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Clinical Trial Report

The LUX-Lung clinical trial program of afatinib for non-small-cell lung cancer

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Pages 673-682 | Published online: 10 Jan 2014

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Ana P. S. Silva, Priscila V. Coelho, Maristella Anazetti & Patricia U. Simioni. (2017) Targeted therapies for the treatment of non-small-cell lung cancer: Monoclonal antibodies and biological inhibitors. Human Vaccines & Immunotherapeutics 13:4, pages 843-853.
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Alanood S Almurshedi, Mahasen A Radwan, Bushra Al Quadeib, Basmah Aldosari, Iman M Alfagih & Salma S Almarshidy. (2023) Pharmacokinetics of Afatinib after Intravenous and Oral Administrations in Rats Using Validated UPLC MS/MS Assay. Journal of Chromatographic Science.
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Seyyed Mortaza Haghgoo, Abdolamir Allameh, Esmaeil Mortaz, Johan Garssen, Gert Folkerts, Peter J. Barnes & Ian M. Adcock. (2015) Pharmacogenomics and targeted therapy of cancer: Focusing on non-small cell lung cancer. European Journal of Pharmacology 754, pages 82-91.
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Robert Pirker. (2015) What is the best strategy for targeting EGF receptors in non-small-cell lung cancer?. Future Oncology 11:1, pages 153-167.
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Sarah A. Hayes, Amanda L. Hudson, Stephen J. Clarke, Mark P. Molloy & Viive M. Howell. (2014) From mice to men: GEMMs as trial patients for new NSCLC therapies. Seminars in Cell & Developmental Biology 27, pages 118-127.
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Wenhua Liang, Xuan Wu, Wenfeng Fang, Yuanyuan Zhao, Yunpeng Yang, Zhihuang Hu, Cong Xue, Jing Zhang, Jianwei Zhang, Yuxiang Ma, Ting Zhou, Yue Yan, Xue Hou, Tao Qin, Xiaoxiao Dinglin, Ying Tian, Peiyu Huang, Yan Huang, Hongyun Zhao & Li Zhang. (2014) Network Meta-Analysis of Erlotinib, Gefitinib, Afatinib and Icotinib in Patients with Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations. PLoS ONE 9:2, pages e85245.
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Gillian M. Keating. (2014) Afatinib: A Review of Its Use in the Treatment of Advanced Non-Small Cell Lung Cancer. Drugs 74:2, pages 207-221.
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Massimo Di MaioCesare Gridelli, Francesco Grossi, Silvia Novello & Filippo de Marinis. (2013) Afatinib in advanced non-small-cell lung cancer. Lung Cancer Management 2:6, pages 493-504.
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Rosselle T. Dungo & Gillian M. Keating. (2013) Afatinib: First Global Approval. Drugs 73:13, pages 1503-1515.
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Kyle W. Robinson & Alan B. Sandler. (2013) EGFR Tyrosine Kinase Inhibitors: Difference in Efficacy and Resistance. Current Oncology Reports 15:4, pages 396-404.
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Fadi S. Farhat & Wissam Houhou. (2013) Targeted therapies in non-small cell lung carcinoma: what have we achieved so far?. Therapeutic Advances in Medical Oncology 5:4, pages 249-270.
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Pascale Tomasini, Laurent Greillier & Fabrice Barlesi. (2012) Advanced non-squamous non-small-cell lung cancer: who and when should be biologically screened today? Tomorrow?. Current Respiratory Care Reports 2:1, pages 17-21.
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Michael Boyer, Pasi Antero Jänne, Tony Mok, Kenneth O’Byrne, Luis Paz-Ares, Suresh S Ramalingam, Jane Liang, Ian Taylor, Alicyn Campbell, Joseph O’Connell, Stephen Letrent & Vladan Antic. (2013) Rationale and study design of ARCHER: a randomized, double-blind, Phase III study of dacomitinib versus erlotinib for advanced non-small-cell lung cancer. Clinical Investigation 3:1, pages 29-35.
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Philip T. CagleTimothy Craig Allen. (2012) Lung Cancer Genotype-Based Therapy and Predictive Biomarkers: Present and Future. Archives of Pathology & Laboratory Medicine 136:12, pages 1482-1491.
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Amartej Merla & Sanjay Goel. (2012) Novel Drugs Targeting the Epidermal Growth Factor Receptor and Its Downstream Pathways in the Treatment of Colorectal Cancer: A Systematic Review. Chemotherapy Research and Practice 2012, pages 1-11.
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Caicun Zhou. 2012. Lung Cancer Therapy Annual 7. Lung Cancer Therapy Annual 7 75 84 .
Vincent Fallet, Anne-Marie Ruppert, Virginie Poulot, Roger Lacave, Laure Belmont, Martine Antoine, Jacques Cadranel, Marie Wislez & Armelle Lavolé. (2012) Secondary Resistance to Erlotinib: Acquired T790M Mutation and Small-Cell Lung Cancer Transformation in the Same Patient. Journal of Thoracic Oncology 7:6, pages 1061-1063.
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