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Original Research

SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis

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Pages 4459-4470 | Published online: 10 Oct 2018

Keep up to date with the latest research on this topic with citation updates for this article.

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Yahui Jiang & Yunhao Tang. (2024) SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2. Nucleosides, Nucleotides & Nucleic Acids 43:3, pages 249-263.
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Tao Tian, Xiangyang Fu, Liangliang Hu, Xiaofeng Yang, Peng Sun & Fengfeng Sun. (2021) FAST1 Predicts Poor Survival of Renal Carcinoma and Promotes Its Progression Through the TGF-β/Smad Pathway. OncoTargets and Therapy 14, pages 1487-1499.
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Wei Hu, Xin Zheng, Jun Liu, Min Zhang, Yan Liang & Ming Song. (2021) MicroRNA MiR-130a-3p promotes gastric cancer by targeting Glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the TGF-β1/SMAD3 pathway. Bioengineered 12:2, pages 11634-11647.
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Yin-Ju Chen, Joseph T Chang, Guo-Rung You, Chun-Yu Huang, Kang-Hsing Fan & Ann-Joy Cheng. (2021) Panel Biomarkers Associated with Cancer Invasion and Prognostic Prediction for Head–Neck Cancer. Biomarkers in Medicine 15:11, pages 861-877.
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Jutang Li, Wei Dong, Qixia Jiang, Fenglian Zhang & Hui Dong. (2021) LINC00668 cooperated with HuR dependent upregulation of PKN2 to facilitate gastric cancer metastasis. Cancer Biology & Therapy 22:4, pages 311-323.
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Articles from other publishers (48)

Tairan Wang, Yan Jin, Mengyao Wang, Boya Chen, Jinyu Sun, Jiaying Zhang, Hui Yang, Xinyao Deng, Xingyue Cao, Lidong Wang & Yuanyuan Tang. (2024) SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms. Molecular Medicine 30:1.
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Zikai Fan, Xiaoyun Xu, Rong Wang, Zhi Meng, Luochun Wang, Xinde Cao & Ziyang Lou. (2023) Distribution and Source Resolution of Heavy Metals in an Electroplating Site and Their Health Risk Assessment. Sustainability 15:16, pages 12166.
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Fatma A. Abouelnazar, Xiaoxin Zhang, Jiahui Zhang, Maoye Wang, Dan Yu, Xueyan Zang, Jiayin Zhang, Yixin Li, Jing Xu, Qiurong Yang, Yue Zhou, Haozhou Tang, Yanzheng Wang, Jianmei Gu & Xu Zhang. (2023) SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression. Cancer Cell International 23:1.
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Chenfei Zhou, Liting Guo, Qu Cai, Wenqi Xi, Fei Yuan, Huan Zhang, Chao Yan, Lei Huang, Zhenggang Zhu & Jun Zhang. (2023) Circulating neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy. Frontiers in Molecular Biosciences 10.
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Si-yu Wang, Yu-xin Wang, Ao Shen, Rui Jian, Nan An & Shu-qiang Yuan. (2023) Construction and validation of a prognostic prediction model for gastric cancer using a series of genes related to lactate metabolism. Heliyon 9:5, pages e16157.
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Fatma A. Abouelnazar, Xiaoxin Zhang, Maoye Wang, Jiahui Zhang, Dan Yu, Xueyan Zang, Jiayin Zhang, Yixin Li, Jing Xu, Qiurong Yang, Yue Zhou, Haozhou Tang, Yanzheng Wang, Jianmei Gu & Xu Zhang. (2023) The new advance of SALL4 in cancer: Function, regulation, and implication . Journal of Clinical Laboratory Analysis 37:9-10.
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Lei Ren, Hong Deng, Yu Jiang & Chunfeng Liu. (2023) Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer. Digestive Diseases and Sciences 68:4, pages 1292-1305.
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Qing‐Dong Wang, Li‐Li Liu, Di Li, Li Gao & Mei‐Jia Zhang. (2022) Salt‐like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin‐specific protease 21 to stabilize Yin Yang 1. Pathology International 73:3, pages 109-119.
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Angélique Vienot, Franck Monnien, Caroline Truntzer, Virginie Mougey, Adeline Bouard, Jean‐René Pallandre, Chloé Molimard, Romain Loyon, Kamal Asgarov, Gerlinde Averous, François Ghiringhelli, Frédéric Bibeau, Paul Peixoto & Christophe Borg. (2023) SALL4 ‐related gene signature defines a specific stromal subset of pancreatic ductal adenocarcinoma with poor prognostic features . Molecular Oncology.
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Xiangfei Sun, Qiang Zhang, Ping Shu, Xiaohan Lin, Xiaodong Gao & Kuntang Shen. (2023) COLEC12 Promotes Tumor Progression and Is Correlated With Poor Prognosis in Gastric Cancer. Technology in Cancer Research & Treatment 22.
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Zhiwen Yang, Xinlin Wu, Junjie Shen, A. Gudamu, Yongxiang Ma, Zishu Zhang & Mingxing Hou. (2022) Ginsenoside Rh1 regulates gastric cancer cell biological behaviours and transplanted tumour growth in nude mice via the TGF ‐β/Smad pathway . Clinical and Experimental Pharmacology and Physiology 49:12, pages 1270-1280.
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Zhengwo Jia, Xiaofang Tang, Xicheng Zhang, Jingen Shen, Yuanlong Sun & Lifen Qian. (2022) miR-153-3p Attenuates the Development of Gastric Cancer by Suppressing SphK2. Biochemical Genetics 60:5, pages 1748-1761.
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Mohammad Mahdi Forghanifard & Somayeh Salehi. (2022) Co-overexpression of self-renewal markers SALL4 and HIWI is correlated with depth of tumor invasion and metastasis in colorectal cancer. Egyptian Journal of Medical Human Genetics 23:1.
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Wenjuan Zhang, Yan Hu, Wenbing Zhang, Ke Yi, Xiaohui Xu & Zhihua Chen. (2022) The Invasion and Metastasis of Colon Adenocarcinoma (COAD) Induced by SALL4. Journal of Immunology Research 2022, pages 1-11.
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Crossref
Jing Ge, Tao Han, Lili Shan, Jing Na, Ya Li & Jun Wang. (2020) Long non-coding RNA THOR promotes ovarian Cancer cells progression via IL-6/STAT3 pathway. Journal of Ovarian Research 13:1.
Crossref
Meng Shao, Jiayin Zhang, Jiahui Zhang, Hui Shi, Yu Zhang, Runbi Ji, Fei Mao, Hui Qian, Wenrong Xu & Xu Zhang. (2020) SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis. Cancer Cell International 20:1.
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Xiqiang Xu & Mengmeng Liu. (2019) miR‐522 stimulates TGF‐β/Smad signaling pathway and promotes osteosarcoma tumorigenesis by targeting PPM1A. Journal of Cellular Biochemistry 120:10, pages 18425-18434.
Crossref
Jun Shan Ruan, Huan Zhou, Lin Yang, Ling Wang, Zong Sheng Jiang, Hong Sun & Shao Ming Wang. (2019) Ursolic Acid Attenuates TGF-β1-Induced Epithelial‐Mesenchymal Transition in NSCLC by Targeting Integrin αVβ5/MMPs Signaling. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27:5, pages 593-600.
Crossref
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Crossref
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Crossref
Aida Giner de Gracia, Cruz Morenilla-Palao, María Teresa López-Cascales, Gerald Muça, Angel Barco & Eloísa Herrera. (2021) Deregulation of the Epithelial-to-Mesenchymal Transition Process Underlies Zic2-Linked Holoprosencephaly. SSRN Electronic Journal.
Crossref