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Original Research

Adherence to disease-modifying therapies and its impact on relapse, health resource utilization, and costs among patients with multiple sclerosis

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Pages 251-260 | Published online: 28 Apr 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Cristina Soria, Lola Prieto, Esther Lázaro & Amalia Ubeda. (2023) Factors Associated with Therapeutic Adherence in Multiple Sclerosis in Spain. Patient Preference and Adherence 17, pages 679-688.
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Lita Araujo, Srikanth Kyatham, Kristen G Bzdek, Keiko Higuchi & Nupur Greene. (2023) Assessing the Health Economic Outcomes from Commercially Insured Relapsing Multiple Sclerosis Patients Who Switched from Other Disease-Modifying Therapies to Teriflunomide, in the United States. ClinicoEconomics and Outcomes Research 15, pages 361-373.
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Uwe Klaus Zettl, Paulus Stefan Rommer, Orhan Aktas, Torsten Wagner, Joachim Richter, Patrick Oschmann, Lukas Cepek, Birte Elias-Hamp, Klaus Gehring, Andrew Chan & Michael Hecker. (2023) Interferon beta-1a sc at 25 years: a mainstay in the treatment of multiple sclerosis over the period of one generation. Expert Review of Clinical Immunology 19:11, pages 1343-1359.
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Nupur Greene, Keiko Higuchi, Katalin Bognar, Eunice Chang & Michael S Broder. (2022) Medication Adherence and Healthcare Utilization in Relapsing-Remitting Multiple Sclerosis Patients Using Teriflunomide. ClinicoEconomics and Outcomes Research 14, pages 755-761.
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Jessica K. Alexander, Rinat Ariely, Ying Wu, Erin Hulbert, Allison Bryant, Zhaohui Su, Michaela Vardi & Jyotsna Kasturi. (2021) Treatment patterns following initiation of generic glatiramer acetate among patients with multiple sclerosis from two large real-world databases in the United States. Current Medical Research and Opinion 37:8, pages 1323-1329.
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Jagadeswara R Earla, George J Hutton, J Douglas Thornton, Hua Chen, Michael L Johnson & Rajender R Aparasu. (2020) Comparative Adherence Trajectories of Oral Fingolimod and Injectable Disease Modifying Agents in Multiple Sclerosis. Patient Preference and Adherence 14, pages 2187-2199.
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Francesco Patti, María Luisa Martínez Ginés, Christiane Norenberg & Fernando Duarte Caron. (2020) BetaEval Global: Prospective, Multinational, Observational Cohort Study of Patients Using BETACONNECT®. Patient Preference and Adherence 14, pages 771-779.
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Emma van Eijndhoven, Michelle Brauer, Rebecca Kee, Joanna MacEwan, Lisa Mucha, Schiffon L. Wong, Adeline Durand & Jason Shafrin. (2020) Modeling the impact of patient treatment preference on health outcomes in relapsing-remitting multiple sclerosis. Journal of Medical Economics 23:5, pages 474-483.
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Aleksandra Kołtuniuk & Joanna Rosińczuk. (2018) Adherence to disease-modifying therapies in patients with multiple sclerosis. Patient Preference and Adherence 12, pages 1557-1566.
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Laura Dumitrescu, Cris S. Constantinescu & Radu Tanasescu. (2018) Recent developments in interferon-based therapies for multiple sclerosis. Expert Opinion on Biological Therapy 18:6, pages 665-680.
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Andrea Zimmer, Michael Coslovsky, Ivo Abraham & Bernhard F Décard. (2017) Adherence to fingolimod in multiple sclerosis: an investigator-initiated, prospective, observational, single-center cohort study. Patient Preference and Adherence 11, pages 1815-1830.
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Articles from other publishers (69)

Maj Jožef, Igor Locatelli, Gregor Brecl Jakob, Uroš Rot & Mitja Kos. (2023) Medication adherence and health outcomes in persons with multiple sclerosis treated with dimethyl fumarate. Multiple Sclerosis and Related Disorders 72, pages 104615.
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L. B. Grech & R. Borland. (2021) Using CEOS theory to inform the development of behaviour change implementation and maintenance initiatives for people with multiple sclerosis. Current Psychology 42:9, pages 7433-7447.
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Brittney Lager, Jacob Liseno, Ivan Božin, Sarah M. England, Sai L. Shankar, Jason P. Mendoza & James B. Lewin. (2022) Real-World Analysis Affirms the High Persistence and Adherence Observed with Diroximel Fumarate in Patients with Multiple Sclerosis. Neurology and Therapy 12:1, pages 145-159.
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Lita Araujo, Svend S. Geertsen, Allen Amedume, Keiko Higuchi & Janneke van Wingerden. (2022) Persistence, Adherence, and Switching to Higher-Cost Therapy in Patients with Multiple Sclerosis Initiating Oral Disease-Modifying Therapies: A Retrospective Real-World Study. Neurology and Therapy 11:4, pages 1735-1748.
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Aleksandra Kołtuniuk, Aleksandra Pytel, Dorota Krówczyńska & Justyna Chojdak-Łukasiewicz. (2022) The Quality of Life and Medication Adherence in Patients with Multiple Sclerosis—Cross-Sectional Study. International Journal of Environmental Research and Public Health 19:21, pages 14549.
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Amanda M. Kibbons, Ryan Moore, Leena Choi, Megan Peter & Autumn D. Zuckerman. (2022) Individual and Community-Level Characteristics and Adherence to Specialty Medications. Journal of Pharmacy Practice, pages 089719002211319.
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Marco Peresson, Salvatore Cottone, Vincenzo Brescia Morra, Giuseppe Salemi, Antonio Gallo, Paola Valentino & Luca Prosperini. (2022) Off-Adherence Keeping (OAK) observational study: intentional off-adherence immunomodulatory multiple sclerosis treatment. Neurodegenerative Disease Management 12:5, pages 241-251.
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N. Giedraitiene, V. Taluntiene & G. Kaubrys. (2022) Relationship between cognition and treatment adherence to disease-modifying therapy in multiple sclerosis: a prospective, cross-sectional study. Scientific Reports 12:1.
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Rashed Bawand, Masoud Ghiasian, Negin Fathoallahi & Abbas Moradi. (2022) Effects of disease-modifying treatments discontinuation in patients with relapsing-remitting multiple sclerosis: A 5 year prospective cohort study. Multiple Sclerosis and Related Disorders 63, pages 103857.
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Gabriel Pardo, Elmor D. PinedaCarmen D. NgDaniel SheinsonNicole G. Bonine. (2022) The Association Between Persistence and Adherence to Disease-Modifying Therapies and Healthcare Resource Utilization and Costs in Patients With Multiple Sclerosis. Journal of Health Economics and Outcomes Research 9:1, pages 111-116.
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Jacqueline A Nicholas, Natalie C Edwards, Roger A Edwards, Anna Dellarole, Luigi Manca, Danielle E Harlow & Amy L Phillips. (2022) Static and group-based trajectory analyses of factors associated with non-adherence in patients with multiple sclerosis newly-initiating once- or twice-daily oral disease-modifying therapy. Multiple Sclerosis Journal - Experimental, Translational and Clinical 8:2, pages 205521732211011.
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Bianca Weinstock-Guttman, Robert Bermel, Gary Cutter, Mark S Freedman, Thomas P Leist, Xiaoye Ma, Deidre Kile, Bruno Musch, Anthony T Reder & Jerry S Wolinsky. (2021) Ocrelizumab treatment for relapsing-remitting multiple sclerosis after a suboptimal response to previous disease-modifying therapy: A nonrandomized controlled trial. Multiple Sclerosis Journal 28:5, pages 790-800.
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Daniel M. Hartung, Kirbee A. JohnstonJessina C. McGregorDennis N. Bourdette. (2022) Characteristics of Prescription Drug Use Among Individuals With Multiple Sclerosis in the US Medicare Population. International Journal of MS Care 24:2, pages 90-97.
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Alessandra Buja, Guendalina Graffigna, Simona F. Mafrici, Tatjana Baldovin, Carlo Pinato, Umberto Bolzonella, Serena Barello, Alessia Tognetto & Gianfranco Damiani. (2021) Adherence to Therapy, Physical and Mental Quality of Life in Patients with Multiple Sclerosis. Journal of Personalized Medicine 11:7, pages 672.
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Machaon Bonafede, Rina Mehta, Gilwan Kim, Ila Sruti, Marc Tian, Corey Pelletier & Neil Goldfarb. (2020) Productivity Loss and Associated Costs Among Employed Patients Receiving Disease-Modifying Treatment for Multiple Sclerosis. PharmacoEconomics - Open 5:1, pages 23-34.
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Wolfgang Köhler, Kirsten Bayer-Gersmann, Thomas Neußer, Markus Schürks & Tjalf Ziemssen. (2021) Predictors of Adherence Among Patients With Multiple Sclerosis Using the BETACONNECT® Autoinjector: A Prospective Observational Cohort Study. Frontiers in Neurology 12.
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Gisela Zanga, Estefania Drzewiscki, Paula Tagliani, Maximiliano Smietniansky, Maria M. Esnaola y Rojas & Diego Caruso. (2021) Predictors of adherence and persistence to disease-modifying therapies in Multiple Sclerosis. Therapeutic Advances in Neurological Disorders 14, pages 175628642110310.
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Jacqueline A. Nicholas, Natalie C. Edwards, Roger A. Edwards, Anna Dellarole, Megan Grosso & Amy L. Phillips. (2020) Real-world adherence to, and persistence with, once- and twice-daily oral disease-modifying drugs in patients with multiple sclerosis: a systematic review and meta-analysis. BMC Neurology 20:1.
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Elizabeth S. Gromisch, Aaron P. Turner, Steven L. Leipertz, John Beauvais & Jodie K. Haselkorn. (2020) Risk Factors for Suboptimal Medication Adherence in Persons With Multiple Sclerosis: Development of an Electronic Health Record-Based Explanatory Model for Disease-Modifying Therapy Use. Archives of Physical Medicine and Rehabilitation 101:5, pages 807-814.
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Ee Ling Yoon & Wing Loong Cheong. (2019) Adherence to oral disease-modifying therapy in multiple sclerosis patients: A systematic review. Multiple Sclerosis and Related Disorders 28, pages 104-108.
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