Advanced search
Publication Cover
Expert Review of Ophthalmology Volume 8, 2013 - Issue 3
Submit an article Journal homepage
139
Views
33
CrossRef citations to date
0
Altmetric
Review

Targeting neovascularization in ischemic retinopathy: recent advances

Mohamed Al-Shabrawey Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA. [email protected]; Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Anatomy, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Daqahlia, Egypt; Vascular Biology Center, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, GRU, Augusta, GA, USA
,
Mohamed Elsherbiny Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA; Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Anatomy, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Daqahlia, Egypt
,
Julian Nussbaum Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA; Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA
,
Amira Othman Department of Anatomy, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Daqahlia, Egypt; Department of Anatomy, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Daqahlia, Egypt
,
Sylvia Megyerdi Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA; Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA
&
Amany Tawfik Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, GRU, Augusta, GA, USA
Pages 267-286 | Published online: 09 Jan 2014

Citations (33)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Chenyue Li, Zichang Zhao & Shihong Zhao. (2022) Annexin A2 promotes development of retinal neovascularization through PI3K/ AKT signaling pathway. Current Eye Research 47:4, pages 579-589.
Read now
Anne Moskowitz, Ronald M Hansen & Anne B Fulton. (2016) Retinal, visual, and refractive development in retinopathy of prematurity. Eye and Brain 8, pages 103-111.
Read now
W Riley Stroman & Jeffrey G Gross. (2014) Review of the latest treatments for proliferative diabetic retinopathy. Expert Review of Ophthalmology 9:5, pages 413-424.
Read now

Articles from other publishers (30)

Mudannan Fang, Beichen Yuan, Meng Wang, Junfeng Liu & Zheng Wang. (2023) Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation. Fermentation 9:11, pages 950.
Crossref
Shao-Ting Tai & Pei-Hsuan Li. (2023) Persistent Visual Loss in a 1-Eyed Patient After Intravenous Thrombolytic Therapy for Acute Ischemic Stroke. Journal of Neuro-Ophthalmology Publish Ahead of Print.
Crossref
Geetika Kaur, Deepti Sharma, Shivantika Bisen, Chandra Sekhar Mukhopadhyay, Katherine Gurdziel & Nikhlesh K. Singh. (2023) Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization. Communications Biology 6:1.
Crossref
R. Ganugula, M. Arora, S. Dwivedi, D. S. Chandrashekar, S. Varambally, E. M. Scott & M. N. V. Ravi Kumar. (2023) Systemic Anti-Inflammatory Therapy Aided by Curcumin-Laden Double-Headed Nanoparticles Combined with Injectable Long-Acting Insulin in a Rodent Model of Diabetes Eye Disease. ACS Nano 17:7, pages 6857-6874.
Crossref
Deepti Sharma, Geetika Kaur, Shivantika Bisen, Anamika Sharma, Ahmed S. Ibrahim & Nikhlesh K. Singh. (2023) IL-33 via PKCμ/PRKD1 Mediated α-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage. Cells 12:5, pages 703.
Crossref
Fen Tang, Kongqian Huang, Biyan Peng, Wen Deng, Ning Su, Fan Xu, Mingyuan Zhang & Haibin Zhong. (2023) RhoA/ROCK Signaling Is Involved in Pathological Retinal Neovascularization. Journal of Vascular Research 60:4, pages 183-192.
Crossref
María Constanza Paz, Cristian Alan Rossetti, María Lina Formica & Santiago Daniel Palma. 2023. Nanotechnology in Ophthalmology. Nanotechnology in Ophthalmology 285 304 .
D. Pereira-Figueiredo, A. A. Nascimento, M. C. Cunha-Rodrigues, R. Brito & K. C. Calaza. (2021) Caffeine and Its Neuroprotective Role in Ischemic Events: A Mechanism Dependent on Adenosine Receptors. Cellular and Molecular Neurobiology 42:6, pages 1693-1725.
Crossref
K.D. Patel, L. Barrios Silva, Y. Park, T. Shakouri, Z. Keskin-Erdogan, P. Sawadkar, K.J. Cho, J.C. Knowles, D.Y.S. Chau & H.-W. Kim. (2022) Recent advances in drug delivery systems for glaucoma treatment. Materials Today Nano 18, pages 100178.
Crossref
Yixin Yu, Yu Qin, Julia Fu, Yanxiu Li, Wei Zhang, Tianye Zhu, Longtan Jiang, Xueding Wang & Yannis M. Paulus. (2021) Long-term multimodal imaging characterization of persistent retinal neovascularization using DL-alpha-aminoadipic acid in pigmented and white rabbits. Experimental Eye Research 207, pages 108577.
Crossref
Zijing Huang, Tsz Kin Ng, Weiqi Chen, Xiaowei Sun, Dingguo Huang, Dezhi Zheng, Jingsheng Yi, Yanxuan Xu, Xi Zhuang & Shaolang Chen. (2021) Nattokinase Attenuates Retinal Neovascularization Via Modulation of Nrf2/HO-1 and Glial Activation. Investigative Opthalmology & Visual Science 62:6, pages 25.
Crossref
Shibani Supe, Archana Upadhya & Kavita Singh. (2021) Role of small interfering RNA (siRNA) in targeting ocular neovascularization: A review. Experimental Eye Research 202, pages 108329.
Crossref
Wei Xu, Weijing Cheng, Xiaoyuan Cui & Guoxing Xu. (2020) Therapeutic effect against retinal neovascularization in a mouse model of oxygen-induced retinopathy: bone marrow-derived mesenchymal stem cells versus Conbercept. BMC Ophthalmology 20:1.
Crossref
Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Shubhra Rajpurohit, Diana R. Gutsaeva, Brian K. Stansfield, Pamela M. Martin & Manuela Bartoli. (2020) Ursodeoxycholic Acid Halts Pathological Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy. Journal of Clinical Medicine 9:6, pages 1921.
Crossref
Kazutaka Hirabayashi, Shinji Kakihara, Masaaki Tanaka, Takayuki Shindo & Toshinori Murata. (2020) Investigation of the therapeutic mechanism of subthreshold micropulse laser irradiation in retina. Graefe's Archive for Clinical and Experimental Ophthalmology 258:5, pages 1039-1047.
Crossref
Jian-Min Lu, Zhen-Zhen Zhang, Xiang Ma, Shi-Feng Fang & Xiu-Hong Qin. (2020) Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. Experimental Eye Research 190, pages 107886.
Crossref
Priyanka Bhatt, Shannon Kelly & Vijaykumar Sutariya. (2019) Nanoscale delivery systems in treatment of posterior ocular neovascularization: strategies and potential applications. Therapeutic Delivery 10:11, pages 737-747.
Crossref
Nathalie Tisch, Aida Freire-Valls, Rosario Yerbes, Isidora Paredes, Silvia La Porta, Xiaohong Wang, Rosa Martín-Pérez, Laura Castro, Wendy Wei-Lynn Wong, Leigh Coultas, Boris Strilic, Hermann-Josef Gröne, Thomas Hielscher, Carolin Mogler, Ralf H. Adams, Peter Heiduschka, Lena Claesson-Welsh, Massimiliano Mazzone, Abelardo López-Rivas, Thomas Schmidt, Hellmut G. Augustin & Carmen Ruiz de Almodovar. (2019) Caspase-8 modulates physiological and pathological angiogenesis during retina development. Journal of Clinical Investigation 129:12, pages 5092-5107.
Crossref
Michel Desjarlais, Jose Carlos Rivera, Isabelle Lahaie, Gaël Cagnone, Maëlle Wirt, Samy Omri & Sylvain Chemtob. (2019) MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model. PLOS ONE 14:6, pages e0218282.
Crossref
Maria Troullinaki, Vasileia‐Ismini Alexaki, Ioannis Mitroulis, Anke Witt, Anne Klotzsche–von Ameln, Kyoung‐Jin Chung, Triantafyllos Chavakis & Matina Economopoulou. (2019) Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis. Journal of Cellular and Molecular Medicine 23:4, pages 2362-2371.
Crossref
Wei Zhang, Yanxiu Li, Van Phuc Nguyen, Ziyi Huang, Zhipeng Liu, Xueding Wang & Yannis M. Paulus. (2018) High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization. Light: Science & Applications 7:1.
Crossref
Yong Li, Joanna Marie Busoy, Ben Alfyan Achirn Zaman, Queenie Shu Woon Tan, Gavin Siew Wei Tan, Veluchamy Amutha Barathi, Ning Cheung, Jay Ji-Ye Wei, Walter Hunziker, Wanjin Hong, Tien Yin Wong & Chui Ming Gemmy Cheung. (2018) A novel model of persistent retinal neovascularization for the development of sustained anti-VEGF therapies. Experimental Eye Research 174, pages 98-106.
Crossref
Modesto A. Rojas, Zu T. Shen, Ruth B. Caldwell & Alexander B. Sigalov. (2018) Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:9, pages 2761-2768.
Crossref
Cong Wang, Seung-Jun Seo, Jin-Seong Kim, Se-Hee Lee, Jae-Kun Jeon, Jae-Woo Kim, Ki-Hong Kim, Jong-Ki Kim & Jungyul Park. (2018) Intravitreal implantable magnetic micropump for on-demand VEGFR-targeted drug delivery. Journal of Controlled Release 283, pages 105-112.
Crossref
Ailing Sui, Yisheng Zhong, Anna M. Demetriades, Qing Lu, Yujuan Cai, Yushuo Gao, Yanji Zhu, Xi Shen & Bing Xie. (2018) Inhibition of integrin α5β1 ameliorates VEGF-induced retinal neovascularization and leakage by suppressing NLRP3 inflammasome signaling in a mouse model. Graefe's Archive for Clinical and Experimental Ophthalmology 256:5, pages 951-961.
Crossref
Alexander B. Sigalov. 2018. Protein-Protein Interactions in Human Disease, Part B. Protein-Protein Interactions in Human Disease, Part B 61 99 .
Joel Fulton, Bismoy Mazumder, Jonathan B Whitchurch, Cintia J Monteiro, Hilary M Collins, Chun M Chan, Maria P Clemente, Miguel Hernandez-Quiles, Elizabeth A Stewart, Winfried M Amoaku, Paula M Moran, Nigel P Mongan, Jenny L Persson, Simak Ali & David M Heery. (2017) Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations. Cell Death & Disease 8:3, pages e2677-e2677.
Crossref
Yujuan Cai, Wei Tan, Xi Shen, Yanji Zhu, Yushuo Gao, Ailing Sui, Qing Lu, Yisheng Zhong & Bing Xie. (2016) Neutralization of IL-23 depresses experimental ocular neovascularization. Experimental Eye Research 146, pages 242-251.
Crossref
Yun Mi Lee, Chan-Sik Kim, Kyuhyung Jo, Eun Jin Sohn, Jin Sook Kim & Junghyun Kim. (2015) Inhibitory effect of Samul-tang on retinal neovascularization in oxygen-induced retinopathy. BMC Complementary and Alternative Medicine 15:1.
Crossref
Joana F. Fangueiro, Amélia M. Silva, Maria L. Garcia & Eliana B. Souto. (2015) Current nanotechnology approaches for the treatment and management of diabetic retinopathy. European Journal of Pharmaceutics and Biopharmaceutics 95, pages 307-322.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.