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Review

Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents

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Pages 47-60 | Published online: 25 Feb 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Dafeng Guo, Yu Yu, Binyu Long, Ping Deng, Dongzhi Ran, Lei Han, Jiecheng Zheng & Zongjie Gan. (2022) Design, synthesis and biological evaluation of 2,4-pyrimidinediamine derivatives as ALK and HDACs dual inhibitors for the treatment of ALK addicted cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2512-2529.
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Ludovica Lospinoso Severini, Francesca Ghirga, Francesca Bufalieri, Deborah Quaglio, Paola Infante & Lucia Di Marcotullio. (2020) The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma. Expert Opinion on Therapeutic Targets 24:11, pages 1159-1181.
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Zlatka Georgieva Dobreva, Boncho Grigorov Grigorov & Spaska Angelova Stanilova. (2016) Suppression of IL-12p40-related regulatory cytokines by suberoylanilide hydroxamic acid an inhibitor of histone deacetylases. Immunopharmacology and Immunotoxicology 38:4, pages 281-285.
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Susmitha Apuri & Lubomir Sokol. (2016) An overview of investigational Histone deacetylase inhibitors (HDACis) for the treatment of non-Hodgkin’s lymphoma. Expert Opinion on Investigational Drugs 25:6, pages 687-696.
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A Tedjaseputra, S Galli, M Ibrahim, CN Harrison & DP McLornan. (2016) Histone deacetylase inhibitors in myeloproliferative neoplasms: current roles and future prospects. Expert Opinion on Orphan Drugs 4:4, pages 417-427.
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Fabiana AS Brandão, Lorena S Derengowski, Patrícia Albuquerque, André M Nicola, Ildinete Silva-Pereira & Marcio J Poças-Fonseca. (2015) Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. Virulence 6:6, pages 618-630.
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Shabir Ahmad Ganai, Shashwath Malli Kalladi & Vijayalakshmi Mahadevan. (2015) HDAC inhibition through valproic acid modulates the methylation profiles in human embryonic kidney cells. Journal of Biomolecular Structure and Dynamics 33:6, pages 1185-1197.
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Stefan Swierczynski, Eckhard Klieser, Romana Illig, Beate Alinger-Scharinger, Tobias Kiesslich & Daniel Neureiter. (2015) Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases. Expert Opinion on Biological Therapy 15:5, pages 651-664.
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Lei Zhang & Wenfang Xu. (2015) Histone deacetylase inhibitors for enhancing activity of antifungal agent: a patent evaluation of WO2014041424(A1). Expert Opinion on Therapeutic Patents 25:2, pages 237-240.
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Shabir Ahmad Ganai, Karthi Shanmugam & Vijayalakshmi Mahadevan. (2015) Energy-optimised pharmacophore approach to identify potential hotspots during inhibition of Class II HDAC isoforms. Journal of Biomolecular Structure and Dynamics 33:2, pages 374-387.
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Eftiola Pojani & Daniela Barlocco. (2022) Selective Inhibitors of Histone Deacetylase 10 (HDAC-10). Current Medicinal Chemistry 29:13, pages 2306-2321.
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Xiaopeng Peng, Ling Li, Jingxuan Chen, Yichang Ren, Jin Liu, Ziwen Yu, Hao Cao & Jianjun Chen. (2022) Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma. Journal of Medicinal Chemistry 65:3, pages 2434-2457.
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Ricardo Ribeiro Gama, Lidia Maria Rebolho Batista Arantes, Bruna Pereira Sorroche, Pedro De Marchi, Matias Eliseo Melendez, Raiany Santos Carvalho, Marcos Alves de Lima, André Luiz Vettore & André Lopes Carvalho. (2021) Evaluation of acetylation and methylation in oral rinse of patients with head and neck cancer history exposed to valproic acid. Scientific Reports 11:1.
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Xiaopeng Peng, Jingxuan Chen, Ling Li, Zhiqiang Sun, Jin Liu, Yichang Ren, Junli Huang & Jianjun Chen. (2021) Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents. Journal of Medicinal Chemistry 64:12, pages 8447-8473.
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Masakazu Hamada & Yoshiaki Yura. (2020) Efficient Delivery and Replication of Oncolytic Virus for Successful Treatment of Head and Neck Cancer. International Journal of Molecular Sciences 21:19, pages 7073.
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Flávia Alves Verza, Umashankar Das, Ana Lúcia Fachin, Jonathan R. Dimmock & Mozart Marins. (2020) Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy. Cancers 12:6, pages 1664.
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Kim, Kwon, Jung, Kim & Jeoung. (2019) FcεRI-HDAC3-MCP1 Signaling Axis Promotes Passive Anaphylaxis Mediated by Cellular Interactions. International Journal of Molecular Sciences 20:19, pages 4964.
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