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Review

Bezlotoxumab: an emerging monoclonal antibody therapy for prevention of recurrent Clostridium difficile infection

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Pages 11-21 | Published online: 18 Jan 2018

Keep up to date with the latest research on this topic with citation updates for this article.

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Jin Zhang, Chuang Wan, Bo Yu, Chen Gao, Liqun Zhao, Xin Cheng, Feng Yang, Hao Gu, Quanming Zou, Jiang Gu & Xingyong Wang. (2019) Prophylactic and therapeutic protection of human IgG purified from sera containing anti-exotoxin A titers against pneumonia caused by Pseudomonas aeruginosa. Human Vaccines & Immunotherapeutics 15:12, pages 2993-3002.
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Andreas H. Laustsen. (2019) How can monoclonal antibodies be harnessed against neglected tropical diseases and other infectious diseases?. Expert Opinion on Drug Discovery 14:11, pages 1103-1112.
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Giovanni Cammarota, Antonella Gallo, Gianluca Ianiro & Massimo Montalto. (2019) Emerging drugs for the treatment of clostridium difficile. Expert Opinion on Emerging Drugs 24:1, pages 17-28.
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Joshua Heuler, Harish Chandra & Xingmin Sun. (2023) Mucosal Vaccination Strategies against Clostridioides difficile Infection. Vaccines 11:5, pages 887.
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Artem A. Derkaev, Ekaterina I. Ryabova, Ilias B. Esmagambetov, Dmitry V. Shcheblyakov, Svetlana A. Godakova, Irina D. Vinogradova, Anatoly N. Noskov, Denis Y. Logunov, Boris S. Naroditsky & Alexander L. Gintsburg. (2022) rAAV expressing recombinant neutralizing antibody for the botulinum neurotoxin type A prophylaxis. Frontiers in Microbiology 13.
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Melanie L. Hyte, Lee J. Arphai, Charles J. Vaughn & Spencer H. Durham. (2022) The Role of Bezlotoxumab for the Prevention of Recurrent Clostridioides difficile Infections: A Review of the Current Literature and Paradigm Shift after 2021. Antibiotics 11:9, pages 1211.
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Hamideh Raeisi, Masoumeh Azimirad, Ali Nabavi-Rad, Hamid Asadzadeh Aghdaei, Abbas Yadegar & Mohammad Reza Zali. (2022) Application of recombinant antibodies for treatment of Clostridioides difficile infection: Current status and future perspective. Frontiers in Immunology 13.
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Hui Wang, Daijie Chen & Huili Lu. (2022) Anti-bacterial monoclonal antibodies: next generation therapy against superbugs. Applied Microbiology and Biotechnology 106:11, pages 3957-3972.
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Sheo B. Singh, Lynn Miesel, Susanne Kramer, Libo Xu, Fangbio Li, Jing Lan, Phillip Lipari, Jon D. Polishook, Gongjie Liu, Lianzhu Liang & Amy M. Flattery. (2022) Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile . Journal of Natural Products 85:4, pages 1141-1146.
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Daisuke Oka, Naomitsu Yamaya, Takuya Kuno, Yuta Asakawa, Toshiyuki Shiragiku, Liang Chen, Jingbo Xue, Abudusaimi Mamuti, Fangguo Ye, Jiangqin Sun, Kinue Ohguro, Hisashi Miyamoto, Yukitaka Uematsu, Katsuya Inagaki, Jie-Fei Cheng & Makoto Matsumoto. (2021) In Vitro and In Vivo Antibacterial Activities of a Novel Quinolone Compound, OPS-2071, against Clostridioides difficile . Antimicrobial Agents and Chemotherapy 65:4.
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Carine A. Nkemngong, Gurpreet K. Chaggar, Xiaobao Li, Peter J. Teska & Haley F. Oliver. (2020) Disinfectant wipes transfer Clostridioides difficile spores from contaminated surfaces to uncontaminated surfaces during the disinfection process. Antimicrobial Resistance & Infection Control 9:1.
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J. Pollock, A.S. Low, R.E. McHugh, A. Muwonge, M.P. Stevens, A. Corbishley & D.L. Gally. (2020) Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use. Clinical Microbiology and Infection 26:12, pages 1617-1621.
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Shashi B. Kumar, Shanvanth R. Arnipalli & Ouliana Ziouzenkova. (2020) Antibiotics in Food Chain: The Consequences for Antibiotic Resistance. Antibiotics 9:10, pages 688.
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Felix Broecker, Erik Wegner, Bruna M. S. Seco, Paulina Kaplonek, Maria Bräutigam, Armin Ensser, Frederick Pfister, Christoph Daniel, Christopher E. Martin, Jochen Mattner & Peter H. Seeberger. (2019) Synthetic Oligosaccharide-Based Vaccines Protect Mice from Clostridioides difficile Infections . ACS Chemical Biology 14:12, pages 2720-2728.
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Ana Paula Guedes Frazzon, Michele Bertoni Mann & Jeverson Frazzon. 2019. Antibiotic Drug Resistance. Antibiotic Drug Resistance 477 502 .
Yan A. Ivanenkov, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Andrey A. Ayginin, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Dmitry A. Skvortsov, Katerina S. Komarova, Alexey V. Chemeris, Liana F. Zainullina, Marina A. Maximova, Zulfiya R. Zileeva, Yulia V. Vakhitova, Alexey Kh. Baymiev, Andrey Kh. Baymiev, Alina A. Sofronova, Alexey E. Machulkin, Rostislav A. Petrov, Dmitry S. Bezrukov, Maria M. Puchinina, Dmitrii A. Lukianov & Olga A. Dontsova. (2019) Substituted Furanocoumarins as Novel Class of Antibacterial Translation Inhibitors. Combinatorial Chemistry & High Throughput Screening 22:6, pages 400-410.
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Hemangi B. Shah, Kenneth Smith, Jonathan D. Wren, Carol F. Webb, Jimmy D. Ballard, Rebecka L. Bourn, Judith A. James & Mark L. Lang. (2019) Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires. Frontiers in Immunology 9.
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Viola Fühner, Philip Alexander Heine, Saskia Helmsing, Sebastian Goy, Jasmin Heidepriem, Felix F. Loeffler, Stefan Dübel, Ralf Gerhard & Michael Hust. (2018) Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile. Frontiers in Microbiology 9.
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Séverine Péchiné, Jean F. Bruxelle, Claire Janoir & Anne Collignon. (2018) Targeting Clostridium difficile Surface Components to Develop Immunotherapeutic Strategies Against Clostridium difficile Infection. Frontiers in Microbiology 9.
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Saša Jaćović, Slobodan Milisavljević, Miloš Milosavljević, Slobodan Janković & Srđan Stefanović. (2018) Modern approach to the therapy of infections caused by Clostridium difficile. Racionalna terapija 10:2, pages 25-31.
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