Advanced search
Publication Cover
Expert Review of Molecular Diagnostics Volume 10, 2010 - Issue 5
Submit an article Journal homepage
266
Views
47
CrossRef citations to date
0
Altmetric
Review

Advances and perspectives from genetic research: development of biological markers in Alzheimer’s disease

Thomas Zetzsche Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Nussbaumstrasse 7, D-80336 München, Germany;[email protected]
,
Dan Rujescu Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Nussbaumstrasse 7, D-80336 München, Germany
,
John Hardy UCL Institute of Neurology, Queen Square and Reta Lila Weston Institute of Neurological Studies, University College London, London, UK
&
Harald Hampel Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany
Pages 667-690 | Published online: 09 Jan 2014

Citations (47)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

H. Hampel, S. E. O’Bryant, S. Durrleman, E. Younesi, K. Rojkova, V. Escott-Price, J-C. Corvol, K. Broich, B. Dubois & S. Lista. (2017) A Precision Medicine Initiative for Alzheimer’s disease: the road ahead to biomarker-guided integrative disease modeling. Climacteric 20:2, pages 107-118.
Read now
Jingrong Luo, Shan Li, Xue Qin, Qiliu Peng, Yanqiong Liu, Shi Yang, Xuejun Qin, Yuqing Xiong & Zhiyu Zeng. (2016) Association of the NQO1 C609T polymorphism with Alzheimer's disease in Chinese populations: a meta-analysis. International Journal of Neuroscience 126:3, pages 199-204.
Read now

Articles from other publishers (45)

Azher Arafah, Saima Khatoon, Iyman Rasool, Andleeb Khan, Mashoque Ahmad Rather, Khaled Abdullah Abujabal, Yazid Abdullilah Hassan Faqih, Hina Rashid, Shahzada Mudasir Rashid, Sheikh Bilal Ahmad, Athanasios Alexiou & Muneeb U. Rehman. (2023) The Future of Precision Medicine in the Cure of Alzheimer’s Disease. Biomedicines 11:2, pages 335.
Crossref
Wan-Chen Wen, Yi-Hui Lin, Tsai-Hui Duh, Chun-Hsien Chen, Chia-Hsien Feng & Yen-Ling Chen. (2023) Fluorescence detection of apolipoprotein E gene polymorphisms based on oligonucleotide ligation and magnetic separation. Analytical Methods.
Crossref
Shivangi Awasthi, Daniel S. Spellman & Nathan G. Hatcher. (2022) Proteomic Discovery and Validation of Novel Fluid Biomarkers for Improved Patient Selection and Prediction of Clinical Outcomes in Alzheimer’s Disease Patient Cohorts. Proteomes 10:3, pages 26.
Crossref
Ram Sagar, Pujita Pathak, Balint Pandur, Sujung Jun Kim, Jiaxin Li & Vasiliki Mahairaki. 2021. GeNeDis 2020. GeNeDis 2020 403 408 .
Jyothirmai J. Simhadri, Christopher A. Loffredo, Tomas Trnovec, Lubica Palkovicova Murinova, Gail Nunlee-Bland, Janna G. Koppe, Greet Schoeters, Siddhartha Sankar Jana & Somiranjan Ghosh. (2020) Biomarkers of metabolic disorders and neurobehavioral diseases in a PCB- exposed population: What we learned and the implications for future research. Environmental Research 191, pages 110211.
Crossref
Md. Sahab Uddin, Md. Tanvir Kabir, Md. Jakaria, Eduardo Sobarzo-Sánchez, George E. Barreto, Asma Perveen, Abdul Hafeez, May N. Bin-Jumah, Mohamed M. Abdel-Daim & Ghulam M. Ashraf. (2020) Exploring the Potential of Neuroproteomics in Alzheimer's Disease. Current Topics in Medicinal Chemistry 20:25, pages 2263-2278.
Crossref
Harald Hampel, Andrea Vergallo, George Perry & Simone Lista. (2019) The Alzheimer Precision Medicine Initiative. Journal of Alzheimer's Disease 68:1, pages 1-24.
Crossref
Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Maria-Teresa Ferretti, Nathalie George, Remy Genthon, Marie-Odile Habert, Karl Herholz, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, Stéphane Lehéricy, Jean Lorenceau, Christian Neri, Robert Nisticò, Francis Nyasse-Messene, Craig Ritchie, Simone Rossi, Emiliano Santarnecchi, Olaf Sporns, Steven R. Verdooner, Andrea Vergallo, Nicolas Villain, Erfan Younesi, Francesco Garaci & Simone Lista. (2018) Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology. Journal of Alzheimer's Disease 64:s1, pages S47-S105.
Crossref
Juan I. Castrillo, Simone Lista, Harald Hampel & Craig W. Ritchie. 2018. Biomarkers for Alzheimer’s Disease Drug Development. Biomarkers for Alzheimer’s Disease Drug Development 31 66 .
Natasha Z. R. Steele, Jessie S. Carr, Luke W. Bonham, Ethan G. Geier, Vincent Damotte, Zachary A. Miller, Rahul S. Desikan, Kevin L. Boehme, Shubhabrata Mukherjee, Paul K. Crane, John S. K. Kauwe, Joel H. Kramer, Bruce L. Miller, Giovanni Coppola, Jill A. Hollenbach, Yadong Huang & Jennifer S. Yokoyama. (2017) Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study. PLOS Medicine 14:3, pages e1002272.
Crossref
Simone Lista, Henrik Zetterberg, Sid E. O’Bryant, Kaj Blennow & Harald Hampel. 2017. Neuroproteomics. Neuroproteomics 101 115 .
Yaping Hou, Fanghua Wang, Linping Cheng, Tao Luo, Jie Xu & Huaqiao Wang. (2016) Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. Neuroscience Bulletin 32:5, pages 455-462.
Crossref
Merve Alaylıoğlu, Duygu Gezen-Ak, Erdinç Dursun, Başar Bilgiç, Haşmet Hanağası, Turan Ertan, Hakan Gürvit, Murat Emre, Engin Eker, Ömer Uysal & Selma Yılmazer. (2016) The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort. Journal of Geriatric Psychiatry and Neurology 29:4, pages 221-226.
Crossref
Bruno Dubois, Harald Hampel, Howard H. Feldman, Philip Scheltens, Paul Aisen, Sandrine Andrieu, Hovagim Bakardjian, Habib Benali, Lars Bertram, Kaj Blennow, Karl Broich, Enrica Cavedo, Sebastian Crutch, Jean‐François Dartigues, Charles Duyckaerts, Stéphane Epelbaum, Giovanni B. Frisoni, Serge Gauthier, Remy Genthon, Alida A. Gouw, Marie‐Odile Habert, David M. Holtzman, Miia Kivipelto, Simone Lista, José‐Luis Molinuevo, Sid E. O'Bryant, Gil D. Rabinovici, Christopher Rowe, Stephen Salloway, Lon S. Schneider, Reisa Sperling, Marc Teichmann, Maria C. Carrillo, Jeffrey Cummings & Cliff R. JackJrJr. (2016) Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimer's & Dementia 12:3, pages 292-323.
Crossref
Maryam Rezazadeh, Aziz Khorrami, Tarlan Yeghaneh, Mahnaz Talebi, Seyed Jalal Kiani, Yaser Heshmati & Jalal Gharesouran. (2015) Genetic Factors Affecting Late-Onset Alzheimer’s Disease Susceptibility. NeuroMolecular Medicine 18:1, pages 37-49.
Crossref
Hui-Zhen Wang, Rui Bi, Qiu-Xiang Hu, Qun Xiang, Chen Zhang, Deng-Feng Zhang, Wen Zhang, Xiaohong Ma, Wanjun Guo, Wei Deng, Liansheng Zhao, Peiyan Ni, Mingli Li, Yiru Fang, Tao Li & Yong-Gang Yao. (2014) Validating GWAS-Identified Risk Loci for Alzheimer’s Disease in Han Chinese Populations. Molecular Neurobiology 53:1, pages 379-390.
Crossref
Simone Lista, Zaven S. Khachaturian, Dan Rujescu, Francesco Garaci, Bruno Dubois & Harald Hampel. 2016. Systems Biology of Alzheimer's Disease. Systems Biology of Alzheimer's Disease 49 67 .
Dongxu Gao, Meifang Wu, Chonggang Wang, Yuanchuan Wang & Zhenghong Zuo. (2015) Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio). Aquatic Toxicology 167, pages 200-208.
Crossref
Simone Lista, Sid E. O’Bryant, Kaj Blennow, Bruno Dubois, Jacques Hugon, Henrik Zetterberg & Harald Hampel. (2015) Biomarkers in Sporadic and Familial Alzheimer’s Disease. Journal of Alzheimer's Disease 47:2, pages 291-317.
Crossref
Hans-Jürgen Möller, Borwin Bandelow, Michael Bauer, Harald Hampel, Sabine C. Herpertz, Michael Soyka, Utako B. Barnikol, Simone Lista, Emanuel Severus & Wolfgang Maier. (2014) DSM-5 reviewed from different angles: goal attainment, rationality, use of evidence, consequences—part 2: bipolar disorders, schizophrenia spectrum disorders, anxiety disorders, obsessive–compulsive disorders, trauma- and stressor-related disorders, personality disorders, substance-related and addictive disorders, neurocognitive disorders. European Archives of Psychiatry and Clinical Neuroscience 265:2, pages 87-106.
Crossref
Jorge Landgrave-Gómez, Octavio Mercado-Gómez & Rosalinda Guevara-Guzmán. (2015) Epigenetic mechanisms in neurological and neurodegenerative diseases. Frontiers in Cellular Neuroscience 9.
Crossref
Simone Lista, B. Dubois & H. Hampel. (2014) Paths to Alzheimer’s disease prevention: From modifiable risk factors to biomarker enrichment strategies. The journal of nutrition, health & aging 19:2, pages 154-163.
Crossref
Paul A. Adlard, Bob A. Tran, David I. Finkelstein, Patricia M. Desmond, Leigh A. Johnston, Ashley I. Bush & Gary F. Egan. (2014) A review of β-amyloid neuroimaging in Alzheimer's disease. Frontiers in Neuroscience 8.
Crossref
Harald Hampel, Simone Lista, Stefan J. Teipel, Francesco Garaci, Robert Nisticò, Kaj Blennow, Henrik Zetterberg, Lars Bertram, Charles Duyckaerts, Hovagim Bakardjian, Alexander Drzezga, Olivier Colliot, Stéphane Epelbaum, Karl Broich, Stéphane Lehéricy, Alexis Brice, Zaven S. Khachaturian, Paul S. Aisen & Bruno Dubois. (2014) Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020. Biochemical Pharmacology 88:4, pages 426-449.
Crossref
Ao Zhan, Xin Xu, Ling Chen, Xuefeng Wang, Xie Yanfeng, Wei Dan, Yan Zhan & Quanhong Shi. (2014) Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model. Synapse 68:4, pages 168-177.
Crossref
Mary J. Savage, Juliya Kalinina, Abigail Wolfe, Katherine Tugusheva, Rachel Korn, Tanesha Cash-Mason, Jill W. Maxwell, Nathan G. Hatcher, Sharie J. Haugabook, Guoxin Wu, Bonnie J. Howell, John J. Renger, Paul J. Shughrue & Alexander McCampbell. (2014) A Sensitive Aβ Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid. The Journal of Neuroscience 34:8, pages 2884-2897.
Crossref
Harald Hampel & Simone Lista. (2013) Have we learnt all we need to know from genetic studies - is genetics over in Alzheimer's disease?. Alzheimer's Research & Therapy 5:2.
Crossref
Yaping Hou, Huayun Chen, Qiong He, Wei Jiang, Tao Luo, Jinhai Duan, Nan Mu, Yunshao He & Huaqiao Wang. (2013) Changes in methylation patterns of multiple genes from peripheral blood leucocytes of Alzheimer's disease patients. Acta Neuropsychiatrica 25:2, pages 66-76.
Crossref
Harald Hampel & Simone Lista. (2012) From inherited to sporadic AD—crossing the biomarker bridge. Nature Reviews Neurology 8:11, pages 598-600.
Crossref
J. Genius, H. Klafki, J. Benninghoff, H. Esselmann & J. Wiltfang. (2012) Current application of neurochemical biomarkers in the prediction and differential diagnosis of Alzheimer’s disease and other neurodegenerative dementias. European Archives of Psychiatry and Clinical Neuroscience 262:S2, pages 71-77.
Crossref
Sylvie Claeysen, Maud Cochet, Romain Donneger, Aline Dumuis, Joël Bockaert & Patrizia Giannoni. (2012) Alzheimer culprits: Cellular crossroads and interplay. Cellular Signalling 24:9, pages 1831-1840.
Crossref
Lyzel S Elias-SonnenscheinLars Bertram & Pieter Jelle Visser. (2012) Relationship between genetic risk factors and markers for Alzheimer’s disease pathology. Biomarkers in Medicine 6:4, pages 477-495.
Crossref
Harald Hampel, Simone Lista & Zaven S. Khachaturian. (2012) Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot. Alzheimer's & Dementia 8:4, pages 312-336.
Crossref
Edward C. Lauterbach. (2012) Psychotropic Drug Effects on Gene Transcriptomics Relevant to Alzheimer Disease. Alzheimer Disease & Associated Disorders 26:1, pages 1-7.
Crossref
Heidi I.L. Jacobs, Martin P.J. Van Boxtel, Jelle Jolles, Frans R.J. Verhey & Harry B.M. Uylings. (2012) Parietal cortex matters in Alzheimer's disease: An overview of structural, functional and metabolic findings. Neuroscience & Biobehavioral Reviews 36:1, pages 297-309.
Crossref
Harald Hampel, David Prvulovic, Stefan Teipel, Frank Jessen, Christian Luckhaus, Lutz Frölich, Matthias W. Riepe, Richard Dodel, Thomas Leyhe, Lars Bertram, Wolfgang Hoffmann & Frank Faltraco. (2011) The future of Alzheimer's disease: The next 10 years. Progress in Neurobiology 95:4, pages 718-728.
Crossref
Harald Hampel, Gordon Wilcock, Sandrine Andrieu, Paul Aisen, Kaj Blennow, K. Broich, Maria Carrillo, Nick C. Fox, Giovanni B. Frisoni, Maria Isaac, Simon Lovestone, Agneta Nordberg, David Prvulovic, Christina Sampaio, Philip Scheltens, Michael Weiner, Bengt Winblad, Nicola Coley & Bruno Vellas. (2011) Biomarkers for Alzheimer's disease therapeutic trials. Progress in Neurobiology 95:4, pages 579-593.
Crossref
Dagmar E. Ehrnhoefer, Bibiana K. Y. Wong & Michael R. Hayden. (2011) Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development. Nature Reviews Drug Discovery 10:11, pages 853-867.
Crossref
Philine Schneider, Katharina Buerger, Stefan Teipel, Olga Uspenskaya, Oliver Hartmann, Oskar Hansson, Lennart Minthon, Dan Rujescu, Hans-Juergen Moeller, Henrik Zetterberg, Kaj Blennow, Andrea Ernst, Andreas Bergmann & Harald Hampel. (2011) Antihypertensive Therapy Is Associated with Reduced Rate of Conversion to Alzheimer's Disease in Midregional Proatrial Natriuretic Peptide Stratified Subjects with Mild Cognitive Impairment. Biological Psychiatry 70:2, pages 145-151.
Crossref
Lars Bertram. (2011) Alzheimer’s Genetics in the GWAS Era: A Continuing Story of ‘Replications and Refutations’. Current Neurology and Neuroscience Reports 11:3, pages 246-253.
Crossref
Hicham Filali, Inmaculada Martin-Burriel, Frank Harders, Luis Varona, Jaber Lyahyai, Pilar Zaragoza, Martí Pumarola, Juan J. Badiola, Alex Bossers & Rosa Bolea. (2011) Gene Expression Profiling and Association with Prion-Related Lesions in the Medulla Oblongata of Symptomatic Natural Scrapie Animals. PLoS ONE 6:5, pages e19909.
Crossref
Milton C Biagioni & James E Galvin. (2011) Using biomarkers to improve detection of Alzheimer’s disease. Neurodegenerative Disease Management 1:2, pages 127-139.
Crossref
Meredith N. Braskie, John M. Ringman & Paul M. Thompson. (2011) Neuroimaging Measures as Endophenotypes in Alzheimer's Disease. International Journal of Alzheimer's Disease 2011, pages 1-15.
Crossref
Letizia Polito, Francesca Prato, Serena Rodilossi, Eleonora Ateri, Daniela Galimberti, Elio Scarpini, Francesca Clerici, Claudio Mariani, Gianluigi Forloni & Diego Albani. (2011) A Novel Study and Meta-Analysis of the Genetic Variation of the Serotonin Transporter Promoter in the Italian Population Do Not Support a Large Effect on Alzheimer's Disease Risk. International Journal of Alzheimer's Disease 2011, pages 1-7.
Crossref
Verena Buschert, Arun L. W. Bokde & Harald Hampel. (2010) Cognitive intervention in Alzheimer disease. Nature Reviews Neurology 6:9, pages 508-517.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.