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Review

Guidelines for aerosol devices in infants, children and adults: which to choose, why and how to achieve effective aerosol therapy

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Pages 561-572 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Arzu Ari, Karen Blain, Said Soubra & Nicola A Hanania. (2021) Treating COPD Patients with Inhaled Medications in the Era of COVID-19 and Beyond: Options and Rationales for Patients at Home. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 2687-2695.
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Arzu Ari & James B Fink. (2020) Recent advances in aerosol devices for the delivery of inhaled medications. Expert Opinion on Drug Delivery 17:2, pages 133-144.
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Christian Vogelberg. (2019) Preschool children with persistent asthmatic symptoms. Therapeutics and Clinical Risk Management 15, pages 451-460.
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Omar S Usmani. (2019) Choosing the right inhaler for your asthma or COPD patient. Therapeutics and Clinical Risk Management 15, pages 461-472.
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Awni M. Al-Subu, Scott Hagen, Marlowe Eldridge & Juan Boriosi. (2017) Aerosol therapy through high flow nasal cannula in pediatric patients. Expert Review of Respiratory Medicine 11:12, pages 945-953.
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Ni Luh Putu Shinta Devi, Nani Nurhaeni & Happy Hayati. (2017) Effect of Audiovisual Distraction on Distress and Oxygenation Status in Children Receiving Aerosol Therapy. Comprehensive Child and Adolescent Nursing 40:sup1, pages 14-21.
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Pieter Nicolaas Richard Dekhuijzen, Federico Lavorini & Omar S Usmani. (2016) Patients’ perspectives and preferences in the choice of inhalers: the case for Respimat® or HandiHaler®. Patient Preference and Adherence 10, pages 1561-1572.
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Arzu Ari & James B Fink. (2013) Aerosol therapy in children: challenges and solutions. Expert Review of Respiratory Medicine 7:6, pages 665-672.
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Articles from other publishers (43)

Arzu Ari & Bshayer Ramadan Alhamad. (2023) Evaluating dry powder inhalers: From in vitro studies to mobile health technologies. Respiratory Medicine 215, pages 107281.
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Arzu Ari, Namita Raghavan, Martha Diaz, Bruce K. Rubin & James B. Fink. (2023) Individualized aerosol medicine: Integrating device into the patient. Paediatric Respiratory Reviews.
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Giuseppe Fiorentino, Maurizia Lanza & Anna Annunziata. 2023. Humidification in the Intensive Care Unit. Humidification in the Intensive Care Unit 257 269 .
Benjamin M. Spence, Worth Longest, Rabijit Dutta, Mohammad A. M. Momin, Sarah Strickler & Michael Hindle. (2022) In Vitro Evaluation of Nebulized Pharmaceutical Aerosol Delivery to the Lungs Using a New Heated Dryer System (HDS). AAPS PharmSciTech 24:1.
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Connor HoweMohammad A.M. MominKarl BassGhali AladwaniSerena BonaseraMichael HindlePhilip Worth Longest. (2022) In Vitro Analysis of Nasal Interface Options for High-Efficiency Aerosol Administration to Preterm Infants . Journal of Aerosol Medicine and Pulmonary Drug Delivery 35:4, pages 196-211.
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Karl Bass, Mohammad A. M. Momin, Connor Howe, Ghali Aladwani, Sarah Strickler, Arun V. Kolanjiyil, Michael Hindle, Robert M. DiBlasi & Worth Longest. (2022) Characterizing the Effects of Nasal Prong Interfaces on Aerosol Deposition in a Preterm Infant Nasal Model. AAPS PharmSciTech 23:5.
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Biju Thomas & Arun Pugalenthi. (2022) Currently Available Inhaled Therapies in Asthma and Advances in Drug Delivery and Devices. Indian Journal of Pediatrics 89:4, pages 387-394.
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Arbel Artzy-Schnirman, Sivan Arber Raviv, Ofri Doppelt Flikshtain, Jeny Shklover, Netanel Korin, Adi Gross, Boaz Mizrahi, Avi Schroeder & Josué Sznitman. (2021) Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics. Advanced Drug Delivery Reviews 176, pages 113901.
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Arzu Ari & James B. Fink. (2021) Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity. Pharmaceutics 13:8, pages 1179.
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Luca Casula, Chiara Sinico, Donatella Valenti, Elena Pini, Rosa Pireddu, Michele Schlich, Francesco Lai & Anna Maria Fadda. (2021) Delivery of beclomethasone dipropionate nanosuspensions with an electronic cigarette. International Journal of Pharmaceutics 596, pages 120293.
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Hülya Durak & Gülzade Uysal. (2021) The Effect of Cartoon Watching and Distraction Card on Physiologic Parameters and Fear Levels During Inhalation Therapy in Children: A Randomized Controlled Study. Journal of Tropical Pediatrics 67:1.
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AdelS Alharbi, AbdullahA Yousef, SalehA Alharbi, Abdullah Al-Shamrani, MansourM Alqwaiee, Mohammed Almeziny, YazanS Said, SalehAli Alshehri, FaisalN Alotaibi, Rafat Mosalli, KhaledAli Alawam & MuslimM Alsaadi. (2021) Application of aerosol therapy in respiratory diseases in children: A Saudi expert consensus. Annals of Thoracic Medicine 16:2, pages 188.
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Mohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. MadneyMohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. Madney. 2021. Essentials of Aerosol Therapy in Critically ill Patients. Essentials of Aerosol Therapy in Critically ill Patients 115 135 .
Mohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. MadneyMohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. Madney. 2021. Essentials of Aerosol Therapy in Critically ill Patients. Essentials of Aerosol Therapy in Critically ill Patients 89 114 .
Mohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. MadneyMohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. Madney. 2021. Essentials of Aerosol Therapy in Critically ill Patients. Essentials of Aerosol Therapy in Critically ill Patients 65 88 .
Mohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. MadneyMohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. Madney. 2021. Essentials of Aerosol Therapy in Critically ill Patients. Essentials of Aerosol Therapy in Critically ill Patients 1 25 .
Hadeer S. Harb, Haitham Saeed, Yasmin M. Madney, Mona A. Abdelrahman, Hasnaa Osama, Antonio M. Esquinas & Mohamed E.A. Abdelrahim. (2020) Update efficacy of aerosol therapy with noninvasive ventilator approach (non-invasive ventilation and nasal high flow). Journal of Drug Delivery Science and Technology 59, pages 101922.
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Kyung Hwa Chang, Sang-Hyub Moon, Sun Kook Yoo, Bong Joo Park & Ki Chang Nam. (2020) Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers. Pharmaceutics 12:8, pages 721.
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Nardos Hailu, Michiel Postema, Ondrej Krejcar & Dawit Assefa. (2020) Nebulization Criteria and Quantification. Fluids 5:2, pages 91.
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Eusebi Chiner Vives, Estrella Fernández Fabrellas, Ramón Agüero Balbín & Miguel Ángel Martínez García. (2020) Aerosolterapia. Open Respiratory Archives 2:2, pages 89-99.
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Yasmin M. Madney, Nabila Ibrahim Laz, Ahmed A. Elberry, Hoda Rabea & Mohamed E.A. Abdelrahim. (2020) The influence of changing interfaces on aerosol delivery within high flow oxygen setting in adults: An in-vitro study. Journal of Drug Delivery Science and Technology 55, pages 101365.
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Haley Hoy & Louise O'Keefe. (2020) Choosing the right inhaler for the right patient: Considerations for effective management of patients with chronic obstructive pulmonary disease or asthma. Journal of the American Association of Nurse Practitioners 32:1, pages 89-99.
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Mahmood A. Alalwan, James B. Fink & Arzu Ari. (2019) In vitro evaluation of aerosol drug delivery with and without high flow nasal cannula in children. Pediatric Pulmonology 54:12, pages 1968-1973.
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Akshay Chandel, Amit K. Goyal, Goutam Ghosh & Goutam Rath. (2019) Recent advances in aerosolised drug delivery. Biomedicine & Pharmacotherapy 112, pages 108601.
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Edward M. KerwinJames F. DonohueGary T. FergusonVaidyanathan GanapathyAyca Ozol-GodfreyKrithika Rajagopalan. (2019) Satisfaction with the Use of eFlow Closed-System Nebulizer in Patients with Moderate-to-Very Severe Chronic Obstructive Pulmonary Disease: Findings from a Long-Term Safety Study. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:1, pages 24-33.
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Nagarjun Rangaraj, Sravanthi Reddy Pailla & Sunitha Sampathi. (2019) Insight into pulmonary drug delivery: Mechanism of drug deposition to device characterization and regulatory requirements. Pulmonary Pharmacology & Therapeutics 54, pages 1-21.
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Angela Mary Fonceca, William Graham Fox Ditcham, Mark L. Everard & Sunalene Devadason. 2019. Kendig's Disorders of the Respiratory Tract in Children. Kendig's Disorders of the Respiratory Tract in Children 257 271.e3 .
Stewart Yeung, Daniela Traini, David Lewis & Paul M. Young. (2018) Dosing challenges in respiratory therapies. International Journal of Pharmaceutics 548:1, pages 659-671.
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Herbert Wachtel, Mark Nagel, Michael Engel, Georges El Azzi, Ashish Sharma & Jason Suggett. (2018) In vitro and clinical characterization of the valved holding chamber AeroChamber Plus ® Flow-Vu ® for administrating tiotropium Respimat ® in 1–5-year-old children with persistent asthmatic symptoms. Respiratory Medicine 137, pages 181-190.
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Qihong Deng, Cuiyun Ou, Jiao Chen & Yuguang Xiang. (2018) Particle deposition in tracheobronchial airways of an infant, child and adult. Science of The Total Environment 612, pages 339-346.
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Herbert Wachtel, Sabine Kattenbeck, Stephen Dunne & Bernd Disse. (2017) The Respimat® Development Story: Patient-Centered Innovation. Pulmonary Therapy 3:1, pages 19-30.
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Andrzej Emeryk, Zbigniew Doniec, Henryk Mazurek, Katarzyna Krenke, Michał Pirożyński, Tomasz Sosnowski & Emil Florkiewicz. (2017) Zasady stosowania komór inhalacyjnych u dzieci. Pediatria Polska 92:3, pages 288-293.
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Jayesh Dhanani, John F. Fraser, Hak-Kim Chan, Jordi Rello, Jeremy Cohen & Jason A. Roberts. (2016) Fundamentals of aerosol therapy in critical care. Critical Care 20:1.
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Arzu AriJames B. Fink. (2016) Differential Medical Aerosol Device and Interface Selection in Patients during Spontaneous, Conventional Mechanical and Noninvasive Ventilation. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:2, pages 95-106.
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Arzu Ari. (2016) Drug delivery interfaces: A way to optimize inhalation therapy in spontaneously breathing children. World Journal of Clinical Pediatrics 5:3, pages 281.
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David PrimeWilfried de BackerMelanie HamiltonAnthony CahnAndrew PreeceDennis KelleherAmanda BainesAlison MooreNoushin BrealeyJackie Moynihan. (2015) Effect of Disease Severity in Asthma and Chronic Obstructive Pulmonary Disease on Inhaler-Specific Inhalation Profiles Through the ELLIPTA ® Dry Powder Inhaler . Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:6, pages 486-497.
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Wolfgang Kamin, David Krackhardt, Rüdiger Gössl, Sabine Kattenbeck, Paul Koker, Petra Moroni-Zentgraf & Herbert Wachtel. (2015) A Handling Study to Assess the Use of the Respimat® Soft Mist™ Inhaler in Children Aged 4–12 Years. Pulmonary Therapy 1:1, pages 53-63.
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Fatemah S. Sunbul, James B. Fink, Robert Harwood, Meryl M. Sheard, Ralph D. Zimmerman & Arzu Ari. (2015) Comparison of HFNC, bubble CPAP and SiPAP on aerosol delivery in neonates: An in-vitro study. Pediatric Pulmonology 50:11, pages 1099-1106.
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Wolfgang KaminMarion FrankSabine KattenbeckPetra Moroni-ZentgrafHerbert WachtelStefan Zielen. (2015) A Handling Study to Assess Use of the Respimat ® Soft Mist™ Inhaler in Children Under 5 Years Old . Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:5, pages 372-381.
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Arzu AriArmele Dornelas de AndradeMeryl SheardBshayer AlHamadJames B. Fink. (2015) Performance Comparisons of Jet and Mesh Nebulizers Using Different Interfaces in Simulated Spontaneously Breathing Adults and Children. Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:4, pages 281-289.
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Jennifer Walsh, Marie-Christine Math, Jörg Breitkreutz, Thomas Zerback & Herbert Wachtel. (2015) Devices for oral and respiratory paediatric medicines: What do healthcare professionals think?. International Journal of Pharmaceutics 492:1-2, pages 304-315.
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Ralph Niven. (2013) Prospects and challenges: inhalation delivery systems. Therapeutic Delivery 4:5, pages 519-522.
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James B. Fink. (2012) Delivery of Inhaled Drugs for Infants and Small Children: A Commentary on Present and Future Needs. Clinical Therapeutics 34:11, pages S36-S45.
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