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Review

Update on the current status of cytomegalovirus vaccines

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Pages 1303-1314 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Xiaofeng Dai, Xuanhao Zhang, Kostya Ostrikov & Levon Abrahamyan. (2020) Host receptors: the key to establishing cells with broad viral tropism for vaccine production. Critical Reviews in Microbiology 46:2, pages 147-168.
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Krishna G Badami. (2014) CMV and transfusions, an old story that's not quite over yet. International Journal of Clinical Transfusion Medicine 2, pages 7-19.
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Julia Hornig & Alistair McGregor. (2014) Design and development of antivirals and intervention strategies against human herpesviruses using high-throughput approach. Expert Opinion on Drug Discovery 9:8, pages 891-915.
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Vijayendra Dasari, Corey Smith & Rajiv Khanna. (2013) Recent advances in designing an effective vaccine to prevent cytomegalovirus-associated clinical diseases. Expert Review of Vaccines 12:6, pages 661-676.
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Devon J. Shedlock, Kendra T. Talbott, Stephan J. Wu, Christine M. Wilson, Kar Muthumani, Jean D. Boyer, Niranjan Y Sardesai, Sita Awasthi & David B. Weiner. (2012) Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice. Human Vaccines & Immunotherapeutics 8:11, pages 1668-1681.
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Vincent C Emery. (2011) Could a vaccine against immune-evading cytomegalovirus become a reality?. Expert Review of Vaccines 10:8, pages 1109-1111.
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M.R. Schleiss. 2022. Encyclopedia of Infection and Immunity. Encyclopedia of Infection and Immunity 545 555 .
Mark R. Schleiss, Claudia Fernández-Alarcón, Nelmary Hernandez-Alvarado, Jian Ben Wang, Adam P. Geballe & Michael A. McVoy. (2021) Inclusion of the Guinea Pig Cytomegalovirus Pentameric Complex in a Live Virus Vaccine Aids Efficacy against Congenital Infection but Is Not Essential for Improving Maternal and Neonatal Outcomes. Viruses 13:12, pages 2370.
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Joanne R. Winter, Graham S. Taylor, Olivia G. Thomas, Charlotte Jackson, Joanna E. A. Lewis & Helen R. Stagg. (2020) Factors associated with cytomegalovirus serostatus in young people in England: a cross-sectional study. BMC Infectious Diseases 20:1.
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Clive Sweet. (2020) Lessons from studies with murine cytomegalovirus that could lead to a safe live attenuated vaccine for human cytomegalovirus. Access Microbiology 2:9.
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Shalja Verma & Anand Kumar Pandey. (2020) A disclosure of hidden secrets in human cytomegalovirus: An in-silico study of identification of novel genes and their analysis for vaccine development. Meta Gene 25, pages 100754.
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Harold R. Neely, Irina B. Mazo, Carmen Gerlach & Ulrich H. von Andrian. (2018) Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination?. Cold Spring Harbor Perspectives in Biology 10:10, pages a029488.
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Mark R. Schleiss & Stanley A. Plotkin. 2018. Plotkin's Vaccines. Plotkin's Vaccines 228 240.e6 .
Fengsheng Li, Daniel C. Freed, Aimin Tang, Richard R. Rustandi, Matthew C. Troutman, Amy S. Espeseth, Ningyan Zhang, Zhiqiang An, Michael McVoy, Hua Zhu, Sha Ha, Dai Wang, Stuart P. Adler & Tong-Ming Fu. (2017) Complement enhances in vitro neutralizing potency of antibodies to human cytomegalovirus glycoprotein B (gB) and immune sera induced by gB/MF59 vaccination. npj Vaccines 2:1.
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Michiel van Boven, Jan van de Kassteele, Marjolein J. Korndewal, Christiaan H. van Dorp, Mirjam Kretzschmar, Fiona van der Klis, Hester E. de Melker, Ann C. Vossen & Debbie van Baarle. (2017) Infectious reactivation of cytomegalovirus explaining age- and sex-specific patterns of seroprevalence. PLOS Computational Biology 13:9, pages e1005719.
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Jixiao Liu, Keke Feng, Lu Zhao, Haining Luo & Yingjun Zhu. (2017) Improvement of cytomegalovirus pp65 DNA vaccine efficacy by co-administration of siRNAs targeting BAK and BAX. Experimental and Therapeutic Medicine 13:6, pages 3275-3280.
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Sha Ha, Fengsheng Li, Matthew C. Troutman, Daniel C. Freed, Aimin Tang, John W. Loughney, Dai Wang, I-Ming Wang, Josef Vlasak, David C. Nickle, Richard R. Rustandi, Melissa Hamm, Pete A. DePhillips, Ningyan Zhang, Jason S. McLellan, Hua Zhu, Stuart P. Adler, Michael A. McVoy, Zhiqiang An & Tong-Ming Fu. (2017) Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex. Journal of Virology 91:7.
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Mark R. Schleiss, Ursula Berka, Elizabeth Watson, Mario Aistleithner, Bettina Kiefmann, Bastien Mangeat, Elizabeth C. Swanson, Peter A. Gillis, Nelmary Hernandez-Alvarado, Claudia Fernández-Alarcón, Jason C. Zabeli, Daniel D. Pinschewer, Anders E. Lilja, Michael Schwendinger, Farshad Guirakhoo, Thomas P. Monath & Klaus K. Orlinger. (2017) Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. Clinical and Vaccine Immunology 24:1.
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Elisabeth A. Pitt, Pranay Dogra, Ravi S. Patel, Angela Williams, Jonathan S. Wall & Tim E. Sparer. (2016) The D-form of a novel heparan binding peptide decreases cytomegalovirus infection in vivo and in vitro. Antiviral Research 135, pages 15-23.
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Tetsuo Koshizuka, Keiichiro Tanaka & Tatsuo Suzutani. (2016) Degradation of host ubiquitin E3 ligase Itch by human cytomegalovirus UL42. Journal of General Virology 97:1, pages 196-208.
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Bala Sai Sundarasetty, Stephan Kloess, Olaf Oberschmidt, Sonja Naundorf, Klaus Kuehlcke, Anusara Daenthanasanmak, Laura Gerasch, Constanca Figueiredo, Rainer Blasczyk, Eliana Ruggiero, Raffaele Fronza, Manfred Schmidt, Christof von Kalle, Michael Rothe, Arnold Ganser, Ulrike Koehl & Renata Stripecke. (2015) Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation. Journal of Translational Medicine 13:1.
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Claudio Ciferri, Sumana Chandramouli, Alexander Leitner, Danilo Donnarumma, Michael A. Cianfrocco, Rachel Gerrein, Kristian Friedrich, Yukti Aggarwal, Giuseppe Palladino, Ruedi Aebersold, Nathalie Norais, Ethan C. Settembre & Andrea Carfi. (2015) Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies. PLOS Pathogens 11:10, pages e1005230.
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Mark R. Schleiss, Craig J. Bierle, Elizabeth C. Swanson, Michael A. McVoy, Jian Ben Wang, Zainab Al-Mahdi & Adam P. Geballe. (2015) Vaccination with a Live Attenuated Cytomegalovirus Devoid of a Protein Kinase R Inhibitory Gene Results in Reduced Maternal Viremia and Improved Pregnancy Outcome in a Guinea Pig Congenital Infection Model. Journal of Virology 89:19, pages 9727-9738.
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Joachim Denner. (2015) Xenotransplantation and porcine cytomegalovirus. Xenotransplantation 22:5, pages 329-335.
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Elizabeth C. Swanson, Pete Gillis, Nelmary Hernandez-Alvarado, Claudia Fernández-Alarcón, Megan Schmit, Jason C. Zabeli, Felix Wussow, Don J. Diamond & Mark R. Schleiss. (2015) Comparison of monovalent glycoprotein B with bivalent gB/pp65 (GP83) vaccine for congenital cytomegalovirus infection in a guinea pig model: Inclusion of GP83 reduces gB antibody response but both vaccine approaches provide equivalent protection against pup mortality. Vaccine 33:32, pages 4013-4018.
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Ramon Arens, Ester B.M. Remmerswaal, Jos A. Bosch & René A.W. van Lier. (2015) 5 th International Workshop on CMV and Immunosenescence ‐ A shadow of cytomegalovirus infection on immunological memory . European Journal of Immunology 45:4, pages 954-957.
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Huadong Wang, Chaoyang Huang, Jinrong Dong, Yanfeng Yao, Zhenyuan Xie, Xueying Liu, Wenjie Zhang, Fang Fang & Ze Chen. (2015) Complete Protection of Mice against Lethal Murine Cytomegalovirus Challenge by Immunization with DNA Vaccines Encoding Envelope Glycoprotein Complex III Antigens gH, gL and gO. PLOS ONE 10:3, pages e0119964.
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