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Expert Review of Anticancer Therapy Volume 10, 2010 - Issue 9
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Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas

Fatih M Uckun Developmental Therapeutics Program, Institute for Pediatric Clinical Research, Children’s Hospital Los Angeles, MS#57, Los Angeles, CA 90027, USA. [email protected]; Division of Hematology-Oncology, Department of Pediatrics, Children’s Center for Cancer and Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA 90027-0367, USA; Developmental Therapeutics Program, Institute for Pediatric Clinical Research, Children’s Hospital Los Angeles, MS#57, Los Angeles, CA 90027, USA. [email protected]; Division of Hematology-Oncology, Department of Pediatrics, Children’s Center for Cancer and Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA 90027-0367, USA
&
Sanjive Qazi Gustavus Adolphus College, 800 W. College Avenue, St Peter, MN 56082, USA; Gustavus Adolphus College, 800 W. College Avenue, St Peter, MN 56082, USA
Pages 1407-1418 | Published online: 10 Jan 2014

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Ciprian Tomuleasa, Cornelia Braicu, Alexandra Irimie, Lucian Craciun & Ioana Berindan-Neagoe. (2014) Nanopharmacology in translational hematology and oncology. International Journal of Nanomedicine 9, pages 3465-3479.
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Osmond J D'Cruz & Fatih M Uckun. (2013) Protein kinase inhibitors against malignant lymphoma. Expert Opinion on Pharmacotherapy 14:6, pages 707-721.
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Matthew Kyle Hadden. (2013) Hedgehog pathway inhibitors: a patent review (2009 – present). Expert Opinion on Therapeutic Patents 23:3, pages 345-361.
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Tadeusz Robak & Ewa Robak. (2012) Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders. Expert Opinion on Investigational Drugs 21:7, pages 921-947.
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Dimitar G Efremov & Luca Laurenti. (2011) The Syk kinase as a therapeutic target in leukemia and lymphoma. Expert Opinion on Investigational Drugs 20:5, pages 623-636.
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Articles from other publishers (17)

Ezzatollah Fathi, Raheleh Farahzadi, Soheila Montazersaheb & Yasin Bagheri. (2021) Epigenetic Modifications in Acute Lymphoblastic Leukemia: From Cellular Mechanisms to Therapeutics. Current Gene Therapy 21:1, pages 60-71.
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Kathleen W. Phelan & Anjali S. Advani. (2018) Novel Therapies in Acute Lymphoblastic Leukemia. Current Hematologic Malignancy Reports 13:4, pages 289-299.
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Mustafa A. Barbhuiya, Manoj K. Kashyap, Vinuth N. Puttamallesh, Rekha Vijay Kumar, Xinyan Wu, Akhilesh Pandey & Harsha Gowda. (2018) Identification of spleen tyrosine kinase as a potential therapeutic target for esophageal squamous cell carcinoma using reverse phase protein arrays. Oncotarget 9:26, pages 18422-18434.
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Virginie Y. Martiny, François Martz, Edithe Selwa & Bogdan I. Iorga. (2015) Blind Pose Prediction, Scoring, and Affinity Ranking of the CSAR 2014 Dataset. Journal of Chemical Information and Modeling 56:6, pages 996-1003.
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Fatih M. Uckun, Dorothea E. Myers, Jianjun Cheng & Sanjive Qazi. (2015) Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice. EBioMedicine 2:6, pages 554-562.
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Connor A. Wathen, Chuck Caldwell, Nripen Chanda, Anandhi Upendran, Ajit Zambre, Zahra Afrasiabi, Sarah E. Chapaman, Nathan Foje, W. Matthew Leevy & Raghuraman Kannan. (2015) Selective X-ray contrast enhancement of the spleen of living mice mediated by gold nanorods. Contrast Media & Molecular Imaging 10:3, pages 188-193.
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Fatih M. Uckun, Hong Ma, Zahide Ozer, Patricia Goodman, Jian Zhang & Sanjive Qazi. (2014) A Previously Unknown Unique Challenge for Inhibitors of SYK ATP-Binding Site: Role of SYK as A Cell Cycle Checkpoint Regulator. EBioMedicine 1:1, pages 16-28.
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Fatih M. Uckun & Sanjive Qazi. (2014) SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia. Journal of Cancer Therapy 05:01, pages 124-131.
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Dorothea E. Myers, Seang Yiv, Sanjive Qazi, Hong Ma, Ingrid Cely, Anoush Shahidzadeh, Martha Arellano, Erin Finestone, Paul S. Gaynon, Amanda Termuhlen, Jianjun Cheng & Fatih M. Uckun. (2014) CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells. Integr. Biol. 6:8, pages 766-780.
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Jonathan Hsu, Jun Zhang, Chris Kitson, Seng-Lai Tan, Satwant Narula, Julie A. DeMartino & Cheng Liao. (2013) Development of a Pharmacodynamic Assay Based on PLCγ2 Phosphorylation for Quantifying Spleen Tyrosine Kinase (SYK)–Bruton’s Tyrosine Kinase (BTK) Signaling. SLAS Discovery 18:8, pages 890-898.
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Fatih M. UckunSanjive QaziIngrid CelyKazim Sahin, Anoush ShahidzadehIbrahim OzercanQian Yin, Paul Gaynon, Amanda Termuhlen, Jianjun Cheng & Seang Yiv. (2013) Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia. Blood 121:21, pages 4348-4354.
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Keith J. August, Aru Narendran & Kathleen A. Neville. (2013) Pediatric Relapsed or Refractory Leukemia: New Pharmacotherapeutic Developments and Future Directions. Drugs 73:5, pages 439-461.
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Lincan Duan, Lianhua Ye, Guangqiang Zhao, Zhengwei Wu, Congguo Jin, Xinyi Cai & Gaofeng Li. (2013) Serum spleen tyrosine kinase and vascular endothelial growth factor-C levels predict lymph node metastasis of oesophageal squamous cell carcinoma. European Journal of Cardio-Thoracic Surgery 43:3, pages e58-e63.
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Fatih M. UckunHong MaJian ZhangZahide OzerSinisa DovatCheney MaoRita IshkhanianPatricia Goodman & Sanjive Qazi. (2012) Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proceedings of the National Academy of Sciences 109:44, pages 18072-18077.
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Ingrid Cely, Seang Yiv, Qian Yin, Anoush Shahidzadeh, Li Tang, Jianjun Cheng & Fatih M. Uckun. (2012) Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles. Journal of Analytical Oncology 1:1, pages 1-9.
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Fatih M. Uckun, Sanjive Qazi, Zahide Ozer, Amanda L. Garner, Jason Pitt, Hong Ma & Kim D. Janda. (2011) Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. British Journal of Haematology 153:6, pages 741-752.
Crossref
Susette C. Mueller & Peter J. Coopman. 2011. Encyclopedia of Cancer. Encyclopedia of Cancer 3589 3592 .

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