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Expert Review of Hematology Volume 5, 2012 - Issue 2
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The role of histone methyltransferase EZH2 in myelodysplastic syndromes

Feng Xu Department of Hematology, the Sixth People’s Hospital affiliated to Shanghai Jiaotong University, Shanghai, China; Department of Hematology, the Sixth People’s Hospital affiliated to Shanghai Jiaotong University, Shanghai, China; Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai Jiaotong University School of Medicine, Shanghai, China
&
Xiao Li Department of Hematology, the Sixth People’s Hospital affiliated to Shanghai Jiaotong University, Shanghai, China; Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai Jiaotong University School of Medicine, Shanghai, China. [email protected]
Pages 177-185 | Published online: 10 Jan 2014

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Lisa Pleyer & Richard Greil. (2015) Digging deep into “dirty” drugs – modulation of the methylation machinery. Drug Metabolism Reviews 47:2, pages 252-279.
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Akiko Urabe, SungGi Chi & Yosuke Minami. (2023) The Immuno-Oncology and Genomic Aspects of DNA-Hypomethylating Therapeutics in Acute Myeloid Leukemia. International Journal of Molecular Sciences 24:4, pages 3727.
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Ali Sakhdari, Caleb Class, Guillermo Montalban-Bravo, Koji Sasaki, Carlos E. Bueso-Ramos, Keyur P. Patel, Mark J. Routbort, Sanam Loghavi, Chi Young Ok, Andres Quesada, Joseph D. Khoury, Sergej N. Konoplev, Hagop P. Kantarjian, Guillermo Garcia-Manero, L. Jeffrey Medeiros & Rashmi Kanagal-Shamanna. (2022) Immunohistochemical loss of enhancer of Zeste Homolog 2 (EZH2) protein expression correlates with EZH2 alterations and portends a worse outcome in myelodysplastic syndromes. Modern Pathology 35:9, pages 1212-1219.
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Cong Shi, Shengping Gong, Tingting Niu, Tongyu Li, An Wu, Xiaojiao Zheng, Shujun Yang, Guifang Ouyang & Qitian Mu. (2022) The Prognostic Value of Pretherapy Peripheral Blood Inflammatory Indices in Myelodysplastic Syndromes. Frontiers in Oncology 12.
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Zhuanzhen Zheng, Ling Li, Guoxia Li, Yaofang Zhang, Chunxia Dong, Fanggang Ren, Wenliang Chen & Yanping Ma. (2021) EZH2/EHMT2 Histone Methyltransferases Inhibit the Transcription of DLX5 and Promote the Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia. Frontiers in Cell and Developmental Biology 9.
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Jinhai Ren, Ying Wang, Lihua Wang, Xiaoling Guo & Xiaonan Guo. (2020) Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression. Experimental Biology and Medicine 245:12, pages 1009-1015.
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Kathy L. McGraw, Johnny Nguyen, Najla H. Al Ali, Rami S. Komrokji, David Sallman, Xiaohui Zhang, Jinming Song, Eric Padron, Jeffrey E. Lancet, Lynn C. Moscinski, Alan F. List & Ling Zhang. (2019) Association of EZH2 protein expression by immunohistochemistry in myelodysplasia related neoplasms with mutation status, cytogenetics and clinical outcomes. British Journal of Haematology 184:3, pages 450-455.
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Anna Palau, Mar Mallo, Laura Palomo, Ines Rodríguez-Hernández, Jeannine Diesch, Diana Campos, Isabel Granada, Jordi Juncà, Hans G. Drexler, Francesc Solé & Marcus Buschbeck. (2017) Immunophenotypic, cytogenetic, and mutational characterization of cell lines derived from myelodysplastic syndrome patients after progression to acute myeloid leukemia. Genes, Chromosomes and Cancer 56:3, pages 243-252.
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Sabah F. Chaudry & Timothy J. T. Chevassut. (2017) Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis. BioMed Research International 2017, pages 1-13.
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Maximilian Stahl, Nathan Kohrman, Steven D. Gore, Tae Kon Kim, Amer M. Zeidan & Thomas Prebet. (2016) Epigenetics in Cancer: A Hematological Perspective. PLOS Genetics 12:10, pages e1006193.
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Chi-Yuan Yao, Hsin-An Hou, Tzung-Yi Lin, Chien-Chin Lin, Wen-Chien Chou, Mei-Hsuan Tseng, Ying-Chieh Chiang, Ming-Chih Liu, Chia-Wen Liu, Yuan-Yeh Kuo, Shang-Ju Wu, Xiu-Wen Liao, Chien-Ting Lin, Bor-Shen Ko, Chien-Yuan Chen, Szu-Chun Hsu, Chi-Cheng Li, Shang-Yi Huang, Ming Yao, Jih-Luh Tang, Woei Tsay, Chieh-Yu Liu & Hwei-Fang Tien. (2016) Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes (h-MDS). Oncotarget 7:39, pages 63177-63188.
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Cristina Mecucci, Valeria Di Battista & Valeria Nofrini. 2016. The Genetic Basis of Haematological Cancers. The Genetic Basis of Haematological Cancers 1 79 .
Atsumi Iida, Toshiro Iwagawa, Yukihiro Baba, Shinya Satoh, Yujin Mochizuki, Hiromitsu Nakauchi, Takahisa Furukawa, Haruhiko Koseki, Akira Murakami & Sumiko Watanabe. (2015) Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation. Developmental Neurobiology 75:9, pages 947-960.
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Jing Ai, Valeria Visconte, Ali Tabarroki, Edy Hasrouni, Betty K. Hamilton, Sudipto Mukherjee, Matt Kalaycio, Ronald Sobecks, Anjali S. Advani, Mikkael A. Sekeres, Shashirekha Shetty & Ramon V. Tiu. (2015) Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic Syndromes. Clinical Lymphoma Myeloma and Leukemia 15:8, pages 489-495.
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Chie Nishioka, Takayuki Ikezoe, Jing Yang & Akihito Yokoyama. (2015) Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells. PLOS ONE 10:5, pages e0125017.
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Andrea Scelfo, Andrea Piunti & Diego Pasini. (2015) The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?. FEBS Journal 282:9, pages 1703-1722.
Crossref
Chiara Vardabasso, Dan Hasson, Kajan Ratnakumar, Chi-Yeh Chung, Luis F. Duarte & Emily Bernstein. (2013) Histone variants: emerging players in cancer biology. Cellular and Molecular Life Sciences 71:3, pages 379-404.
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Emma Conway O’Brien, Steven Prideaux & Timothy Chevassut. (2014) The Epigenetic Landscape of Acute Myeloid Leukemia. Advances in Hematology 2014, pages 1-15.
Crossref
Valeria Santini, Ari Melnick, Jaroslaw P. Maciejewski, Estelle Duprez, Clara Nervi, Lucio Cocco, Kevin G. Ford & Ghulam Mufti. (2013) Epigenetics in focus: Pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents. Critical Reviews in Oncology/Hematology 88:2, pages 231-245.
Crossref
Bin XuSamuel AbourbihKanishka SircarWassim KassoufJose Joao MansureArmen AprikianSimon TanguayFadi Brimo. (2013) Enhancer of Zeste Homolog 2 Expression Is Associated With Metastasis and Adverse Clinical Outcome in Clear Cell Renal Cell Carcinoma: A Comparative Study and Review of the Literature. Archives of Pathology & Laboratory Medicine 137:10, pages 1326-1336.
Crossref
H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau & Charlotte NiemeyerGuillermo Garcia-Manero. 2013. Myelodysplastic Syndromes. Myelodysplastic Syndromes 153 167 .

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