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The NordiNet® International Outcome Study and NovoNet® ANSWER Program®: rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therapy (Norditropin®)

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Pages 119-127 | Published online: 26 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Richard F Pollock, Anne-Marie Kappelgaard & Lisa Seitz. (2015) An analysis of product wastage arising from dosing increment granularity in four modern growth hormone administration devices. Expert Opinion on Drug Delivery 12:3, pages 353-360.
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Richard F Pollock, Yujun Qian, Tami Wisniewski, Lisa Seitz & Anne-Marie Kappelgaard. (2013) Product wastage from modern human growth hormone administration devices: a laboratory and computer simulation analysis. Medical Devices: Evidence and Research 6, pages 107-114.
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Articles from other publishers (27)

Beverly M K Biller, Charlotte Höybye, Jean-Marc Ferran, Nicky Kelepouris, Navid Nedjatian, Anne Helene Olsen, Matthias M Weber & Murray B Gordon. (2023) Long-term Effectiveness and Safety of GH Replacement Therapy in Adults ≥60 Years: Data From NordiNet® IOS and ANSWER. Journal of the Endocrine Society 7:6.
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Philippe Backeljauw, Joanne C Blair, Jean-Marc Ferran, Nicky Kelepouris, Bradley S Miller, Alberto Pietropoli, Michel Polak, Lars Sävendahl, Franciska Verlinde & Tilman R Rohrer. (2023) Early GH Treatment Is Effective and Well Tolerated in Children With Turner Syndrome: NordiNet® IOS and Answer Program. The Journal of Clinical Endocrinology & Metabolism.
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Judith Ross, Moshe Fridman, Nicky Kelepouris, Kristine Murray, Nils Krone, Michel Polak, Tilman R Rohrer, Alberto Pietropoli, Neil Lawrence & Philippe Backeljauw. (2023) Factors Associated With Response to Growth Hormone in Pediatric Growth Disorders: Results of a 5-year Registry Analysis. Journal of the Endocrine Society 7:5.
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Parisa Eslami, Fatemeh Sayarifard, Reza Safdari, Leila Shahmoradi & Zahra Karbasi. (2022) Global perspective on pediatric growth hormone registries: a systematic review. Journal of Pediatric Endocrinology and Metabolism 35:6, pages 709-726.
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Tal Ben-Ari, Gabriel Chodick, Varda Shalev, Dalit Goldstein, Roy Gomez & Zohar Landau. (2021) Real-World Treatment Patterns and Outcomes of Growth Hormone Treatment Among Children in Israel Over the Past Decade (2004–2015). Frontiers in Pediatrics 9.
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Beverly M. K. Biller, Charlotte Höybye, Paul Carroll, Murray B. Gordon, Anna Camilla Birkegård, Nicky Kelepouris, Navid Nedjatian & Matthias M. Weber. (2021) Pregnancy outcomes in women receiving growth hormone replacement therapy enrolled in the NordiNet® International Outcome Study (IOS) and the American Norditropin® Studies: Web-Enabled Research (ANSWER) Program. Pituitary 24:4, pages 611-621.
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Lars Sävendahl, Michel Polak, Philippe Backeljauw, Joanne C Blair, Bradley S Miller, Tilman R Rohrer, Anita Hokken-Koelega, Alberto Pietropoli, Nicky Kelepouris & Judith Ross. (2021) Long-Term Safety of Growth Hormone Treatment in Childhood: Two Large Observational Studies: NordiNet IOS and ANSWER. The Journal of Clinical Endocrinology & Metabolism 106:6, pages 1728-1741.
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Moris Angulo, M. Jennifer Abuzzahab, Alberto Pietropoli, Vlady Ostrow, Nicky Kelepouris & Maithe Tauber. (2020) Outcomes in children treated with growth hormone for Prader-Willi syndrome: data from the ANSWER Program® and NordiNet® International Outcome Study. International Journal of Pediatric Endocrinology 2020:1.
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Bradley S. Miller, Judith Ross & Vlady Ostrow. (2020) Height outcomes in children with growth hormone deficiency and idiopathic short stature treated concomitantly with growth hormone and aromatase inhibitor therapy: data from the ANSWER program. International Journal of Pediatric Endocrinology 2020:1.
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Matthias M. Weber, Murray B. Gordon, Charlotte Höybye, Jens Otto L. Jørgensen, Gediminas Puras, Vera Popovic-Brkic, Mark E. Molitch, Vlady Ostrow, Natalia Holot, Alberto Pietropoli & Beverly M.K. Biller. (2020) Growth hormone replacement in adults: Real-world data from two large studies in US and Europe. Growth Hormone & IGF Research 50, pages 71-82.
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Lars Sävendahl, Michel Polak, Philippe Backeljauw, Jo Blair, Bradley S Miller, Tilman R Rohrer, Alberto Pietropoli, Vlady Ostrow & Judith Ross. (2019) Treatment of Children With GH in the United States and Europe: Long-Term Follow-Up From NordiNet® IOS and ANSWER Program. The Journal of Clinical Endocrinology & Metabolism 104:10, pages 4730-4742.
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Young-Jun Rhie, Jae-Ho Yoo, Jin-Ho Choi, Hyun-Wook Chae, Jae Hyun Kim, Sochung Chung, Il Tae Hwang, Choong Ho Shin, Eun Young Kim & Ho-Seong Kim. (2019) Long-term safety and effectiveness of growth hormone therapy in Korean children with growth disorders: 5-year results of LG Growth Study. PLOS ONE 14:5, pages e0216927.
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G. Migliaretti, S. Ditaranto, C. Guiot, S. Vannelli, P. Matarazzo, N. Cappello, I. Stura & F. Cavallo. (2018) Long-term response to recombinant human growth hormone treatment: a new predictive mathematical method. Journal of Endocrinological Investigation 41:7, pages 839-848.
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Michel Polak, Daniel Konrad, Birgitte Tønnes Pedersen, Gediminas Puras & Marta Šnajderová. (2018) Still too little, too late? Ten years of growth hormone therapy baseline data from the NordiNet ® International Outcome Study . Journal of Pediatric Endocrinology and Metabolism 31:5, pages 521-532.
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Kirstine Stochholm & Wieland Kiess. (2018) Long-term safety of growth hormone-A combined registry analysis. Clinical Endocrinology 88:4, pages 515-528.
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Sochung Chung, Jae-Ho Yoo, Jin Ho Choi, Young-Jun Rhie, Hyun-Wook Chae, Jae Hyun Kim, Il Tae Hwang, Choong Ho Shin, Eun Young Kim & Kee-Hyoung Lee. (2018) Design of the long-term observational cohort study with recombinant human growth hormone in Korean children: LG Growth Study. Annals of Pediatric Endocrinology & Metabolism 23:1, pages 43-50.
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Charlotte Höybye, Matthias M. Weber, Effie Pournara, Birgitte Tønnes Pedersen & Beverly M. K. Biller. (2017) Is GH dosing optimal in female patients with adult-onset GH deficiency? An analysis from the NordiNet ® International Outcome Study . Clinical Endocrinology 86:6, pages 798-805.
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Matthias M. Weber, Beverly M.K. Biller, Birgitte Tønnes Pedersen, Effie Pournara, Jens Sandahl Christiansen & Charlotte Höybye. (2016) The effect of growth hormone ( GH ) replacement on blood glucose homeostasis in adult nondiabetic patients with GH deficiency: real‐life data from the NordiNet ® International Outcome Study . Clinical Endocrinology 86:2, pages 192-198.
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Ulla Feldt-Rasmussen & Marianne Klose. (2016) Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients. Endocrine 54:1, pages 15-23.
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Henrik Thybo Christesen, Birgitte Tønnes Pedersen, Effie Pournara, Isabelle Oliver Petit & Pétur Benedikt Júlíusson. (2016) Short Stature: Comparison of WHO and National Growth Standards/References for Height. PLOS ONE 11:6, pages e0157277.
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Lars Sävendahl, Effie Pournara, Birgitte Tønnes Pedersen & Oliver Blankenstein. (2016) Is safety of childhood growth hormone therapy related to dose? Data from a large observational study. European Journal of Endocrinology 174:5, pages 681-691.
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MurrayB. Gordon, RichardA. Levy, Robert. Gut & John. Germak. (2016) Trends In Growth Hormone Stimulation Testing And Growth Hormone Dosing In Adult Growth Hormone Deficiency Patients: Results From The Answer Program. Endocrine Practice 22:4, pages 396-405.
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Peter A. Lee, Judith L. Ross, Birgitte Tønnes Pedersen, Primoz Kotnik, John A. Germak & Henrik T. Christesen. (2015) Noonan syndrome and Turner syndrome patients respond similarly to 4 years’ growth-hormone therapy: longitudinal analysis of growth-hormone-naïve patients enrolled in the NordiNet® International Outcome Study and the ANSWER Program. International Journal of Pediatric Endocrinology 2015:1.
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Judith L Ross, Peter A Lee, Robert Gut & John Germak. (2015) Increased height standard deviation scores in response to growth hormone therapy to near-adult height in older children with delayed skeletal maturation: results from the ANSWER Program. International Journal of Pediatric Endocrinology 2015:1.
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Susan R. Rose, Grafton Reeves, Robert Gut & John Germak. (2015) Attention-Deficit/Hyperactivity Disorder Medication Treatment Impact on Response to Growth Hormone Therapy: Results from the ANSWER Program, a Non-Interventional Study. The Journal of Pediatrics 167:6, pages 1389-1396.
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Judith L. Ross, Peter A. Lee, Robert Gut & John Germak. (2015) Attaining genetic height potential: Analysis of height outcomes from the ANSWER Program in children treated with growth hormone over 5 years. Growth Hormone & IGF Research 25:6, pages 286-293.
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Oliver Blankenstein, Birgitte Tønnes Pedersen, Michael Schlumpf, Arne Haahr Andreasen & Pétur Benedikt Júlíusson. (2015) Management and interpretation of heterogeneous observational data: Using insulin-like growth factor-I data from the NordiNet® International Outcome Study. Growth Hormone & IGF Research 25:1, pages 41-46.
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