeoghElana HenningInes BarrosoEdson Mendes de OliveiraGowri Chandrashekar, Erik S. Clutter, Yixin Hu, Jeanne Stuckey, I. Sadaf FarooqiMartin G. MyersJr.Jr. & Christin Carter-Su. (2019) Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance. Diabetes 68:11, pages 2049-2062.
Crossref
Ana Azevedo, Susana Silva & José Rueff. 2019. Tyrosine Kinases as Druggable Targets in Cancer. Tyrosine Kinases as Druggable Targets in Cancer.
Henrik M. Hammarén, Anniina T. Virtanen, Juuli Raivola & Olli Silvennoinen. (2019) The regulation of JAKs in cytokine signaling and its breakdown in disease. Cytokine 118, pages 48-63.
Crossref
Haraprasad Pati & Karthika Kundil Veetil. (2019) Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes: Molecular Pathogenetic Mechanisms and Their Implications. Indian Journal of Hematology and Blood Transfusion 35:1, pages 3-11.
Crossref
Emira Bousoik & Hamidreza Montazeri Aliabadi. (2018) “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway. Frontiers in Oncology 8.
Crossref
C. F. Nystrand, W. Ghanima, A. Waage & C. M. Jonassen. (2017) JAK 2 V617F mutation can be reliably detected in serum using droplet digital PCR . International Journal of Laboratory Hematology 40:2, pages 181-186.
Crossref
Faramarz Naeim, P. Nagesh Rao, Sophie X. Song & Ryan T. Phan. 2018. Atlas of Hematopathology. Atlas of Hematopathology 193 202 .
Ana Paula Azevedo, Susana N. Silva, Alice Reichert, Fernando Lima, Esmeraldina Júnior & José Rueff. (2017) Prevalence of the Janus kinase 2 V617F mutation in Philadelphia-negative myeloproliferative neoplasms in a Portuguese population. Biomedical Reports 7:4, pages 370-376.
Crossref
Joan How, Amy Zhou & Stephen T. Oh. (2016) Splanchnic vein thrombosis in myeloproliferative neoplasms: pathophysiology and molecular mechanisms of disease. Therapeutic Advances in Hematology 8:3, pages 107-118.
Crossref
Hongwei Wang, Minghui Xu, Qingjie Kong, Peng Sun, Fengyun Yan, Wenying Tian & Xin Wang. (2017) Research and progress on ClC-2. Molecular Medicine Reports 16:1, pages 11-22.
Crossref
GYEONGMIN JEONG, JINHYONG KIM, SEEUN HAN, JONGMIN LEE, KYUNGHYE PARK, CHUIYONG PAK, JI-HUN LIM, HEE JEONG CHA, HAWK KIM & JAE-CHEOL JO. (2016) Coexistence of follicular lymphoma and an unclassifiable myeloproliferative neoplasm in a treatment-naïve patient: A case report. Oncology Letters 11:2, pages 1469-1473.
Crossref
Brady L. SteinStephen T. OhDmitriy BerenzonGabriela S. HobbsMarina KremyanskayaRaajit K. RampalCamille N. AbboudKenneth AdlerMark L. HeaneyElias J. JabbourRami S. KomrokjiAlison R. MoliternoEllen K. RitchieLawrence RiceJohn MascarenhasRonald Hoffman. (2015) Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F . Journal of Clinical Oncology 33:33, pages 3953-3960.
Crossref
E K Engle, D A C Fisher, C A Miller, M D McLellan, R S Fulton, D M Moore, R K Wilson, T J Ley & S T Oh. (2014) Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia 29:4, pages 869-876.
Crossref
Zohreh Hosseinzadeh, Jamshed Warsi, Bernat Elvira, Ahmad Almilaji, Ekaterina Shumilina & Florian Lang. (2015) Up-regulation of Kv1.3 Channels by Janus Kinase 2. The Journal of Membrane Biology 248:2, pages 309-317.
Crossref
Kenji Oritani, Shinichiro Okamoto, Tetsuzo Tauchi, Shigeki Saito, Kohshi Ohishi, Hiroshi Handa, Katsuto Takenaka, Prashanth Gopalakrishna, Taro Amagasaki, Kazuo Ito & Koichi Akashi. (2015) A multinational, open-label, phase 2 study of ruxolitinib in Asian patients with myelofibrosis: Japanese subset analysis. International Journal of Hematology 101:3, pages 295-304.
Crossref
Katerina Zoi & Nicholas C. P. Cross. (2014) Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable. International Journal of Hematology 101:3, pages 229-242.
Crossref
Srdan Verstovsek, Ronald Hoffman, John Mascarenhas, Jean-Charles Soria, Ratislav Bahleda, Patricia McCoon, Weifeng Tang, Jorge Cortes, Hagop Kantarjian & Vincent Ribrag. (2015) A phase I, open-label, multi-center study of the JAK2 inhibitor AZD1480 in patients with myelofibrosis. Leukemia Research 39:2, pages 157-163.
Crossref
Greg L. Plosker. (2015) Ruxolitinib: A Review of Its Use in Patients with Myelofibrosis. Drugs 75:3, pages 297-308.
Crossref
Zohreh Hosseinzadeh, Ahmad Almilaji, Sabina Honisch, Tatsiana Pakladok, GuoXing Liu, Shefalee K. Bhavsar, Peter Ruth, Ekaterina Shumilina & Florian Lang. (2014) Upregulation of the large conductance voltage- and Ca 2+ -activated K + channels by Janus kinase 2 . American Journal of Physiology-Cell Physiology 306:11, pages C1041-C1049.
Crossref
Zohreh Hosseinzadeh, Dong Luo, Mentor Sopjani, Shefalee K. Bhavsar & Florian Lang. (2014) Down-Regulation of the Epithelial Na+ Channel ENaC by Janus kinase 2. The Journal of Membrane Biology 247:4, pages 331-338.
Crossref
S. Leah EtheridgeMegan E. CosgroveVeena SangkhaeLana M. CorboMichelle E. RohMarkus A. Seeliger, Edward L. Chan & Ian S. Hitchcock. (2014) A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis. Blood 123:7, pages 1059-1068.
Crossref
Nathalie Chami & Guillaume Lettre. (2014) Lessons and Implications from Genome-Wide Association Studies (GWAS) Findings of Blood Cell Phenotypes. Genes 5:1, pages 51-64.
Crossref
Jason Gotlib. (2013) JAK inhibition in the myeloproliferative neoplasms: lessons learned from the bench and bedside. Hematology 2013:1, pages 529-537.
Crossref
Ruben A Mesa & Jorge Cortes. (2013) Optimizing management of ruxolitinib in patients with myelofibrosis: the need for individualized dosing. Journal of Hematology & Oncology 6:1.
Crossref
Zohreh Hosseinzadeh, Mentor Sopjani, Tatsiana Pakladok, Shefalee K. Bhavsar & Florian Lang. (2013) Downregulation of KCNQ4 by Janus Kinase 2. The Journal of Membrane Biology 246:4, pages 335-341.
Crossref
Manzar Shojaiefard, Zohreh Hosseinzadeh, Tatsiana Pakladok, Shefalee K. Bhavsar & Florian Lang. (2013) Stimulation of Na+ coupled phosphate transporter NaPiIIa by janus kinase JAK2. Biochemical and Biophysical Research Communications 431:2, pages 186-191.
Crossref
Lori N. Griner, Kathy L. McGraw, Joseph O. Johnson, Alan F. List & Gary W. Reuther. (2012) JAK 2‐ V 617 F ‐mediated signalling is dependent on lipid rafts and statins inhibit JAK 2‐ V 617 F ‐dependent cell growth . British Journal of Haematology 160:2, pages 177-187.
Crossref
Faramarz Naeim, P. Nagesh Rao, Sophie X. Song & Wayne W. Grody. 2013. Atlas of Hematopathology. Atlas of Hematopathology 149 154 .
Rachel R. Stine & Erika L. Matunis. 2013. Transcriptional and Translational Regulation of Stem Cells. Transcriptional and Translational Regulation of Stem Cells 247 267 .
Maria Kleppe & Ross L. Levine. (2012) New pieces of a puzzle: The current biological picture of MPN. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826:2, pages 415-422.
Crossref
Charlie Mantel, Steven Messina-Graham, Akira Moh, Scott Cooper, Giao Hangoc, Xin-Yuan Fu & Hal E. Broxmeyer. (2012) Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype. Blood 120:13, pages 2589-2599.
Crossref
Zohreh Hosseinzadeh, Manzar Shojaiefard, Shefalee K. Bhavsar & Florian Lang. (2012) Up-regulation of the betaine/GABA transporter BGT1 by JAK2. Biochemical and Biophysical Research Communications 420:1, pages 172-177.
Crossref
Manzar Shojaiefard, Zohreh Hosseinzadeh, Shefalee K. Bhavsar & Florian Lang. (2012) Downregulation of the Creatine Transporter SLC6A8 by JAK2. The Journal of Membrane Biology 245:3, pages 157-163.
Crossref
Zohreh Hosseinzadeh, Shefalee K. Bhavsar & Florian Lang. (2012) Down-Regulation of the Myoinositol Transporter SMIT by JAK2. Cellular Physiology and Biochemistry 30:6, pages 1473-1480.
Crossref
Nicholas C. P. Cross. (2011) Genetic and Epigenetic Complexity in Myeloproliferative Neoplasms. Hematology 2011:1, pages 208-214.
Crossref
Shefalee K. Bhavsar, Zohreh Hosseinzadeh, Katja Merches, Shuchen Gu, Stefan Bröer & Florian Lang. (2011) Stimulation of the amino acid transporter SLC6A19 by JAK2. Biochemical and Biophysical Research Communications 414:3, pages 456-461.
Crossref
Jung‐Sook Ha & Dong‐Seok Jeon. (2011) Possible new LNK mutations in myeloproliferative neoplasms . American Journal of Hematology 86:10, pages 866-868.
Crossref
Zohreh Hosseinzadeh, Shefalee K. Bhavsar, Manzar Shojaiefard, Ambrish Saxena, Katja Merches, Mentor Sopjani, Ioana Alesutan & Florian Lang. (2011) Stimulation of the glucose carrier SGLT1 by JAK2. Biochemical and Biophysical Research Communications 408:2, pages 208-213.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.