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Expert Review of Anti-infective Therapy Volume 10, 2012 - Issue 9
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Review

Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs

Miguel Viveiros Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal; Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal. [email protected]
,
Marta Martins Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium; UCD School of Public Health, Physiotherapy and Population Science, UCD Centre for Food Safety, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland; Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium; UCD School of Public Health, Physiotherapy and Population Science, UCD Centre for Food Safety, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland
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Liliana Rodrigues Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium; Grupo de Genética de Micobacterias, Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, Calle Domingo Miral s/n, 50009 Zaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain; Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium; Grupo de Genética de Micobacterias, Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, Calle Domingo Miral s/n, 50009 Zaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain
,
Diana Machado Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal
,
Isabel Couto Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal; Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal; Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
,
José Ainsa Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium; Grupo de Genética de Micobacterias, Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, Calle Domingo Miral s/n, 50009 Zaragoza, Spain; Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium; Grupo de Genética de Micobacterias, Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, Calle Domingo Miral s/n, 50009 Zaragoza, Spain; Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
&
Leonard Amaral Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal; Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium; Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal; Cost Action BM0701 (ATENS) of the European Commission/European Science Foundation, Brussels, Belgium
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Pages 983-998 | Published online: 10 Jan 2014

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Liliana Rodrigues, Pedro Cravo & Miguel Viveiros. (2020) Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs. Expert Review of Anti-infective Therapy 18:8, pages 741-757.
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Davide Benedetto Tiz, Danijel Kikelj & Nace Zidar. (2018) Overcoming problems of poor drug penetration into bacteria: challenges and strategies for medicinal chemists. Expert Opinion on Drug Discovery 13:6, pages 497-507.
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Carina Beatrice Vibe, Federico Fenaroli, David Pires, Steven Ray Wilson, Vanya Bogoeva, Raja Kalluru, Martin Speth, Elsa Anes, Gareth Griffiths & Jon Hildahl. (2016) Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish. Nanotoxicology 10:6, pages 680-688.
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Liem Nguyen & Michael R Jacobs. (2012) Counterattacking drug-resistant tuberculosis: molecular strategies and future directions. Expert Review of Anti-infective Therapy 10:9, pages 959-961.
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