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Drug Profile

Bivalirudin: a review of the pharmacology and clinical application

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Pages 1673-1681 | Published online: 10 Jan 2014

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Vera S. Chernonosova, Alexander A. Gostev, Yuriy A. Chesalov, Andrey A. Karpenko, Alexander M. Karaskov & Pavel P. Laktionov. (2019) Study of hemocompatibility and endothelial cell interaction of tecoflex-based electrospun vascular grafts. International Journal of Polymeric Materials and Polymeric Biomaterials 68:1-3, pages 34-43.
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Jianguo Zhang & Nana Lan. (2018) Hirudin variants production by genetic engineered microbial factory. Biotechnology and Genetic Engineering Reviews 34:2, pages 261-280.
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Articles from other publishers (38)

Stefano Benenati, Giovanni Luigi De Maria, Francesco Della Mora, Leonardo Portolan, Rafail Kotronias, Rajesh K. Kharbanda, Italo Porto & Adrian P. Banning. (2023) Periprocedural antithrombotic strategies in acute coronary syndromes undergoing percutaneous coronary intervention: Have we discarded bivalirudin too soon?. Cardiovascular Revascularization Medicine 57, pages 70-79.
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Ana Novo de Oliveira, Andreimar Martins Soares & Saulo Luís Da Silva. (2023) Why to Study Peptides from Venomous and Poisonous Animals?. International Journal of Peptide Research and Therapeutics 29:5.
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Yaowei Tong, Julaiti Rouzhahong, Wangtao Zhou, Rui Wang, Yuqiang Wang, Yucheng Ren, Ju Guo, Ying Li, Zhengkai Wang & Yunlin Song. (2023) Comparison of bivalirudin versus heparin in adult extracorporeal membrane oxygenation anticoagulant therapy: A retrospective case-control study. The International Journal of Artificial Organs 46:3, pages 162-170.
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Brittany Salter & Mark Crowther. (2022) A Historical Perspective on the Reversal of Anticoagulants. Seminars in Thrombosis and Hemostasis 48:08, pages 955-970.
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Marco Heestermans, Géraldine Poenou, Hind Hamzeh-Cognasse, Fabrice Cognasse & Laurent Bertoletti. (2022) Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications. Cells 11:20, pages 3214.
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Sasa Rajsic, Robert Breitkopf, Dragana Jadzic, Marina Popovic Krneta, Helmuth Tauber & Benedikt Treml. (2022) Anticoagulation Strategies during Extracorporeal Membrane Oxygenation: A Narrative Review. Journal of Clinical Medicine 11:17, pages 5147.
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Roman M. Sniecinski, Vance G. Nielsen & Kenichi Tanaka. (2022) Searching for an Alternate Anticoagulant for Cardiopulmonary Bypass: Does Two Plus Two Equal Two?. Anesthesia & Analgesia 135:1, pages 49-51.
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Jeremy Daugherty, Caroline Heyrend, Michael Profsky, Brent Kay, Christina VanderPluym, Eric R. Griffiths & Lindsay J. May. (2020) Time in Therapeutic Range for Bivalirudin Among Pediatric Ventricular Assist Device Recipients. ASAIO Journal 67:5, pages 588-593.
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Donald J. AbrahamMimi L. Quan, Peter W. Glunz & Joseph M. Luettgen. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 45 .
Tomasz Urbanowicz, Anna Olasińska-Wiśniewska, Marcin Ligowski, Ewa Goszczyńska & Marek Jemielity. (2021) Bivalirudin resistance during heart transplantation surgery.. Transplantation Reports 6:1, pages 100072.
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Andrea Montisci, Giancarlo Micheletto, Serena Sibilio, Francesco Donatelli, Maurizio Tespili, Carlo Banfi, Francesco Casilli, Daniele Cosseta, Antonio Miceli, Silvia Cirri & Federico Pappalardo. (2020) Impella 5.0 supported oncological surgery as bridge to LVAD. ESC Heart Failure 8:1, pages 167-170.
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Sukhdeep Bhogal, Debabrata Mukherjee, Jayant Bagai, Huu T. Truong, Hemang B. Panchal, Ghulam Murtaza, Mustafa Zaman, Rajesh Sachdeva & Timir K. Paul. (2020) Bivalirudin Versus Heparin During Intervention in Acute Coronary Syndrome: A Systematic Review of Randomized Trials. Cardiovascular & Hematological Disorders-Drug Targets 20:1, pages 3-15.
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Yan K. Gernhofer, Dalia A. Banks, Eugene Golts & Victor Pretorius. (2020) Novel Use of Cangrelor With Heparin During Cardiopulmonary Bypass in Patients With Heparin-Induced Thrombocytopenia Who Require Cardiovascular Surgery: A Case Series. Seminars in Thoracic and Cardiovascular Surgery 32:4, pages 763-769.
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Rahman Shah, Samuel B. Latham, Jennifer M. Porta, Arshi Naz, Khalid Matin & Sunil V. Rao. (2019) Bivalirudin with a post‐procedure infusion versus heparin monotherapy for the prevention of stent thrombosis. Catheterization and Cardiovascular Interventions 94:2, pages 210-215.
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Danny Eytan & Gail M. Annich. 2019. Pediatric Critical Care. Pediatric Critical Care 231 241 .
David Stepensky. (2018) Pharmacokinetics of Toxin-Derived Peptide Drugs. Toxins 10:11, pages 483.
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Juan Kuang, Lan Li, Xiang Ma, Jihong Gan & Shubin Jiang. (2018) Efficacy and Safety of Bivalirudin Plus Half/Full Dose of Tirofiban in Patients Undergoing Emergency Percutaneous Coronary Intervention. International Journal of Pharmacology 14:4, pages 506-512.
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Chenguang Li, Rende Xu, Yi Shen, Yuxiang Dai, Feng Zhang, Jianying Ma, Lei Ge, Juying Qian & Junbo Ge. (2018) Bivalirudin in percutaneous coronary intervention for chronic total occlusion: A single-center pilot study. Catheterization and Cardiovascular Interventions 91:4, pages 679-685.
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Nilay K. Patel & Sammy Elmariah. 2018. Anticoagulation Therapy. Anticoagulation Therapy 197 216 .
Rahman Shah, Khalid Matin, Kelly C. Rogers & Sunil V. Rao. (2017) Effect of post-primary percutaneous coronary intervention bivalirudin infusion on net adverse clinical events and mortality: A comprehensive pairwise and network meta-analysis of randomized controlled trials. Catheterization and Cardiovascular Interventions 90:2, pages 196-204.
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Heyang Wang, Zhenyang Liang, Yi Li, Bin Li, Junming Liu, Xueyi Hong, Xin Lu, Jiansheng Wu, Wei Zhao, Qiang Liu, Jian An, Linfeng Li, Fanli Pu, Qiang Ming & Yaling Han. (2017) Effect of postprocedural full-dose infusion of bivalirudin on acute stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: Outcomes in a large real-world population. Cardiovascular Therapeutics 35:3, pages e12251.
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Ožbej Zupančič, Julia Anita Grießinger, Hung Thanh Lam & Andreas Bernkop-Schnürch. (2017) Storage Stability of Bivalirudin: Hydrophilic Versus Lipophilic Solutions. Journal of Pharmaceutical Sciences 106:5, pages 1322-1330.
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Rahman Shah, Kelly C. Rogers, Agha J. Ahmed, Bryan J. King & Sunil V. Rao. (2016) Effect of Post–Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis. JACC: Cardiovascular Interventions 9:13, pages 1313-1320.
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Zhuguo Liu, Zheng Yu, Yuanyuan Huang, Yan Zhang, Guozhu Han, Xian Li, Mingxin Dong, Shuo Yu, Yu Wang, Jie Hu, Huiqin Guo, Yuanguo Cheng, Li Lv & Qiuyun Dai. (2015) A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity. Scientific Reports 5:1.
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Roman M. Sniecinski & Jerrold H. Levy. (2015) Anticoagulation management associated with extracorporeal circulation. Best Practice & Research Clinical Anaesthesiology 29:2, pages 189-202.
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J. Harenberg, V. A.-T. Hentschel, S. Du, S. Zolfaghari, R. Krämer, C. Weiss, B. K. Krämer & M. Wehling. (2017) Anticoagulation in patients with impaired renal function and with haemodialysis. Hämostaseologie 35:01, pages 77-83.
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Marc Aldenkortt & Marc Licker. 2015. Perioperative Hemostasis. Perioperative Hemostasis 391 417 .
Lynne M. Sylvia, Linda Ordway, Duc T. Pham, David DeNofrio & Michael Kiernan. (2014) Bivalirudin for Treatment of LVAD Thrombosis. ASAIO Journal 60:6, pages 744-747.
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Mehdi Ben Saida & Sami Guermazi. (2013) Thrombopénies induites par l’héparine. Revue Francophone des Laboratoires 2013:457, pages 51-59.
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Anne M. Winkler & Christopher A. Tormey. (2013) Pathology Consultation on Monitoring Direct Thrombin Inhibitors and Overcoming Their Effects in Bleeding Patients. American Journal of Clinical Pathology 140:5, pages 610-622.
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Barry S. Coller. (2012) Translating from the rivers of Babylon to the coronary bloodstream. Journal of Clinical Investigation 122:11, pages 4293-4299.
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Ziad Sergie, Roxana Mehran & Gregg W. Stone. (2012) What is the optimal antithrombotic strategy in primary percutaneous coronary intervention?. Current Opinion in Cardiology 27:4, pages 361-367.
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Falk Rohrbach, Maha I. Fatthalla, Tina Kupper, Bernd Pötzsch, Jens Müller, Michael Petersen, Erik B. Pedersen & Günter Mayer. (2012) Chemical Maturation of a Bivalent Aptamer by Single Domain Variation. ChemBioChem 13:5, pages 631-634.
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Glenn M. LaMuraglia, Rabih Houbballah & Michael Laposata. (2012) The identification and management of heparin-induced thrombocytopenia in the vascular patient. Journal of Vascular Surgery 55:2, pages 562-570.
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Linda Shore-Lesserson & Liza J. Enriquez. (2012) Hematological Issues in Cardiovascular Surgery Patients. ASA Refresher Courses in Anesthesiology 40:1, pages 129-135.
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Roman M. Sniecinski & Wayne L. Chandler. (2011) Activation of the Hemostatic System During Cardiopulmonary Bypass. Anesthesia & Analgesia 113:6, pages 1319-1333.
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John G.T. Augoustides. (2011) Update in Hematology: Heparin-Induced Thrombocytopenia and Bivalirudin. Journal of Cardiothoracic and Vascular Anesthesia 25:2, pages 371-375.
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Dongmei Zhang, Zining Wang, Xia Zhao, Wei Lu, Jingkai Gu & Yimin Cui. (2011) Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Single Doses of Bivalirudin in Healthy Chinese Subjects. Biological and Pharmaceutical Bulletin 34:12, pages 1841-1848.
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