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Expert Review of Cardiovascular Therapy Volume 10, 2012 - Issue 1
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Drug Profile

Carvedilol: a third-generation β-blocker should be a first-choice β-blocker

James J DiNicolantonio Wegmans Pharmacy, 500 South Meadow Street, Ithaca, NY 14850, USA. [email protected]; Wegmans Pharmacy, 500 South Meadow Street, Ithaca, NY 14850, USA. [email protected]
&
Daniel G Hackam Division of Clinical Pharmacology, Department of Medicine, and Departments of Clinical Neurological Sciences and Epidemiology & Biostatistics, University of Western Ontario Stroke Prevention and Atherosclerosis Research Centre (SPARC), Robarts Research Institute, and the Premature Atherosclerosis Program, London Health Sciences Centre, London, ON, Canada; Division of Clinical Pharmacology, Department of Medicine, and Departments of Clinical Neurological Sciences and Epidemiology & Biostatistics, University of Western Ontario Stroke Prevention and Atherosclerosis Research Centre (SPARC), Robarts Research Institute, and the Premature Atherosclerosis Program, London Health Sciences Centre, London, ON, Canada
Pages 13-25 | Published online: 10 Jan 2014

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Steven G. Chrysant & George S. Chrysant. (2022) Antihypertensive and cardioprotective effects of three generations of beta-adrenergic blockers: an historical perspective. Hospital Practice 50:3, pages 196-202.
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James J. DiNicolantonio, Flavio D. Fuchs & James H. O'Keefe. (2014) It Takes the Right Medications to Prevent a Million Heart Attacks and Strokes. Postgraduate Medicine 126:7, pages 164-167.
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Articles from other publishers (26)

Chunye Zhang, Jiazheng Liu, Yuxiang Sui, Shuai Liu & Ming Yang. (2023) In silico drug repurposing carvedilol and its metabolites against SARS-CoV-2 infection using molecular docking and molecular dynamic simulation approaches. Scientific Reports 13:1.
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Maha Sabry, Seham Mostafa, Samaa Kamar, Laila Rashed & Suzanne Estaphan. (2021) The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis. PLOS ONE 16:10, pages e0258254.
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Ping-Hsun Wu, Yi-Ting Lin, Jia-Sin Liu, Yi-Chun Tsai, Mei-Chuan Kuo, Yi-Wen Chiu, Shang-Jyh Hwang & Juan-Jesus Carrero. (2021) Comparative effectiveness of bisoprolol and carvedilol among patients receiving maintenance hemodialysis. Clinical Kidney Journal 14:3, pages 983-990.
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Maha Sabry, Seham Mostafa, Laila Rashed, Marwa Abdelgwad, Samaa Kamar & Suzanne Estaphan. (2021) Matrix metalloproteinase 9 a potential major player connecting atherosclerosis and osteoporosis in high fat diet fed rats. PLOS ONE 16:2, pages e0244650.
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James T. Pearson, Hamish P. Thambyah, Mark T. Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P. Ngo, Connie P.C. Ow, Takashi Sonobe, Yi Ching Chen, Amanda J. Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J. Kelly, Hirotsugu Tsuchimochi & Mikiyasu Shirai. (2021) β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat. Clinical Science 135:2, pages 327-346.
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Misuzu Nakanishi, Akira Kuriyama & Mutsuo Onodera. (2019) Persistent wheezing caused by carvedilol overdose in a non‐asthmatic man. Acute Medicine & Surgery 7:1.
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Ting Wu, Haixin Li, Qunsheng Lan, Ze‐an Zhao, Ying Cao, Pingzheng Zhou, Shanhe Wan, Jiajie Zhang, Hong Jiang, Qun Zhang & Jianxin Pang. (2019) Protective effects of S ‐carvedilol on doxorubicin‐induced damages to human umbilical vein endothelial cells and rats . Journal of Applied Toxicology 39:8, pages 1233-1244.
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Rui Zhang, Ling-Jun Jie, Wei-Yin Wu, Zhi-Quan Wang, Hai-Ying Sun, Guo-Sheng Xiao, Yan Wang, Yi-Gang Li & Gui-Rong Li. (2019) Comparative study of carvedilol and quinidine for inhibiting hKv4.3 channel stably expressed in HEK 293 cells. European Journal of Pharmacology 853, pages 74-83.
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Ying Cao, Shujun Chen, Yemei Liang, Ting Wu, Jianxin Pang, Shuwen Liu & Pingzheng Zhou. (2018) Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels by β-blocker carvedilol. British Journal of Pharmacology 175:20, pages 3963-3975.
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Bruna Eibel, Melissa Kristochek, Thiago R. Peres, Lucinara D. Dias, Daniela R. Dartora, Karina R. Casali, Renato A. K. Kalil, Alexandre M. Lehnen, Maria Claudia Irigoyen & Melissa M. Markoski. (2018) β-blockers interfere with cell homing receptors and regulatory proteins in a model of spontaneously hypertensive rats. Cardiovascular Therapeutics 36:4, pages e12434.
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Hamish CG Prosser, Cynthia Gregory, Dagmara Hering, Graham S Hillis, Greg Perry, Johan Rosman, Carl Schultz, Mark Thomas, Gerald F Watts & Markus P Schlaich. (2017) Preferred Fourth-Line Pharmacotherapy for Resistant Hypertension: Are We There Yet?. Current Hypertension Reports 19:4.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 201 214 .
Lucília N. Diogo, Sofia A. Pereira, Ana R. Nunes, Ricardo A. Afonso, Ana I. Santos & Emília C. Monteiro. (2015) Efficacy of carvedilol in reversing hypertension induced by chronic intermittent hypoxia in rats. European Journal of Pharmacology 765, pages 58-67.
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Jingqun ZhangQiang ZhouChris D. Smith, Haiyan ChenZhen TanBiyi ChenAlma NaniGuogen WuLong-Sheng SongMichael FillThomas G. Back & S.R. Wayne Chen. (2015) Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure. Biochemical Journal 470:2, pages 233-242.
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James J DiNicolantonio, Hassan Fares, Asfandyar K Niazi, Saurav Chatterjee, Fabrizio D'Ascenzo, Enrico Cerrato, Giuseppe Biondi-Zoccai, Carl J Lavie, David S Bell & James H O'Keefe. (2015) β-Blockers in hypertension, diabetes, heart failure and acute myocardial infarction: a review of the literature. Open Heart 2:1, pages e000230.
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Mazen Kurdi & George W. Booz. (2014) Carvedilol protects the infarcted heart by upregulating miR-133: First evidence that disease state affects β-adrenergic arrestin-biased signaling?. Journal of Molecular and Cellular Cardiology 76, pages 12-14.
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Suzanne V. Arnold, John A. Spertus, Kasia J. Lipska, David E. Lanfear, Fengming Tang, Anna Grodzinsky, Darren K. McGuire, M. Odette Gore, Abhinav Goyal, Thomas M. Maddox & Mikhail Kosiborod. (2014) Type of ?-blocker use among patients with versus without diabetes after myocardial infarction. American Heart Journal 168:3, pages 273-279.e1.
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James J. DiNicolantonio, Craig J. Beavers, Arthur R. Menezes, Carl J. Lavie, James H. O'Keefe, Pascal Meier, András Vorobcsuk, Dániel Aradi, András Komócsi, Saurav Chatterjee, Fabrizio D'Ascenzo, Mauro Gasparini, Jasper Brugts & Giuseppe Biondi-Zoccai. (2014) Meta-Analysis Comparing Carvedilol Versus Metoprolol for the Prevention of Postoperative Atrial Fibrillation Following Coronary Artery Bypass Grafting. The American Journal of Cardiology 113:3, pages 565-569.
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A. Nobili, L. Pasina & R. Latini. 2014. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 267 273 .
Aleksandra Cati?-?or?evi?Valentina Nikoli?Slavoljub ?ivanovi?Nikola Stefanovi?Radmila Veli?kovi?-Radovanovi?. (2013) CARVEDILOL POPULATION PHARMACOKINETIC ANALYSIS ? APPLIED VALIDATION PROCEDURE. Acta medica medianae, pages 18-24.
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Catherine E. Erickson, Rukhsana Gul, Christopher P. Blessing, Jenny Nguyen, Tammy Liu, Lakshmi Pulakat, Murat Bastepe, Edwin K. Jackson & Bradley T. Andresen. (2013) The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist. PLoS ONE 8:8, pages e71980.
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Valentina N. Nikolic, Slobodan M. Jankovic, Radmila Velickovic-Radovanovlć, Svetlana Apostolovlć, Dragana Stanojevic, Slavoljub Zivanovic, Nikola Stefanovic, Srdjan Pesic, Tatjana Jevtovic-Stoimenov, Janko Djuric, Veroljub Markovic & Jasmina R. Milovanovic. (2013) Population Pharmacokinetics of Carvedilol in Patients with Congestive Heart Failure. Journal of Pharmaceutical Sciences 102:8, pages 2851-2858.
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. 2013. Essential Cardiac Electrophysiology. Essential Cardiac Electrophysiology 38 49 .
Paul M Vanhoutte & Yuansheng Gao. (2013) Beta blockers, nitric oxide, and cardiovascular disease. Current Opinion in Pharmacology 13:2, pages 265-273.
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Congxin Huang. (2013) The effects of carvedilol on cardiac structural remodeling: The role of endogenous nitric oxide in the activity of carvedilol. Molecular Medicine Reports.
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Stephen L. Belmonte & Burns C. Blaxall. (2012) Conducting the G-protein coupled receptor (GPCR) signaling symphony in cardiovascular diseases: New therapeutic approaches. Drug Discovery Today: Disease Models 9:3, pages e85-e90.
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