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Expert Review of Cardiovascular Therapy Volume 10, 2012 - Issue 9
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Theme: Inflammation & Infection - Review

Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction

Michelle Kreke Capricor, Inc., 8700 Beverly Blvd, Davis Building, Rm 1099, Los Angeles, CA 90048, USA; Cedars-Sinai Heart Institute, 8700 Beverly Blvd, Davis Building, Rm 1090, Los Angeles, CA 90048, USA; Capricor, Inc., 8700 Beverly Blvd, Davis Building, Rm 1099, Los Angeles, CA 90048, USA. [email protected]
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Rachel Ruckdeschel Smith Capricor, Inc., 8700 Beverly Blvd, Davis Building, Rm 1099, Los Angeles, CA 90048, USA; Cedars-Sinai Heart Institute, 8700 Beverly Blvd, Davis Building, Rm 1090, Los Angeles, CA 90048, USA; Capricor, Inc., 8700 Beverly Blvd, Davis Building, Rm 1099, Los Angeles, CA 90048, USA; Cedars-Sinai Heart Institute, 8700 Beverly Blvd, Davis Building, Rm 1090, Los Angeles, CA 90048, USA
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Linda Marbán Capricor, Inc., 8700 Beverly Blvd, Davis Building, Rm 1099, Los Angeles, CA 90048, USA; Cedars-Sinai Heart Institute, 8700 Beverly Blvd, Davis Building, Rm 1090, Los Angeles, CA 90048, USA; Capricor, Inc., 8700 Beverly Blvd, Davis Building, Rm 1099, Los Angeles, CA 90048, USA; Cedars-Sinai Heart Institute, 8700 Beverly Blvd, Davis Building, Rm 1090, Los Angeles, CA 90048, USA
&
Eduardo Marbán Capricor, Inc., 8700 Beverly Blvd, Davis Building, Rm 1099, Los Angeles, CA 90048, USA; Cedars-Sinai Heart Institute, 8700 Beverly Blvd, Davis Building, Rm 1090, Los Angeles, CA 90048, USA; Capricor, Inc., 8700 Beverly Blvd, Davis Building, Rm 1099, Los Angeles, CA 90048, USA; Cedars-Sinai Heart Institute, 8700 Beverly Blvd, Davis Building, Rm 1090, Los Angeles, CA 90048, USA
Pages 1185-1194 | Published online: 10 Jan 2014

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Yong Sun, Di Chi, Miaoxin Tan, Kai Kang, Maomao Zhang, Xiangyuan Jin, Xiaoping Leng, Rui Cao, Xianglan Liu, Bo Yu & Jian Wu. (2016) Cadaveric cardiosphere-derived cells can maintain regenerative capacity and improve the heart function of cardiomyopathy. Cell Cycle 15:9, pages 1248-1256.
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Veronica Crisostomo, Javier G Casado, Claudia Baez-Diaz, Rebeca Blazquez & Francisco M Sanchez-Margallo. (2015) Allogeneic cardiac stem cell administration for acute myocardial infarction. Expert Review of Cardiovascular Therapy 13:3, pages 285-299.
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Articles from other publishers (35)

Ziqing Xiong, Qi An, Liqiang Chen, Yucheng Xiang, Lian Li & Yaxian Zheng. (2023) Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types. Journal of Materials Chemistry B 11:41, pages 9867-9888.
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Md Nur Ahad Shah & Toshifumi Yokota. (2023) Cardiac therapies for Duchenne muscular dystrophy. Therapeutic Advances in Neurological Disorders 16.
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Liang Mao, Yun-Da Li, Ruo-Lan Chen, Gang Li, Xiao-Xia Zhou, Fei Song, Chan Wu, Yu Hu, Yi-Xiang Hong, Xitong Dang, Gui-Rong Li & Yan Wang. (2022) Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy. Journal of Nanobiotechnology 20:1.
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Behnaz Maleki, Behrang Alani, Seyed Saeed Tamehri Zadeh, Somayeh Saadat, Ali Rajabi, Seyed Mohammad Jalal Ayoubzadeh, Javad Verdi, Alireza Farrokhian, Hossein Ghanbarian, Mahdi Noureddini & Majid Nejati. (2022) MicroRNAs and exosomes: Cardiac stem cells in heart diseases. Pathology - Research and Practice 229, pages 153701.
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Alessandra Ciullo, Chang Li, Liang Li, Korie C. Ungerleider, Kiel Peck, Eduardo Marbán & Ahmed G.E. Ibrahim. (2022) Biodistribution of unmodified cardiosphere‐derived cell extracellular vesicles using single RNA tracing. Journal of Extracellular Vesicles 11:1.
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Melika Parchehbaf-Kashani, Hassan Ansari, Elena Mahmoudi, Maryam Barekat, Mohammadmajid Sepantafar, Sarah Rajabi & Sara Pahlavan. (2021) Heart Repair Induced by Cardiac Progenitor Cell Delivery within Polypyrrole-Loaded Cardiogel Post-ischemia. ACS Applied Bio Materials 4:6, pages 4849-4861.
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Ann-Sophie Walravens, Sasha Smolgovsky, Liang Li, Lauren Kelly, Travis Antes, Kiel Peck, Tanner Quon, Ahmed Ibrahim, Eduardo Marbán, Benjamin Berman, Linda Marbán, Luis R.-Borlado & Geoffrey de Couto. (2021) Mechanistic and therapeutic distinctions between cardiosphere-derived cell and mesenchymal stem cell extracellular vesicle non-coding RNA. Scientific Reports 11:1.
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Leila Montazeri, Motahareh Sobat, Reza Kowsari‐Esfahan, Shahram Rabbani, Hassan Ansari, Maryam Barekat, Saman Firoozi, Sarah Rajabi, Sadaf Vahdat, Hossein Baharvand & Sara Pahlavan. (2020) Vascular endothelial growth factor sustained delivery augmented cell therapy outcomes of cardiac progenitor cells for myocardial infarction. Journal of Tissue Engineering and Regenerative Medicine 14:12, pages 1939-1944.
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Saman Firoozi, Sara Pahlavan, Mohammad-Hossein Ghanian, Shahram Rabbani, Shima Tavakol, Maryam Barekat, Saeed Yakhkeshi, Elena Mahmoudi, Mansoureh Soleymani & Hossein Baharvand. (2020) A Cell-Free SDKP-Conjugated Self-Assembling Peptide Hydrogel Sufficient for Improvement of Myocardial Infarction. Biomolecules 10:2, pages 205.
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Gabriella Andriolo, Elena Provasi, Andrea Brambilla, Viviana Lo Cicero, Sabrina Soncin, Lucio Barile, Lucia Turchetto & Marina Radrizzani. 2021. Stem Cells and Good Manufacturing Practices. Stem Cells and Good Manufacturing Practices 131 166 .
Xiaowei Bian, Kui Ma, Cuiping Zhang & Xiaobing Fu. (2019) Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases. Stem Cell Research & Therapy 10:1.
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Cixia Li, Yuqiao Chang, Yangyang Jia & Zhikun Guo. (2019) A new structure from cardiac cells cultured in vitro: Cardiomyocyte‐annulation of neonatal rats. Journal of Cellular Biochemistry 120:10, pages 18533-18543.
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Ahmed G. E. Ibrahim, Chang Li, Russel Rogers, Mario Fournier, Liang Li, Sharon D. Vaturi, Travis Antes, Lizbeth Sanchez, Akbarshakh Akhmerov, Jennifer Johnson Moseley, Brooke Tobin, Luis Rodriguez-Borlado, Rachel R. Smith, Linda Marbán & Eduardo Marbán. (2019) Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories. Nature Biomedical Engineering 3:9, pages 695-705.
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Li Qiao, Shiqi Hu, Suyun Liu, Hui Zhang, Hong Ma, Ke Huang, Zhenhua Li, Teng Su, Adam Vandergriff, Junnan Tang, Tyler Allen, Phuong-Uyen Dinh, Jhon Cores, Qi Yin, Yongjun Li & Ke Cheng. (2019) microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. Journal of Clinical Investigation 129:6, pages 2237-2250.
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Linda CambierJorge F. GianiWeixin LiuTakeshi IjichiAntonio K. EchavezJackelyn ValleEduardo Marbán. (2018) Angiotensin II–Induced End-Organ Damage in Mice Is Attenuated by Human Exosomes and by an Exosomal Y RNA Fragment. Hypertension 72:2, pages 370-380.
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Lucio Barile, Elisabetta Cervio, Vincenzo Lionetti, Giuseppina Milano, Alessandra Ciullo, Vanessa Biemmi, Sara Bolis, Claudia Altomare, Marco Matteucci, Dario Di Silvestre, Francesca Brambilla, Tudor Emanuel Fertig, Tiziano Torre, Stefanos Demertzis, Pierluigi Mauri, Tiziano Moccetti & Giuseppe Vassalli. (2018) Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A. Cardiovascular Research 114:7, pages 992-1005.
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Helia Namazi, Elham Mohit, Iman Namazi, Sarah Rajabi, Azam Samadian, Ensiyeh Hajizadeh‐Saffar, Nasser Aghdami & Hossein Baharvand. (2018) Exosomes secreted by hypoxic cardiosphere‐derived cells enhance tube formation and increase pro‐angiogenic miRNA. Journal of Cellular Biochemistry 119:5, pages 4150-4160.
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Akira Fujita, Akihito Mikamo, Kimikazu Hamano & Tohru Hosoyama. 2018. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
David J. LeferEduardo Marbán. (2017) Is Cardioprotection Dead?. Circulation 136:1, pages 98-109.
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Linda Cambier, Geoffrey de Couto, Ahmed Ibrahim, Antonio K Echavez, Jackelyn Valle, Weixin Liu, Michelle Kreke, Rachel R Smith, Linda Marbán & Eduardo Marbán. (2017) Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL ‐10 expression and secretion . EMBO Molecular Medicine 9:3, pages 337-352.
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Jennifer K. Lang, Rebeccah F. Young, Hashmat Ashraf & John M. Canty. (2016) Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro. PLOS ONE 11:11, pages e0165926.
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Leslie W. Miller & Emerson C. Perin. 2016. Stem Cell and Gene Therapy for Cardiovascular Disease. Stem Cell and Gene Therapy for Cardiovascular Disease 3 11 .
Kiyotake Ishikawa. (2015) Intracoronary Injection of Large Stem Cells. Circulation: Cardiovascular Interventions 8:5.
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Hye-Jin Chung, Jong-Tae Kim, Hee-Jung Kim, Hei-Won Kyung, Pramila Katila, Jeong-Han Lee, Tae-Hyun Yang, Young-Il Yang & Seung-Jin Lee. (2015) Epicardial delivery of VEGF and cardiac stem cells guided by 3-dimensional PLLA mat enhancing cardiac regeneration and angiogenesis in acute myocardial infarction. Journal of Controlled Release 205, pages 218-230.
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Adam C. Vandergriff, James Bizetto Meira de Andrade, Junnan Tang, M. Taylor Hensley, Jorge A. Piedrahita, Thomas G. Caranasos & Ke Cheng. (2015) Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy. Stem Cells International 2015, pages 1-8.
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Shaina Ailawadi, Xiaohong Wang, Haitao Gu & Guo-Chang Fan. (2015) Pathologic function and therapeutic potential of exosomes in cardiovascular disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:1, pages 1-11.
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Vasileios Sousonis, Konstantinos Malliaras, John Terrovitis & John Nanas. 2015. Introduction to Translational Cardiovascular Research. Introduction to Translational Cardiovascular Research 565 582 .
Polina GoichbergJerway ChangRonglih LiaoAnnarosa Leri. (2014) Cardiac Stem Cells: Biology and Clinical Applications. Antioxidants & Redox Signaling 21:14, pages 2002-2017.
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Wangde Dai, Gregory L. Kay & Robert A. Kloner. (2014) The Therapeutic Effect of Cell Transplantation Versus Noncellular Biomaterial Implantation on Cardiac Structure and Function Following Myocardial Infarction. Journal of Cardiovascular Pharmacology and Therapeutics 19:4, pages 350-357.
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Ahmed Gamal-Eldin Ibrahim, Ke Cheng & Eduardo Marbán. (2014) Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy. Stem Cell Reports 2:5, pages 606-619.
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Konstantinos Malliaras, Raj R. Makkar, Rachel R. Smith, Ke Cheng, Edwin Wu, Robert O. Bonow, Linda Marbán, Adam Mendizabal, Eugenio Cingolani, Peter V. Johnston, Gary Gerstenblith, Karl H. Schuleri, Albert C. Lardo & Eduardo Marbán. (2014) Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction. Journal of the American College of Cardiology 63:2, pages 110-122.
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Paola Romagnani. (2013) Of mice and men: the riddle of tubular regeneration. The Journal of Pathology 229:5, pages 641-644.
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Paola Romagnani & Hans-Joachim Anders. (2013) What can tubular progenitor cultures teach us about kidney regeneration?. Kidney International 83:3, pages 351-353.
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Eduardo Marbán & Eugenio Cingolani. (2012) Heart to heart: Cardiospheres for myocardial regeneration. Heart Rhythm 9:10, pages 1727-1731.
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