Citations (82)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (13)
Richard L Rauck, Neal E Slatkin, Nancy Stambler & Robert J Israel. (2019) Safety of oral methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain. Journal of Pain Research 12, pages 139-150.
Read now
Read now
Lynn R Webster & Robert J Israel. (2018) Oral methylnaltrexone is efficacious and well tolerated for the treatment of opioid-induced constipation in patients with chronic noncancer pain receiving concomitant methadone. Journal of Pain Research 11, pages 2509-2516.
Read now
Read now
Lynn R Webster & Robert J Israel. (2018) Oral methylnaltrexone does not negatively impact analgesia in patients with opioid-induced constipation and chronic noncancer pain. Journal of Pain Research 11, pages 1503-1510.
Read now
Read now
Eric T Wittbrodt, Tong J Gan, Catherine Datto, Charles McLeskey & Meenal Sinha. (2018) Resource use and costs associated with opioid-induced constipation following total hip or total knee replacement surgery. Journal of Pain Research 11, pages 1017-1025.
Read now
Read now
Carsten Bantel, Shiva S Tripathi, David Molony, Tony Heffernan, Susmita Oomman, Vivek Mehta & Sara Dickerson. (2018) Prolonged-release oxycodone/naloxone reduces opioid-induced constipation and improves quality of life in laxative-refractory patients: results of an observational study. Clinical and Experimental Gastroenterology 11, pages 57-67.
Read now
Read now
Stephanie C Yoon & Heather C Bruner. (2017) Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Preference and Adherence 11, pages 1265-1271.
Read now
Read now
Gineke Koopmans-Klein, Joeri Van Op den Bosch, Yvonne van Megen, Hans Prenen, Frank Huygen & Isabelle Mancini. (2017) Prolonged release oxycodone and naloxone treatment counteracts opioid-induced constipation in patients with severe pain compared to previous analgesic treatment. Current Medical Research and Opinion 33:12, pages 2217-2227.
Read now
Read now
Waldemar Siemens & Gerhild Becker. (2016) Methylnaltrexone for opioid-induced constipation: review and meta-analyses for objective plus subjective efficacy and safety outcomes. Therapeutics and Clinical Risk Management 12, pages 401-412.
Read now
Read now
Gineke Koopmans-Klein, Michel F.M. Wagemans, Hans C.H. Wartenberg, Yvonne J.B. Van Megen & Frank J.P.M. Huygen. (2016) The efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: a small Dutch observational pilot study. Expert Review of Gastroenterology & Hepatology 10:4, pages 547-553.
Read now
Read now
Lynn R Webster, Darren M Brenner, Andrew C Barrett, Craig Paterson, Enoch Bortey & William P Forbes. (2015) Analysis of opioid-mediated analgesia in Phase III studies of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain. Journal of Pain Research 8, pages 771-780.
Read now
Read now
Heather C Bruner, Rabia S Atayee, Kyle P Edmonds & Gary T Buckholz. (2015) Clinical utility of naloxegol in the treatment of opioid-induced constipation. Journal of Pain Research 8, pages 289-294.
Read now
Read now
Waldemar Siemens, Jan Gaertner & Gerhild Becker. (2015) Advances in pharmacotherapy for opioid-induced constipation – a systematic review. Expert Opinion on Pharmacotherapy 16:4, pages 515-532.
Read now
Read now
Maura Corsetti & Jan Tack. (2015) Naloxegol, a new drug for the treatment of opioid-induced constipation. Expert Opinion on Pharmacotherapy 16:3, pages 399-406.
Read now
Read now
Articles from other publishers (69)
Ricki Nero, Bryan Allen, Kirubel Hailu, Refat Noor & Kimberly Theiss. (2022) Impact of oral naloxegol vs subcutaneous methylnaltrexone in treatment of opioid-induced constipation in the hospital setting. American Journal of Health-System Pharmacy.
Crossref
Crossref
V. Andresen, G. Becker, T. Frieling, M. Goebel-Stengel, F. Gundling, A. Herold, M. Karaus, J. Keller, M. Kim, P. Klose, H. Krammer, M. E. Kreis, R. Kuhlbusch-Zicklam, J. Langhorst, P. Layer, R. Lenzen-Großimlinghaus, A. Madisch, H. Mönnikes, S. Müller-Lissner, D. Rubin, M. Schemann, J. Schwille-Kiuntke, A. Stengel, M. Storr, I. van der Voort, W. Voderholzer, T. Wedel, S. Wirz, H. Witzigmann & C. Pehl. (2022) Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie & Motilität (DGNM) – April 2022 – AWMF-Registriernummer: 021–019. Zeitschrift für Gastroenterologie 60:10, pages 1528-1572.
Crossref
Crossref
Bridget Candy, Louise Jones, Victoria Vickerstaff, Philip J Larkin & Patrick Stone. (2022) Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care. Cochrane Database of Systematic Reviews 2022:9.
Crossref
Crossref
Brooks D. Cash. (2022) Incidence, pathophysiology, and implications of opioid‐induced constipation and suggestions for patient‐provider interactions. Alimentary Pharmacology & Therapeutics 55:S2.
Crossref
Crossref
Alexander R. Tryson, Erin K. Hennessey & Andrew J. Crannage. (2020) Evaluation of a Pharmacist-Driven Protocol for the Treatment of Opioid-Induced Constipation. Journal of Pharmacy Practice 35:2, pages 218-222.
Crossref
Crossref
Kai-Uwe Kern, Tobias Vogelmann & Thomas R. Tölle. (2022) Tapentadol versus klassische WHO-III-Opioide bei chronischen RückenschmerzenTapentadol versus classical WHO-III opioids for chronic back pain. Health services research study based on representative data from health insurance funds. MMW - Fortschritte der Medizin 164:S6, pages 19-27.
Crossref
Crossref
Joy J. Liu & Darren M. Brenner. (2022) Opioid-Related Constipation. Gastroenterology Clinics of North America 51:1, pages 107-121.
Crossref
Crossref
Regina Gironés Sarrió, Agnès Calsina-Berna, Adoración Gozalvo García, José Miguel Esparza-Miñana, Esther Falcó Ferrer & Josep Porta-Sales. (2021) Delphi consensus on strategies in the management of opioid-induced constipation in cancer patients. BMC Palliative Care 20:1.
Crossref
Crossref
Giustino Varrassi, Vivek Banerji, Walter Gianni, Franco Marinangeli & Carmine Pinto. (2021) Impact and Consequences of Opioid-Induced Constipation: A Survey of Patients. Pain and Therapy 10:2, pages 1139-1153.
Crossref
Crossref
Hideki Mori, Jan Tack & Hidekazu Suzuki. (2021) Magnesium Oxide in Constipation. Nutrients 13:2, pages 421.
Crossref
Crossref
Martin E. Hale, James E. Wild, Tadaaki Yamada, Takaaki Yokota, Jan Tack, Viola Andresen & Asbjørn Mohr Drewes. (2021) Naldemedine is effective in the treatment of opioid-induced constipation in patients with chronic non-cancer pain who had a poor response to laxatives. Therapeutic Advances in Gastroenterology 14, pages 175628482110323.
Crossref
Crossref
Charles E. Argoff. (2020) Opioid-induced Constipation. The Clinical Journal of Pain 36:9, pages 716-722.
Crossref
Crossref
Priya Vijayvargiya, Michael Camilleri, Pooja Vijayvargiya, Patricia Erwin & M. Hassan Murad. (2020) Systematic review with meta-analysis: efficacy and safety of treatments for opioid-induced constipation. Alimentary Pharmacology & Therapeutics 52:1, pages 37-53.
Crossref
Crossref
Darren M. Brenner, Charles E. Argoff, Susan M. Fox, Wieslaw Bochenek, Patricia D'Astoli, Rick E. Blakesley, David S. Reasner, Christopher R. O'Dea & Brooks D. Cash. (2020) Efficacy and safety of linaclotide for opioid-induced constipation in patients with chronic noncancer pain syndromes from a phase 2 randomized study. Pain 161:5, pages 1027-1036.
Crossref
Crossref
Soichi Fumita, Hisao Imai, Toshiyuki Harada, Toshio Noriyuki, Makio Gamoh, Yusaku Akashi, Hiroki Sato, Yoshiyuki Kizawa & Akihiro Tokoro. (2020) Patients' Self-Assessment of the Symptoms and Impact of Opioid-Induced Constipation: Results From a Prospective Observational Cohort Study of Japanese Patients With Cancer. Journal of Pain and Symptom Management 59:5, pages 1043-1051.e2.
Crossref
Crossref
Fern FitzHenry, Svetlana K. Eden, Jason Denton, Hui Cao, Aize Cao, Ruth Reeves, Guanhua Chen, Glenn Gobbel, Nancy Wells & Michael E. Matheny. (2020) Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort. Pain Research and Management 2020, pages 1-11.
Crossref
Crossref
O.D. Ostroumova, E.Yu. Shakhova & A.I. Kochetkov. (2020) Drug-induced constipation. Dokazatel'naya gastroenterologiya 9:1, pages 20.
Crossref
Crossref
Michelle S. Keller, Alma Jusufagic & Brennan M. R. Spiegel. (2019) Patient and provider differences in the treatment of opioid-induced constipation: a qualitative study. BMC Gastroenterology 19:1.
Crossref
Crossref
Ricard Mesía, Juan Antonio Virizuela Echaburu, Jose Gómez, Tamara Sauri, Gloria Serrano & Eduardo Pujol. (2019) Opioid-Induced Constipation in Oncological Patients: New Strategies of Management. Current Treatment Options in Oncology 20:12.
Crossref
Crossref
Hannah A. Blair. (2019) Naldemedine: A Review in Opioid-Induced Constipation. Drugs 79:11, pages 1241-1247.
Crossref
Crossref
Robert B. Raffa, Robert TaylorJr.Jr. & Joseph V. PergolizziJr.Jr.. (2019) Treating opioid‐induced constipation in patients taking other medications: Avoiding CYP450 drug interactions. Journal of Clinical Pharmacy and Therapeutics 44:3, pages 361-371.
Crossref
Crossref
Kenichi Nishie, Shuhei Yamamoto, Takayoshi Yamaga, Naoto Horigome & Masayuki Hanaoka. (2019) Peripherally acting μ‐opioid antagonist for the treatment of opioid‐induced constipation: Systematic review and meta‐analysis. Journal of Gastroenterology and Hepatology 34:5, pages 818-829.
Crossref
Crossref
Roberta Dume & Michael Shuman. (2019) Naloxegol. Orthopaedic Nursing 38:3, pages 209-211.
Crossref
Crossref
April Hazard Vallerand, Sarah Hendry, Elizabeth Baldys, Yiqun Hu & Catherine Datto. (2019) Analysis of Patient–Provider Interactions Regarding the Burden and Treatment of Opioid-Induced Constipation in Adults with Chronic Noncancer Pain. Pain Medicine 20:5, pages 889-896.
Crossref
Crossref
Eugene R. Viscusi. (2019) Clinical Overview and Considerations for the Management of Opioid-induced Constipation in Patients With Chronic Noncancer Pain. The Clinical Journal of Pain 35:2, pages 174-188.
Crossref
Crossref
Perry G. Fine, Yen-Wen Chen, Eric Wittbrodt & Catherine Datto. (2018) Impact of opioid-induced constipation on healthcare resource utilization and costs for cancer pain patients receiving continuous opioid therapy. Supportive Care in Cancer 27:2, pages 687-696.
Crossref
Crossref
Maura Corsetti, Jasper Pannemans & Peter Whorwell. (2019) Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research 8, pages 257.
Crossref
Crossref
Stephen J Ziegler. (2019) Please Release Me, Let Me Go: How the Failure to Discuss and Treat OIC Can Result in Adverse Medico-Legal Outcomes. Pain Medicine 20:1, pages 3-4.
Crossref
Crossref
Seth D. Crockett, Katarina B. Greer, Joel J. Heidelbaugh, Yngve Falck-Ytter, Brian J. Hanson & Shahnaz Sultan. (2019) American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation. Gastroenterology 156:1, pages 218-226.
Crossref
Crossref
John M. Streicher & Edward J. Bilsky. (2017) Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications. Journal of Pharmacy Practice 31:6, pages 658-669.
Crossref
Crossref
Anita Gupta, Karin S Coyne, Catherine Datto & Christine Venuti. (2018) The Burden of Opioid-Induced Constipation in Younger Patients with Chronic Noncancer Pain. Pain Medicine 19:12, pages 2459-2468.
Crossref
Crossref
Viola Andresen, Vivek Banerji, Genevieve Hall, Amir Lass & Anton V Emmanuel. (2018) The patient burden of opioid‐induced constipation: New insights from a large, multinational survey in five European countries. United European Gastroenterology Journal 6:8, pages 1254-1266.
Crossref
Crossref
Shuo Qi, Hezheng Lai, Yayue Zhang, Qing Dong & Xiaoshu Zhu. (2018) Chinese herbal medicine for opioid induced constipation in cancer patients. Medicine 97:39, pages e12594.
Crossref
Crossref
Manuel Merlos, Enrique Portillo-Salido, Alex Brenchat, Bertrand Aubel, Jordi Buxens, Angels Fisas, Xavier Codony, Luz Romero, Daniel Zamanillo & José Miguel Vela. (2018) Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats. European Journal of Pharmacology 833, pages 370-378.
Crossref
Crossref
Andrea Gaisser. (2018) Probleme effektiver Schmerztherapie. Schmerzmedizin 34:4, pages 62-63.
Crossref
Crossref
Bridget Candy, Louise Jones, Victoria Vickerstaff, Philip J Larkin & Patrick Stone. (2018) Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care. Cochrane Database of Systematic Reviews 2018:6.
Crossref
Crossref
Lynn R. Webster, Srinivas Nalamachu, Bart Morlion, Jyotsna Reddy, Yuko Baba, Tadaaki Yamada & Juan C. Arjona Ferreira. (2018) Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study. Pain 159:5, pages 987-994.
Crossref
Crossref
Ulf Schutter. (2018) Rückenschmerzen — Sichere Schmerztherapie in Klinik und Praxis. Schmerzmedizin 34:3, pages 28-31.
Crossref
Crossref
Adam D Farmer, Caroline Bruckner Holt, Thomas J Downes, Eugenio Ruggeri, Sara Del Vecchio & Roberto De Giorgio. (2018) Pathophysiology, diagnosis, and management of opioid-induced constipation. The Lancet Gastroenterology & Hepatology 3:3, pages 203-212.
Crossref
Crossref
Chang Ju HwangSung Soo ChungKyu-Yeol LeeJae Hyup LeeSeong-Hwan MoonJin-Hyok KimKyu-Jung ChoJae-Sung AhnDong-Soo KimYe-Soo ParkHye-Jeong Park. (2018) Analgesic Efficacy and Safety of Prolonged-Release Oxycodone/Naloxone in Korean Patients with Chronic Pain from Spinal Disorders. Clinics in Orthopedic Surgery 10:1, pages 33.
Crossref
Crossref
Gerhild Becker & Waldemar Siemens. (2017) Opioid-induced constipation: reflections on efficacy assessment. The Lancet Gastroenterology & Hepatology 2:8, pages 540-541.
Crossref
Crossref
Richard Rauck, Neal E. Slatkin, Nancy Stambler, Joseph R. Harper & Robert J. Israel. (2017) Randomized, Double-Blind Trial of Oral Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain. Pain Practice 17:6, pages 820-828.
Crossref
Crossref
Khanh Bui, Bruce Birmingham, Ulysses Diva & Bruce Berger. (2017) An Open-Label, Randomized Bioavailability Study of Alternative Methods of Oral Administration of Naloxegol in Healthy Subjects. Clinical Pharmacology in Drug Development 6:4, pages 420-427.
Crossref
Crossref
Khanh Bui, Diansong Zhou, Hongmei Xu, Eike Floettmann & Nidal Al-Huniti. (2016) Clinical Pharmacokinetics and Pharmacodynamics of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist. Clinical Pharmacokinetics 56:6, pages 573-582.
Crossref
Crossref
Jens Søndergaard, Helene Nordahl Christensen, Rikke Ibsen, Dorte Ejg Jarbøl & Jakob Kjellberg. (2017) Healthcare resource use and costs of opioid-induced constipation among non-cancer and cancer patients on opioid therapy: A nationwide register-based cohort study in Denmark. Scandinavian Journal of Pain 15:1, pages 83-90.
Crossref
Crossref
Tso-Chou Lin, Luo-Ping Ger, Joseph V. PergolizziJr.Jr., Robert B. Raffa, Ju-O Wang & Shung-Tai Ho. (2017) Long-term use of opioids in 210 officially registered patients with chronic noncancer pain in Taiwan: A cross-sectional study. Journal of the Formosan Medical Association 116:4, pages 257-265.
Crossref
Crossref
Richard L. Rauck, Kyung-soo Jason Hong & James North. (2017) Opioid-Induced Constipation Survey in Patients with Chronic Noncancer Pain. Pain Practice 17:3, pages 329-335.
Crossref
Crossref
Robert S. Epstein, J. Russell Teagarden, Ali Cimen, Mark Sostek & Tehseen Salimi. (2017) When People with Opioid-Induced Constipation Speak: A Patient Survey. Advances in Therapy 34:3, pages 725-731.
Crossref
Crossref
April Hazard Vallerand. (2017) Opioid-induced Constipation. The Journal for Nurse Practitioners 13:2, pages 170-174.e3.
Crossref
Crossref
Richard Lawson, James Ryan, Frederic King, Jo Wern Goh, Eszter Tichy & Kevin Marsh. (2016) Cost Effectiveness of Naloxegol for Opioid-Induced Constipation in the UK. PharmacoEconomics 35:2, pages 225-235.
Crossref
Crossref
Karin S. Coyne, Jiat-Ling Poon, Christine Thompson, Yiqun Hu, Catherine J. Datto & Mark Sostek. (2017) Translating Clinical Findings into the Patient’s Perspective: Post-hoc Pooled Analysis of Bowel Movement Changes as a Predictor of Improvement in Patients’ Opioid-induced Constipation Symptoms and Outcomes. Clinical Therapeutics 39:1, pages 75-88.
Crossref
Crossref
Merja Kokki, Moona Kuronen, Toivo Naaranlahti, Timo Nyyssönen, Ira Pikkarainen, Sakari Savolainen & Hannu Kokki. (2016) Opioid-Induced Bowel Dysfunction in Patients Undergoing Spine Surgery: Comparison of Oxycodone and Oxycodone-Naloxone Treatment. Advances in Therapy 34:1, pages 236-251.
Crossref
Crossref
Paul S. J. Miller, Harry Hill & Fredrik L. Andersson. (2016) Nocturia Work Productivity and Activity Impairment Compared with Other Common Chronic Diseases. PharmacoEconomics 34:12, pages 1277-1297.
Crossref
Crossref
Catherine J Datto, Robert J LoCasale, Mary Kay Margolis, Christine L Thompson & Karin S Coyne. (2016) Laxative utilization over time in chronic pain patients with opioid-induced constipation. Pain Management 6:6, pages 531-541.
Crossref
Crossref
Sita Chokhavatia, Elizabeth S. John, Mary Barna Bridgeman & Deepali Dixit. (2016) Constipation in Elderly Patients with Noncancer Pain: Focus on Opioid-Induced Constipation. Drugs & Aging 33:8, pages 557-574.
Crossref
Crossref
Richard Lawson, Frederic King, Kevin Marsh, Arman Altincatal & Ali Cimen. (2016) Impact of Treatment with Naloxegol for Opioid-Induced Constipation on Patients’ Health State Utility. Advances in Therapy 33:8, pages 1331-1346.
Crossref
Crossref
Karin S. Coyne, Chris Sexton, Robert J. LoCasale, Frederic R. King, Mary Kay Margolis & Sam H. Ahmedzai. (2016) Opioid-Induced Constipation among a Convenience Sample of Patients with Cancer Pain. Frontiers in Oncology 6.
Crossref
Crossref
Helene Nordahl Christensen, Urban Olsson, Jesper From & Harald Breivik. (2016) Opioid-induced constipation, use of laxatives, and health-related quality of life. Scandinavian Journal of Pain 11:1, pages 104-110.
Crossref
Crossref
Robert J. LoCasaleCatherine DattoMary Kay MargolisKarin S. Coyne. (2016) Satisfaction with Therapy Among Patients with Chronic Noncancer Pain with Opioid-Induced Constipation. Journal of Managed Care & Specialty Pharmacy 22:3, pages 246-253.
Crossref
Crossref
Robert J. LoCasaleCatherine DattoHilary WilsonKaren YeomansKarin S. Coyne. (2016) The Burden of Opioid-Induced Constipation: Discordance Between Patient and Health Care Provider Reports. Journal of Managed Care & Specialty Pharmacy 22:3, pages 236-245.
Crossref
Crossref
Alfred D. Nelson & Michael Camilleri. (2016) Opioid-induced constipation: advances and clinical guidance. Therapeutic Advances in Chronic Disease 7:2, pages 121-134.
Crossref
Crossref
H. Christian Weber. (2016) Opioid-induced constipation in chronic noncancer pain. Current Opinion in Endocrinology, Diabetes & Obesity 23:1, pages 11-17.
Crossref
Crossref
R. J. LoCasale, C. J. Datto, M. K. Margolis, J. Tack & K. S. Coyne. (2015) The impact of opioid-induced constipation among chronic pain patients with sufficient laxative use. International Journal of Clinical Practice 69:12, pages 1448-1456.
Crossref
Crossref
Jan Tack, Jaakko Lappalainen, Ulysses Diva, Raj Tummala & Mark Sostek. (2015) Efficacy and safety of naloxegol in patients with opioid‐induced constipation and laxative‐inadequate response. United European Gastroenterology Journal 3:5, pages 471-480.
Crossref
Crossref
Katherine M. Hunold, Samantha A. Smith & Timothy F. Platts-Mills. (2015) Constipation Prophylaxis Is Rare for Adults Prescribed Outpatient Opioid Therapy From U.S. Emergency Departments. Academic Emergency Medicine 22:9, pages 1118-1121.
Crossref
Crossref
Alfred D. Nelson & Michael Camilleri. (2015) Chronic opioid induced constipation in patients with nonmalignant pain: challenges and opportunities. Therapeutic Advances in Gastroenterology 8:4, pages 206-220.
Crossref
Crossref
Jun-Ping Li. (2015) Neurochemical features of endomorphin-2-containing neurons in the submucosal plexus of the rat colon. World Journal of Gastroenterology 21:34, pages 9936.
Crossref
Crossref
Robert S. Epstein, Ali Cimen, Hannah Benenson, Ronald E. Aubert, Mona Khalid, Mark B. Sostek & Tehseen Salimi. (2014) Patient Preferences for Change in Symptoms Associated with Opioid-Induced Constipation. Advances in Therapy 31:12, pages 1263-1271.
Crossref
Crossref
. (2014) Opioid-induced constipation: effects on work productivity, QOL. PharmacoEconomics & Outcomes News 704:1, pages 8-8.
Crossref
Crossref