References
- Bristow MR, Ginsburg R, Umans V et al. β1- and β2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective β1-receptor down-regulation in heart failure. Circ. Res.59, 297–309 (1986).
- Packer M. Do β-blockers prolong survival in heart failure only by inhibiting the β1-receptor? A perspective on the results of the COMET Trial. J. Card. Fail.9, 429–443 (2003).
- Forster C, Armstrong PW. Pacing-induced heart failure in the dog: evaluation of peripheral vascular alpha-adrenoceptor subtypes. J. Cardiol. Pharmacol.16, 708–718 (1990).
- Hall JA, Kaumann AJ, Brown MJ. Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium. Circ. Res.66, 1610–1623 (1990).
- Motomura S, Deighton NM, Zerkowski HR et al. Chronic beta 1-adrenoceptor antagonist treatment sensitizes beta 2-adrenoceptors, but desensitizes M2-muscarinic receptors in the human right atrium. Br. J. Pharmacol.101, 363–369 (1990).
- Xu XL, Zang WJ, Lu J et al. Effects of carvedilol on M2 receptors and cholinesterase-positive nerves in adriamycin-induced rat failing heart. Auton. Neurosci.130, 6–16 (2006).
- Du XJ, Autelitano DJ, Dilley RJ et al. β2-adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis. Circulation101, 71–77 (2000).
- Grupp IL, Lorenz JN, Walsh RA et al. Overexpression of alpha1B-adrenergic receptor induces left ventricular dysfunction in the absenceof hypertrophy. Am. J. Physiol.275, H1338–H1350 (1998).
- Kaddoura S, Firth JD, Boheler KR et al. Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo. Acute effects of bosentan, an orally active, mixed endothelin ETA and ETB receptor antagonist. Circulation93, 2068–2079 (1996).
- Qin F, Rounds NK, Mao W et al. Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets. Cardiovasc. Res.51, 736–748 (2001).
- Ohlstein EH, Arleth AJ, Storer B et al. Carvedilol inhibits endothelin-1 biosynthesis in cultured human coronary artery endothelial cells. J. Mol. Cell. Cardiol.30, 167–173 (1998).
- Houle MS, Altschuld RA, Billman GE. Enhanced in vivo and in vitro contractile responses to beta(2)-adrenergic receptor stimulation in dogs susceptible to lethal arrhythmias. J. Appl. Physiol.91, 1627–1637 (2001).
- Lang CC, Rayos GH, Chomsky DB, Wood AJJ, Wilson JR. Effects of sympatho inhibition on exercise performance in heart failure. Circulation96, 238–245 (1997).
- Kindermann M, Maack C, Schaller S et al. Carvedilol but not metoprolol reduces β-adrenergic responsiveness after complete elimination from plasma in vivo. Circulation109, 3182–3190 (2004).
- Pini R, Cavallini MC, Palmieri V et al. Central but not brachial blood pressure predicts cardiovascular events in an unselected geriatric population: the ICARe Dicomano study. J. Am. Coll. Cardiol.51, 2432–2439 (2008).
- Polónia J, Barbosa L, Silva JA et al. Different patterns of peripheral versus central blood pressure in hypertensive patients treated with β-blockers either with or without vasodilator properties or with angiotensin receptor blockers. Blood Press. Monit.15(5), 235–239 (2010).
- The CAFÉ Investigators. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation113, 1213–1225 (2006).
- Williams B, Lacy PS. Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate. J. Am. Coll. Cardiol.54, 705–713 (2009).
- Packer M, Antonopoulos GV, Berlin JA et al. Comparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure: results of a meta-analysis. Am. Heart J.141, 899–907 (2001).
- The Captopril-Digoxin Multicenter Research Group. Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. JAMA59, 539–544 (1998).
- Cleland JG, Charlesworth A, Lubsen J et al. A comparison of the effects of carvedilol and metoprolol on well-being, morbidity, and mortality in patients with heart failure; a report from the Carvedilol or Metoprolol European Trial (COMET). J. Am. Coll. Cardiol.47, 1603–1611 (2006).
- Remme WJ, Cleland JG, Erhardt L et al. Effect of carvedilol and metoprolol on the mode of death in patients with heart failure. Eur. J. Heart Fail.9, 1128–1135 (2007).
- Martsevich SY, Kutishenko NP, Deev AD et al. Comparison of antihypertensive and metabolic effects of carvedilol and metoprolol in hypertensive patients with overweight and obesity. J. Hypertens.28, e560 (2010).
- Giugliano D, Acampora R, Marfella R et al. Metabolic and cardiovascular effects of carvedilol and atenolol in non-insulin-dependent diabetes mellitus and hypertension. A randomized, controlled trial. Ann. Intern. Med.126, 955–959 (1997).
- Gilbert EM, Abraham WT, Olsen S. Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart. Circulation94, 2817–2825 (1996).
- Morimoto S, Shimizu K, Yamada K et al. Can beta-blocker therapy be withdrawn from patients with dilated cardiomyopathy? Am. Heart J.138, 456–459 (1999).
- Lang CC, Rayos GH, Chomsky DB, Wood, AJJ, Wilson JR. Effects of sympatho inhibition on exercise performance in heart failure. Circulation96, 238–245 (1997).
- Marfella R, Ziniscalchi M, Nappo F et al. Regression of carotid atherosclerosis by control of morning blood pressure peak in newly diagnosed hypertnesive patients. Am. J. Hypertens.18, 308–318 (2005).
- Hauf-Zachariou U, Wildmann L, Zulsdorf B et al. A double-blind comparison of the effects of carvedilol and captopril on serum lipid concentrations in patients with mild to moderate essential hypertension and dyslipidaemia. Eur. J. Clin. Pharmacol.45, 95–100 (1993).
- Fonseca VA. Effect of β-blockers on glucose and lipid metabolism. Curr. Med. Res. Opin.26, 615–629 (2010).
- Williams B, Lacy PS. Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate. J. Am. Coll. Cardiol.54, 705–713 (2009).
- Frishman W, Henderson L, Lukas MA. Controlled-release carvedilol in the management of systemic hypertension and myocardial dysfunction. Vasc. Health Risk Manag.4, 1387–1400 (2008).
- McGill JB, Bakris GL, Fonseca V et al. Beta-blocker use and diabetes symptom score: results from the GEMINI study. Diabetes. Obes. Metab.9, 408–417 (2007).
- Maisel AS, Peacock WF, McMullin N et al. Timing of immunoreactive B-type natriuretic peptide levels and treatment delay in acute decompensated heart failure. An ADHERE (Acute Decompensated Heart Failure National Registry) analysis. J. Am. Coll. Cardiol.52, 534–540 (2008).
- Wannamethee SG, Welsh P, Lowe GD et al. N-terminal pro-brain natriuretic peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in older men with and without preexisting cardiovascular disease. J. Am. Coll. Cardiol.58, 56–64 (2011).
- Chirinos JA, Zambrano JP, Chakko S et al. Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary artery disease. Hypertension45, 980–985 (2005).
- de Peuter OR, Lussan F, Peters RJG et al. A systematic review of selective and non-selective beta blockers for prevention of vascular events in patients with acute coronary syndrome or heart failure. Neth. J. Med.67, 284–294 (2009).
- Carlberb B, Samuelsson O, Lindholm LH et al. Atenolol in hypertension: is it a wise choice? Lancet364, 1684–1689 (2004).
- Aurnes I, Osnes JB, Tvete IF, Gasemyr J Natvig B. Does atenolol differ from other β-adrenergic blockers? BMC Clin. Pharmacol.7, 4 (2007).
- Lindholm LH, Carlberg B, Samuelsson O. Should β blockers remain first choice in the treatment of primary hypertension? A meta-analysis. Lancet366, 1545–1553 (2005).
- McAllister FA, Wiebe N, Ezekowitz JA et al. Meta-analysis: β-blocker dose, heart rate reduction, and death in patients with heart failure. Ann. Intern. Med.150(11), 784–794 (2009).
- Packer M, Fowler MB, Roecker EB et al. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study. Circulation106, 2194–2199 (2002).
- Dargie HJ. Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomized trial. Lancet357, 1385–1390 (2001).
- Lopressor Intervention Trial Research Group. Multicentre study of metoprolol in survivors of acute myocardial infarction. Eur. Heart J.8, 1056–1064 (1987).
- Jonsson G, Abdelnoor M, Muller C et al. A comparison of the two β-blockers carvedilol and atenolol on left ventricular ejection fraction and clinical endpoints after myocardial infarction: a single-centre, randomized study of 232 patients. Cardiology103, 148–155 (2005).
- Jonsson G, Abdelnoor M, Muller C et al. Effects of carvedilol compared to atenolol on ejection fraction and clinical endpoints after myocardial infarction. Eur. Heart J.24, 555 (2003) (Abstract P2892).
- Jonsson G, Abdelnoor M, Muller C et al. Effects of carvedilol compared to atenolol on ejection fraction and clinical endpoints after myocardial infarction. J. Am. Coll. Cardiol.43(Suppl. A), 289A (2004) (Abstract 1118–1177).
- Shen X, Nair CK, Aronow WS et al. Effect of carvedilol versus metoprolol CR/XL on mortality in patients with heart failure treated with cardiac resynchronization therapy: a COX multivariate regression analysis. Am. J. Ther. doi:10.1097/MJT.0b013e3181f2abb3 (2011) (Epub ahead of print).
- Poole-Wilson PA, Swedberg K, Cleland JG et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomized controlled trial. Lancet362, 7–13 (2003).
- Lopressor Intervention Trial Research Group. Multicentre study of metoprolol in survivors of acute myocardial infarction. Eur. Heart J.8, 1056–1064 (1987).
- ISIS-1 Collaborative Group. Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaborative Group. Lancet2, 57–66 (1986).
- Hjalmarson A, Herlitz J, Holmberg S et al. The Göteborg metoprolol trial. Effects on mortality and morbidity in acute myocardial infarction. Circulation67, I26–I32 (1983).
- MIAMI Trial Research Group. Metoprolol in Acute Myocardial Infarction (MIAMI). A randomized placebo-controlled international trial. Eur. Heart. J.6, 199–226 (1985).
- Roberts R, Rogers WJ, Mueller HS et al. Immediate versus deferred beta-blockade following thrombolytic therapy in patients with acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) II-B study. Circulation83, 422–437 (1991).
- Torp-Pedersen C, Metra M, Charlesworth A et al. Effects of metoprolol and carvedilol on pre-existing and new onset diabetes in patients with chronic heart failure; data from the Carvedilol Or Metoprolol European Trial (COMET). Heart93, 968–973 (2007).
- COMMIT collaborative group. Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised, placebo-controlled trial. Lancet366, 1622–1632 (2005).
- Acikel S, Bozbas H, Gultekin B et al. Comparison of the efficacy of metoprolol and carvedilol for preventing atrial fibrillation after coronary bypass surgery. Int. J. Cardiol.135, 393–396 (2009).
- Khamoushi AJ, Emkanjoo Z, Fazelifar AF et al. Optimal β-blocker for prevention of atrial fibrillation after on-pump coronary artery bypass graft surgery: carvedilol versus metoprolol. Heart Rhythm4, 1140–1174 (2007).
- No authors listed. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet353, 2001–2007 (1999).
- Australia/New Zealand Heart Failure Research Collaborative Group. Randomised, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischemic heart disease. Lancet349, 375–380 (1997).
- Packer M, Bristow MR, Cohn JN et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N. Engl. J. Med.334, 1349–1355 (1996).
- CIBIS Investigators and Committees. A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). Circulation90, 1765–1773 (1994).
- No authors listed. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomized trial. Lancet353, 9–13 (1999).
- Willenheimer R, van Veldhuisen DJ, Silke B et al.; on behalf of the CIBIS III investigators. Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III. Circulation112, 2426–2435 (2005).
- Willenheimer R, Silke B. Possible clinical implications of the Cardiac Insufficiency Bisoprolol (CIBIS) III trial. Br. J. Cardiol.12, 448–454 (2005).
- Willenheimer R. The current role of beta-blockers in chronic heart failure: with special emphasis on the CIBIS III trial. Eur. Heart J.11, A15–A20 (2009).
- Flather MD, Shibata MC, Coats AJ et al.; on behalf of SENIORS Investigators. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur. Heart J.26, 215–225 (2005).
- Tolg R, Witt M, Schwarz B et al. Comparison of carvedilol and metoprolol in patients with acute myocardial infarction undergoing primary coronary intervention – the PASSAT study. Clin. Res. Cardiol.95, 31–41 (2006).
- Basu S, Senior R, Raval U, Van Der Does R, Bruckner T, Lahiri A. Benefical effects of intravenous and oral carvedilol treatment in acute myocardial infarction. A placebo controlled randomized trial. Circulation96, 183–191 (1997).