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Review

Efficacy and safety of bazedoxifene for postmenopausal osteoporosis

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Pages 151-160 | Published online: 21 Jun 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Moon Hee Lee, Seok-Kyu Yoon, Hyungsub Kim, Yong-Soon Cho, Sungpil Han, Shi Hyang Lee, Kyun-Seop Bae, Jina Jung, Sung Hee Hong & Hyeong-Seok Lim. (2023) Pharmacokinetic Interactions Between Bazedoxifene and Cholecalciferol: An Open-Label, Randomized, Crossover Study in Healthy Male Volunteers. Drug Design, Development and Therapy 17, pages 1107-1114.
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Alexandra G. Ellis, Jean-Yves Reginster, Xuemei Luo, Andrew G. Bushmakin, Robert Williams, Santosh Sutradhar, Sebastian Mirkin & Jeroen P. Jansen. (2014) Indirect comparison of bazedoxifene vs oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women. Current Medical Research and Opinion 30:8, pages 1617-1626.
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Loredana Cavalli & Maria Luisa Brandi. (2012) Targeted approaches in the treatment of osteoporosis: differential mechanism of action of denosumab and clinical utility. Therapeutics and Clinical Risk Management 8, pages 253-266.
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Articles from other publishers (20)

Masato Okano, Mitsuhiko Sato & Shinji Kageyama. (2022) Detection of bazedoxifene, a selective estrogen receptor modulator, in human urine by liquid chromatography‐tandem mass spectrometry. Drug Testing and Analysis 14:11-12, pages 1995-2001.
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Yunkyung Jeon & In-Joo Kim. (2022) Pharmacological treatment of osteoporosis: 2022 update. Journal of the Korean Medical Association 65:4, pages 241-248.
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Jing Li, Yi Zhang, Jing Sun, Leyuan Chen, Wenfeng Gou, Chi‐Wei Chen, Yuan Zhou, Zhuqing Li, David W. Chan, Ruili Huang, Huadong Pei, Wei Zheng, Yiliang Li, Menghang Xia & Wenge Zhu. (2021) Discovery and characterization of potent And‐1 inhibitors for cancer treatment. Clinical and Translational Medicine 11:12.
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Jae Nam Yun, Hye‐Su Kan, Ji‐Sun Yeun, Jae‐Hoon Kim, Minyu Lee, Namsick Kim, Tae‐Young Oh, Seung‐Kwan Nam, Yoon Seok Choi, In Sun Kwon, Kwang Lae Hoe & Jang Hee Hong. (2021) Bioequivalence for a Fixed‐Dose Combination Formulation of Bazedoxifene and Cholecalciferol Compared With the Corresponding Single Entities Given Together. Clinical Pharmacology in Drug Development 10:8, pages 850-858.
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Nuno A. Padrão, Isabel Mayayo-Peralta & Wilbert Zwart. (2020) Targeting mutated estrogen receptor alpha: Rediscovering old and identifying new therapeutic strategies in metastatic breast cancer treatment. Current Opinion in Endocrine and Metabolic Research 15, pages 43-48.
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Pauline M. Camacho, Steven M. Petak, Neil Binkley, Dima L. Diab, Leslie S. Eldeiry, Azeez Farooki, Steven T. Harris, Daniel L. Hurley, Jennifer Kelly, E. Michael Lewiecki, Rachel Pessah-Pollack, Michael McClung, Sunil J. Wimalawansa & Nelson B. Watts. (2020) American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis—2020 Update. Endocrine Practice 26, pages 1-46.
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Yilin Zhu, Zhonglian Huang, Yan Wang, Weicai Xu, Hongjiang Chen, Jiankun Xu, Shaowei Luo, Yuantao Zhang, Di Zhao & Jun Hu. (2020) The efficacy and safety of denosumab in postmenopausal women with osteoporosis previously treated with bisphosphonates: A review. Journal of Orthopaedic Translation 22, pages 7-13.
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Ji-Sun Yeun, Hye-Su Kan, Minyu Lee, Namsick Kim, Tae-Young Oh, Seung-Kwan Nam, Yoon Seok Choi, In Sun Kwon & Jang Hee Hong. (2020) Pharmacokinetic comparison of two bazedoxifene acetate 20 mg tablet formulations in healthy Korean male volunteers. Translational and Clinical Pharmacology 28:2, pages 102.
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Haiyan Ma, Dan Yan, Yina Wang, Wei Shi, Tianshu Liu, Chongqiang Zhao, Shengqi Huo, Jialin Duan, Jingwen Tao, Maocai Zhai, Pengcheng Luo, Junyi Guo, Lei Tian, Lulu Mageta, David Jou, Cuntai Zhang, Chenglong Li, Jiayuh Lin, Jiagao Lv, Sheng Li & Li Lin. (2019) Bazedoxifene exhibits growth suppressive activity by targeting interleukin-6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma. Cancer Science 110:3, pages 950-961.
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Suzanne E Wardell, John D Norris & Donald P McDonnell. (2019) Targeting mutant estrogen receptors. eLife 8.
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Xiao-Feng Li, Chun-Bo Lin, Fu-Rong Xie, Wei-Guo Liang, Jing Ji & Yuan Yang. (2016) Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats. American Journal of Therapeutics 23:6, pages e1630-e1636.
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Tina Trdan Lušin, Aleš Mrhar, Bruno Stieger, Albin Kristl, Katja Berginc & Jurij Trontelj. (2015) Efflux and uptake transporters involved in the disposition of bazedoxifene. European Journal of Drug Metabolism and Pharmacokinetics 41:3, pages 251-257.
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Yu Cong, Jiang-Ying Ru, Ni-Rong Bao, Ting Guo & Jian-Ning Zhao. (2014) A single nucleotide polymorphism in the TGF-β1 gene (rs1982073 C>T) may contribute to increased risks of bone fracture, osteoporosis, and osteoarthritis: a meta-analysis. Clinical Rheumatology 35:4, pages 973-985.
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J.Y. Reginster, A. Neuprez, N. Dardenne, C. Beaudart, P. Emonts & O. Bruyere. (2014) Efficacy and safety of currently marketed anti-osteoporosis medications. Best Practice & Research Clinical Endocrinology & Metabolism 28:6, pages 809-834.
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Alexandra G. Ellis, Jean-Yves Reginster, Xuemei Luo, Joseph C. Cappelleri, Arkadi Chines, Santosh Sutradhar & Jeroen P. Jansen. (2014) Bazedoxifene versus Oral Bisphosphonates for the Prevention of Nonvertebral Fractures in Postmenopausal Women with Osteoporosis at Higher Risk of Fracture: A Network Meta-Analysis. Value in Health 17:4, pages 424-432.
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Erik R. Nelson, Suzanne E. Wardell & Donald P. McDonnell. (2013) The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: Implications for the treatment and prevention of osteoporosis. Bone 53:1, pages 42-50.
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Russell E. McDaniel, Philipp Y. Maximov & V. Craig Jordan. 2013. Hormones and Breast Cancer. Hormones and Breast Cancer 1 49 .
Anja Schäfer, Anja Wellner, Martin Strauss, Andreas Schäfer, Gerhard Wolber & Ronald Gust. (2012) Influence of Chlorine or Fluorine Substitution on the Estrogenic Properties of 1-Alkyl-2,3,5-tris(4-hydroxyphenyl)-1 H -pyrroles . Journal of Medicinal Chemistry 55:22, pages 9607-9618.
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Zhonghui Li, Ming Yan, Zhoumin Li, Maika Vuki, Dan Wu, Fei Liu, Wenying Zhong, Luyong Zhang & Danke Xu. (2012) A multiplexed screening method for agonists and antagonists of the estrogen receptor protein. Analytical and Bioanalytical Chemistry 403:5, pages 1373-1384.
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Tina Trdan Lušin, Tihomir Tomašić, Jurij Trontelj, Aleš Mrhar & Lucija Peterlin-Mašič. (2012) In vitro bioactivation of bazedoxifene and 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol in human liver microsomes. Chemico-Biological Interactions 197:1, pages 8-15.
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